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    • 15. 发明申请
    • ADHESIVE CARTILAGE IMPLANT
    • 胶粘剂植入物
    • WO2010078043A1
    • 2010-07-08
    • PCT/US2009/068494
    • 2009-12-17
    • HOWMEDICA OSTEONICS CORP.SONG, Lin
    • SONG, Lin
    • A61F2/08
    • A61F2/30756A61F2/3094A61F2002/30762A61L27/227A61L27/34A61L27/3817A61L27/3852A61L27/3895A61L2430/06
    • A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration.
    • 一种生产软骨植入体的方法,其可以包括用热敏聚合物涂覆底物,将聚合物与包含可分化成类细胞细胞的细胞的细胞悬浮液接种,其中接种可以在第一温度下进行,培养 细胞悬浮液在升高的温度下,由此悬浮液中的细胞可能粘附到聚合物上并分化成软骨细胞样细胞,其可以形成软骨植入物,并降低聚合物的温度,这可允许植入物从聚合物中分离 。 本发明还可以包括基于该方法的植入物。 本发明还可以包括用于有需要的患者的软骨植入物,其可以包括分化细胞的随机三维构型,其可以在三维细胞的外表面的至少一部分上具有天然粘合表面, 尺寸配置。