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11. 发明申请

WO2003079401A3 DIRECTED ASSEMBLY OF FUNCTIONAL HETEROSTRUCTURES 审中-公开
公开(公告)号：WO2003079401A3
公开(公告)日：2003-09-25
申请号：PCT/US2002/020023
申请日：2002-06-21
申请人： BIOARRAY SOLUTIONS, LTD. , BANERJEE, Sukanta , SEUL, Michael , PODUAL, Kairali , HONG, Ye
发明人： BANERJEE, Sukanta , SEUL, Michael , PODUAL, Kairali , HONG, Ye
IPC分类号： G01N21/00
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films. This invention also provides simple methods and apparatus for synthesizing thin films of tailored composition and morphology.

12. 发明申请

WO2007081778A3 MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES 审中-公开
标题翻译：多重检测抗红细胞抗体
公开(公告)号：WO2007081778A3
公开(公告)日：2007-09-13
申请号：PCT/US2007000234
申请日：2007-01-04
申请人： BIOARRAY SOLUTIONS LTD , BANERJEE SUKANTA
发明人： BANERJEE SUKANTA
IPC分类号： G01N33/53
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525
摘要： Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection of clinically important allo-immune antibodies to blood group antigens. Specifically the method involves generating fluorescently encoded red blood cells or red blood cell ghosts with known antigen presentation and using them to detect the presence of antibody in serum/plasma with a fluorescent sandwich type immunoassay. The assay results can be read using flow cytometric or fluorescent microscope based imaging techniques.
摘要翻译：公开了用于检测样品中的抗体的方法，其中抗体靶向由红细胞或红细胞鬼影表达的抗原。本发明的方法不是检测特定抗原抗体对之间的结合事件（如在传统的基于凝集的测定中），而是允许对血型抗原的临床上重要的同种免疫抗体进行多重检测。具体而言，该方法涉及产生具有已知抗原呈递的荧光编码的红血细胞或红细胞重影，并使用它们通过荧光三明治型免疫测定来检测血清/血浆中抗体的存在。可以使用基于流式细胞术或基于荧光显微镜的成像技术来读取测定结果。

13. 发明申请

WO2006130347A2 CREATION OF FUNCTIONALIZED MICROPARTICLE LIBRARIES BY OLIGONUCLEOTIDE LIGATION OR ELONGATION 审中-公开
标题翻译：通过寡核苷酸结合或延伸产生功能化的微生物图谱
公开(公告)号：WO2006130347A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/019203
申请日：2006-05-17
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , YANG, Jiacheng , BANERJEE, Sukanta
发明人： SEUL, Michael , YANG, Jiacheng , BANERJEE, Sukanta
CPC分类号： B01J19/0046 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C12N15/1093 , C40B20/04 , C40B50/14
摘要： Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5 '-end, (or possibly at the 3' end) to an encoded carrier such as a color-coded microparticle ("bead"). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.
摘要翻译：公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法在5'端，（或可能在3'端）与经编码的载体（如着色微粒（“珠”））相连。也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

14. 发明申请

WO2005043117A3 GEL-SHELL BEADS WITH ADSORBED OR BOUND BIOMOLECULES 审中-公开
标题翻译：具有吸附或固体生物分子的凝胶珠
公开(公告)号：WO2005043117A3
公开(公告)日：2006-08-17
申请号：PCT/US2004035437
申请日：2004-10-26
申请人： BIOARRAY SOLUTIONS LTD , BANERJEE SUKANTA , TAN ENQING
发明人： BANERJEE SUKANTA , TAN ENQING
IPC分类号： C12Q1/68 , G01N20060101 , G01N33/543 , A23J1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N11/02 , C12N11/04 , G01N33/53 , G01N33/536 , G01N33/537 , G01N33/539 , G01N33/541 , G01N33/542 , G01N33/544 , G01N33/545 , G01N33/546 , G01N33/549 , G01N33/551 , G01N33/552 , G01N33/553 , G01N33/557
CPC分类号： G01N33/5436
摘要： Disclosed are gel-coated beads (including Hydrogel TM -coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gelcoated beads with absorbed or adsorbed biomolecules are suitable for use in an assays, purification or other purposes. The beads have a core made from any of a number of materials, including latex, coated with the gel shell. The biomolecules can be retained within the gel, following adsorption, by covalent attachment, or, by selection of conditions of ambient pH and/or ionic strength such that they are retained without further reaction. Therefore, adsorbed proteins would retain the ability to bind to their respective ligands.
摘要翻译：公开了能够吸附或吸收蛋白质和其它生物分子到凝胶涂层上或凝胶涂层上的凝胶涂覆的珠粒（包括水凝胶涂覆的珠粒）。具有吸附或吸附的生物分子的凝胶珠适用于测定，纯化或其它目的。珠粒具有由许多材料制成的芯，包括用凝胶壳涂覆的胶乳。生物分子可以保留在凝胶内，吸附后，通过共价连接，或通过选择环境pH和/或离子强度的条件使得它们在没有进一步反应的情况下被保留。因此，吸附的蛋白质将保留结合其各自配体的能力。

15. 发明申请

WO2005043117A2 GEL-SHELL BEADS WITH ADSORBED OR BOUND BIOMOLECULES 审中-公开
标题翻译：具有吸附或固体生物分子的凝胶珠
公开(公告)号：WO2005043117A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/035437
申请日：2004-10-26
申请人： BIOARRAY SOLUTIONS LTD. , BANERJEE, Sukanta , TAN, Enqing
发明人： BANERJEE, Sukanta , TAN, Enqing
IPC分类号： G01N
CPC分类号： G01N33/5436
摘要： Disclosed are gel-coated beads (including Hydrogel TM -coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gelcoated beads with absorbed or adsorbed biomolecules are suitable for use in an assays, purification or other purposes. The beads have a core made from any of a number of materials, including latex, coated with the gel shell. The biomolecules can be retained within the gel, following adsorption, by covalent attachment, or, by selection of conditions of ambient pH and/or ionic strength such that they are retained without further reaction. Therefore, adsorbed proteins would retain the ability to bind to their respective ligands.
摘要翻译：公开了能够吸附或吸收蛋白质和其它生物分子到凝胶涂层上或凝胶涂层上的凝胶涂覆的珠粒（包括水凝胶涂层的珠粒）。具有吸附或吸附的生物分子的凝胶珠适用于测定，纯化或其它目的。珠粒具有由许多材料制成的芯，包括用凝胶壳涂覆的胶乳。生物分子可以保留在凝胶内，吸附后，通过共价连接，或通过选择环境pH和/或离子强度的条件使得它们在没有进一步反应的情况下被保留。因此，吸附的蛋白质将保留结合其各自配体的能力。

16. 发明申请

WO2005042763A3 OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CAPTURE PROBES 审中-公开
公开(公告)号：WO2005042763A3
公开(公告)日：2005-05-12
申请号：PCT/US2004/035426
申请日：2004-10-26
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , BANERJEE, Sukanta , YANG, Jiacheng , VENER, Tatiana
发明人： SEUL, Michael , BANERJEE, Sukanta , YANG, Jiacheng , VENER, Tatiana
IPC分类号： C12Q1/68
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target "engineering", as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized ("grafted") probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3' terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

17. 发明申请

WO2005031305A2 SURFACE IMMOBILIZED POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS CAPABLE OF COVALENTLY BONDING TO BIOMOLECULES 审中-公开
标题翻译：具有多个功能组合的表面固定聚电解质，可共同连接生物分子
公开(公告)号：WO2005031305A2
公开(公告)日：2005-04-07
申请号：PCT/US2004/031058
申请日：2004-09-22
申请人： BIOARRAY SOLUTIONS, LTD. , WANG, Xinwen , BANERJEE, Sukanta
发明人： WANG, Xinwen , BANERJEE, Sukanta
IPC分类号： G01N
CPC分类号： C12Q1/6834 , C07H21/04 , G01N33/54353 , C12Q2563/119
摘要： A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.
摘要翻译：具有多个暴露的官能团的聚电解质，每个这样的基团能够共价键合到分子，固定在表面上用于与生物分子结合的目的。生物分子可以是例如核酸，例如胺官能化的寡核苷酸。聚电解质可以包括例如BSA（牛血清白蛋白），其使用共价固定策略结合到官能化表面，例如与甲苯磺酰基活化的微粒的表面反应。在这样的反应之后，蛋白质上暴露的反应性官能团如胺，羧基，硫醇，羟基可进一步用于使用合适的化学物质共价连接感兴趣的寡核苷酸。

18. 发明申请

WO2003058199A3 ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2003058199A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041623
申请日：2002-12-27
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
发明人： SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
IPC分类号： G01N33/543
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays acccording to the methods described herein. The chip and/or multichip arrays of this invention are useful for chemical and biological assays.

19. 发明申请

WO2003058199A2 ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF 审中-公开
标题翻译：微阵列阵列及其制备方法
公开(公告)号：WO2003058199A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041623
申请日：2002-12-27
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
发明人： SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
IPC分类号： G01N
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays acccording to the methods described herein. The chip and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在可根据本文描述的方法组合形成多芯片阵列的芯片上。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

20. 发明申请

WO2002076585A1 ANALYSIS AND FRACTIONATION OF PARTICLES NEAR SURFACES 审中-公开
标题翻译：颗粒附近的表面分析和分离
公开(公告)号：WO2002076585A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/008706
申请日：2002-03-21
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , BANERJEE, Sukanta , PODUAL, Kairali
发明人： SEUL, Michael , BANERJEE, Sukanta , PODUAL, Kairali
IPC分类号： B01D57/02
CPC分类号： G01N15/0266 , B03C5/026 , C02F1/469 , G01N2015/0294
摘要： A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS ("Light-controlled Electrokinetic Assembly of Particles near Surfaces") is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode and an electrolyte solution. A mixture of particles are fractionated according to their relaxation frequencies, which in turn reflect differences in size or surface composition of the particles. Particles may also be analyzed to determine their physical and chemical properties based on particle relaxation frequency and maximal velocity.
摘要翻译：提供了一种用于分级颗粒混合物和用于颗粒分析的方法和装置，其中使用LEAPS（“靠近表面的颗粒的光控电动组装”）分级分析悬浮在电极和电解质溶液。颗粒的混合物根据它们的松弛频率进行分级，这又反映了颗粒的尺寸或表面组成的差异。还可以分析颗粒以基于颗粒松弛频率和最大速度确定其物理和化学性质。

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