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11. 发明申请

WO2007143426A2 DEVICE AND METHOD FOR ACCESSING FLUID IN CONTAINER 审中-公开
标题翻译：用于容器中流体流动的装置和方法
公开(公告)号：WO2007143426A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/069735
申请日：2007-05-25
申请人： ADVANCED SCIENTIFICS, INC. , MARTIN, Carl
发明人： MARTIN, Carl
IPC分类号： F16K5/10
CPC分类号： B67D7/0294 , Y10T137/86501
摘要： A device (10) and method for aseptically or non-aseptically accessing a fluid in a container (210) using an existing container opening (211). The device (10) includes a sanitary fitting (12) for attaching the device to the container over the existing container opening, and a sample coupling (14) associated with the sanitary fitting. The sanitary fitting (12) includes a first port (32), and the sample coupling (14) includes at least two second ports (52). The sample coupling (14) is rotatable relative to the sanitary fitting (12) in one direction to cause the first port (32) to successively align with each of the second ports (52), and thereby allows access to the fluid through the aligned first and second ports (32, 52).
摘要翻译：一种使用现有容器开口（211）无菌或非无菌地进入容器（210）中的流体的装置（10）和方法。装置（10）包括用于将装置连接到现有容器开口上的容器的卫生用品（12）和与卫生配件相关联的样品联接器（14）。卫生配件（12）包括第一端口（32），并且样品联接器（14）包括至少两个第二端口（52）。样品联接器（14）可以在一个方向上相对于卫生配件（12）旋转，以使第一端口（32）与每个第二端口（52）连续对准，从而允许通过对准第一和第二端口（32,52）。

12. 发明申请

WO2015142696A1 MIXING ASSEMBLY AND MIXING METHOD 审中-公开
标题翻译：混合组装和混合方法
公开(公告)号：WO2015142696A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/020665
申请日：2015-03-16
申请人： ADVANCED SCIENTIFICS, INC.
发明人： PAVLIK, Rudolf
IPC分类号： B01F3/12 , B01F11/00 , B01F15/00 , C12M1/06
CPC分类号： B01F15/0085 , B01F3/1221 , B01F11/0048 , B01F11/0082 , B01F15/00129 , B01F15/00155 , B01F15/00207 , B01F15/00253 , B01F15/00259 , B01F15/00402 , B01F15/00467 , B01F15/00538 , B01F2215/0073 , C12M23/14
摘要： A mixing system and mixing method are provided. The mixing system includes a tank assembly, a container (202) positioned within the tank assembly, a mixer (204) disposed within a compartment of the container, a linear motor, and a shaft (208) having a first end secured to the mixer (204) and an opposing second end secured to the linear motor. The linear motor provides a variable stroke length for the shaft. The mixing method includes providing a tank assembly having a linear motor, positioning a mixing assembly including a mixing bag (202) in the tank assembly, combining two or more components in a compartment of the mixing bag (202), attaching a mixing shaft (208) extending from a mixer (204) disposed within the mixing bag (202) to the linear motor, and raising and lowering the mixing shaft (208) to mix the two or more components. A stroke length of the mixing shaft (208) during the raising and lowering is varied.
摘要翻译：提供了一种混合系统和混合方法。混合系统包括罐组件，定位在罐组件内的容器（202），设置在容器的隔室内的混合器（204），线性马达和轴（208），其具有固定到混合器（204）和固定到线性电动机的相对的第二端。线性电机为轴提供了可变行程长度。混合方法包括提供具有线性马达的罐组件，将包括混合袋（202）的混合组件定位在罐组件中，将混合袋（202）的隔室中的两个或更多个部件组合在一起，将混合轴（ 208），其从设置在所述混合袋（202）内的混合器（204）延伸到所述线性马达，以及升高和降低所述混合轴（208）以混合所述两个或更多个部件。在升降过程中混合轴（208）的冲程长度是变化的。

13. 发明授权

US11179687B2 Transportable mixing system for biological and pharmaceutical materials 有权
公开(公告)号：US11179687B2
公开(公告)日：2021-11-23
申请号：US16515322
申请日：2019-07-18
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： B01F13/00 , B01F15/00 , B01F7/16 , B65D77/06 , B01F1/00
摘要： A mixing system includes a container having a support plate and a mixing assembly supported on the support plate. The mixing assembly includes a pliable enclosure containing a fluid and a mixing device. A portion of the mixing device extends from the pliable enclosure and is adapted to be detachably coupled to a drive mechanism. A first plate is detachably secured to the rigid container. The pliable enclosure is disposed between the first plate and the support plate. A mixing arrangement includes a docking station having a drive cradle and a drive mechanism. The mixing system is removably positioned within the drive cradle so that the drive mechanism is removably coupled to the mixing device.

14. 发明申请

US20190046401A1 BAG ASSEMBLY AND BAG SYSTEM FOR USE WITH A FLUID 审中-公开
公开(公告)号：US20190046401A1
公开(公告)日：2019-02-14
申请号：US16162125
申请日：2018-10-16
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： A61J1/16 , A01N1/02 , B65D30/16 , A61J1/10 , F25D31/00 , A61J1/14
CPC分类号： A61J1/16 , A01N1/0263 , A01N1/0268 , A61J1/10 , A61J1/1475 , B65D31/06 , F25D31/00
摘要： A bag assembly includes a first panel secured to a second panel by a seam so that a cavity is formed between the first panel and the second panel, the seam encircling the cavity. A first seal couples together the first panel and the second panel at a location spaced apart from the seam so that the cavity encircles the first seal. In one embodiment, the first seal can be circular. A first port communicates with the cavity.

15. 发明申请

US20170259228A1 TRANSPORTABLE MIXING SYSTEM FOR BIOLOGICAL AND PHARMACEUTICAL MATERIALS 审中-公开
公开(公告)号：US20170259228A1
公开(公告)日：2017-09-14
申请号：US15602804
申请日：2017-05-23
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： B01F13/00 , B01F7/16 , B65D77/06 , B01F15/00
CPC分类号： B01F13/00 , B01F1/0011 , B01F7/162 , B01F7/1695 , B01F13/0032 , B01F15/00435 , B01F15/00733 , B01F15/00837 , B01F15/0085 , B01F2015/00584 , B01F2015/00597 , B01F2215/0032 , B01F2215/0073 , B65D77/06
摘要： A mixing system includes a container having a support plate and a mixing assembly supported on the support plate. The mixing assembly includes a pliable enclosure containing a fluid and a mixing device. A portion of the mixing device extends from the pliable enclosure and is adapted to be detachably coupled to a drive mechanism. A first plate is detachably secured to the rigid container. The pliable enclosure is disposed between the first plate and the support plate. A mixing arrangement includes a docking station having a drive cradle and a drive mechanism. The mixing system is removably positioned within the drive cradle so that the drive mechanism is removably coupled to the mixing device.

16. 发明授权

US09476794B2 Pressure decay testing system and testing device for a connector and method of testing 有权
标题翻译：用于连接器的压力衰减测试系统和测试装置以及测试方法
公开(公告)号：US09476794B2
公开(公告)日：2016-10-25
申请号：US13934684
申请日：2013-07-03
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： G01M3/08 , G01M3/26
CPC分类号： G01M3/26
摘要： A pressure decay testing system including a testing device for determining the reliability of connectors is provided and includes a pneumatic cylinder that raises and lowers a sealing member that closes a second end of a connector inserted in the device. A base member is adjacent pneumatic cylinder and includes a receiving surface having at least one receiving member for holding the connector. A channel is disposed therethrough though the receiving surface of the base member and aligns with an inner bore of the connector inserted in the testing device. An air line is attached to base member fluidly connecting inner bore of the connector with decay tester. Decay tester introduces a pressure differential through the channel to reach a predetermined set point pressure when the connector is closed by the testing device. Decay tester is configured to measure a change in pressure over time with respect to the predetermined set point.
摘要翻译：提供了包括用于确定连接器的可靠性的测试装置的压力衰减测试系统，并且包括气动缸，其升高并降低了封闭插入到装置中的连接器的第二端的密封构件。基座构件邻近气缸，并且包括具有用于保持连接器的至少一个接收构件的接收表面。通道穿过基底构件的接收表面设置并与插入测试装置中的连接器的内孔对准。将空气管线连接到基座部件上，使连接器的内孔与衰减测试器流体连接。当连接器被测试装置关闭时，衰减测试仪通过通道引入压差以达到预定的设定点压力。衰减测试器被配置成测量相对于预定设定点的时间上的压力变化。

17. 发明授权

US09101893B1 Mixing assembly and mixing method 有权
标题翻译：混合组装和混合方法
公开(公告)号：US09101893B1
公开(公告)日：2015-08-11
申请号：US14338573
申请日：2014-07-23
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： B01F11/00 , B01F15/00
CPC分类号： B01F15/0085 , B01F3/1221 , B01F11/0048 , B01F11/0082 , B01F15/00129 , B01F15/00155 , B01F15/00207 , B01F15/00253 , B01F15/00259 , B01F15/00402 , B01F15/00467 , B01F15/00538 , B01F2215/0073 , C12M23/14
摘要： A mixing system and mixing method are provided. The mixing system includes a tank assembly, a container positioned within the tank assembly, a mixer disposed within a compartment of the container, a linear motor, and a shaft having a first end secured to the mixer and an opposing second end secured to the linear motor. The linear motor provides a variable stroke length for the shaft. The mixing method includes providing a tank assembly having a linear motor, positioning a mixing assembly including a mixing bag in the tank assembly, combining two or more components in a compartment of the mixing bag, attaching a mixing shaft extending from a mixer disposed within the mixing bag to the linear motor, and raising and lowering the mixing shaft to mix the two or more components. A stroke length of the mixing shaft during the raising and lowering is varied.
摘要翻译：提供了一种混合系统和混合方法。混合系统包括罐组件，位于罐组件内的容器，设置在容器的隔室内的混合器，线性马达和具有固定到混合器的第一端的轴，以及固定到线性的相对的第二端发动机。线性电机为轴提供了可变行程长度。该混合方法包括提供具有线性马达的罐组件，将包括混合袋的混合组件定位在罐组件中，将混合袋的隔室中的两个或更多个部件组合在一起，将从设置在该混合袋内的混合器延伸的混合轴混合袋到线性马达，以及升降混合轴以混合两个或更多个部件。混合轴在升降过程中的行程长度变化。

18. 发明申请

WO2016003615A1 PLUNGE-MIXING BAG ARRANGEMENT AND PLUNGE-MIXING SYSTEM 审中-公开
标题翻译： PLUNGE-MIXING BAG ARRANGEMENT和PLUNGE-MIXING SYSTEM
公开(公告)号：WO2016003615A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/035158
申请日：2015-06-10
申请人： ADVANCED SCIENTIFICS, INC.
发明人： PAVLIK, Rudolf
IPC分类号： B01F3/04 , B01F11/00 , B01F15/00 , C12M1/04
CPC分类号： B01F13/0238 , B01F3/04248 , B01F11/0082 , B01F15/0085 , C12M23/14 , C12M29/06
摘要： A plunge-mixing bag arrangement (100) includes a flexible mixing bag (101) defining a mixing region (102), and a shaft (103) extending from outside of the flexible mixing bag (101) into the mixing region (102), the shaft (103) comprising a sparger (105) within the mixing region (102). The sparger (105) comprises an interior channel and ports (109) extending from the interior channel. The shaft (103) is capable of axial movement within the bag (101) to fracture gas bubbles being released from the interior channel through the ports (109). A plunge-mixing system includes a mechanism (117) for raising and lowering the shaft (103).
摘要翻译：插入式混合袋装置（100）包括限定混合区域（102）的柔性混合袋（101）和从柔性混合袋（101）的外部延伸到混合区域（102）中的轴（103）所述轴（103）在所述混合区域（102）内包括喷射器（105）。喷射器（105）包括内部通道和从内部通道延伸的端口（109）。轴（103）能够在袋（101）内轴向移动，以破坏通过端口（109）从内部通道释放的气泡。插入式混合系统包括用于升高和降低轴（103）的机构（117）。

19. 发明申请

WO2015200218A1 FREEZER BAG, STORAGE SYSTEM, AND METHOD OF FREEZING 审中-公开
标题翻译：冷冻袋，储存系统和冷冻方法
公开(公告)号：WO2015200218A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036998
申请日：2015-06-22
申请人： ADVANCED SCIENTIFICS, INC.
发明人： PAVLIK, Rudolf
IPC分类号： F25C1/24 , A61F7/10 , B65D30/16
CPC分类号： A61J1/16 , A01N1/0263 , A01N1/0268 , A61J1/10 , A61J1/1475 , B65D31/06 , F25D31/00
摘要： A freezer bag, a storage system, and a method of freezing are provided. The freezer bag includes a pliable housing including at least one panel and a seam, the at least one panel and the seam defining a cavity within the pliable housing, a port extending from the pliable housing, and a tufting coupling opposing sides of the pliable housing, the tufting dividing the cavity into a plurality of regions.
摘要翻译：提供冷冻袋，储存系统和冷冻方法。冷冻袋包括柔韧的壳体，其包括至少一个面板和接缝，所述至少一个面板和接缝限定柔性外壳内的空腔，从柔性外壳延伸的端口，以及与柔性外壳，簇绒将空腔分成多个区域。

20. 发明授权

US11191700B2 Aseptic connector 有权
公开(公告)号：US11191700B2
公开(公告)日：2021-12-07
申请号：US16143048
申请日：2018-09-26
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： A61M5/14 , A61J1/20 , A61M39/10 , A61M39/18 , A61M39/16 , A61M39/12 , B65B3/00 , A61M39/24
摘要： An aseptic connector assembly includes a body portion having a receptacle configured to receive a corresponding fill connector. A pivot portion is movably coupled to the body portion, the pivot portion having a channel formed therein. A conduit portion is slidably disposed within the channel formed in the pivot portion. The pivot portion has a ready position and an operative position, the pivot portion being adjustable from the ready position to the operative position via relative movement with respect to the body portion.

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