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11. 发明申请

WO2011031351A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：WO2011031351A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/033794
申请日：2010-05-05
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter
发明人： RULE, Peter
IPC分类号： A61B5/00
CPC分类号： G10L21/0208 , A61M5/168 , A61M5/1723
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e g insulin, dextrose, etc ) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

12. 发明申请

WO2011011462A1 ADJUSTABLE CONNECTOR AND DEAD SPACE REDUCTION 审中-公开
标题翻译：可调节连接器和减少空间
公开(公告)号：WO2011011462A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/042664
申请日：2010-07-20
申请人： OPTISCAN BIOMEDICAL CORPORATION , BUTLER, Michael
发明人： BUTLER, Michael
IPC分类号： A61B5/00
CPC分类号： A61B5/157 , A61B5/0059 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14552 , A61B5/14557 , A61B5/1459 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/412 , A61B5/6866 , A61B2560/0228 , A61B2562/0233 , A61B2562/0238 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M5/1723 , A61M39/10 , A61M39/1011 , A61M2005/14208 , A61M2039/1033 , A61M2205/12 , A61M2205/128 , G01N21/03 , G01N21/07 , G01N21/35 , G01N33/491 , G01N2021/0346 , G06F19/00 , G06F19/3468
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can be connected to the source of bodily fluid via a connector that is configured to maintain uniform velocity across the connector and reduce the dead space volume.
摘要翻译：描述了用于确定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。分析物监测系统可以经由连接器连接到体液源，该连接器被配置为保持穿过连接器的均匀速度并减少死空间体积。

13. 发明申请

WO2008144575A2 FLUID INJECTION AND SAFETY SYSTEM 审中-公开
标题翻译：流体注射和安全系统
公开(公告)号：WO2008144575A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/063996
申请日：2008-05-16
申请人： OPTISCAN BIOMEDICAL CORPORATION , KEENAN, Rich, L. , RIVAS, Gil , CHIOU, Jeffrey, T. , BUTLER, Michael , LIM, Eugene
发明人： KEENAN, Rich, L. , RIVAS, Gil , CHIOU, Jeffrey, T. , BUTLER, Michael , LIM, Eugene
IPC分类号： A61B5/145 , A61B5/00 , A61M25/00 , A61M5/00
CPC分类号： G01N1/10 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/150854 , A61B5/153 , A61B5/157 , A61M5/1415 , A61M5/1723 , A61M39/02 , A61M39/10 , A61M2039/1077 , A61M2039/1094 , A61M2230/201 , G06F19/10 , Y10T436/11 , Y10T436/144444
摘要： Various medical systems and methods are described, including a medical monitoring system ( 102, 400, 700, 800, 2632). The medical monitoring system can have a fluid system (404, 510. 801, 901) configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion (408, 410, 710, 804. 904. 1000, 4218). The removable portion can have an opening with a port (3912, 3916. 4216). The system can also have a container (2812, 3112) configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe (2812). a dock (3912) with a port (3916, 4216), and an adapter (3312, 2814) configured to connect the syringe to the port. The dock can also have a tab (3918) configured to move with the port.
摘要翻译：描述了各种医疗系统和方法，包括医疗监视系统（102,400,700,800,6632）。医疗监测系统可以具有被配置为接收体液并且光学分析所述流体以确定分析物浓度的流体系统（404,510,801,801）。流体系统可以具有可移除部分（408,410,710,804,904,150,418）。可拆卸部分可以具有带有端口（3912,3916.4116）的开口。该系统还可以具有配置成容纳抗凝血剂的容器（2812,3122）。容器可以具有配置成与可移除部分的端口配合的部分。容器可进一步构造成不适合传统的鲁尔接头。还描述了一种抗凝剂插入装置。该装置可以具有注射器（2812）。具有端口（3916,4216）的坞站（3912）和被配置为将注射器连接到端口的适配器（3312,2814）。坞站还可以具有配置为与端口一起移动的选项卡（3918）。

14. 发明申请

WO2007143591A2 METHOD AND APPARATUS FOR DRIVING A RADIATION SOURCE 审中-公开
标题翻译：用于驱动辐射源的方法和装置
公开(公告)号：WO2007143591A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/070280
申请日：2007-06-01
申请人： OPTISCAN BIOMEDICAL CORPORATION , HEPPELL, Kevin
发明人： HEPPELL, Kevin
CPC分类号： G01J3/108 , G01N21/35 , G01N2201/06186 , H05B1/025
摘要： A method and apparatus are described for driving a modulated radiation source (which can be, for example, an infrared light source). The method affects the power driving a light source in such as way so as to minimize the warm-up time of the source. The apparatus permits feedback control of a light source to specified powers or temperatures. Disclosed embodiments can improve source performance and lifetime and decrease the operating costs of the source.
摘要翻译：描述了用于驱动调制辐射源（其可以是例如红外光源）的方法和装置。该方法以这样的方式影响驱动光源的功率，以便最小化源的预热时间。该设备允许将光源的反馈控制到指定的功率或温度。公开的实施例可以改善源性能和寿命并降低源的操作成本。

15. 发明申请

WO2006127724A2 SPECTROSCOPIC ANALYSIS OF A BIOLOGICAL FLUID REACTED WITH AN ENZYME 审中-公开
标题翻译：用酶反应的生物流体的光谱分析
公开(公告)号：WO2006127724A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/019952
申请日：2006-05-23
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James R. , WITTE, Kenneth G. , MAGARIAN, Margaret , SHEILL, Jane J. , STERLING, Bernhard B.
发明人： BRAIG, James R. , WITTE, Kenneth G. , MAGARIAN, Margaret , SHEILL, Jane J. , STERLING, Bernhard B.
CPC分类号： C12Q1/26 , C12Q1/32 , C12Q1/52 , C12Q1/54
摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.
摘要翻译：提出了使用组合酶分光法估计分析物浓度的装置。提供葡萄糖和乳酸盐检测的实例。将生物流体的样品与特定于目的分析物的酶混合或接触，并且用包括至少一种对分析物浓度和至少一种波长的波长的波长的光学系统探测反应流体，对分析物浓度不敏感。光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

16. 发明申请

WO2006088785A1 ANALYTE DETECTION SYSTEM WITH DISTRIBUTED SENSING 审中-公开
标题翻译：分布式感知分析检测系统
公开(公告)号：WO2006088785A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005005
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
发明人： BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
IPC分类号： A61B5/15 , A61M1/36
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

17. 发明申请

WO2006047182A3 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 审中-公开
公开(公告)号：WO2006047182A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/037606
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORPORATION , HALL, W., Dale
发明人： HALL, W., Dale
IPC分类号： G06F19/00 , G01N33/50
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of know analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

18. 发明申请

WO2005111580A1 SAMPLE ELEMENT WITH FRINGING-REDUCTION CAPABILITIES 审中-公开
标题翻译：具有减少能力的样品元件
公开(公告)号：WO2005111580A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/015888
申请日：2005-05-06
申请人： OPTISCAN BIOMEDICAL CORPORATION , WECHSLER, Mark , WHITE, Kenneth, G. , KEENAN, Rich , LI, Ken, I. , SMITH, Andrew, C. , BRAIG, James, R.
发明人： WECHSLER, Mark , WHITE, Kenneth, G. , KEENAN, Rich , LI, Ken, I. , SMITH, Andrew, C. , BRAIG, James, R.
IPC分类号： G01N21/03
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/025 , B01L2300/045 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/0303 , G01N21/0332 , G01N21/31 , G01N2021/0346 , G01N2021/036 , G01N2021/0389
摘要： A sample element configured to hold a material sample for determining a concentration of an analyte in the material sample. The sample element comprises a first window, a sample chamber partially defined by the first window, and a second, moveable window substantially aligned with the first window and the sample chamber. The second window is moveable from a first position in which the second window is spaced from the sample chamber, to a second position in which the second window covers and at least partially encloses the sample chamber.
摘要翻译：样品元件，构造成保持材料样品以确定材料样品中分析物的浓度。样品元件包括第一窗口，部分地由第一窗口限定的样品室和与第一窗口和样品室基本对齐的第二可移动窗口。第二窗口可从第二窗口与样品室间隔开的第一位置移动到第二位置，在第二位置，第二窗口覆盖并且至少部分地包围样品室。

19. 发明申请

WO2005110601A1 SAMPLE ELEMENT WITH SEPARATOR 审中-公开
标题翻译：样品元件与分离器
公开(公告)号：WO2005110601A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/016003
申请日：2005-05-06
申请人： OPTISCAN BIOMEDICAL CORPORATION , HOUKAL, Jeff , CLEMMENS, John , KEENAN, Rich , STERLING, Bernhard , BRAIG, Jim
发明人： HOUKAL, Jeff , CLEMMENS, John , KEENAN, Rich , STERLING, Bernhard , BRAIG, Jim
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2300/0654 , B01L2300/0681 , B01L2300/0825 , B01L2300/0887 , B01L2400/0478 , B01L2400/0481 , B01L2400/049
摘要： A sample element for use with an analyte detection system comprises a supply opening (808a) configured to receive a material sample. A separator (808b) communicates with the supply opening (808a) , and separates an element of interest from the material sample. A sample chamber (802,804) communicates with the separator (808b) and receives the element of interest.
摘要翻译：用于分析物检测系统的样品元件包括被配置为接收材料样品的供应开口（808a）。分离器（808b）与供给开口（808a）连通，并将目标元素与材料样品分离。样品室（802,804）与分离器（808b）连通并接收感兴趣的元件。

20. 发明申请

WO2004062493A1 WEARABLE DEVICE FOR MEASURING ANALYTE CONCENTRATION 审中-公开
标题翻译：用于测量分析仪浓度的可测装置
公开(公告)号：WO2004062493A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041579
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/14532 , A61B5/1455
摘要： An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
摘要翻译：分析物检测系统包括第一耐磨模块，检测器和处理器。第一可佩戴模块具有光学输入，电磁辐射可通过该输入进入所述第一可穿戴模块。第一可穿戴模块被配置为佩戴在活体佩戴者的身体上并使其接合，使得佩戴者的身体省略的电磁辐射可经由光学输入进入第一佩戴模块。检测器与光学输入端光学通信。处理器与检测器通信。处理器被配置为基于发射的电磁辐射来估计穿着者组织中的分析物的浓度。

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