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11. 发明申请

US20090062197A1 Sp1 Polypeptides, Modified Sp1 Polypeptides and Uses Thereof 有权
标题翻译： Sp1多肽，修饰的Sp1多肽及其用途
公开(公告)号：US20090062197A1
公开(公告)日：2009-03-05
申请号：US11988314
申请日：2006-07-09
申请人： Amnon Wolf , Yenonathan Pouny , Ira Marton , Or Dgany , Arie Altman , Oded Shoseyov
发明人： Amnon Wolf , Yenonathan Pouny , Ira Marton , Or Dgany , Arie Altman , Oded Shoseyov
IPC分类号： A61K38/17 , C07K14/435 , A61P43/00 , C07H21/00
CPC分类号： A61K47/48246 , A61K38/17 , A61K47/48884 , A61K47/64 , A61K47/6929 , B82Y30/00 , C07K14/415
摘要： SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
摘要翻译：提供了能够与物质形成可逆分子缔合的SP1和修饰的SP1变体多肽，包含其的物质组合物及其用途。

12. 发明授权

US07253341B2 Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof 有权
标题翻译：变性剂稳定和/或蛋白酶抗性，伴侣样寡聚蛋白，编码它们的多核苷酸，其用途和提高其比活性的方法
公开(公告)号：US07253341B2
公开(公告)日：2007-08-07
申请号：US10233409
申请日：2002-09-04
申请人： Wangxia Wang , Dan Pelah , Tal Alegrand , Yehonathan Pouny , Ira Marton , Amnon Wolf , Oded Shoseyov , Arie Altman
发明人： Wangxia Wang , Dan Pelah , Tal Alegrand , Yehonathan Pouny , Ira Marton , Amnon Wolf , Oded Shoseyov , Arie Altman
IPC分类号： C12N15/79 , C12N15/82 , A01H5/00
CPC分类号： C12P21/02 , A61K38/00 , C07K14/415 , C07K2319/00 , C07K2319/20 , C07K2319/35 , C12N9/96 , C12N15/62 , C12N15/8257 , C12N15/8271 , C12N15/8273
摘要： Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.
摘要翻译：新型变性剂稳定，蛋白酶抗性，同源寡聚蛋白，本文也称为具有伴侣样活性的稳定蛋白（SP）; SP的生产和净化方法; 编码SP的核酸; 分离编码SP的核酸的方法; 识别SP的抗体; 使用SP来稳定，重折叠，修复，防止聚集和聚集大分子如蛋白质; 融合蛋白包括SP; 编码融合蛋白的核酸构建体; 及其在各种方法和应用中的应用。

13. 发明授权

US06664368B1 Inhibition of nuclear import by backbone cyclic peptide analogs 失效
标题翻译：通过骨架环肽类似物抑制核进口
公开(公告)号：US06664368B1
公开(公告)日：2003-12-16
申请号：US09564677
申请日：2000-05-04
申请人： Assaf Friedler , Abraham Loyter , Chaim Gilon , Amnon Wolf
发明人： Assaf Friedler , Abraham Loyter , Chaim Gilon , Amnon Wolf
IPC分类号： C07K750
CPC分类号： C07K14/005 , C12N2740/16322
摘要： The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12 &mgr;M exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75% in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes.
摘要翻译：公开了功能上模拟大分子的核定位信号（NLS）区域的骨架环肽类似物的设计和合成。对于HIV-1蛋白Vif的人免疫缺陷病毒1型蛋白MA，Vpr，Tat和NLS样序列的NLS序列，举例说明了本发明的原理。我们公开了一种称为BCvir的新型高效骨架环肽的发现，其抑制核导入，IC50值为35nM。将该抑制效力与线性亲本HIV-1 MA NLS肽显示的12μM进行比较。在感染的非分裂培养的人类T细胞中，BCvir还将艾滋病毒1的产量降低了75％，并且相对抗胰蛋白酶消化。这些性质使NLS或NLS样序列的骨架环肽类似物作为基于阻断核进入病毒基因组的新型药物的候选物。

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