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11. 发明授权

US6006132A Atrial defibrillation system including a portable audible speech communication device 失效
标题翻译：心房除颤系统包括便携式声音通话装置
公开(公告)号：US6006132A
公开(公告)日：1999-12-21
申请号：US60544
申请日：1998-04-15
申请人： Willis A. Tacker, Jr. , Darrell O. Wagner
发明人： Willis A. Tacker, Jr. , Darrell O. Wagner
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395
摘要： An atrial defibrillation system monitors activity of a heart, detects atrial fibrillation, and cardioverts detected atrial fibrillation. The system includes an implantable atrial defibrillator including a plurality of operating stages for monitoring heart activity, detecting atrial fibrillation, and cardioverting atrial fibrillation, a message generator for generating messages indicative of operating stage operation status, and a transmitter to transmit the messages indicative of operating stage operating status. A nonimplantable communication device is dimensioned to be hand-held and includes a receiver for receiving the transmitted messages indicative of operating stage operation status, an addressable memory for storing a plurality of voice signals, a decoder responsive to received messages indicative of operating stage operation status for addressing selected ones of the stored voice signals, and a converter for converting the selected voice signals to audible sound.
摘要翻译：心房除颤系统监测心脏的活动，检测心房颤动，以及心律失常检测心房颤动。该系统包括可植入心房除颤器，其包括用于监测心脏活动的多个操作阶段，检测心房纤维性颤动和心律转复心房颤动，用于产生指示操作阶段操作状态的消息的消息发生器，以及发送器，用于发送指示操作的消息阶段运行状态。不可植入通信设备的尺寸被设计为手持式的，并且包括用于接收指示操作级操作状态的所发送消息的接收器，用于存储多个语音信号的可寻址存储器，响应于接收到的指示操作级操作状态的消息的解码器用于寻址所存储的语音信号中的所选择的一个;以及用于将所选择的语音信号转换成可听见的声音的转换器。

12. 发明授权

US5350402A Atrial defibrillator and method for providing T wave detection and interval timing prior to cardioversion 失效
标题翻译：心房除颤器和在心脏复律前提供T波检测和间隔时间的方法
公开(公告)号：US5350402A
公开(公告)日：1994-09-27
申请号：US67688
申请日：1993-05-26
申请人： Kenneth R. Infinger , Gregory M. Ayers , Darrell O. Wagner , John M. Adams
发明人： Kenneth R. Infinger , Gregory M. Ayers , Darrell O. Wagner , John M. Adams
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator and method provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting R waves of the heart, a second detector for detecting T waves of the heart, and a third detector for detecting atrial activity of the heart. An atrial fibrillation detector is responsive to the third detector for determining when the atria of the heart are in need of cardioversion. A cardioverting stage applies the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion, after the second detector detects a T wave, and in timed relation to an R wave detected by the first detector after the detected T wave is completed. The atrial defibrillator includes a timer for timing a predetermined delay time after the T wave is detected, which delay time must be completed before the atria are cardioverted in timed relation to a detected R wave to assure that the detected T wave is completed.
摘要翻译：可植入心房除颤器和方法为需要心脏复律的心脏心房提供心律转复的电能。心房除颤器包括用于检测心脏的R波的第一检测器，用于检测心脏的T波的第二检测器，以及用于检测心脏的心房活动的第三检测器。心房颤动检测器响应于第三检测器，用于确定心脏心房何时需要心脏复律。当心脏的心房需要心脏复律时，在第二检测器检测到T波之后，以及在与第一检测器之后检测到的R波的定时关系中，心脏转换的电能将心脏转换的能量应用于心脏的心房检测到T波完成。心房除颤器包括：定时器，用于在检测到T波之后定时预定的延迟时间，该延迟时间必须在心跳与检测的R波的定时关系转换之前完成，以确保检测到的T波完成。

13. 发明授权

US5259381A Apparatus for the automatic calibration of signals employed in oximetry 失效
标题翻译：用于自动校准血氧饱和度信号的装置
公开(公告)号：US5259381A
公开(公告)日：1993-11-09
申请号：US377722
申请日：1989-07-10
申请人： Peter W. Cheung , Karl F. Gauglitz , Scott W. Hunsaker , Stephen J. Prosser , Darrell O. Wagner , Robert E. Smith
发明人： Peter W. Cheung , Karl F. Gauglitz , Scott W. Hunsaker , Stephen J. Prosser , Darrell O. Wagner , Robert E. Smith
IPC分类号： A61B5/00 , A61B5/024 , G01N21/27
CPC分类号： G01N21/274 , A61B5/02427 , A61B5/14552 , A61B5/1495 , A61B2560/0252 , A61B2562/08
摘要： Under the present invention, a method and apparatus are provided for compensating for the effect temperature variations have on the wavelength of light emitted by the oximeter sensor light source (40, 42). In pulse oximetry, LEDs (40, 42) are typically employed to expose tissue to light at two different wavelengths. The light illuminating the tissue is received by a detector (38) where signals proportional to the intensity of light are produced. These signals are then processed by the oximeter circuitry to produce an indication of oxygen saturation. Because current oximetry techniques are dependent upon the wavelengths of light emitted by the LEDs (40, 42), the wavelengths must be known. Even when predetermined combinations of LEDs (40, 42) having relatively precise wavelengths are employed, variations in the wavelength of light emitted may result. Because the sensor (12) may be exposed to a significant range of temperatures while in use, the effect of temperature on the wavelengths may be significant. To compensate for this effect, a temperature sensor (50) is included in the sensor (12) to produce a signal indicative of sensor temperature. This signal is interpreted by the oximeter circuitry including, for example, a microcomputer (16), where the effect of temperature on wavelength is compensated for. In a preferred arrangement, this compensation takes the form of a computation of an alternative calibration curve from which the oxygen saturation is indicated, given a particular processing of signals from the detector (38).
摘要翻译：在本发明中，提供了一种方法和装置，用于补偿由血氧计传感器光源（40,42）发射的光的波长对温度变化的影响。在脉搏血氧测定中，通常使用LED（40,42）来将组织暴露于两个不同波长的光。照射组织的光被检测器（38）接收，其中产生与光强度成比例的信号。然后，这些信号由血氧计电路处理以产生氧饱和度的指示。因为目前的血氧测定技术取决于由LED（40,42）发射的光的波长，所以波长必须是已知的。即使当使用具有相对精确波长的LED（40,42）的预定组合时，也可能导致发射的光的波长的变化。因为传感器（12）可能在使用时暴露于显着的温度范围内，所以温度对波长的影响可能是显着的。为了补偿这种效果，传感器（12）中包括温度传感器（50），以产生指示传感器温度的信号。该信号由包括例如温度对波长的影响得到补偿的微计算机（16）的血氧计电路解释。在优选的布置中，给定来自检测器（38）的信号的特定处理，该补偿采用计算替代校准曲线的形式，从该氧化饱和度被指示。

14. 发明授权

US08874207B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US08874207B2
公开(公告)日：2014-10-28
申请号：US12963224
申请日：2010-12-08
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

15. 发明申请

US20110137385A1 METHOD AND APPARATUS FOR RELIEVING ANGINA SYMPTOMS USING LIGHT 审中-公开
标题翻译：使用光来消除神经症状的方法和装置
公开(公告)号：US20110137385A1
公开(公告)日：2011-06-09
申请号：US13024975
申请日：2011-02-10
申请人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
发明人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
IPC分类号： A61N5/06
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译：可植入医疗装置包括并入血管内支架中的发光电路。发光电路将光发射到缺血区域。该光具有适合于重现与缺血相关的心绞痛症状的特征。

16. 发明授权

US07885710B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US07885710B2
公开(公告)日：2011-02-08
申请号：US11318263
申请日：2005-12-23
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/372
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

17. 发明申请

US20080058881A1 METHOD AND SYSTEM FOR TREATING POST-MI PATIENTS 审中-公开
标题翻译：治疗后MI患者的方法和系统
公开(公告)号：US20080058881A1
公开(公告)日：2008-03-06
申请号：US11469767
申请日：2006-09-01
申请人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
发明人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
IPC分类号： A61N1/05
CPC分类号： A61N5/0601 , A61N1/3627 , A61N1/36585 , A61N1/3962 , A61N5/062 , A61N2005/063
摘要： An implantable device for delivering phototherapy is described that enables the phototherapy to be delivered to internal locations in either a clinical or ambulatory setting for treatment of post-MI patients. Telemetry circuitry enables the device to deliver the phototherapy upon command or be programmed to delivery the phototherapy according to a specified schedule. The device may also incorporate one or more sensing modalities that can be used to trigger delivery of phototherapy upon occurrence of a sensed event or condition. In one particular embodiment, the phototherapy device is incorporated into a cardiac rhythm management device that also delivers pacing and/or defibrillation therapy.
摘要翻译：描述了用于递送光疗法的可植入装置，其使得光疗能够在临床或动态设置中被输送到内部位置以用于治疗MI后患者。遥测电路使得设备能够根据命令传送光疗，或者被编程为根据指定的时间表传送光疗。该装置还可以包括一个或多个感测模式，其可以用于在感测的事件或状况发生时触发光疗的传送。在一个特定实施例中，光疗装置被并入还可以进行起搏和/或除颤疗法的心律管理装置中。

18. 发明授权

US5813999A Implantable atrial defibrillator providing reduced cardioversion discomfort 失效
标题翻译：植入性心房除颤器提供减少心脏复律不适
公开(公告)号：US5813999A
公开(公告)日：1998-09-29
申请号：US576671
申请日：1995-12-21
申请人： Gregory M. Ayers , Darrell O. Wagner
发明人： Gregory M. Ayers , Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/395
摘要： An implantable atrial cardiovertor applies cardioverting electrical energy to atria of a heart with reduced discomfort to a patient. The cardiovertor includes a storage capacitor having a capacitance and a discharge control for controlling discharge of the storage capacitor to apply the cardioverting electrical energy to the atria of the heart. The discharge control causes the applied cardioverting electrical energy to have a biphasic waveform having a first phase and a second phase of opposite polarity and equal time duration. The time durations of the first and second phases are each greater than four milliseconds, and the capacitance of the storage capacitor is greater than or equal to 120 .mu.F.
摘要翻译：可植入心房心律转换器将心脏转换电能施加到心脏的心房，使患者的不适感降低。心律转换器包括具有电容和放电控制的存储电容器，用于控制存储电容器的放电，以将心电转换电能施加到心脏的心房。放电控制使得所施加的心脏转换电能具有具有相反极性和相等持续时间的第一相位和第二相位的双相波形。第一相和第二相的持续时间大于四毫秒，并且存储电容器的电容大于或等于120μF。

19. 发明授权

US07142912B2 Method and apparatus for assessing and treating atrial fibrillation risk 有权
标题翻译：评估和治疗房颤风险的方法和装置
公开(公告)号：US07142912B2
公开(公告)日：2006-11-28
申请号：US10194435
申请日：2002-07-12
申请人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
发明人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
IPC分类号： A61N1/08
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for assessing the risk of atrial fibrillation in a patient by calculating the relative frequency of short and long intervals between successive heart beats during sinus rhythm is presented. An imbalance of short over long sinus intervals has been found to indicate a higher risk of atrial fibrillation. An implantable cardiac device may be configured to automatically deliver interventional therapy to restore sinus interval balance when such an imbalance is detected.
摘要翻译：提出了一种通过计算窦性心律连续心脏跳动之间的短间隔和长间隔的相对频率来评估患者心房颤动风险的方法和装置。发现短窦间隔短暂的不平衡表明心房颤动的风险更高。可植入的心脏装置可以被配置为当检测到这种不平衡时，自动地进行介入治疗以恢复窦间隔平衡。

20. 发明授权

US06546287B1 Controlled-power defibrillator and method of defibrillation 失效
标题翻译：控制功率除颤器和除颤方法
公开(公告)号：US06546287B1
公开(公告)日：2003-04-08
申请号：US09680790
申请日：2000-10-06
申请人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
发明人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
IPC分类号： A61N136
CPC分类号： A61N1/3937 , A61N1/3912
摘要： A controlled-power defibrillator and method of defibrillation for automatically compensating for changes in patient resistance during delivery of a defibrillation pulse. A switching power converter is connected between a storage capacitor and a pair of electrodes adapted for connection to a patient's body, either internally or externally. A closed-loop power control circuit is operatively connected to the power converter for control of the power delivered to the patient, the power control circuit generating a target voltage signal for the storage capacitor, the target voltage signal having a defined relationship with the waveform of the power desired to be delivered to the patient. The power control circuit monitors the actual voltage on the storage capacitor and adjusts the delivery of power to the patient as a function of the difference between desired and actual storage capacitor voltage. The power converter is adapted to capture energy from the discharge of an existing defibrillator and to convert captured energy from the existing defibrillator to a waveform different from that generated by the existing defibrillator.
摘要翻译：一种控制功率除颤器和除颤方法，用于在除颤脉冲输送期间自动补偿患者阻力的变化。开关功率转换器连接在存储电容器和适于连接到患者身体的一对电极之间，内部或外部。闭环功率控制电路可操作地连接到功率转换器，用于控制传递给患者的功率，功率控制电路产生用于存储电容器的目标电压信号，目标电压信号与期望输送给患者的功率。功率控制电路监视存储电容器上的实际电压，并根据期望的和实际的存储电容器电压之间的差异来调整向患者的电力输送。功率转换器适于从现有除颤器的放电中捕获能量，并且将来自现有除颤器的捕获能量转换为与现有除颤器产生的波形不同的波形。

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