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    • 11. 发明申请
    • PHOSPHATE CONVERSION COATING COMPOSITION AND PROCESS
    • 磷酸盐转化涂料组合物和工艺
    • WO1992007974A1
    • 1992-05-14
    • PCT/US1991007668
    • 1991-10-16
    • HENKEL CORPORATIONISHII, HitoshiMIYAWAKI, ToshiTANAKA, Shigeo
    • HENKEL CORPORATION
    • C23C22/36
    • C23C22/365
    • A phosphate conversion coating composition that gives superior results, particularly in phosphating surfaces including aluminum, has a composition containing water and: (A) 0.4 - 2.5 g/L of zinc(II) ions, (B) 0.5 to 3.5 g/L of nickel(II) ions, (C) 0.4 to 2.0 g/L manganese(II) ions, (D) at least 8 g/L of phosphate ions, (E) 2.0 to 20 g/L of nitrate ions, (F) 10 to 250 ppm of nitrite ions, (G) not more than 1,000 ppm of aluminum ions, and (H) 10 to 3,500 ppm total fluorine in anions, and the composition has a nickel ion to aluminum ion molar ratio that is at least 1.6, a total fluorine to aluminum ion molar ratio that is at least 5.0, and a nickel ion to total fluorine molar ratio that is at least 0.3.
    • 具有优异结果的磷酸盐转化涂料组合物,特别是在包括铝的磷化表面中,具有含水的组成,(A)0.4-2.5g / L的锌(II)离子,(B)0.5-3.5g / L的 镍(II)离子,(C)0.4〜2.0g / L锰(II)离子,(D)至少8g / L磷酸根离子,(E)2.0〜20g / L硝酸根离子,(F) 10-250ppm的亚硝酸根离子,(G)不超过1,000ppm的铝离子,和(H)阴离子中的总氟含量为10至3,500ppm,并且组成的镍离子与铝离子的摩尔比至少为1.6 ,氟与铝的总摩尔比为5.0以上,镍离子与总氟的摩尔比为0.3以上。
    • 13. 发明申请
    • ANTI-CANCER AGENT
    • WO2021044183A1
    • 2021-03-11
    • PCT/IB2019/001067
    • 2019-10-21
    • ISHII, Hitoshi
    • ISHII, Hitoshi
    • A61K33/00A61P35/00C07K14/47
    • An object of the present invention is to provide an anticancer agent for stopping the division of cancer cells. [Solution] When adding acid, The enzyme ASB7, which causes cancer cell division, has an optimum pH, so if the pH value in the cancer cell is deviated from the optimum pH value, the enzyme will not work, so the hydrogen ion concentration in the cancer cell If the acid is added to the cancer cells to make it acidic, the pH in the cancer cells changes and deviates from the optimum pH value, so the enzyme ASB7 that causes cancer cell division does not work. An anticancer agent called an acid solute,which is the result of cancer cell division stopping. When adding a base, The enzyme ASB7, which causes cancer cell division, has an optimum pH, so if the pH value in the cancer cell is deviated from the optimum pH value, the enzyme will not work, so the hydrogen ion concentration in the cancer cell If the base is added to the cancer cell to make it basic, the pH in the cancer cell changes and deviates from the optimum pH value, so the enzyme ASB7 that causes cancer cell division works. An anti-cancer drug called a solute of a base that results from the disappearance of cancer cells.
    • 14. 发明申请
    • GROWTH PROMOTER USING DNA DENATURANT
    • WO2021038265A1
    • 2021-03-04
    • PCT/IB2019/001093
    • 2019-10-28
    • ISHII, Hitoshi
    • ISHII, Hitoshi
    • A23K20/00
    • Task The present invention relates to a growth promoter using a DNA denaturant that accelerates the growth speed of an organism. MEANS FOR SOLVING PROBLEMS The growth promoter of the present invention is used to inactivate living organisms with a buffer solution such as TAE or TBE or an oxidation such as DTT against one of DNA denaturants such as urea, formamide and DMSO. It is a growth promoter used in addition to one of the reducing agents. As a result of administering the growth promoter to an organism,DNAdenaturation occurs and the mechanism of DNA reconstruction is changed. DNA is hydrogen-bonded between bases, but if it is made alkaline by adding denaturing agents such as urea, formamide, or DMSO to the DNA solution, it denatures to release hydrogen ions, and each double helix of DNA is stranded. Separate into two. When cell division occurs with separation, there is no need to unwind the two strands or break the base bond, and at the same time, new DNA with the same sequence of bases is generated, and the two pairs of DNA are It stays in the chromosome in a separated state without a double helix shape, and the mass of the chromosome separates into two nuclei that divide cells. In this case, it is not necessary to unwind the DNA strand or release the base bond during cell division, so cell division occurs efficiently and growth is accelerated. As a result, the production amount can be increased.