专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20060173049A1 Amino-pyridines as inhibitors of beta-secretase 失效
标题翻译：氨基吡啶作为β-分泌酶的抑制剂
公开(公告)号：US20060173049A1
公开(公告)日：2006-08-03
申请号：US11344432
申请日：2006-01-31
申请人： Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
发明人： Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
IPC分类号： C07D403/02 , A61K31/4439
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的氨基 - 吡啶化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

12. 发明申请

US20060148808A1 Substituted heterocycle fused gamma-carbolines 有权
标题翻译：取代的杂环稠合的γ-咔啉
公开(公告)号：US20060148808A1
公开(公告)日：2006-07-06
申请号：US11375125
申请日：2006-03-14
申请人： Albert Robichaud , Taekyu Lee , Wei Deng , Ian Mitchell , Michael Yang , Simon Haydar , Wenting Chen , Christopher McClung , Emilie Calvello , David Zawrotny
发明人： Albert Robichaud , Taekyu Lee , Wei Deng , Ian Mitchell , Michael Yang , Simon Haydar , Wenting Chen , Christopher McClung , Emilie Calvello , David Zawrotny
IPC分类号： A61K31/498 , C07D487/14
CPC分类号： C07D471/06 , C07D221/18 , C07D223/32 , C07D471/16 , C07D487/06 , C07D491/06 , C07D495/06 , C07D513/06 , C07D513/16 , C07D519/00
摘要： The present invention is directed to compounds useful for treating addictive behavior and sleep disorders represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The compounds used in the method of treatment of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including addictive behavior and sleep disorders.
摘要翻译：本发明涉及可用于治疗由结构式（I）或其药学上可接受的盐形式表示的成瘾行为和睡眠障碍的化合物，其中R 1，R 5， R 6a，R 6b，R 7，R 8，R 9， X，b，k，m和n，这里描述虚线。用于治疗本发明的方法中的化合物是血清素激动剂和拮抗剂，并且可用于控制或预防中枢神经系统疾病，包括上瘾行为和睡眠障碍。

13. 发明授权

US06638934B2 Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands 有权
标题翻译：取代的吡嗪喹喔啉衍生物作为血清素受体激动剂和拮抗剂配体
公开(公告)号：US06638934B2
公开(公告)日：2003-10-28
申请号：US10026404
申请日：2001-12-19
申请人： Albert Robichaud , Ian S. Mitchell , Taekyu Lee , Wenting Chen
发明人： Albert Robichaud , Ian S. Mitchell , Taekyu Lee , Wenting Chen
IPC分类号： C07D48702
CPC分类号： C07D487/04
摘要： The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n, and X are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep and sexual disorders, migraine and other conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
摘要翻译：本发明涉及由结构式（I）和（Ia）表示的新化合物：或其药学上可接受的盐，其中R 1，R 4a，R 4b，R 5， R 6，R 7，R 8，R 9，n和X如本文所述。本发明还涉及包含这些新化合物作为活性成分的药物制剂，以及新型化合物及其制剂在治疗某些疾病中的用途。本发明的化合物是血清素激动剂和拮抗剂，可用于控制或预防中枢神经系统疾病，包括肥胖症，焦虑症，抑郁症，精神病，精神分裂症，睡眠和性障碍，偏头痛和与头痛相关的其他病症，社交恐怖症，以及胃肠道疾病如胃肠道运动功能障碍。

14. 发明申请

US20070037802A1 Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands 有权
标题翻译：取代的3-磺基吲唑衍生物作为5-羟色胺-6配体
公开(公告)号：US20070037802A1
公开(公告)日：2007-02-15
申请号：US11504350
申请日：2006-08-14
申请人： Hassan Elokdah , Alexander Greenfield , Kevin Liu , Robert McDevitt , Geraldine McFarlane , Cristina Grosanu , Jennifer Lo , Yanfang Li , Albert Robichaud , Ronald Bernotas
发明人： Hassan Elokdah , Alexander Greenfield , Kevin Liu , Robert McDevitt , Geraldine McFarlane , Cristina Grosanu , Jennifer Lo , Yanfang Li , Albert Robichaud , Ronald Bernotas
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/416 , C07D413/02 , C07D403/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

15. 发明申请

US20070004730A1 Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation 失效
标题翻译：氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070004730A1
公开(公告)日：2007-01-04
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
发明人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
IPC分类号： A61K31/53 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

16. 发明申请

US20050250798A1 Pyrimidoindolones and methods for using same 失效
标题翻译：嘧啶二酮和其使用方法
公开(公告)号：US20050250798A1
公开(公告)日：2005-11-10
申请号：US11061144
申请日：2005-02-18
申请人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler
发明人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler
IPC分类号： A61K31/519 , C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要翻译：公开了新的嘧啶吲哚酮化合物。还公开了使用嘧啶吲哚酮酮化合物和含有该化合物的组合物在治疗和/或预防与炎症，神经变性，骨关节炎和细胞凋亡相关的疾病和其它病状的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式