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11. 发明授权

US08066727B2 Methods and devices for cutting and collecting soft tissue 失效
标题翻译：切割和收集软组织的方法和装置
公开(公告)号：US08066727B2
公开(公告)日：2011-11-29
申请号：US11742391
申请日：2007-04-30
申请人： James W. Vetter , Ary S. Chernomorsky , Mark J. Clifford , Daniel M. Brounstein , Scott C. Anderson
发明人： James W. Vetter , Ary S. Chernomorsky , Mark J. Clifford , Daniel M. Brounstein , Scott C. Anderson
IPC分类号： A61B17/32 , A61B17/22
CPC分类号： A61B10/0266 , A61B2017/00287 , A61B2017/008 , A61B2018/1407
摘要： A method of cutting breast tissue for removal may include a step of providing a tissue cutting device having an elongate cutting element, the cutting element being movable between a bowed position and a retracted position, the cutting element having a radially outer side and a radially inner side. The tissue cutting device may be introduced into a breast and the elongate cutting element may be moved to the bowed position. A power source may be coupled to the elongate cutting element; and the cutting element may be rotated after the moving step so that the cutting element cuts the breast tissue. The radially outer side of the cutting element may have a larger surface area for transmitting energy to cut the tissue than the radially inner side.
摘要翻译：切割乳房组织以便去除的方法可以包括提供具有细长切割元件的组织切割装置的步骤，所述切割元件可在弓形位置和缩回位置之间移动，所述切割元件具有径向外侧和径向内部侧。组织切割装置可以被引入到乳房中，并且细长切割元件可以移动到弓形位置。电源可以耦合到细长切割元件; 并且切割元件可以在移动步骤之后旋转，使得切割元件切割乳房组织。切割元件的径向外侧可以具有比径向内侧更大的用于传递切割组织的能量的表面积。

12. 发明授权

US07553310B2 Methods and systems for in situ tissue marking and orientation stabilization 失效
标题翻译：用于原位组织标记和取向稳定的方法和系统
公开(公告)号：US07553310B2
公开(公告)日：2009-06-30
申请号：US10871790
申请日：2004-06-17
申请人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
发明人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
IPC分类号： A61B18/18
CPC分类号： A61B10/0266 , A61B18/148 , A61B2018/00333 , A61B2018/00601 , A61B2018/141 , A61B2018/1475 , A61B2090/3908 , A61B2090/3937 , A61B2090/395
摘要： A method of marking an orientation of a cut specimen of tissue prior to excision thereof from a body includes steps of disposing a tissue-marking probe in the body adjacent the cut specimen, the tissue-marking probe including a tissue-marking tool configured to selectively mark the cut specimen. A surface of the cut specimen is then marked with the tissue-marking tool such that the orientation of the cut specimen within the body is discernable after the cut specimen is excised from the body. The tissue-marking tool may be configured to selectively bow out of and back into a window defined near a distal tip of the probe and the marking step may include a step of selectively bowing the tissue-marking tool out of the window and following the surface of the cut specimen while rotating the probe. The tissue-marking tool may include an RF cutting tool and the marking step may include a step of coagulating or cauterizing a selected portion of the surface of the cut specimen with the RF cutting tool. Alternatively, the marking step may include a step of delivering dye onto selected portions of the surface of the cut specimen.
摘要翻译：在从身体切除之前标记组织切割样本的取向的方法包括以下步骤：将组织标记探针设置在与切割的样本相邻的身体中，组织标记探针包括组织标记工具，其被配置为选择性地标记切割标本。然后用组织标记工具标记切割的样品的表面，使得在切割的样品从身体切除之后，切割的样品在体内的取向是可辨别的。组织标记工具可以被配置为选择性地弯曲到限定在探针的远侧末端附近的窗口中，并且标记步骤可以包括将组织标记工具选择性地弯曲出窗户并且跟随表面的步骤同时旋转探头。组织标记工具可以包括RF切割工具，并且标记步骤可以包括用RF切割工具凝固或烧灼切割样品表面的选定部分的步骤。或者，标记步骤可以包括将染料递送到切割样品的表面的选定部分上的步骤。

13. 发明授权

US07537788B2 Post-biopsy cavity treatment implants and methods 失效
标题翻译：活检后腔内治疗植入物和方法
公开(公告)号：US07537788B2
公开(公告)日：2009-05-26
申请号：US10688289
申请日：2003-10-16
申请人： Ary S. Chernomorsky , James W. Vetter , Simon Chernomorsky
发明人： Ary S. Chernomorsky , James W. Vetter , Simon Chernomorsky
IPC分类号： A61K33/00 , A61K9/24
CPC分类号： A61L31/146 , A61B17/0057 , A61B90/39 , A61B2017/00654 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/04 , A61L31/18
摘要： A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix defining a first controlled pore architecture. The shell portion is coupled to the core portion and includes a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture.
摘要翻译：活检后腔治疗植入物包括不透射线元件，芯部分和壳部分。芯部分耦合到不透射线的元件，并且包括限定第一受控孔结构的第一多孔基体。壳部分耦合到芯部分并且包括限定与第一受控孔结构不同的第二受控孔结构的第二多孔基质。

14. 发明申请

US20080287967A1 Device and Methods for Suturing Tissue 审中-公开
标题翻译：缝合组织的装置和方法
公开(公告)号：US20080287967A1
公开(公告)日：2008-11-20
申请号：US12182836
申请日：2008-07-30
申请人： Bernard H. Andreas , Michael Barrett , Mark J. Foley , Brian gore , Lewis Isbell , Ronald Songer , James W. Vetter
发明人： Bernard H. Andreas , Michael Barrett , Mark J. Foley , Brian gore , Lewis Isbell , Ronald Songer , James W. Vetter
IPC分类号： A61B17/062
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019 , Y10S604/90
摘要： Systems for suturing a tissue layer having two sides with a suture be releasably retaining at least a portion of the suture in a stationary position on one side of the tissue layer. The portion of the suture is retrieved through the tissue layer from the opposite side whereby the suture is drawn from one side to the opposite side. Systems for suturing the wall of a tubular graft having two sides is also provided using a suture by releasably retaining at least a portion of the suture on one side of the wall. the portion of the length of suture is retrieved through the wall of the graft to the opposite side of the wall.
摘要翻译：用缝合线缝合具有两侧的组织层的系统可释放地将缝合线的至少一部分保持在组织层一侧的静止位置。缝线的部分从相对侧通过组织层回收，由此将缝合线从一侧拉到相对侧。还可以使用缝合线通过可释放地将至少一部分缝合线保持在壁的一侧上来缝合具有两侧的管状移植物的壁的系统。缝合长度的一部分通过移植物的壁回收到壁的相对侧。

15. 发明授权

US07029451B2 Excisional devices having selective cutting and atraumatic configurations and methods of using same 失效
标题翻译：具有选择性切割和无创伤构造的切除装置及其使用方法
公开(公告)号：US07029451B2
公开(公告)日：2006-04-18
申请号：US10290051
申请日：2002-11-06
申请人： Scott C. Anderson , Daniel M. Brounstein , Ary S. Chernomorsky , Mark J. Clifford , James W. Vetter
发明人： Scott C. Anderson , Daniel M. Brounstein , Ary S. Chernomorsky , Mark J. Clifford , James W. Vetter
IPC分类号： A61B10/00
CPC分类号： A61B10/0266
摘要： Surgical devices include a selectively cutting and atraumatic distal tip that is configured to assume a first configuration in which cutting surface or surfaces thereof are effective to cut tissue and a second configuration in which the cutting surface or surfaces thereof are ineffective to cut tissue.
摘要翻译：手术装置包括选择性切割和无创伤的远端尖端，其构造成呈现切割表面或其表面有效切割组织的第一构造和其中切割表面或其表面对切割组织无效的第二构造。

16. 发明授权

US06863676B2 Excisional biopsy devices and methods 失效
公开(公告)号：US06863676B2
公开(公告)日：2005-03-08
申请号：US10066353
申请日：2002-01-31
申请人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
发明人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
IPC分类号： A61B10/02 , A61B8/12 , A61B10/00 , A61B10/04 , A61B17/22 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/32
CPC分类号： A61B10/0266 , A61B10/0041 , A61B10/02 , A61B10/04 , A61B17/320725 , A61B18/1482 , A61B2018/00011 , A61B2018/00333 , A61B2018/1407 , A61B2018/1475 , A61B2090/3782 , A61B2090/3784 , A61B2218/002
摘要： An excisional biopsy system includes a tubular member that has a proximal end and a distal end in which one or more windows are defined. A first removable probe has a proximal portion that includes a cutting tool extender and a distal portion that includes a cutting tool. The first removable probe may be configured to fit at least partially within the tubular member to enable the cutting tool to selectively bow out of and to retract within one of the windows when the cutting tool extender is activated. A second removable probe has a proximal section that includes a tissue collection device extender and a distal section that includes a tissue collection device. The second removable probe may also be configured to fit at least partially within the tubular member to enable the tissue collection device to extend out of and to retract within one of the windows when the tissue collection device extender is activated. A third removable probe may also be provided. The third removable probe may also be configured to fit at least partially within the tubular member and may include an imaging device, such as an ultrasound transducer, mounted therein. By selectively activating the cutting tool and the tissue collection device while rotating the excisional device, a tissue specimen may be cut from the surrounding tissue and collected for later analysis.

17. 发明授权

US06849080B2 Excisional biopsy device and methods 失效
标题翻译：切除活检装置及方法
公开(公告)号：US06849080B2
公开(公告)日：2005-02-01
申请号：US10066437
申请日：2002-01-31
申请人： Roberta Lee , James W. Vetter
发明人： Roberta Lee , James W. Vetter
IPC分类号： A61B10/02 , A61B1/00 , A61B8/12 , A61B10/00 , A61B10/04 , A61B10/06 , A61B17/22 , A61B17/28 , A61B17/32 , A61B17/3211 , A61B18/14 , G01B17/00 , G01B17/06
CPC分类号： A61B8/085 , A61B8/461 , A61B10/02 , A61B10/0266 , A61B10/0275 , A61B10/04 , A61B17/320725 , A61B18/1482 , A61B2017/00287 , A61B2018/00011 , A61B2018/1407 , A61B2018/1475 , A61B2090/3782 , A61B2090/3784 , A61B2218/002
摘要： An excisional biopsy device includes a tubular member having a window near a distal tip thereof; a cutting tool, a distal end of the cutting tool being attached near the distal tip of the tubular member, at least a distal portion of the cutting tool being configured to selectively bow out of the window and to retract within the window; and a tissue collection device externally attached at least to the tubular member, the tissue collection device collecting tissue excised by the cutting tool as the biopsy device is rotated and the cutting tool is bowed. An excisional biopsy method for soft tissue includes the steps of inserting a generally tubular member into the tissue, the tubular member including a cutting tool adapted to selectively bow away from the tubular member and an external tissue collection device near a distal tip of the tubular member; rotating the tubular member; selectively varying a degree of bowing of the cutting tool; collecting tissue severed by the cutting tool in the tissue collection device; and retracting the tubular member from the soft tissue. The tubular member may include an imaging transducer and the method may include the step of displaying information received from the transducer on a display device and the step of varying the degree of bowing of the cutting tool based upon the displayed information from the imaging transducer. Alternatively, the imaging transducer may be disposed within a removable transducer core adapted to fit within the tubular member.
摘要翻译：切除活检装置包括：管状构件，其具有靠近其顶端的窗口; 切割工具，所述切割工具的远端附接在所述管状构件的远侧末端附近，所述切割工具的至少远端部分被配置为选择性地弯曲出窗外并在窗内缩回; 以及组织收集装置，其至少外部连接到所述管状构件，所述组织收集装置收集由所述活检装置旋转并且所述切割工具弯曲时由所述切割工具切除的组织。用于软组织的切除活检方法包括将大致管状构件插入组织的步骤，所述管状构件包括适于选择性地远离管状构件弓形的切割工具和在管状构件的远侧末端附近的外部组织收集装置 ; 旋转管状构件; 选择性地改变切割工具的弯曲程度; 收集由组织收集装置中的切割工具切断的组织; 并从软组织缩回管状构件。管状构件可以包括成像传感器，并且该方法可以包括在显示装置上显示从换能器接收的信息的步骤，以及基于来自成像换能器的显示的信息来改变切割工具的弯曲程度的步骤。或者，成像换能器可以设置在适于装配在管状构件内的可移除换能器芯内。

18. 发明授权

US06780179B2 Methods and systems for in situ tissue marking and orientation stabilization 失效
标题翻译：用于原位组织标记和取向稳定的方法和系统
公开(公告)号：US06780179B2
公开(公告)日：2004-08-24
申请号：US10155570
申请日：2002-05-22
申请人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
发明人： Roberta Lee , James W. Vetter , Ary S. Chernomorsky
IPC分类号： A61B1818
CPC分类号： A61B10/0266 , A61B18/148 , A61B2018/00333 , A61B2018/00601 , A61B2018/141 , A61B2018/1475 , A61B2090/3908 , A61B2090/3937 , A61B2090/395
摘要： A method of marking an orientation of a cut specimen of tissue prior to excision thereof from a body includes steps of disposing a tissue-marking probe in the body adjacent the cut specimen, the tissue-marking probe including a tissue-marking tool configured to selectively mark the cut specimen. A surface of the cut specimen is then marked with the tissue-marking tool such that the orientation of the cut specimen within the body is discernable after the cut specimen is excised from the body. The tissue-marking tool may be configured to selectively bow out of and back into a window defined near a distal tip of the probe and the marking step may include a step of selectively bowing the tissue-marking tool out of the window and following the surface of the cut specimen while rotating the probe. The tissue-marking tool may include an RF cutting tool and the marking step may include a step of coagulating or cauterizing a selected portion of the surface of the cut specimen with the RF cutting tool. Alternatively, the marking step may include a step of delivering dye onto selected portions of the surface of the cut specimen.
摘要翻译：在从身体切除之前标记组织切割样本的取向的方法包括以下步骤：将组织标记探针设置在与切割的样本相邻的身体中，组织标记探针包括组织标记工具，其被配置为选择性地标记切割标本。然后用组织标记工具标记切割的样品的表面，使得在切割的样品从身体切除之后，切割的样品在体内的取向是可辨别的。组织标记工具可以被配置为选择性地弯曲到限定在探针的远侧末端附近的窗口中，并且标记步骤可以包括将组织标记工具选择性地弯曲出窗户并且跟随表面的步骤同时旋转探头。组织标记工具可以包括RF切割工具，并且标记步骤可以包括用RF切割工具凝固或烧灼切割样品表面的选定部分的步骤。或者，标记步骤可以包括将染料递送到切割样品的表面的选定部分上的步骤。

19. 发明授权

US6146377A Breast stabilization devices and methods 有权
标题翻译：乳房稳定装置和方法
公开(公告)号：US6146377A
公开(公告)日：2000-11-14
申请号：US158215
申请日：1998-09-22
申请人： Roberta Lee , James W. Vetter , Natalie N. Hyland
发明人： Roberta Lee , James W. Vetter , Natalie N. Hyland
IPC分类号： A61B19/00 , A61B6/04 , A61B8/00 , A61B8/08 , A61B5/055
CPC分类号： A61B8/0825 , A61B90/17 , A61B90/10
摘要： A breast stabilization device includes a substantially rigid outer member and an inner member joined to the outer member. The inner member is configured to conform to the shape of the female breast. An opening is disposed through the outer and inner members, the opening being centered on the nipple/areolar complex of the breast and exposing at least a portion of the areola surrounding the nipple. A rigid rim may surround the periphery of the opening and may rise above the surface of the outer member. The device stabilizes the breast in an uncompressed or slightly expanded state to allow interventional and imaging procedures to be carried out without compressing the breast. The opening allows access to the breast through the areola and the rim allows one or more instruments to be attached thereto. A method of imaging a breast, according to the present invention, includes the steps of placing a generally breast shaped member on the breast, the breast shaped member having one or more imaging port therein; expanding the breast to come into intimate contact with the breast shaped member; and imaging the breast through the imaging port(s). The imaging step may be carried out by directing ultrasonic energy through the port(s).
摘要翻译：乳房稳定装置包括基本刚性的外部构件和连接到外部构件的内部构件。内部构件被配置成符合女性乳房的形状。通过外部和内部构件设置开口，该开口位于乳房的乳头/非极性复合体的中心，并暴露乳头周围的至少一部分乳晕。刚性边缘可以围绕开口的周边并且可以在外部构件的表面上方升高。该装置将乳房稳定在未压缩或稍微膨胀的状态，以允许在不压缩乳房的情况下进行介入和成像过程。开口允许通过乳晕进入乳房，并且边缘允许一个或多个仪器附接到乳房。根据本发明的乳房成像方法包括以下步骤：在乳房上放置一般为胸部的构件，该乳房形构件在其中具有一个或多个成像端口; 扩大乳房以与乳房状构件紧密接触; 并通过成像端口成像乳房。成像步骤可以通过引导超声波能量通过端口来进行。

20. 发明授权

US5465733A Guide wire for catheters and method for its use 失效
标题翻译：导管导丝及其使用方法
公开(公告)号：US5465733A
公开(公告)日：1995-11-14
申请号：US137321
申请日：1993-10-14
申请人： Tomoaki Hinohara , James W. Vetter
发明人： Tomoaki Hinohara , James W. Vetter
IPC分类号： A61M25/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09175 , A61M25/09033
摘要： An improved guide wire for use with cardiovascular catheters, particularly angioplasty or balloon dilatation catheters. The guide wire has a solid core wire which makes up the proximal end of the guide wire. The core wire is tapered toward the distal end to increase flexibility. The tapered distal end of the core wire is surrounded by a coil spring, which may be made completely or partially from a highly radiopaque material. A tapered transition device is attached to the coil spring at a selected distance from the distal end of the guide wire. The transition device is roughly bullet-shaped with a tapered distal edge which provides a smooth transition to aid the dilatation catheter in crossing a stenosis. The tapered transition device also serves to predilate very tight stenoses, making it easier to cross the lesion with an angioplasty balloon or other therapeutic device. The transition device can be made of metal or plastic with a radiopaque filler for easier visualization by x-ray or fluoroscopy. A removably attachable handle for maneuvering the guide wire and a method of use for the improved guide wire are also disclosed. An angioplasty catheter with a reinforced proximal shaft, which allows easier one-handed operation of the catheter and guide wire system, is also presented.
摘要翻译：用于心血管导管，特别是血管成形术或球囊扩张导管的改进的导丝。引导线具有构成导丝的近端的实心芯线。芯线朝向远端逐渐变细，以增加灵活性。芯线的锥形远端由螺旋弹簧围绕，螺旋弹簧可以由高度不透射线的材料完全或部分地制成。锥形过渡装置以与导丝的远端一定距离的螺旋弹簧连接。过渡装置大致为子弹状，具有锥形远端边缘，其提供平滑过渡以帮助扩张导管横穿狭窄。锥形过渡装置还用于预防非常紧张的狭窄，使得更容易用血管成形术球囊或其它治疗装置穿过病变。过渡装置可以由具有不透射线填充物的金属或塑料制成，以通过X射线或荧光透视来更容易地观察。还公开了用于操纵导丝的可拆卸地安装的手柄和用于改进的导丝的方法。还提供了具有加强的近侧轴的血管成形术导管，其允许更容易地单手操作导管和导丝系统。

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