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11. 发明授权

US08679313B2 Method and apparatus for concentrating molecules 有权
标题翻译：浓缩分子的方法和装置
公开(公告)号：US08679313B2
公开(公告)日：2014-03-25
申请号：US12689978
申请日：2010-01-19
申请人： Jason O. Fiering , Mark Keegan
发明人： Jason O. Fiering , Mark Keegan
IPC分类号： B01D57/02
CPC分类号： G01N27/44769
摘要： A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules.
摘要翻译：用于连续分离或浓缩分子的方法和装置，其包括使层流中的两种流体流过电场并在三个输出中的一个输出处捕获具有不同浓度分子的流体流。

12. 发明申请

US20120264224A1 SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER 有权
标题翻译：微流量计的系统和方法
公开(公告)号：US20120264224A1
公开(公告)日：2012-10-18
申请号：US13350022
申请日：2012-01-13
申请人： Jason O. Fiering , Dale Larson , Gregory Kowalski , Mehmet Sen
发明人： Jason O. Fiering , Dale Larson , Gregory Kowalski , Mehmet Sen
IPC分类号： G01N25/48 , G01N25/00
CPC分类号： G01N25/482 , B82Y15/00 , G01K17/006 , G01N21/05 , G01N21/554 , G01N25/4873 , G01N2021/0346
摘要： Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.
摘要翻译：本文公开了用于微流量计量计装置的系统和方法。微流量计量计系统包括量热法装置和与装置相关的处理器。该装置包括连接到两个入口的微流体层流通道，用于将流体流入层流通道。在层流通道下面是通道中已知位置处的多个微型温度传感器。该处理器与离散的温度传感器相关联，并且基于由微型温度传感器输出的数据和通道中传感器的相应位置导出的局部温度来确定量热测量。

13. 发明申请

US20100323916A1 High-Throughput Biological Screening 有权
标题翻译：高通量生物筛选
公开(公告)号：US20100323916A1
公开(公告)日：2010-12-23
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
IPC分类号： C40B30/06 , C40B60/12
CPC分类号： C12M23/12 , C12M35/04
摘要： In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.
摘要翻译：在一个实施例中，高通量流量系统包括井的阵列和位于每个井内的单独的机械末端。每个机械末端分别致动以赋予剪切应力模式。

14. 发明申请

US20080249510A1 MEMBRANE-BASED FLUID CONTROL IN MICROFLUIDIC DEVICES 有权
标题翻译：微流控器件中基于膜的流体控制
公开(公告)号：US20080249510A1
公开(公告)日：2008-10-09
申请号：US12023653
申请日：2008-01-31
申请人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
发明人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
IPC分类号： A61M5/148 , B01L3/00 , B81B3/00 , F15C3/04 , F16K7/16 , A61K9/22
CPC分类号： F16K99/0015 , A61M5/141 , A61M5/14276 , A61M5/16809 , A61M5/16813 , A61M31/002 , A61M39/22 , A61M2039/226 , A61M2205/0244 , A61M2206/22 , F16K99/0001 , F16K99/0034 , F16K99/0042 , F16K99/0055 , F16K2099/0069 , F16K2099/0076 , F16K2099/008 , F16K2099/0088 , G05D7/0113 , G05D7/012 , Y10T137/0318 , Y10T137/0396
摘要： A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.
摘要翻译：微流体装置可以包括限定流量控制腔的衬底和与流量控制腔流体连通的第一和第二通道。用于调节通过流动控制腔的流体流动的柔性膜可以围绕流动控制腔的至少一部分。

15. 发明授权

US09184496B2 Inductors having fluidic constructs that permit reconfiguration of the inductors 有权
标题翻译：具有允许重新配置电感器的流体结构的电感器
公开(公告)号：US09184496B2
公开(公告)日：2015-11-10
申请号：US13252695
申请日：2011-10-04
申请人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Brian R. Smith
发明人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Brian R. Smith
IPC分类号： H01Q1/00 , H01Q1/36 , H01Q3/01 , H01Q3/44
CPC分类号： H01Q1/364 , H01Q3/01 , H01Q3/44
摘要： In various embodiments, an inductance of an inductor is tuned by adjusting a position of a conductor and/or a magnetic material with respect to a conducting wire of the inductor, thereby changing the electro-magnetic characteristics of the conducting wire. The conductor and/or magnetic material can be disposed in a microfluidic channel and can be moved within the microfluidic channel using a suitable actuator mechanism.
摘要翻译：在各种实施例中，通过相对于电感器的导线调节导体和/或磁性材料的位置来调节电感器的电感，由此改变导线的电磁特性。导体和/或磁性材料可以设置在微流体通道中并且可以使用合适的致动器机构在微流体通道内移动。

16. 发明授权

US09180054B2 Drug delivery apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US09180054B2
公开(公告)日：2015-11-10
申请号：US12986067
申请日：2011-01-06
申请人： Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , Michael J. McKenna , William F. Sewell
发明人： Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , Michael J. McKenna , William F. Sewell
IPC分类号： A61M11/00 , A61M31/00 , A61M5/142 , A61F11/00
CPC分类号： A61F11/002 , A61M5/14216 , A61M5/14224 , A61M5/14276 , A61M31/002 , A61M2205/0244 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译：一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。流体可以包含体液，例如外淋巴液和药物。该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。

17. 发明申请

US20130048565A1 SYSTEM AND METHOD FOR BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING 有权
标题翻译：通过微流体声学聚焦进行血液分离的系统和方法
公开(公告)号：US20130048565A1
公开(公告)日：2013-02-28
申请号：US13598401
申请日：2012-08-29
申请人： Jason O. FIERING , Shivshankar Sundaram
发明人： Jason O. FIERING , Shivshankar Sundaram
IPC分类号： A61M1/36 , B01J39/00 , B01D29/00 , B01D12/00 , B01D15/00
CPC分类号： A61M1/3693 , A61M1/362 , B01D21/283 , B01D2221/10 , G01N33/491
摘要： Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.
摘要翻译：本文公开了用于清洗血液的系统和方法。所述方法包括将结合到捕获颗粒的不需要的颗粒与形成的全血的元素进行声学分离。在将捕获颗粒引入含有不需要的颗粒的全血之后，全血和捕获颗粒流过微流体分离通道。至少一个体声换能器连接到微流体分离通道。通过体声换能器在通道及其内容物上施加的声波驱动所形成的元件和结合以将颗粒捕获到特定聚集轴的不期望的颗粒。在聚集颗粒之后，形成的元件通过第一出口离开分离通道并返回给患者。与捕获颗粒结合的不需要的颗粒通过第二个出口排出，可以丢弃以保存以备后续研究。

18. 发明授权

US09731062B2 System and method for blood separation by microfluidic acoustic focusing 有权
公开(公告)号：US09731062B2
公开(公告)日：2017-08-15
申请号：US13598401
申请日：2012-08-29
申请人： Jason O. Fiering , Shivshankar Sundaram
发明人： Jason O. Fiering , Shivshankar Sundaram
IPC分类号： A61M1/36 , B01J39/00 , B01D29/00 , B01D12/00 , B01D15/00 , B01D21/28 , G01N33/49
CPC分类号： A61M1/3693 , A61M1/362 , B01D21/283 , B01D2221/10 , G01N33/491
摘要： Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

19. 发明授权

US09377422B2 System and method for a microfluidic calorimeter 有权
标题翻译：微流量计的系统和方法
公开(公告)号：US09377422B2
公开(公告)日：2016-06-28
申请号：US13350022
申请日：2012-01-13
申请人： Jason O. Fiering , Dale Larson , Gregory Kowalski , Mehmet Sen
发明人： Jason O. Fiering , Dale Larson , Gregory Kowalski , Mehmet Sen
IPC分类号： G01N25/48 , G01N25/00 , B82Y15/00 , G01K17/00 , G01N21/05 , G01N21/552 , G01N21/03
CPC分类号： G01N25/482 , B82Y15/00 , G01K17/006 , G01N21/05 , G01N21/554 , G01N25/4873 , G01N2021/0346
摘要： Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.
摘要翻译：本文公开了用于微流量计量计装置的系统和方法。微流量计量计系统包括量热法装置和与装置相关的处理器。该装置包括连接到两个入口的微流体层流通道，用于将流体流入层流通道。在层流通道下面是通道中已知位置处的多个微型温度传感器。该处理器与离散的温度传感器相关联，并且基于由微型温度传感器输出的数据和通道中传感器的相应位置导出的局部温度来确定量热测量。

20. 发明授权

US09156037B2 Microfluidic device and uses thereof 有权
标题翻译：微流体装置及其用途
公开(公告)号：US09156037B2
公开(公告)日：2015-10-13
申请号：US13144572
申请日：2010-01-15
申请人： Chong Wing Yung , Donald E. Ingber , Jason O. Fiering , Mathew Varghese
发明人： Chong Wing Yung , Donald E. Ingber , Jason O. Fiering , Mathew Varghese
IPC分类号： C12Q1/68 , B03C1/01 , B03C1/28 , G01N33/543 , G01N1/40
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.
摘要翻译：用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。收集通道可以包括滞留的收集流体，直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分离开收集渠道。随后分析目标成分进行检测和诊断。

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