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11. 发明授权

US07132436B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 失效
公开(公告)号：US07132436B2
公开(公告)日：2006-11-07
申请号：US10296552
申请日：2001-05-22
申请人： Guido Kurz , Marianne Nilsson
发明人： Guido Kurz , Marianne Nilsson
IPC分类号： C07D277/52 , C07D409/12 , A61K31/426 , A61K31/427
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D277/56 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/08 , C07D513/04
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

12. 发明授权

US07074788B2 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 失效
公开(公告)号：US07074788B2
公开(公告)日：2006-07-11
申请号：US10302329
申请日：2002-11-22
申请人： Guido Kurz , Marianne Nilsson , Jerk Vallgårda , Meredith Williams
发明人： Guido Kurz , Marianne Nilsson , Jerk Vallgårda , Meredith Williams
IPC分类号： C07D417/06 , A61K31/5377
CPC分类号： A61K31/381 , A61K31/433 , C07D231/12 , C07D233/56 , C07D249/08 , C07D285/08 , C07D285/135 , C07D333/36 , C07D409/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

13. 发明授权

US06540404B1 Sintered plain bearing for engines and gears 有权
标题翻译：用于发动机和齿轮的烧结滑动轴承
公开(公告)号：US06540404B1
公开(公告)日：2003-04-01
申请号：US09554299
申请日：2000-11-15
申请人： Gerd Dornhoefer , Hans-Peter Koch , Andreas Vogt , Thomas Broghammer , Guido Kurz , Werner Stehr
发明人： Gerd Dornhoefer , Hans-Peter Koch , Andreas Vogt , Thomas Broghammer , Guido Kurz , Werner Stehr
IPC分类号： F16C3310
CPC分类号： F16C33/1065 , H02K5/1672 , Y10S384/902
摘要： A sintered plain bearing for motors and gear drives, having a running surface formed by a bearing bore and capable of having lubricant applied to it from lubricant reservoirs in the bearing, in which the bearing bore has, alternatingly distributed over the circumference, high-compaction small-pore running surfaces and axially extending low-compaction open-pore lubricant reservoirs. Lubrication is improved, especially in the initial phases of operation, by the fact that the lubricant reservoirs are constituted by channel structures having at least two longitudinal channels, and that at least in some of the channel structures, some of the channel crests remaining between adjacent longitudinal channels are in contact with the shaft received by the bearing bore in order to transfer lubricant.
摘要翻译：一种用于马达和齿轮传动装置的烧结滑动轴承，其具有由轴承孔形成的行进表面，并且能够使润滑剂从其中轴承孔中具有的轴承孔中的润滑剂储存器交替地分布在圆周上，小孔运行表面和轴向延伸的低压开放孔隙润滑油储层。改善润滑性，特别是在初始操作阶段，润滑油储存器由具有至少两个纵向通道的通道结构构成，并且至少在一些通道结构中，一些通道波峰保持在相邻的纵向通道与由轴承孔接收的轴接触以便传递润滑剂。

14. 发明申请

US20060287374A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 审中-公开
公开(公告)号：US20060287374A1
公开(公告)日：2006-12-21
申请号：US11511224
申请日：2006-08-29
申请人： Tjeerd Barf , Marianne Nilsson , Jerk Vallgarda , Guido Kurz
发明人： Tjeerd Barf , Marianne Nilsson , Jerk Vallgarda , Guido Kurz
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D277/56 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/08 , C07D513/04
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

15. 发明授权

US06723277B1 Method for producing a milling disc and milling disc produced according to the inventive method 失效
标题翻译：根据本发明方法生产的研磨盘和研磨盘的方法
公开(公告)号：US06723277B1
公开(公告)日：2004-04-20
申请号：US09937546
申请日：2002-03-21
申请人： Guido Kurz , Herbert König , Thomas Broghammer
发明人： Guido Kurz , Herbert König , Thomas Broghammer
IPC分类号： B22F708
CPC分类号： B28D1/181 , B22F7/06 , B22F2998/10 , B22F3/02 , B22F3/1007 , B22F3/24
摘要： A method for producing a milling disc with embedded insets of hard metal, ceramics or other similar hard materials. The milling disc has a centrical bore in the base body of the disc. The tips of the insets protrude over the circumference of the disc body. The invention also relates to a milling disc produced according to the method wherein a powdery sintered metal material is filled into the recess of a mold pertaining to a compression molding die, and the mold matches the outer contour of the disc base body. Pre-fabricated insets are inserted into the sintered metal material and are positioned in the mold of the compression molding die. A green compact is subsequently pressed in the compression molding die and then taken out of the compression molding die. The green compact is sintered with the pressed insets and is subjected to hardening and/or surface treatment, if required. According to the milling disc, the resistance of the insets in the disc base body and the properties of the disc base body are improved.
摘要翻译：一种用硬质金属，陶瓷或其他类似硬质材料嵌入的铣削盘的制造方法。研磨盘在盘的基体中具有中心孔。插图的尖端突出在盘体的圆周上。本发明还涉及根据以下方法生产的研磨盘，其中将粉末烧结金属材料填充到与压缩成型模具相关的模具的凹部中，并且该模具匹配盘基体的外轮廓。将预制的插入件插入烧结金属材料中并且被定位在压缩模制模具的模具中。随后在压缩成型模具中压制生坯，然后从压缩模具中取出。如果需要，将压坯与压制的嵌入件烧结并进行硬化和/或表面处理。根据研磨盘，盘基体中的插入物的阻力和盘基体的特性得到改善。

16. 发明申请

US20090156644A1 Use of thiazole derivatives and analogues in the treatment of cancer 审中-公开
标题翻译：噻唑衍生物和类似物在癌症治疗中的应用
公开(公告)号：US20090156644A1
公开(公告)日：2009-06-18
申请号：US11989029
申请日：2006-07-21
申请人： Jacob Westman , Guido Kurz , Bjorn Eriksson , Christian Hedberg
发明人： Jacob Westman , Guido Kurz , Bjorn Eriksson , Christian Hedberg
IPC分类号： A61K31/426 , C07D277/14 , A61K31/4439 , C07D417/02
CPC分类号： A61K31/421 , A61K31/426 , A61K31/704
摘要： There is provided a use of a compound of formula (I), wherein X, Y, T, W, A1, A2R1, R5 and R6 have meanings given in the description for the manufacture of a medicament for the treatment of cancer.
摘要翻译：提供式（I）化合物的用途，其中X，Y，T，W，A1，A2R1，R5和R6具有在制备用于治疗癌症的药物的描述中给出的含义。

17. 发明申请

US20090136472A1 Use of thiazole derivatives and analogues in disorders caused by free fatty acids 审中-公开
标题翻译：在游离脂肪酸引起的疾病中使用噻唑衍生物和类似物
公开(公告)号：US20090136472A1
公开(公告)日：2009-05-28
申请号：US11989001
申请日：2006-07-21
申请人： Jacob Westman , Guido Kurz , Bjorn Eriksson , Christian Hdberg
发明人： Jacob Westman , Guido Kurz , Bjorn Eriksson , Christian Hdberg
IPC分类号： A61K38/28 , C07D277/14 , A61K31/426 , A61K38/43 , A61P3/00 , C12Q1/02 , A61K31/4439 , C07D413/02
CPC分类号： A61K31/421 , A61K31/426 , A61K31/704
摘要： There is provided a use of a compound of formula I, whereinX, T, Y, W, A1, A2, R1, R5 and R6 have meanings given in the description, for the manufacture of a medicament for the treatment of a disorder or condition caused by, linked to, or contributed to by, free fatty acids, such as hyperinsulinemia and associated conditions, including type 2 diabetes and the like.
摘要翻译：提供式I化合物的用途，其中X，T，Y，W，A1，A2，R 1，R 5和R 6具有在说明书中给出的含义，用于制备用于治疗病症或由游离脂肪酸引起的，与之相关或由其贡献的疾病，如高胰岛素血症和相关病症，包括2型糖尿病等。

18. 发明授权

US06329383B1 2-amino-5-pyrimidine acetic acid compounds 失效
标题翻译： 2-氨基-5-嘧啶乙酸化合物
公开(公告)号：US06329383B1
公开(公告)日：2001-12-11
申请号：US09490232
申请日：2000-01-24
申请人： Charles Hedgecock , Eric Desarbre , Guido Kurz , Martin Norin , Marguerite Luthman , Cathrin Widerståhl
发明人： Charles Hedgecock , Eric Desarbre , Guido Kurz , Martin Norin , Marguerite Luthman , Cathrin Widerståhl
IPC分类号： C07D40312
CPC分类号： C07D403/12 , C07D417/12
摘要： The present invention relates to new benzimidazole compounds with the following general structure (I): in which Y—X is >C═X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or Y—X is >C—X when X is H, alkyl, substituted alkyl, aryl, substituted aryl, OR9 or NHR9 and R2 is a bond to Y; Z is O, S or NR12; R1 is H, alkyl, substituted alkyl, aryl or substituted aryl; R3 is H, alkyl, substituted alkyl, aryl or substituted aryl, OR9 or NHR9; R4, R5, R6 and R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination and/or two adjacent R4, R5, R6 or R7 form a carbocyclic or heterocyclic ring; and R8, R9, R10, R11, R12 and R13 are H, alkyl, substituted alkylaryl, aryl and/or substituted aryl in any combination. These compounds are useful as a human Growth Hormone (hGH) mimetic, which trigger GH agonist effects in animals and especially as an orally available human Growth Hormone (hGH).
摘要翻译：本发明涉及具有以下一般结构（I）的新的苯并咪唑化合物：当X是NR 8，O或S且Y是X时，X = C = X，R 2是H，烷基，取代的烷基芳基或取代的芳基; 当X为H，烷基，取代的烷基，芳基，取代的芳基，OR9或NHR9时，或Y-X为> CX，R2为与Y的键; Z为O，S或NR12; R1为H，烷基，取代的烷基，芳基或取代的芳基; R3是H，烷基，取代的烷基，芳基或取代的芳基，OR9或NHR9; R4，R5，R6和R7是H，卤素，OR10，NR10，R11，NO2，CF3，CN，COR8，COOR8，任何组合和/或两个相邻的R4，R5，R6或R7中的CONHR8和/或N3形成碳环或杂环; 和R 8，R 9，R 10，R 11，R 12和R 13是任何组合中的H，烷基，取代的烷基芳基，芳基和/或取代的芳基。这些化合物可用作人类生长激素（hGH）模拟物，其在动物中引发GH激动剂效应特别是作为口服可用的人生长激素（hGH）。

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