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    • 2. 发明申请
    • ADHESIVE CARTILAGE IMPLANT
    • 胶粘剂植入物
    • WO2010078043A1
    • 2010-07-08
    • PCT/US2009/068494
    • 2009-12-17
    • HOWMEDICA OSTEONICS CORP.SONG, Lin
    • SONG, Lin
    • A61F2/08
    • A61F2/30756A61F2/3094A61F2002/30762A61L27/227A61L27/34A61L27/3817A61L27/3852A61L27/3895A61L2430/06
    • A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration.
    • 一种生产软骨植入体的方法,其可以包括用热敏聚合物涂覆底物,将聚合物与包含可分化成类细胞细胞的细胞的细胞悬浮液接种,其中接种可以在第一温度下进行,培养 细胞悬浮液在升高的温度下,由此悬浮液中的细胞可能粘附到聚合物上并分化成软骨细胞样细胞,其可以形成软骨植入物,并降低聚合物的温度,这可允许植入物从聚合物中分离 。 本发明还可以包括基于该方法的植入物。 本发明还可以包括用于有需要的患者的软骨植入物,其可以包括分化细胞的随机三维构型,其可以在三维细胞的外表面的至少一部分上具有天然粘合表面, 尺寸配置。
    • 4. 发明申请
    • DEVICE AND METHOD TO ACTIVATE PLATELETS
    • 用于激活平板的装置和方法
    • WO2012121807A1
    • 2012-09-13
    • PCT/US2012/021830
    • 2012-01-19
    • HOWMEDICA OSTEONICS CORP.LONG, MarcSONG, Lin
    • LONG, MarcSONG, Lin
    • C12N5/071
    • A61K35/19
    • The present invention includes a method for activating platelets in a platelet solution, the method may include passing the platelet solution through an activator (10) at least once to activate at least one of the platelets in the platelet solution to produce an activated platelet solution. The activator (10) may further include a flow disruption element (15). The method may further induce administering the activated platelet solution to the repair site of a patient. The present invention may also be a system for treating a medical condition at a repair site within a patient in need thereof, which may include a platelet solution container (30) for housing a platelet solution; an activator (10,110) to activate at least one platelet; and an introducer to direct the at least one activated platelet to the repair site.
    • 本发明包括用于激活血小板溶液中的血小板的方法,所述方法可以包括使血小板溶液通过活化剂(10)至少一次以活化血小板溶液中的至少一种血小板以产生活化的血小板溶液。 活化剂(10)还可以包括流动破坏元件(15)。 该方法还可以诱导将活化的血小板溶液施用于患者的修复部位。 本发明还可以是用于治疗有需要的患者内的修复部位的医疗状况的系统,其可以包括用于容纳血小板溶液的血小板溶液容器(30) 活化剂(10,110)以激活至少一种血小板; 以及导引器,用于将所述至少一个活化的血小板引导至所述修复部位。