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11. 发明申请

US20110115089A1 Semiconductor device, production method for the same, and substrate 有权
公开(公告)号：US20110115089A1
公开(公告)日：2011-05-19
申请号：US12929425
申请日：2011-01-24
申请人： Motoharu Haga , Yasumasa Kasuya , Hiroaki Matsubara
发明人： Motoharu Haga , Yasumasa Kasuya , Hiroaki Matsubara
IPC分类号： H01L23/488 , B23K1/20
CPC分类号： H01L24/29 , H01L23/49811 , H01L23/49866 , H01L24/32 , H01L24/48 , H01L24/73 , H01L24/83 , H01L2224/04026 , H01L2224/29 , H01L2224/29101 , H01L2224/29109 , H01L2224/29111 , H01L2224/29144 , H01L2224/2919 , H01L2224/29298 , H01L2224/32225 , H01L2224/32507 , H01L2224/451 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/83444 , H01L2224/83801 , H01L2924/00013 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/0105 , H01L2924/01051 , H01L2924/01058 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0132 , H01L2924/0133 , H01L2924/0134 , H01L2924/014 , H01L2924/0665 , H01L2924/14 , H01L2924/1433 , H01L2924/15311 , H01L2924/15788 , H01L2924/181 , H01L2924/01028 , H01L2924/00012 , H01L2924/01049 , H01L2924/01083 , H01L2924/3512 , H01L2924/00 , H01L2224/29099 , H01L2224/29199 , H01L2224/29299 , H01L2224/2929 , H01L2224/45099 , H01L2224/05599
摘要： A semiconductor device is provided in which a semiconductor chip is bonded to a substrate with a sufficiently increased bonding strength and cracking is assuredly prevented which may otherwise occur due to heat shock, heat cycle and the like. The semiconductor device includes a semiconductor chip and a substrate having a bonding area to which the semiconductor chip is bonded via a metal layer. The metal layer includes an Au—Sn—Ni alloy layer and a solder layer provided on the Au—Sn—Ni alloy layer. Undulations are formed in an interface between the Au—Sn—Ni alloy layer and the solder layer.

12. 发明申请

US20100303909A1 PREPARATION FOR TREATING HEART DISEASE USED IN CELL THERAPY 有权
标题翻译：用于治疗细胞治疗中使用的心脏疾病的准备
公开(公告)号：US20100303909A1
公开(公告)日：2010-12-02
申请号：US12681940
申请日：2008-10-09
申请人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
发明人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
IPC分类号： A61K35/34 , A61K9/00 , A61P9/00
CPC分类号： A61L27/24 , A61L27/222 , A61L27/3834 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/414 , C12N5/0657 , C12N2501/115 , C12N2533/54
摘要： An object of the present invention is to establish a cell transplantation method which can markedly improve the survival of grafted pluripotent stem cells and the efficiency of cardiomyocyte regeneration in cell therapy using pluripotent stem cells derived from heart tissue and can treat heart disease further effectively. Specifically, according to the present invention, enhancement in the survival of grafted pluripotent stem cells and significant improvement in the efficiency of cardiomyocyte regeneration are achieved by using, in combination, pluripotent stem cells derived from heart tissue and a hydrogel containing a basic fibroblast growth factor (bFGF) in cell therapy for heart disease.
摘要翻译：本发明的目的是建立一种可以显着提高移植多能干细胞的存活率和使用源自心脏组织的多能干细胞进行细胞治疗的心肌细胞再生的效率的细胞移植方法，并可进一步有效治疗心脏病。具体地，根据本发明，通过组合使用衍生自心脏组织的多能干细胞和含有碱性成纤维细胞生长因子的水凝胶来实现移植多能干细胞的存活的增强和心肌细胞再生效率的显着改善（bFGF）在心脏病的细胞治疗中。

13. 发明申请

US20100062882A1 DART 有权
标题翻译：镖
公开(公告)号：US20100062882A1
公开(公告)日：2010-03-11
申请号：US12553148
申请日：2009-09-03
申请人： Hiroaki Matsubara
发明人： Hiroaki Matsubara
IPC分类号： A63B65/02
CPC分类号： F42B6/003
摘要： The present invention provides a dart having a durable and break-resistant structure. A dart in accordance with an embodiment of the present invention has, in order from the front thereof, a tip, a barrel, a shaft, and a flight. At the rear of the shaft, a cap-receiving portion having a diameter smaller than that existing elsewhere is formed, this cap-receiving portion being capable of receiving a cap-like portion of the flight. At the front end of the flight, a hollow cylindrical cap-like portion containing a hole for attachment to the cap-receiving portion of the shaft is formed. The shaft and the flight are connected to each other by a sliding engagement method.
摘要翻译：本发明提供一种具有耐久和抗断裂结构的飞镖。根据本发明的实施例的飞镖从前面依次具有尖端，筒体，轴和飞行。在轴的后部，形成直径小于其他位置的直径的盖接收部，该盖接收部能够接收飞行的帽状部分。在飞行器的前端形成有一个中空的圆柱形盖状部分，其中包含一个孔，用于连接到轴的盖接收部分。轴和飞行通过滑动接合方式彼此连接。

14. 发明申请

US20080241111A1 Pluripotent Stem Cell Derived from Cardiac Tissue 审中-公开
标题翻译：多能干细胞源自心脏组织
公开(公告)号：US20080241111A1
公开(公告)日：2008-10-02
申请号：US11885111
申请日：2006-03-03
申请人： Hidemasa Oh , Kento Tateishi , Hiroaki Matsubara
发明人： Hidemasa Oh , Kento Tateishi , Hiroaki Matsubara
IPC分类号： A61K35/12 , C12N5/02 , C12N5/08 , A61P43/00 , C12N5/00
CPC分类号： C12N5/0668 , A61K35/12 , C12N2501/11 , C12N2501/115
摘要： An object of the present invention is to provide a stem cell applicable to regenerative therapeutic method, and to provide a technique to carry out regenerative therapy using the cell. A collected cardiac tissue fragment is enzymatically treated to prepare a cell suspension. Then using the cell suspension, following steps are carried out: (1) separation of cells by the density gradient method, (2) suspension-culture in a culture medium containing fibroblast growth factor and epidermal growth factor and (3) selection and separation of cells forming a floating sphere to obtain pluripotent stem cells. Thus-obtained pluripotent stem cells are used to carry out regenerative therapy.
摘要翻译：本发明的目的是提供一种适用于再生治疗方法的干细胞，并提供使用该细胞进行再生治疗的技术。收集的心脏组织片段被酶处理以制备细胞悬浮液。然后使用细胞悬浮液，进行以下步骤：（1）通过密度梯度法分离细胞，（2）在含有成纤维细胞生长因子和表皮生长因子的培养基中悬浮培养，（3）选择和分离形成浮球以获得多能干细胞的细胞。这样获得的多能干细胞用于进行再生治疗。

15. 发明申请

US20050037092A1 Vascularization therapy by highly concentrated carbonated warm water bath 审中-公开
标题翻译：通过高浓度碳酸温水浴进行血管化治疗
公开(公告)号：US20050037092A1
公开(公告)日：2005-02-17
申请号：US10676270
申请日：2003-10-02
申请人： Hiroki Sakakibara , Ken Ooyachi , Hiroaki Matsubara
发明人： Hiroki Sakakibara , Ken Ooyachi , Hiroaki Matsubara
IPC分类号： A61H33/02 , A61K33/00 , A61K35/28 , A61K38/18 , A61K45/06
CPC分类号： A61K45/06 , A61K33/00 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K2300/00
摘要： A treatment method capable of regenerating new blood vessels at an affected site of a peripheral blood vessel that is highly safe with respect to the human body and is easily performed. More specifically, a vascularization therapy that increases the number of newly formed blood vessels of an affected site by immersing in carbonated warm water having a carbon dioxide concentration of 700 ppm or more and a water temperature of 33 to 42° C. A vascularization therapy that increases the number of vascular endothelial cells in tissue of an affected site by 1.5 times or more and that increases the number of endothelial precursor cells in the peripheral blood at an affected site by 1.1 times or more by immersing the affected site of a peripheral blood vessel in the aforementioned carbonated warm water.
摘要翻译：能够在相对于人体高度安全且容易进行的外周血管的受影响部位再生新血管的治疗方法。更具体地，是通过将二氧化碳浓度为700ppm以上，水温为33〜42℃的碳酸化温水浸渍在受影响部位的新形成的血管的数量的血管化治疗。将受影响部位组织中的血管内皮细胞数量增加1.5倍以上，通过将受影响部位的外周血管浸润，将受影响部位的外周血中的内皮前体细胞数增加1.1倍以上在上述碳酸温水中。

16. 发明授权

US6085578A Apparatus and method for detecting mass eccentricity 失效
标题翻译：用于检测质量偏心的装置和方法
公开(公告)号：US6085578A
公开(公告)日：2000-07-11
申请号：US83236
申请日：1998-05-22
申请人： Hiroaki Tanaka , Yoshiyuki Okido , Yutaka Yoshida , Hideki Sano , Hiroaki Matsubara
发明人： Hiroaki Tanaka , Yoshiyuki Okido , Yutaka Yoshida , Hideki Sano , Hiroaki Matsubara
IPC分类号： G01M1/14 , G01M1/06 , G01M1/16 , G01M1/00
CPC分类号： G01M1/16 , G01M1/06
摘要： A spherical object is positioned on a rotation stage, the rotation stage is rotated, and a deviation detector detects whether the spherical object deviates from the rotation stage or not. A rotation frequency of the rotation stage when the object deviates from the rotation stage is detected by a rotation frequency detector, and a judgement system judges whether the object is mass eccentric or not, comparing the detected rotation frequency with a predetermined rotation frequency which is set beforehand.
摘要翻译：球面物体位于旋转台上，旋转台旋转，偏差检测器检测球形物体是否偏离旋转台。通过旋转频率检测器检测出物体偏离旋转台的旋转台的旋转频率，并且判断系统判断物体是否是质量偏心的，将检测到的旋转频率与设定的预定旋转频率进行比较预先。

17. 发明授权

US09301917B2 Sustained-release pharmaceutical composition 有权
标题翻译：持续释放药物组合物
公开(公告)号：US09301917B2
公开(公告)日：2016-04-05
申请号：US13824598
申请日：2011-10-14
申请人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
发明人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
IPC分类号： A61K38/00 , A61K9/00 , A61K31/7004 , A61K31/7008 , A61K45/06 , A61K38/39 , A61K9/51 , A61K47/26 , A61K47/42 , A61K38/27 , A61K38/18
CPC分类号： A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要： Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译：本发明提供包含药物和胶原的药物组合物，其组合物的操作性良好且具有缓释性。缓释药物组合物包括：药物; 胶原蛋白和选自单糖，二糖，三糖和四糖中的至少一种糖。本发明的发明人已经发现，含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。基于该发现，本发明人发现含有药物，胶原和糖的组合物可以控制药物的释放速度，并且这种组合物可以用作缓释药物组合物。

18. 发明申请

US20130305397A1 GENE CAPABLE OF REGULATING OBESITY/INSULIN SENSITIVITY 审中-公开
标题翻译：基因能调节肥胖/胰岛素敏感性
公开(公告)号：US20130305397A1
公开(公告)日：2013-11-14
申请号：US13980653
申请日：2012-01-20
申请人： Koji Ikeda , Hiroaki Matsubara , Yoshiki Akakabe
发明人： Koji Ikeda , Hiroaki Matsubara , Yoshiki Akakabe
IPC分类号： C12Q1/68 , G01N33/50 , C12N15/85
CPC分类号： C12Q1/6897 , A01K67/0271 , A01K2227/105 , A01K2267/0362 , C12N15/85 , G01N33/5023 , G01N33/6893 , G01N2800/044
摘要： This invention relates to a cell comprising a reporter gene under control of an ARIA gene promoter, the cell being used for searching for an agent for prevention or treatment of diseases attributed to reduced insulin sensitivity, for searching for an obesity-controlling substance, or for searching for an obesity-inducing substance.
摘要翻译：本发明涉及一种包含ARIA基因启动子控制下的报告基因的细胞，该细胞用于寻找一种用于预防或治疗归因于胰岛素敏感性降低的疾病，用于寻找肥胖控制物质或用于寻找引起肥胖的物质。

19. 发明授权

US08368234B2 Semiconductor device, production method for the same, and substrate 有权
标题翻译：半导体装置及其制造方法以及基板
公开(公告)号：US08368234B2
公开(公告)日：2013-02-05
申请号：US12929425
申请日：2011-01-24
申请人： Motoharu Haga , Yasumasa Kasuya , Hiroaki Matsubara
发明人： Motoharu Haga , Yasumasa Kasuya , Hiroaki Matsubara
IPC分类号： H01L23/52 , H01L23/48 , H01L29/40
CPC分类号： H01L24/29 , H01L23/49811 , H01L23/49866 , H01L24/32 , H01L24/48 , H01L24/73 , H01L24/83 , H01L2224/04026 , H01L2224/29 , H01L2224/29101 , H01L2224/29109 , H01L2224/29111 , H01L2224/29144 , H01L2224/2919 , H01L2224/29298 , H01L2224/32225 , H01L2224/32507 , H01L2224/451 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/83444 , H01L2224/83801 , H01L2924/00013 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/0105 , H01L2924/01051 , H01L2924/01058 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0132 , H01L2924/0133 , H01L2924/0134 , H01L2924/014 , H01L2924/0665 , H01L2924/14 , H01L2924/1433 , H01L2924/15311 , H01L2924/15788 , H01L2924/181 , H01L2924/01028 , H01L2924/00012 , H01L2924/01049 , H01L2924/01083 , H01L2924/3512 , H01L2924/00 , H01L2224/29099 , H01L2224/29199 , H01L2224/29299 , H01L2224/2929 , H01L2224/45099 , H01L2224/05599
摘要： A semiconductor device is provided in which a semiconductor chip is bonded to a substrate with a sufficiently increased bonding strength and cracking is assuredly prevented which may otherwise occur due to heat shock, heat cycle and the like. The semiconductor device includes a semiconductor chip and a substrate having a bonding area to which the semiconductor chip is bonded via a metal layer. The metal layer includes an Au—Sn—Ni alloy layer and a solder layer provided on the Au—Sn—Ni alloy layer. Undulations are formed in an interface between the Au—Sn—Ni alloy layer and the solder layer.
摘要翻译：提供一种半导体器件，其中半导体芯片以足够高的接合强度结合到基板上，可靠地防止由于热冲击，热循环等而发生的开裂。半导体器件包括半导体芯片和具有通过金属层与半导体芯片接合的接合区域的基板。金属层包括Au-Sn-Ni合金层和设置在Au-Sn-Ni合金层上的焊料层。在Au-Sn-Ni合金层和焊料层之间的界面中形成凹凸。

20. 发明申请

US20100013095A1 SEMICONDUCTOR DEVICE, PRODUCTION METHOD FOR THE SAME, AND SUBSTRATE 有权
标题翻译：半导体器件及其制造方法和衬底
公开(公告)号：US20100013095A1
公开(公告)日：2010-01-21
申请号：US12064434
申请日：2006-08-18
申请人： Motoharu Hada , Yasumasa Kasuya , Hiroaki Matsubara
发明人： Motoharu Hada , Yasumasa Kasuya , Hiroaki Matsubara
IPC分类号： H01L23/488 , H01L21/60 , B23K31/02
CPC分类号： H01L24/29 , H01L23/49811 , H01L23/49866 , H01L24/32 , H01L24/48 , H01L24/73 , H01L24/83 , H01L2224/04026 , H01L2224/29 , H01L2224/29101 , H01L2224/29109 , H01L2224/29111 , H01L2224/29144 , H01L2224/2919 , H01L2224/29298 , H01L2224/32225 , H01L2224/32507 , H01L2224/451 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/83444 , H01L2224/83801 , H01L2924/00013 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/0105 , H01L2924/01051 , H01L2924/01058 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0132 , H01L2924/0133 , H01L2924/0134 , H01L2924/014 , H01L2924/0665 , H01L2924/14 , H01L2924/1433 , H01L2924/15311 , H01L2924/15788 , H01L2924/181 , H01L2924/01028 , H01L2924/00012 , H01L2924/01049 , H01L2924/01083 , H01L2924/3512 , H01L2924/00 , H01L2224/29099 , H01L2224/29199 , H01L2224/29299 , H01L2224/2929 , H01L2224/45099 , H01L2224/05599
摘要： A semiconductor device is provided in which a semiconductor chip is bonded to a substrate with a sufficiently increased bonding strength and cracking is assuredly prevented which may otherwise occur due to heat shock, heat cycle and the like. The semiconductor device includes a semiconductor chip and a substrate having a bonding area to which the semiconductor chip is bonded via a metal layer. The metal layer includes an Au—Sn—Ni alloy layer and a solder layer provided on the Au—Sn—Ni alloy layer. Undulations are formed in an interface between the Au—Sn—Ni alloy layer and the solder layer.
摘要翻译：提供一种半导体器件，其中半导体芯片以足够高的接合强度结合到基板上，可靠地防止由于热冲击，热循环等而发生的开裂。半导体器件包括半导体芯片和具有通过金属层与半导体芯片接合的接合区域的基板。金属层包括Au-Sn-Ni合金层和设置在Au-Sn-Ni合金层上的焊料层。在Au-Sn-Ni合金层和焊料层之间的界面中形成凹凸。

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