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11. 发明申请

WO2013033524A2 HYDRAULIC BED SENSOR AND SYSTEM FOR NON-INVASIVE MONITORING OF PHYSIOLOGICAL DATA 审中-公开
标题翻译：液压床传感器和系统用于非生物数据的非入侵监测
公开(公告)号：WO2013033524A2
公开(公告)日：2013-03-07
申请号：PCT/US2012053325
申请日：2012-08-31
申请人： UNIV MISSOURI , HEISE DAVID , ROSALES LICET , SKUBIC MARJORIE
发明人： HEISE DAVID , ROSALES LICET , SKUBIC MARJORIE
IPC分类号： A61B5/024
CPC分类号： A61B5/0205 , A61B5/024 , A61B5/0816 , A61B5/1102 , A61B5/113 , A61B5/6892 , A61B5/72 , A61B2562/0247
摘要： Disclosed herein is a new and improved non-invasive bed sensing system for detecting and monitoring physiological movements such as heartbeat and respiration. The system may employ a hydraulic fluid to transduce the physiological pressures to an integrated pressure sensor and a new and improved signal processing method to identify individual cardiac pulses from the electronic signals generated by the hydraulic transducer. The system provides increased sensitivity capable of capturing quantitative pulse and respiration rates with subtle changes, ability to distinguish between instances of low pulse rate and shallow breathing, and improved comfort over existing system.
摘要翻译：本文公开了一种新的和改进的非侵入性床感测系统，用于检测和监测诸如心跳和呼吸的生理运动。该系统可以使用液压流体将生理压力转换成集成的压力传感器和新的改进的信号处理方法，以从由液压换能器产生的电子信号中识别各个心脏脉冲。该系统提供增强的灵敏度，能够捕捉定量脉冲和呼吸速率，微妙的变化，区分低脉搏和浅呼吸的情况，以及改善现有系统的舒适度。

12. 发明申请

WO2013016547A2 ENGINEERED COMESTIBLE MEAT 审中-公开
标题翻译：工程化的可口肉
公开(公告)号：WO2013016547A2
公开(公告)日：2013-01-31
申请号：PCT/US2012048357
申请日：2012-07-26
申请人： UNIV MISSOURI , FORGACS GABOR , MARGA FRANCOISE , JAKAB KAROLY ROBERT
发明人： FORGACS GABOR , MARGA FRANCOISE , JAKAB KAROLY ROBERT
IPC分类号： A23L1/31 , A23L1/317
CPC分类号： A23L13/00 , A23L13/03 , C12M21/08 , C12N5/0062 , C12N5/0697 , C12N2502/1347 , C12N2502/28 , C12N2506/1307 , C12N2533/76
摘要： Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient- permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers.
摘要翻译：提供工程化肉制品，其形成为多个至少部分熔合的层，其中每个层包含至少部分融合的包含非人类肌细胞的多细胞体，并且其中工程化肉是可食用的。还提供了包含相互粘附和/或粘附的多个非人类肌细胞的多细胞体; 其中所述多细胞体邻近地布置在营养渗透性支撑基底上并维持培养以允许所述多细胞体至少部分融合以形成用于形成工程化肉的基本平坦的层。本文进一步描述了利用所述层形成工程化肉的方法。

13. 发明申请

WO2012109332A3 INTRAMAMMARY INJECTION DEVICE 审中-公开
标题翻译：内窥镜注射装置
公开(公告)号：WO2012109332A3
公开(公告)日：2012-12-06
申请号：PCT/US2012024299
申请日：2012-02-08
申请人： UNIV MISSOURI , BARNETT MICHAEL A , DODAM JOHN R , MIDDLETON JOHN R , SHAW MIRANDA N , SIFUENTES XANDRA M
发明人： BARNETT MICHAEL A , DODAM JOHN R , MIDDLETON JOHN R , SHAW MIRANDA N , SIFUENTES XANDRA M
IPC分类号： A61D1/02 , A61J1/06 , A61M5/24
CPC分类号： A61M5/24 , A61B17/00491 , A61D1/02 , A61J1/062 , A61M5/001
摘要： In various embodiments, the present disclosure provides an injection system (10) for injecting a fluidic treatment substance into an orifice of an animal. In various implementations the system comprises a treatment cartridge (14) having a hollow body (138) that is structured and operable to retain a treatment substance within the hollow body (138). The system further comprises a plunger assembly (18) structured and operable to removably retain the treatment cartridge (14) and controllably dispense the treatment substance from the treatment cartridge (14). In various implementations the injection system (10) can additionally include an injection site cleaning adaptor (22) that is removably connectable to the treatment cartridge (14) and is structured and operable to clean a site in which the treatment substance is to be injected.
摘要翻译：在各种实施方案中，本公开提供了一种用于将流体处理物质注入动物孔中的注射系统（10）。在各种实施方式中，该系统包括具有空心体（138）的处理盒（14），其被构造和操作以将处理物质保持在中空体（138）内。所述系统还包括柱塞组件（18），所述柱塞组件（18）被构造和操作以可移除地保持所述处理盒（14）并且可控地从所述处理盒（14）分配所述处理物质。在各种实施方案中，注射系统（10）还可以包括可移除地连接到治疗药筒（14）的注射部位清洁适配器（22），并且其被构造和操作以清洁其中要注射治疗物质的部位。

14. 发明申请

WO2012162487A2 PUMP HAVING PORT PLATE PRESSURE CONTROL 审中-公开
标题翻译：具有端口板压力控制的泵
公开(公告)号：WO2012162487A2
公开(公告)日：2012-11-29
申请号：PCT/US2012039322
申请日：2012-05-24
申请人： CATERPILLAR INC , UNIV MISSOURI , MEHTA VIRAL S , DU HONGLIU , NELSON BRYAN E , MANRING NOAH
发明人： MEHTA VIRAL S , DU HONGLIU , NELSON BRYAN E , MANRING NOAH
IPC分类号： F04B1/29 , F04B1/20
CPC分类号： F04B1/306
摘要： A pump (28) is disclosed. The pump may have a housing (42), a body (46) rotatably disposed within the housing and at least partially defining a plurality of barrels (48), a plurality of plungers (50) associated with the plurality of barrels, and a swashplate (56) tiltable by a swivel torque to vary a displacement of the plurality of plungers relative to the plurality of barrels. The pump may also have a port plate (53) with an inlet port (72), a discharge port (74), and a protrusion (94). The port plate may be configured to engage an end of the rotatable body. The pump may further have at least one piston (90, 92)disposed within the housing and configured to selectively engage the protrusion of the port plate to rotate the port plate and adjust the swivel torque.
摘要翻译：公开了一种泵（28）。泵可以具有壳体（42），可旋转地设置在壳体内并且至少部分地限定多个筒（48）的主体（46），与多个筒相关联的多个柱塞（50）和斜盘（56）可通过旋转扭矩倾斜，以改变多个柱塞相对于多个筒的位移。泵还可以具有带有入口端口（72），排出口（74）和突起（94）的端口板（53）。端口板可以构造成接合可旋转主体的端部。所述泵还可以具有设置在所述壳体内的至少一个活塞（90,92），并且构造成选择性地接合所述端口板的突出部以使所述端口板旋转并调节所述旋转扭矩。

15. 发明申请

WO2012094529A3 GENES IMPLICATED IN RESISTANCE TO SOYBEAN CYST NEMATODE INFECTION AND METHODS OF THEIR USE 审中-公开
标题翻译：影响大豆胞囊线虫感染的基因及其使用方法
公开(公告)号：WO2012094529A3
公开(公告)日：2012-11-22
申请号：PCT/US2012020375
申请日：2012-01-05
申请人： UNIV MISSOURI , MITCHUM MELISSA GOELLNER , KANDOTH PRAMOD KAITHERI , YECKEL GREG , ITHAL NAGABHUSHANA
发明人： MITCHUM MELISSA GOELLNER , KANDOTH PRAMOD KAITHERI , YECKEL GREG , ITHAL NAGABHUSHANA
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8285 , C07K14/415 , Y02A40/164
摘要： To gain new insights into the mechanism of soybean resistance to the soybean cyst nematode (Heterodera glycines), gene expression profiles of developing syncytia in soybean near-isogenic lines (NILs) differing at the at Rhg1 locus were compared. Gene expression profiling revealed that 1,447 genes were differentially expressed between the line that is resistant to SCN and the line that is sensitive to SCN infection. These results indicate that syncytia induced in the resistant line are undergoing severe oxidative stress and imbalanced endoplasmic reticulum homeostasis, both of which likely contribute to the resistance reaction. Defense-related genes up-regulated within syncytia of the resistant line included those predominantly involved in apoptotic cell death, the plant hypersensitive response, and salicylic acid (SA)-mediated defense signaling; many of these genes were partially suppressed by a virulent soybean cyst nematode population for successful nematode reproduction and development on the resistant line. Expression of these SCN responsive genes may be manipulated to obtain SCN resistant lines.
摘要翻译：为了获得大豆对大豆胞囊线虫（Heterodera glycines）抗性机制的新见解，比较了在Rhg1基因座处不同的大豆近等基因系（NIL）中发育合胞体的基因表达谱。基因表达谱分析显示，在对SCN有抗性的品系和对SCN感染敏感的品系之间差异表达了1447个基因。这些结果表明，在抗性系中诱导的合胞体正在经历严重的氧化应激和内质网平衡不平衡，这两者都可能有助于抗性反应。在抗性系的合胞体中上调的防御相关基因包括主要参与凋亡细胞死亡，植物超敏反应和水杨酸（SA）介导的防御信号传导的那些基因; 许多这些基因被强毒大豆胞囊线虫种群部分抑制，以用于成功的线虫繁殖和抗性品系的发育。可以操纵这些SCN应答基因的表达以获得SCN抗性系。

16. 发明申请

WO2012009578A3 NANOPORE-FACILITATED SINGLE MOLECULE DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：纳米孔易化的单分子检测核酸
公开(公告)号：WO2012009578A3
公开(公告)日：2012-04-05
申请号：PCT/US2011044082
申请日：2011-07-14
申请人： UNIV MISSOURI , GU LI-QUN , WANG YONG , TIAN KAI
发明人： GU LI-QUN , WANG YONG , TIAN KAI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6886 , C12Q2600/178 , G01N33/48721 , C12Q2523/307 , C12Q2525/161 , C12Q2525/207 , C12Q2565/631
摘要： The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3' terminus, 5' terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.
摘要翻译：本发明提供了基于纳米孔技术的新型和改进的寡核苷酸检测方法，其中探针含有与靶寡核苷酸互补的序列以及在探针3'末端，5'末端或两个末端处的末端延伸。带有探针的改进的纳米孔传感器可以对目标寡核苷酸如miRNA进行灵敏，选择性和直接的检测，分化和定量。基于患者血液样品中的miRNA水平，本发明的检测方法还可以用作用于癌症检测的非侵入性和成本有效的诊断方法。

17. 发明申请

WO2011112779A3 JOINT IMPLANT AND PROSTHESIS AND METHOD 审中-公开
标题翻译：联合植入和预防和方法
公开(公告)号：WO2011112779A3
公开(公告)日：2012-01-19
申请号：PCT/US2011027840
申请日：2011-03-10
申请人： UNIV MISSOURI , SMITH MATTHEW J
发明人： SMITH MATTHEW J
IPC分类号： A61F2/30 , A61B17/86 , A61F2/46
CPC分类号： A61F2/4003 , A61B17/1637 , A61F2/30749 , A61F2/4081 , A61F2/4612 , A61F2002/30163 , A61F2002/30289 , A61F2002/30332 , A61F2002/30574 , A61F2002/30779 , A61F2002/3085 , A61F2002/4619 , A61F2002/4677
摘要： Disclosed herein is a minimally invasive ball joint implant and prosthesis 10 for the treatment of arthritis, trauma, and other medical conditions leading to joint destruction and pain, as well as methods of use. In various cases, the prosthesis 10 does not require reaming into the intramedullary canal and does not require diaphyseal fit for any bones associated with the joint, thereby resulting in more rapid and complete recovery. In various cases, the prosthesis 10 incorporates an anchoring stem 38 specifically designed to be impacted into the bone and to facilitate bony ingrowth after implantation, thereby strengthening the implanted prosthesis 10 and preventing rotation thereof.
摘要翻译：本文公开了一种用于治疗导致关节破坏和疼痛的关节炎，创伤和其他医学状况以及使用方法的微创球关节植入物和假体10。在各种情况下，假体10不需要铰接到髓内管中，并且不需要对于与关节相关联的骨骼进行骨干合并，从而导致更快速和完全的恢复。在各种情况下，假体10包括专门设计成撞击到骨中的锚固杆38，并且在植入之后便于骨向内生长，从而加强植入的假体10并防止其旋转。

18. 发明申请

WO2011097107A3 DEVICE TO ASSIST DELIVERY OF FETAL HEAD AT CESAREAN SECTION 审中-公开
标题翻译：设备协助交付在CESAREAN部分的胎头
公开(公告)号：WO2011097107A3
公开(公告)日：2011-12-01
申请号：PCT/US2011022673
申请日：2011-01-27
申请人： UNIV MISSOURI , BARRIER BRETON F , CLARK GARY F
发明人： BARRIER BRETON F , CLARK GARY F
IPC分类号： A61B17/42 , A61M1/00
CPC分类号： A61B17/442
摘要： In various embodiments, an obstetrical device 10 is provided for assisting a cesarean section delivery of a neonate having a fetal presenting part well seated within the mother's pelvis. Generally, the device 10 comprises a tubular tail 22 having an internal lumen 30 and a hollow head 26 extending from a distal end 58 of the tail 22 and having an internal chamber 34 fluidly connected to the lumen 30. The head 26 includes at least one aperture 38 extending through an exterior wall. The device 10 is operable to position the head 26 near or in contact with the fetal presenting part to provide air into an area near and/or between contact surfaces 62 of the fetal presenting part and a vagina 14 and/or a cervix 18 of the mother. Providing the air will reduce or release a suction formed between the contact surfaces 62 such that the well seated fetal presenting part can be easily separated from the vagina 14 and/or the cervix 18.
摘要翻译：在各种实施例中，提供产科装置10用于辅助剖宫产输送新生儿，所述新生儿具有良好地坐在母亲骨盆内的胎儿呈现部分。通常，装置10包括具有内腔30和从尾部22的远端58延伸并具有流体地连接到腔30的内室34的中空头部26的管状尾部22.头部26包括至少一个孔38延伸穿过外壁。装置10可操作以将头部26定位在胎儿呈现部分附近或与胎儿呈现部分接触，以将空气提供到胎儿呈现部分的接触表面62和胎儿呈现部分的阴道14和/或宫颈18附近和/或之间的区域母亲。提供空气将减少或释放在接触表面62之间形成的抽吸，使得安放好的胎儿先露部分能够容易地与阴道14和/或子宫颈18分离。

19. 发明申请

WO2010129850A3 CIRCUIT AND METHOD TO SUPPRESS THE PARASITIC RESONANCE FROM A DC/DC CONVERTER 审中-公开
标题翻译：从DC / DC转换器抑制PARASITIC共振的电路和方法
公开(公告)号：WO2010129850A3
公开(公告)日：2011-02-24
申请号：PCT/US2010034004
申请日：2010-05-07
申请人： UNIV MISSOURI , POMMERENKE DAVID , KAM KEONG , BHARGAVA ANKIT , PENG SHAO , CHANG XIN , LI HONGYU
发明人： POMMERENKE DAVID , KAM KEONG , BHARGAVA ANKIT , PENG SHAO , CHANG XIN , LI HONGYU
IPC分类号： H02M3/28 , H02M1/34
CPC分类号： H02M1/34 , H02M2001/348 , Y10T29/4902
摘要： A snubber circuit for use with a DC/DC converter broadly comprises a snubber resistor connected in parallel with a snubber inductor. The DC/DC converter may include a voltage source, a first switching element, a second switching element, an output inductor, and an output capacitor. The voltage source may include a positive terminal and a negative terminal connected to a ground node. The first switching element may include a first terminal connected to the positive terminal of the voltage source The second switching element may be connected to a second terminal of the first switching element. The series combination of the output inductor and the output capacitor may be connected between the second terminal of the first switching element and the ground node. The snubber circuit may be connected between the second switching element and the ground node.
摘要翻译：用于DC / DC转换器的缓冲电路广泛地包括与缓冲电感器并联连接的缓冲电阻器。 DC / DC转换器可以包括电压源，第一开关元件，第二开关元件，输出电感器和输出电容器。电压源可以包括连接到接地节点的正极端子和负极端子。第一开关元件可以包括连接到电压源的正极端子的第一端子。第二开关元件可以连接到第一开关元件的第二端子。输出电感器和输出电容器的串联组合可以连接在第一开关元件的第二端子和接地节点之间。缓冲电路可以连接在第二开关元件和接地节点之间。

20. 发明申请

WO2009143476A3 NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTASE 审中-公开
标题翻译：新型抗逆转录酶抑制剂
公开(公告)号：WO2009143476A3
公开(公告)日：2010-04-08
申请号：PCT/US2009045057
申请日：2009-05-22
申请人： UNIV MISSOURI , MICHALOWSKI DANIEL , BURKE-AGUERO DONALD H
发明人： MICHALOWSKI DANIEL , BURKE-AGUERO DONALD H
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N15/115 , C12N2310/151 , C12N2310/17 , C12N2310/3519
摘要： Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure.
摘要翻译：公开了核酸分子及其使用方法，其具有包括双螺旋结构域和通过可能是核苷或非核苷酸的接头结构域物理连接的G-四链体结构域的特定结构。这些适体表现出对系统发育不同的灵长类动物慢病毒逆转录酶的有效抑制，其效果在很大程度上独立于适体序列，条件是适体具有特定的结构。

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