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11. 发明申请

US20080292775A1 Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses 审中-公开
标题翻译：天然高效甜味剂组合物的输送系统，其配制方法和用途
公开(公告)号：US20080292775A1
公开(公告)日：2008-11-27
申请号：US12120857
申请日：2008-05-15
申请人： Indra Prakash , Grant E. DuBois
发明人： Indra Prakash , Grant E. DuBois
IPC分类号： A23G3/00 , C07H15/04
CPC分类号： A23L27/75 , A23L27/33 , A23L27/34 , A23L27/36 , A23L27/70 , A23L27/88 , A23V2002/00 , A23V2250/258 , A23V2250/61 , A23V2250/628
摘要： The present invention provides substantially water soluble, substantially non-dusting delivery systems for natural high-potency sweeteners, methods for their formulation, and uses. In particular, the present invention relates to different delivery systems of sweetener compositions comprising at least one non-caloric or low-caloric natural high-potency sweetener.
摘要翻译：本发明为天然高效甜味剂提供基本上水溶性，基本上不起粉尘的递送系统，其制备方法和用途。特别地，本发明涉及包含至少一种非热量或低热量的天然高效甜味剂的甜味剂组合物的不同递送系统。

12. 发明申请

US20070275147A1 SYNTHETIC SWEETENER COMPOSITIONS WITH IMPROVED TEMPORAL PROFILE AND/OR FLAVOR PROFILE, METHODS FOR THEIR FORMULATION, AND USES 审中-公开
标题翻译：具有改进的时间特征和/或风味简介的合成维生素组合物，其配方和用途的方法
公开(公告)号：US20070275147A1
公开(公告)日：2007-11-29
申请号：US11561158
申请日：2006-11-17
申请人： Indra Prakash , Grant DuBois , Prashanthi Jella , George King , Rafael San Miguel , Kelly Specic , Deepthi Weerasinghe , Newton White
发明人： Indra Prakash , Grant DuBois , Prashanthi Jella , George King , Rafael San Miguel , Kelly Specic , Deepthi Weerasinghe , Newton White
IPC分类号： A23L1/236
CPC分类号： A23L27/37 , A23L27/32 , A23L27/34 , A23L29/37 , A23V2002/00 , A23V2200/16 , A23V2250/24 , A23V2250/2484 , A23V2250/0618 , A23V2200/222 , A23V2250/21
摘要： The present invention relates generally to improving the taste of synthetic sweeteners and compositions sweetened therewith. In particular, the present invention relates to compositions that can improve the taste of synthetic sweeteners by imparting a more sugar-like taste or characteristic. In particular, the compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile, including osmotic taste.
摘要翻译：本发明一般涉及改善合成甜味剂及其甜味组合物的味道。特别地，本发明涉及通过赋予更多的糖样味道或特性来改善合成甜味剂的味道的组合物。特别地，组合物和方法提供了更多的糖样时间分布，包括甜度起始和甜度徘徊，和/或更多的糖样香味特征，包括渗透味。

13. 发明申请

US20070116829A1 Pharmaceutical Composition with High-Potency Sweetener 审中-公开
标题翻译：药物组合物与高效甜味剂
公开(公告)号：US20070116829A1
公开(公告)日：2007-05-24
申请号：US11555991
申请日：2006-11-02
申请人： Indra Prakash , Grant DuBois
发明人： Indra Prakash , Grant DuBois
IPC分类号： A23L1/236
CPC分类号： C07H15/24 , A23L27/34 , A23L27/36 , A23L33/15 , A23V2002/00 , A61K9/0056 , C07H1/08 , A23V2250/6402 , A23V2250/262 , A23V2250/156
摘要： The present invention relates generally to pharmaceutical compositions comprising non-caloric or low-caloric high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different pharmaceutical compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and a pharmaceutically active substance. The present invention also relates to pharmaceutical compositions and methods that can improve the tastes of non-caloric or low-caloric natural and/or synthetic,, high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the pharmaceutical compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
摘要翻译：本发明一般涉及包含非热量或低热量的高效甜味剂的药物组合物及其制备和使用方法。特别地，本发明涉及包含至少一种非热量或低热量天然和/或合成高效甜味剂，至少一种甜味改善组合物和药物活性物质的不同药物组合物。本发明还涉及可以通过赋予更多的糖样味道或特征来改善非热量或低热量天然和/或合成的高效甜味剂的口味的药物组合物和方法。特别地，药物组合物和方法提供了更多的糖样时间特征，包括甜度起始和甜度徘徊，和/或更多的糖样香味。

14. 发明申请

US20070116823A1 HIGH-POTENCY SWEETENER FOR HYDRATION AND SWEETENED HYDRATION COMPOSITION 审中-公开
标题翻译：用于水化和水化水化组合物的高吸收剂
公开(公告)号：US20070116823A1
公开(公告)日：2007-05-24
申请号：US11555812
申请日：2006-11-02
申请人： Indra Prakash , Grant DuBois
发明人： Indra Prakash , Grant DuBois
IPC分类号： A23L1/236
CPC分类号： A23L2/60 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/36 , A23L33/11 , A23L33/16 , A23L33/17
摘要： The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as a hydration product. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
摘要翻译：本发明一般涉及包含非热量或低热量天然和/或合成高效甜味剂的功能甜味剂组合物及其制备和使用方法。特别地，本发明涉及包含至少一种非热量或低热量天然和/或合成高效甜味剂，至少一种甜味改善组合物和至少一种功能成分的不同功能甜味剂组合物，例如水化产品。本发明还涉及功能性甜味剂组合物和方法，其可以通过赋予更多的糖样味道或特征来改善非热量或低热量的高效甜味剂的口味。特别地，功能性甜味剂组合物和方法提供了更多的糖样时间分布，包括甜度起始和甜度徘徊，和/或更多的糖样香味。

15. 发明授权

US07030281B2 Synthesis of 3,3,-dimethylbutyraldehyde by the reduction of 3,3,-dimethylbutyric acid 失效
标题翻译：通过还原3,3'-二甲基丁酸合成3,3'-二甲基丁醛
公开(公告)号：US07030281B2
公开(公告)日：2006-04-18
申请号：US10390846
申请日：2003-03-18
申请人： Indra Prakash , Robert L. Augustine , Setrak K. Tanielyan
发明人： Indra Prakash , Robert L. Augustine , Setrak K. Tanielyan
IPC分类号： C07C45/29 , C07C29/00
CPC分类号： C07C45/41 , C07C47/02
摘要： A process for the production of 3,3-dimethylbutyraldehyde is disclosed. The 3,3-dimethylbutyraldehyde is obtained by the reduction of 3,3-dimethylbutyric acid using trimethylacetic anhydride and a phosphine. The 3,3-dimethylbutyric acid is preferably obtained by a process in which tert-butanol and vinylidene chloride are reacted in the presence of sulfuric acid. The disclosed process has improved cost and yield.
摘要翻译：公开了一种制备3,3-二甲基丁醛的方法。通过使用三甲基乙酸酐和膦还原3,3-二甲基丁酸得到3,3-二甲基丁醛。 3,3-二甲基丁酸优选通过在硫酸存在下使叔丁醇和偏二氯乙烯反应的方法获得。所公开的方法具有改善的成本和产量。

16. 发明授权

US06852875B2 Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives 有权
标题翻译：使用恶唑烷酮衍生物合成N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯
公开(公告)号：US06852875B2
公开(公告)日：2005-02-08
申请号：US09859439
申请日：2001-05-18
申请人： Indra Prakash
发明人： Indra Prakash
IPC分类号： C07K5/072 , C07K5/075 , C07C229/00 , C07D263/42
CPC分类号： C07K5/06113
摘要： Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.
摘要翻译：通过用酮处理N-（3,3-二甲基丁基）-L-天冬氨酸得到恶唑烷酮，合成N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯衍生物，与L-苯丙氨酸甲酯缩合。

17. 发明授权

US06720446B2 Catalyst modification to enhance neotame production 失效
标题翻译：催化剂改性以增强新生儿的生产
公开(公告)号：US06720446B2
公开(公告)日：2004-04-13
申请号：US10010381
申请日：2001-11-05
申请人： Mike G. Scaros , Indra Prakash
发明人： Mike G. Scaros , Indra Prakash
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , B01J21/18 , B01J23/44 , B01J23/464 , B01J23/96 , Y02P20/584
摘要： Processes for using modified catalysts with improved functionality in the production of neotame are disclosed. The modified catalysts surprisingly have been found to improve the selectivity over conventional catalysts and to reduce the level of certain impurities in neotame production processes.
摘要翻译：公开了使用改进的催化剂在制备neotame中具有改进的功能的方法。已经发现改性催化剂令人惊奇地提高了与常规催化剂的选择性，并降低了neotame生产过程中某些杂质的含量。

18. 发明授权

US06642406B2 Synthesis of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester using L-&agr;-aspartyl-L-phenylalanine 1-methyl ester precursors 有权
标题翻译：使用L-α-天冬氨酰-L-苯丙氨酸1-甲酯前体合成N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯
公开(公告)号：US06642406B2
公开(公告)日：2003-11-04
申请号：US09859438
申请日：2001-05-18
申请人： Indra Prakash , Zhi Guo , Steve Schroeder , Kurt L. Wachholder
发明人： Indra Prakash , Zhi Guo , Steve Schroeder , Kurt L. Wachholder
IPC分类号： C07C22900
CPC分类号： C07K5/06113
摘要： N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
摘要翻译： N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯是通过3,3-二甲基丁醛和L-α-天冬氨酰基 - L-苯丙氨酸1-甲酯。特别地，使用L-α-天冬氨酰基-L-苯丙氨酸1-甲酯的酸式盐制备N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯或N-保护的L-α-天冬氨酰基-L-苯丙氨酸1-甲酯。与常规N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯合成相比，该方法是有效且成本低的。

19. 发明授权

US06627431B1 Chemoenzymatic synthesis of neotame 失效
标题翻译：新霉素的化学酶合成
公开(公告)号：US06627431B1
公开(公告)日：2003-09-30
申请号：US09570408
申请日：2000-05-12
申请人： Indra Prakash , Robert Y. Zhao
发明人： Indra Prakash , Robert Y. Zhao
IPC分类号： C07C100
CPC分类号： C07K5/06113 , C12P21/02
摘要： A chemoenzymatic method is disclosed for preparing N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester via the enzymatic regioselective hydrolysis of neotame esters using lipases or esterases.
摘要翻译：公开了通过使用脂肪酶或酯酶通过酶抑制区域选择性水解新甜菜酯来制备N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯的化学酶学方法。

20. 发明授权

US06573409B1 Process for the preparation of 3,3-dimethylbutanal 有权
标题翻译：制备3,3-二甲基丁醛的方法
公开(公告)号：US06573409B1
公开(公告)日：2003-06-03
申请号：US09575107
申请日：2000-05-19
申请人： Jerry R. Ebner , Zhi Guo , Arnold Hershman , Loraine M. Klein , William D. McGhee , Mark D. Paster , Indra Prakash
发明人： Jerry R. Ebner , Zhi Guo , Arnold Hershman , Loraine M. Klein , William D. McGhee , Mark D. Paster , Indra Prakash
IPC分类号： C07C4500
CPC分类号： C07C303/24 , C07C17/275 , C07C29/095 , C07C29/12 , C07C29/124 , C07C29/132 , C07C29/147 , C07C29/149 , C07C45/002 , C07C45/38 , C07C47/02 , C07K5/06113 , Y02P20/127 , C07C19/01 , C07C305/08 , C07C31/125
摘要： 3,3-Dimethylbutanal is prepared from 3,3-dimethylbutanol. Intermediate 3,3-dimethylbutanol is obtained by reacting ethylene, isopropylene and sulfuric acid to produce a 3,3-dimethylbutyl ester which is hydrolyzed to the alcohol. The hvdrolysis step is effectively carried out by reactive distillation. Alternatively, 3,3-dimethylbutanal is prepared from 3,3-dimethylbutanol obtained by reduction of the corresponding carboxylic acid or 1,2-epoxy-3,3-dimethylbutane, or by hydrolysis of 1-halo-3,3-dimethylbutane. Fixed bed gas phase and stirred tank liquid phase processes are provided for converting 3,3-dimethylbutanol to 3,3-dimethylbutanal by catalytic dehydrogenation.
摘要翻译： 3,3-二甲基丁醛由3,3-二甲基丁醇制备。中间体3,3-二甲基丁醇通过使乙烯，异丙烯和硫酸反应得到3,3-二甲基丁酯，将其水解成醇。氢解步骤通过反应蒸馏有效地进行。或者，通过还原相应的羧酸或1,2-环氧-3,3-二甲基丁烷或通过1-卤代-3,3-二甲基丁烷的水解得到的3,3-二甲基丁醇制备3,3-二甲基丁醛。提供固定床气相和搅拌釜液相方法，通过催化脱氢将3,3-二甲基丁醇转化为3,3-二甲基丁醛。

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