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11. 发明申请

WO2009053867A3 VIRTUAL REALITY SIMULATIONS FOR HEALTH CARE CUSTOMER MANAGEMENT 审中-公开
标题翻译：虚拟现实模拟医疗保健顾客管理
公开(公告)号：WO2009053867A3
公开(公告)日：2009-08-06
申请号：PCT/IB2008053955
申请日：2008-09-29
申请人： KIMBERLY CLARK CO , ANDERSON JOEL , BOGA RAMESHBABU , BOWMAN DANIEL , CANSLER VALERIE , CLEMENT GARY , GAKHAR SUDHANSHU , HASTINGS PATRICK , LYNCH WILLIAM , PHILLIPS ERICA , RANGANATHAN SRIDHAR , TIMMERS RICHARD
发明人： ANDERSON JOEL , BOGA RAMESHBABU , BOWMAN DANIEL , CANSLER VALERIE , CLEMENT GARY , GAKHAR SUDHANSHU , HASTINGS PATRICK , LYNCH WILLIAM , PHILLIPS ERICA , RANGANATHAN SRIDHAR , TIMMERS RICHARD
IPC分类号： G06Q50/00 , G09B9/00
CPC分类号： G09B19/0076 , G06Q10/06 , G06Q50/22 , G09B23/28
摘要： Embodiments of the invention provide virtual reality tools and simulations used for improved health care customer management. The virtual reality tools may be used by a product manufacturer or seller to assist in relationship management with health care partners including identifying improved solutions for a variety of problems, strengthening infection prevention processes and systems, improving order and flow in the operating room and other care-delivery environments, identifying benefits from new products, providing techniques for evaluating new health care systems and processes, etc.
摘要翻译：本发明的实施例提供用于改进医疗保健客户管理的虚拟现实工具和模拟。产品制造商或卖方可以使用虚拟现实工具来协助与医疗保健合作伙伴进行关系管理，包括确定各种问题的改进解决方案，加强感染预防过程和系统，改善手术室和其他护理中的顺序和流程交付环境，确定新产品的好处，提供评估新医疗保健系统和流程的技术等。

12. 发明申请

WO2008072112A1 DETECTION OF FORMALDEHYDE IN URINE SAMPLES 审中-公开
标题翻译：尿素样品中的甲醛检测
公开(公告)号：WO2008072112A1
公开(公告)日：2008-06-19
申请号：PCT/IB2007/053957
申请日：2007-09-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , BOGA, Rameshbabu , MARTIN, Stephanie, M. , SMITH, Molly, K. , MCGRATH, Kevin, Peter
发明人： BOGA, Rameshbabu , MARTIN, Stephanie, M. , SMITH, Molly, K. , MCGRATH, Kevin, Peter
IPC分类号： G01N31/22
CPC分类号： G01N31/224 , A61F13/15 , A61F13/42 , A61F13/8405 , A61F2013/8473 , G01N21/78 , G01N33/52 , Y10T436/200833 , Y10T436/202499
摘要： A method for rapidly detecting the presence of formaldehyde in a urine sample (e.g., urine or a urinary material associated therewith, such as headspace gas located associated with urine) is provided. The method includes contacting the urine sample with a substrate on which is disposed a colorant that is capable of undergoing a detectable color change in the presence of formaldehyde. Without intending to be limited by theory, it is believed that oxidation of the colorant by formaldehyde induces either a shift of the absorption maxima towards the red end of the spectrum ("bathochromic shift") or towards the blue end of the spectrum ("hypsochromic shift"). The absorption shift provides a color difference that is detectable, either visually or through instrumentation, to indicate the presence of formaldehyde within the urine sample. For example, prior to contact with a urine sample, the colorant may be colorless or it may possess a certain color. However, after contacting the urine sample and reacting with formaldehyde, the colorant exhibits a color that is different than its initial color. The color change may thus be readily correlated to the presence of formaldehyde in the urine sample.
摘要翻译：提供了一种用于快速检测尿液样品中甲醛存在的方法（例如，尿液或与其相关的尿液，如与尿液相关联的顶部空间气体）。该方法包括使尿样与底物接触，其上设置有能够在甲醛存在下经历可检测的颜色变化的着色剂。不期望受理论的限制，据信甲醛对着色剂的氧化会诱发吸收最大值朝向光谱红色端（“红移”）或朝向光谱蓝色端（“变色” 转移”）。吸收移位提供了色彩差异，可以在视觉上或通过仪器检测来显示尿液样品中甲醛的存在。例如，在与尿样接触之前，着色剂可以是无色的或可以具有一定的颜色。然而，在接触尿液样品并与甲醛反应之后，着色剂显示与其初始颜色不同的颜色。因此，颜色变化可能容易地与尿液样品中甲醛的存在相关。

13. 发明申请

WO2005093414A3 ASSAY DEVICES UTILIZING CHEMICHROMIC DYES 审中-公开
标题翻译：使用化学染料的测定装置
公开(公告)号：WO2005093414A3
公开(公告)日：2006-03-02
申请号：PCT/US2005000681
申请日：2005-01-06
申请人： KIMBERLY CLARK CO , BOGA RAMESHBABU , MACDONALD JOHN GAVIN
发明人： BOGA RAMESHBABU , MACDONALD JOHN GAVIN
IPC分类号： G01N33/52
CPC分类号： G01N33/523
摘要： An assay device for detecting amines within a test sample (e.g., vaginal fluid) is provided. The assay device comprises a detection zone within which a chemichromic dye is contained. The chemichromic dye is capable of undergoing a color change upon exposure to one or more amines within the test sample.
摘要翻译：提供了用于检测测试样品（例如阴道液）中的胺的测定装置。测定装置包括其中含有化学染料的检测区域。化学染料染料能够在暴露于测试样品中的一种或多种胺之前发生颜色变化。

14. 发明申请

WO2006006960A1 ONE-STEP ENZYMATIC AND AMINE DETECTION TECHNIQUE 审中-公开
标题翻译：一步酶和胺检测技术
公开(公告)号：WO2006006960A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/011050
申请日：2005-03-31
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SONG, Xuedong , BOGA, RameshBabu , CHIDEBELU-EZE, Chibueze, Obi
发明人： SONG, Xuedong , BOGA, RameshBabu , CHIDEBELU-EZE, Chibueze, Obi
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , C12Q1/04
摘要： A technique for detecting the presence or quantity of an enzyme (or enzyme inhibitor) and/or an amine within a test sample is provided. For example, in one embodiment, a diagnostic test kit is employed that utilizes reactive complexes that each includes a substrate joined ( e.g., covalently bonded, physically adsorbed, etc.) to a reporter and a separation species. Upon contacting the reactive complexes, enzymes may cleave the substrate and release the reporter. Moreover, the test kit may also employ a chemichromic dye, i.e., a dye that exhibits a detectable color change upon chemical reaction with one or more functional groups, such as amino groups. The signal generated (directly or indirectly) by the reporter and chemichromic dye may then be used to indicate the presence or quantity of an enzyme (or enzyme inhibitor) and amine, respectively, within the test sample.
摘要翻译：提供了用于检测测试样品中酶（或酶抑制剂）和/或胺的存在或量的技术。例如，在一个实施方案中，使用诊断测试试剂盒，其使用各自包含连接的底物的反应性复合物（<

15. 发明申请

WO2005093414A2 ASSAY DEVICES UTILIZING CHEMICHROMIC DYES 审中-公开
标题翻译：使用化学染料的测定装置
公开(公告)号：WO2005093414A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/000681
申请日：2005-01-06
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , BOGA, RameshBabu , MACDONALD, John, Gavin
发明人： BOGA, RameshBabu , MACDONALD, John, Gavin
IPC分类号： G01N33/52
CPC分类号： G01N33/523
摘要： An assay device for detecting amines within a test sample (e.g., vaginal fluid) is provided. The assay device comprises a detection zone within which a chemichromic dye is contained. The chemichromic dye is capable of undergoing a color change upon exposure to one or more amines within the test sample.
摘要翻译：提供了用于检测测试样品（例如阴道液）中的胺的测定装置。测定装置包括其中含有化学染料的检测区域。化学染料染料能够在暴露于测试样品中的一种或多种胺之前发生颜色变化。

16. 发明申请

WO2005040794A3 VISUAL INDICATING DEVICE FOR BAD BREATH 审中-公开
标题翻译：视觉指示装置
公开(公告)号：WO2005040794A3
公开(公告)日：2005-09-09
申请号：PCT/US2004027626
申请日：2004-08-23
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , HUANG YANBIN , MCGRATH KEVIN PETER , BOGA RAMESHBABU
发明人： MACDONALD JOHN GAVIN , HUANG YANBIN , MCGRATH KEVIN PETER , BOGA RAMESHBABU
IPC分类号： B41M5/136 , B41M5/30 , G01N31/22 , G01N33/00 , G01N33/497
CPC分类号： G01N33/497 , B41M5/30 , G01N31/223 , G01N33/52 , G01N33/54346
摘要： The invention provides a breath testing device which includes a visual indicating agent which changes color in the presence of an odor associated with bad breath, such as sulfur and ammonia odors. An example of the visual indicating agent is 4,4'-bis(dimethylamino)-benzhydrol (Michler's hydrol or BDMB) and related dyes having a similar chemical structure. The indicating agent is applied to a substrate which is then inserted into a tube or straw, or which covers one end of a straw. When a user with bad breath blows into the tube or straw, the indicating agent will change color. The breath testing devices provide a quick and affordable means for a user to test their breath, and they may be packaged in discreet, pocket-sized dispensers which can be carried in a pocket or purse.
摘要翻译：本发明提供了一种呼吸测试装置，其包括在存在与口臭相关的气味（例如硫和氨气味）的情况下改变颜色的视觉指示剂。视觉显示剂的一个实例是4,4'-双（二甲基氨基） - 二苯甲醇（Michler's hydrol或BDMB）和具有相似化学结构的相关染料。将指示剂施加到基材上，然后将其插入管或吸管中，或覆盖吸管的一端。当口臭的用户吹入管或吸管时，指示剂会改变颜色。呼吸测试装置为用户提供了一种快速且经济实惠的手段来测试他们的呼吸，并且它们可以被包装在谨慎的袖珍尺寸的分配器中，该分配器可以携带在口袋或钱包中。

17. 发明申请

WO2005068969A1 SELF-CONTAINED SWAB-BASED DIAGNOSTIC SYSTEMS 审中-公开
标题翻译：自包含基于SWAB的诊断系统
公开(公告)号：WO2005068969A1
公开(公告)日：2005-07-28
申请号：PCT/US2004/025860
申请日：2004-08-09
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , KAYLOR, Rosann, Marie, Matthews , BOGA, RameshBabu , YANG, Kaiyuan , COHEN, David, Samuel , VELAZQUEZ, Herb , O'CONNOR, Amanda, Lee
发明人： KAYLOR, Rosann, Marie, Matthews , BOGA, RameshBabu , YANG, Kaiyuan , COHEN, David, Samuel , VELAZQUEZ, Herb , O'CONNOR, Amanda, Lee
IPC分类号： G01N1/02
CPC分类号： G01N1/02 , C12M33/02 , G01N2001/028 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second end. A swab is disposed at the first end of the stem, the swab being configured to collect a test sample derived from a biological source that is suspected of containing an analyte. The test unit also comprises a fluid chamber configured to contain a fluid, wherein the fluid chamber is in fluid communication with the swab via the flow channel. The test unit also comprises a rupturable seal that inhibits leakage of the fluid from the fluid chamber prior to use, and an assay for detecting the presence or absence of the analyte. The assay is in fluid communication with the swab, the flow channel, and the fluid chamber.
摘要翻译：提供诊断测试单元。测试单元包括具有第一端和第二端的杆，所述杆限定在第一端和第二端之间延伸的至少一个流动通道。拭子设置在茎的第一端，拭子被配置为收集源自怀疑含有分析物的生物源的测试样品。测试单元还包括被配置为容纳流体的流体室，其中流体室经由流动通道与拭子流体连通。测试单元还包括可破坏的密封，其在使用之前抑制流体从流体室的泄漏，以及用于检测分析物的存在或不存在的测定。测定与拭子，流动通道和流体室流体连通。

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