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11. 发明授权

US06670143B2 Method of screening compounds that inhibit lysophosphatidic acid acyltransferase 失效
标题翻译：筛选抑制溶血磷脂酰基转移酶的化合物的方法
公开(公告)号：US06670143B2
公开(公告)日：2003-12-30
申请号：US09970989
申请日：2001-10-05
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： C12Q148
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

12. 发明授权

US5756511A Method for treating symptoms of a neurodegenerative condition 失效
标题翻译：治疗神经退行性疾病症状的方法
公开(公告)号：US5756511A
公开(公告)日：1998-05-26
申请号：US416270
申请日：1995-04-03
申请人： James W. West , David W. Leung , J. Peter Klein , Gail E. Underiner , Anil M. Kumar
发明人： James W. West , David W. Leung , J. Peter Klein , Gail E. Underiner , Anil M. Kumar
IPC分类号： A61K31/522 , A01N43/90
CPC分类号： A61K31/522
摘要： A method for treating symptoms of Alzheimer's Disease by administering an effective amount of a compound, racemate, isolated R or S enantionmer, solvate, hydrate or salt having the formula: X--terminal heterocyclic moiety. In the above formula, the terminal heterocyclic moiety is a 3,7-dimethylxanthinyl, 3-methylxanthinyyl or xanthinyl moiety and X is: ##STR1## n is zero or an integer from one to four; and m is an integer from seven to fourteen. For compounds useful in the inventive method, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. w may be an integer from one to twenty and R.sub.5 is preferably an hydroxyl, halo C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. R.sub.3 in compounds useful in the inventive method may be either an hydroxyl group, an oxygen atom, the single bond represented being instead a double bond, or --O--R.sub.4, R.sub.4 being a C.sub.1-6 oxoalkyl.
摘要翻译：通过施用有效量的具有下式的化合物，外消旋物，分离的R或S对映体，溶剂合物，水合物或盐，来治疗阿尔茨海默病症状的方法：在上式中，末端杂环部分为 3,7-二甲基黄烷基，3-甲基黄嘌呤基或xanthinyl部分，X为：n为0或1至4的整数; m为7〜14的整数。对于可用于本发明方法的化合物，R 1和R 2是氢，直链或支链烷基，链烯基或炔基，其长度为至多20个碳原子或 - （CH 2）w R 5。 w可以是从一到二十的整数，R 5优选为羟基，卤代C 1-8烷氧基或取代或未取代的碳环或杂环。可用于本发明方法的化合物中的R 3可以是羟基，氧原子，所表示的单键代替双键，或-O-R4，R4是C1-6氧代烷基。

13. 发明授权

US4857637A Methods and compositions for immunologically modulating growth hormone receptor activity 失效
标题翻译：用于免疫调节生长激素受体活性的方法和组合物
公开(公告)号：US4857637A
公开(公告)日：1989-08-15
申请号：US61942
申请日：1987-06-12
申请人： R. Glenn Hammonds , David W. Leung , David W. Martin, Jr. , Steven A. Spencer , William I. Wood
发明人： R. Glenn Hammonds , David W. Leung , David W. Martin, Jr. , Steven A. Spencer , William I. Wood
IPC分类号： A61K39/00 , C07K14/71 , C07K16/26 , C07K16/28 , C12N15/38
CPC分类号： C07K16/2863 , C07K14/71 , C07K16/26 , A61K39/00 , Y10S530/81 , Y10S930/30
摘要： The activity of growth-associated receptors is modulated in vivo in a controlled and reproducible fashion by immunizing animals against target growth-associated receptors. This is accomplished by the use of immunogens predetermined to induce primarily agonist or antagonist responses. The immunogens include anti-ligand antibodies and receptor derivatives.
摘要翻译：生长相关受体的活性以受控和可重复的方式通过免疫动物抵抗靶生长相关受体而在体内进行调节。这是通过使用预先诱导主要激动剂或拮抗剂反应的免疫原实现的。免疫原包括抗配体抗体和受体衍生物。

14. 发明授权

US07608620B2 LPAAT-β inhibitors and uses thereof 失效
标题翻译： LPAAT-β抑制剂及其用途
公开(公告)号：US07608620B2
公开(公告)日：2009-10-27
申请号：US11601513
申请日：2006-11-16
申请人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
发明人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
IPC分类号： C07D251/52 , C07D251/38 , A61K31/53 , A61P35/00
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
摘要翻译：本发明涉及三嗪及其用于抑制溶血磷脂酰基转移酶β（LPAAT-β）活性的用途。本发明还涉及使用所述三嗪治疗癌症的方法。本发明还涉及用于筛选LPAAT-β活性的方法。

15. 发明授权

US07064125B2 LPAAT-β inhibitors and uses thereof 失效
公开(公告)号：US07064125B2
公开(公告)日：2006-06-20
申请号：US10712900
申请日：2003-11-13
申请人： Baoqing Gong , John Tulinsky , Lynn Bonham , J. Peter Klein , Robert E. Finney , David M. Hollenback , Scott A. Shaffer , Norina M. Tang , Thayer H. White , David W. Leung
发明人： Baoqing Gong , John Tulinsky , Lynn Bonham , J. Peter Klein , Robert E. Finney , David M. Hollenback , Scott A. Shaffer , Norina M. Tang , Thayer H. White , David W. Leung
IPC分类号： A01N43/66
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.

16. 发明授权

US06944580B1 Method and system for designing frames and cases 有权
标题翻译：设计框架和案例的方法和系统
公开(公告)号：US06944580B1
公开(公告)日：2005-09-13
申请号：US09608620
申请日：2000-06-30
申请人： Karl Blume , Dennis L. Mackey , Amy U. Serwinowski , David W. Leung , Charlie Quackenbush , Jeffrey Simpson , Duncan C. Meyers , Frank Shurick , Henry Huizinga , Robert Rozelle , Gregory E. Chetta , Jonathan Schmid
发明人： Karl Blume , Dennis L. Mackey , Amy U. Serwinowski , David W. Leung , Charlie Quackenbush , Jeffrey Simpson , Duncan C. Meyers , Frank Shurick , Henry Huizinga , Robert Rozelle , Gregory E. Chetta , Jonathan Schmid
IPC分类号： G06F17/50
CPC分类号： G06F17/5018 , G06F2217/46
摘要： A method for designing an engine case static structure of a gas turbine engine includes creating signals representing an engine case static structure knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of an engine case static structure, wherein the knowledge base comprises at least one data value signal for each of the plurality of design rule signals. A desired data value signal is entered for a selected one of the plurality of parameter signals of an associated element of the engine case static structure and compared to the corresponding data value signal in the knowledge base for the corresponding one of the plurality of design rule signals. Signals representative of a geometric representation of the selected parameter signal may be created.
摘要翻译：一种用于设计燃气涡轮发动机的发动机壳体静态结构的方法包括产生表示发动机壳体静态结构的信息知识库的信号。知识库相对于发动机壳体静态结构的相关元件的相应多个参数信号具有多个设计规则信号，其中知识库包括用于多个设计规则信号中的每一个的至少一个数据值信号。对于发动机壳体静态结构的相关元件的多个参数信号中的所选择的一个输入期望的数据值信号，并与多个设计规则信号中相应的一个设计规则信号的知识库中的相应数据值信号进行比较。可以创建代表所选择的参数信号的几何表示的信号。

17. 发明授权

US06503700B1 Mammalian CDP-diacylglycerol synthase 失效
公开(公告)号：US06503700B1
公开(公告)日：2003-01-07
申请号：US09282218
申请日：1999-03-31
申请人： David W. Leung
发明人： David W. Leung
IPC分类号： C12N912
CPC分类号： C12N9/1241 , C12Y207/07041
摘要： There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.

18. 发明授权

US06200769B1 Mammalian CDP-diacylglycerol synthase 失效
标题翻译：哺乳动物CDP-二酰基甘油合酶
公开(公告)号：US06200769B1
公开(公告)日：2001-03-13
申请号：US09333696
申请日：1999-06-16
申请人： David W. Leung , Reitha Weeks
发明人： David W. Leung , Reitha Weeks
IPC分类号： C12Q148
CPC分类号： C12N9/1241
摘要： There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.
摘要翻译：公开了具有酶CDP-二酰基甘油合成酶（CDS）活性的cDNA序列和多肽。 CDS也称为CTP：磷脂酰胞苷酰转移酶。进一步公开了分离和产生参与哺乳动物细胞中磷脂酸代谢和信号传导的多肽的方法，特别是生产纯化形式的CDS。

19. 发明授权

US4775622A Expression, processing and secretion of heterologous protein by yeast 失效
标题翻译：酵母表达，处理和分泌异源蛋白质
公开(公告)号：US4775622A
公开(公告)日：1988-10-04
申请号：US438236
申请日：1982-11-01
申请人： Ronald A. Hitzeman , David W. Leung
发明人： Ronald A. Hitzeman , David W. Leung
IPC分类号： C12N15/09 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/575 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/76 , C12N1/16 , C12N1/19 , C12N15/00 , C12N15/12 , C12N15/20 , C12N15/21 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/265 , C12R1/645 , C12R1/865 , C12N1/18 , C12P19/34
CPC分类号： C12N15/81 , C07K14/555 , C07K14/61 , C07K2319/02 , Y10S930/12 , Y10S930/142 , Y10S930/30
摘要： Yeast organisms are caused to express, process, and secrete protein that is normally heterologous to yeast and not required for its viability by transforming yeast with an expression vector containing a gene encoding heterologous protein and a signal sequence also heterologous to yeast.
摘要翻译：通过用含有编码异源蛋白质的基因和与酵母异源的信号序列的表达载体转化酵母，使酵母生物体通过酵母表达，加工和分泌通常与酵母异源并且不需要其生存力的蛋白质。

20. 发明申请

US20100189726A1 LPAAT-BETA INHIBITORS AND USES THEREOF 审中-公开
标题翻译： LPAAT-BETA抑制剂及其用途
公开(公告)号：US20100189726A1
公开(公告)日：2010-07-29
申请号：US12569639
申请日：2009-09-29
申请人： Lynn BONHAM , J. Peter Klein , Robert E. Finney , David M. Hollenback , Scott A. Shaffer , Norina M. Tang , Thayer H. White , David W. Leung , Baoqing Gong , John Tulinsky
发明人： Lynn BONHAM , J. Peter Klein , Robert E. Finney , David M. Hollenback , Scott A. Shaffer , Norina M. Tang , Thayer H. White , David W. Leung , Baoqing Gong , John Tulinsky
IPC分类号： A61K31/53 , C07D251/50 , C07D405/12 , C07D251/52 , A61K39/00 , A61P35/00
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
摘要翻译：本发明涉及三嗪及其用于抑制溶血磷脂酰基转移酶的用途。（LPAAT-＆bgr）活动。本发明还涉及使用所述三嗪治疗癌症的方法。本发明还涉及用于筛选LPAAT-＆bgr的方法; 活动。

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