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11. 发明申请

WO1997010812A2 SUPERSATURATED TRANSDERMAL DRUG DELIVERY SYSTEMS, AND METHODS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：超级传送药物递送系统及其制造方法
公开(公告)号：WO1997010812A2
公开(公告)日：1997-03-27
申请号：PCT/US1996014331
申请日：1996-09-06
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , FARINAS, Kathleen, C. , MILLER, Chad, M. , SONI, Pravin, L.
IPC分类号： A61K09/70
CPC分类号： A61K9/7061 , A61K9/7053 , A61K9/7069
摘要： Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug reservoir components to a predetermined temperature. Generally, this temperature is higher than the depressed melting temperature of the polymer-drug admixture which will serve as the drug reservoir. In an alternative embodiment, wherein heat treatment of the reservoir components results in a system having two liquid phases, the predetermined temperature is calculated so as to be higher than the melting temperature of the pure drug. Drug reservoirs and novel transdermal delivery systems prepared using the disclosed techniques are provided as well.
摘要翻译：提供了用于制造含有过饱和药物储库的透皮药物递送系统的方法，从而获得更高的药物通量。所述方法包括将药物储存器部件加热至预定温度。通常，该温度高于用作药物储存器的聚合物 - 药物混合物的熔融温度降低。在替代实施例中，其中储存器部件的热处理导致具有两个液相的系统，计算预定温度以高于纯药物的熔解温度。还提供了使用所公开的技术制备的药物储存器和新颖的透皮递送系统。

12. 发明申请

WO1997010499A1 ELECTRODE 审中-公开
标题翻译：电极
公开(公告)号：WO1997010499A1
公开(公告)日：1997-03-20
申请号：PCT/US1996011803
申请日：1996-07-16
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , KURNIK, Ronald, T. , TAMADA, Janet , TIERNEY, Michael
IPC分类号： G01N27/30
CPC分类号： G01N27/3272
摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which assembly includes a scavenging electrode is disclosed. The electrode of the invention is comprised of 1) a working electrode; 2) a scavenging electrode; and 3) an electrically insulating gap defined by adjacent edges of 1) and 2) and electrically isolating 1) and 2). The scavenging electrode substantially reduces or eliminates "edge-effects" or error in signal transported to the working electrode via a path which includes a radial vector component, i.e., eliminates chemical signal other than that which moves to the catalytic surface of the working electrode via a path which is substantially perpendicular to catalytic surface of the working electrode.
摘要翻译：公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，该组件包括扫气电极。本发明的电极包括1）工作电极; 2）清扫电极; 和3）由1）和2）的相邻边缘限定的电绝缘间隙，并且电隔离1）和2）。扫气电极通过包括径向矢量分量的路径，大大减少或消除了传输到工作电极的信号的“边缘效应”或误差，即除去除了通过工作电极通孔的催化表面移动的化学信号之外的化学信号基本上垂直于工作电极的催化剂表面的路径。

13. 发明申请

WO1997009971A2 HIGH CAPACITY, SUPERABSORBENT DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：高容量，超吸收药物储存用于转运药物输送系统
公开(公告)号：WO1997009971A2
公开(公告)日：1997-03-20
申请号：PCT/US1996014784
申请日：1996-09-13
申请人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming , JONA, Janan , JOSHI, Priti , RAMDAS, Asha
发明人： CYGNUS, INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/703 , A61K9/7084
摘要： High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are comprised of a superabsorbent material, typically a cross-linked polymer, which is capable of absorbing an amount of drug formulation corresponding to at least 15 grams formulation per gram of material. Methods for making and using transdermal systems containing such reservoirs are provided as well.
摘要翻译：提供高容量药物储存器用于并入透皮药物递送系统。药物储存器由超吸收材料（通常为交联聚合物）组成，其能够吸收对应于每克材料至少15克制剂的一定量的药物制剂。还提供了制备和使用含有这种储存器的透皮系统的方法。

14. 发明申请

WO1997002811A1 HYDROGEL PATCH 审中-公开
公开(公告)号：WO1997002811A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011675
申请日：1996-07-11
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , ABRAHAM, William , BERNER, Bret , JOSHI, Priti, S. , PLANTE, Phillip, J. , VIJAYAKUMAR, Prema
IPC分类号： A61K09/20
CPC分类号： C12Q1/00 , A61N1/0436
摘要： A hydrogel patch is disclosed which is comprised of a polymeric material which forms a gel with water with the material being present in an amount of about 0.5 % to 40 % by weight based on the weight of the patch. Electrical conductivity of the water is increased by the addition of an electrolyte. The patch comprises an enzyme which is capable of catalyzing a reaction with a biomedically important molecule such as glucose. Glucose drawn into the patch undergoes a reaction with the aid of the enzyme and the hydrogen peroxide released flows through the electrically conductivity of the water and may react at an electrode surface to generate a signal related to the amount of glucose entering the patch. The patch is also preferably comprised of a buffer which maintains the pH of the patch in the range of from about 3 to 9, and may be further comprised of a cross-linking agent, a biocide, a humectant, and a surfactant. The patch is preferably in the form of a thin (5 mu m - 50 mils), flat circular disc (0.5 to 10 cm of area) which will conform to the contours of human skin and may have a non-woven fabric embedded therein and removable release liners on each surface.
摘要翻译：公开了一种水凝胶贴片，其由与水形成凝胶的聚合物材料组成，该材料的存在量为贴剂重量的约0.5重量％至40重量％。通过添加电解液来增加水的导电性。贴剂包含能够催化与生物医学上重要的分子如葡萄糖的反应的酶。吸入贴剂的葡萄糖借助于酶发生反应，释放的过氧化氢流过水的电导率，并可在电极表面反应，产生与进入贴剂的葡萄糖量相关的信号。贴剂还优选由将贴剂的pH保持在约3至9范围内的缓冲剂组成，并且还可以包含交联剂，杀生物剂，保湿剂和表面活性剂。该贴片优选为薄（5微米-50密耳）扁平圆盘（0.5至10厘米2的面积）的形式，其将符合人体皮肤的轮廓，并且可以具有无纺织物嵌入其中以及每个表面上的可拆卸的隔离衬垫。

15. 发明申请

WO2003082098A3 IMPROVING PERFORMANCE OF AN ANALYTE MONITORING DEVICE 审中-公开
公开(公告)号：WO2003082098A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/008914
申请日：2003-03-21
申请人： CYGNUS, INC.
发明人： BARTKOWIAK, Miroslaw , HARPER, Wesley, S. , KULCU, Eray , LESHO, Matthew, J. , TAMADA, Janet, A.
IPC分类号： A61B5/00
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

16. 发明申请

WO2003054070A2 HIGHLY CATALYTIC SCREEN-PRINTING INK 审中-公开
标题翻译：高级催化筛印
公开(公告)号：WO2003054070A2
公开(公告)日：2003-07-03
申请号：PCT/US2002/040762
申请日：2002-12-19
申请人： CYGNUS, INC.
发明人： TIERNEY, Michael, J.
IPC分类号： C08K3/08
CPC分类号： C09D11/52 , C08K3/04 , C08K3/08 , C09D11/101 , C09D11/30
摘要： The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, methods of making, and methods of using thereof. An exemplary ink material comprises platinum black and/or platinum-on-carbon as the catalyst, graphite as a conducting material, a polymer binding material, and an organic solvent. The polymer binding material is typically or copolymer of hydrophilic and hydrophobic monomers. The conductive polymer compositions of the present invention can be used, for example, to make electrochemical sensors. Such sensors can be used in a variety of analyte monitoring devices to monitor analyte amount or concentrations in subjects, for example, glucose monitoring devices to monitor glucose levels in subjects with diabetes.
摘要翻译：本发明涉及导电聚合物组合物，催化油墨组合物（例如，用于丝网印刷），通过沉积油墨组合物制备的电极，制备方法及其使用方法。示例性的油墨材料包括铂黑和/或铂 - 碳作为催化剂，石墨作为导电材料，聚合物粘合材料和有机溶剂。聚合物结合材料通常是亲水和疏水单体的共聚物。本发明的导电性聚合物组合物可以用于例如制造电化学传感器。这些传感器可用于各种分析物监测装置中，以监测受试者中的分析物量或浓度，例如葡萄糖监测装置，以监测糖尿病患者的葡萄糖水平。

17. 发明申请

WO1997024059A1 CONTINUOUS MONITORING OF PHYSIOLOGICAL ANALYTE 审中-公开
标题翻译：生理分析的连续监测
公开(公告)号：WO1997024059A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020591
申请日：1996-12-20
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , KURNIK, Ronald, T. , TAMADA, Janet , TIERNEY, Michael , POTTS, Russell, Owen
IPC分类号： A61B05/00
CPC分类号： A61B5/14532
摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.
摘要翻译：用于连续监测受试者中的生理分析物的方法包括以下步骤：使受试者与收集储存器接触，使得分析物可以从受试者移动到收集容器中，收集储存器的内容物与检测器操作性地通信，收集储存器中的分析物，使用检测器检测收集储存器中的分析物，一旦检测到分析物，就使检测器不能检测到分析物。此外，用于连续监测受试者中的生理分析物的装置包括用于从受试者接收分析物的收集储存器，收集储存器的内容物与检测储存器中的分析物的检测器处于操作关系，以及用于渲染的装置被检测到的分析物，不能被储存器检测到。

18. 发明申请

WO1996040087A2 PRESSURE SENSITIVE ACRYLATE ADHESIVE COMPOSITION CROSS-LINKED WITH ALUMINUM ACETYLACETONATE AND CONTAINING A DRUG HAVING A REACTIVE AROMATIC HYDROXYL GROUP 审中-公开
标题翻译：与乙酸乙烯酯交联并含有具有反应性芳族羟基的药物的压力敏感性丙烯酸酯胶粘剂组合物
公开(公告)号：WO1996040087A2
公开(公告)日：1996-12-19
申请号：PCT/US1996008492
申请日：1996-06-03
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , LI, Chunhua , SCHONFELD, Edward , CHU, Tara , CHIANG, Chia-Ming
IPC分类号： A61K09/70
CPC分类号： A61K9/7061
摘要： Non-yellowing organic solvent based pressure sensitive acrylate adhesives that have good cohesive strength and cold flow properties and are useful in fabricating transdermal drug delivery patches are made from an organic solvent based pressure sensitive acrylate adhesive cross-linked with aluminum acetylacetonate and combined with a drug, such as estradiol, that has a reactive aromatic hydroxyl group.
摘要翻译：具有良好内聚强度和冷流动性的非黄变有机溶剂型压敏丙烯酸酯粘合剂可用于制造透皮药物递送贴片，由与乙酰丙酮铝交联并与药物组合的有机溶剂型压敏丙烯酸酯粘合剂，如雌二醇，其具有反应性芳族羟基。

19. 发明申请

WO2005018443A1 MICROPROCESSORS, DEVICES, AND METHODS FOR USE IN MONITORING OF PHYSIOLOGICAL ANALYTES 审中-公开
标题翻译：用于监测生理分析的微处理器，器件和方法
公开(公告)号：WO2005018443A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/024672
申请日：2004-07-30
申请人： CYGNUS, INC.
发明人： FORD, Russell , LESHO, Matthew, J. , TAMADA, Janet, A. , TIERNEY, Michael, J.
IPC分类号： A61B5/00
CPC分类号： A61B5/4283 , A61B5/14532 , A61B5/4266 , A61B5/4881 , A61B5/7267 , A61B2560/0252 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流/电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

20. 发明申请

WO1997024148A1 SYSTEMS AND METHODS FOR THE TRANSDERMAL ADMINISTRATION OF ANDROGENIC AGENTS 审中-公开
标题翻译：用于远程管理并发原子的系统和方法
公开(公告)号：WO1997024148A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020365
申请日：1996-12-27
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming , JONA, Janan , JOSHI, Priti , RAMDAS, Asha
IPC分类号： A61L15/44
CPC分类号： A61K9/7084
摘要： Drug delivery systems and methods for transdermally administering androgenic agents are provided. The systems are generally laminated composites containing a pharmaceutical formulation within a drug reservoir, wherein an androgenic agent is present in the formulation at or above saturation concentration. The composite is also provided with a means for adhering to the skin or mucosal tissue. The reservoirs are typically comprised of "high capacity" materials such as polyurethane hydrogels or superabsorbent materials. The androgenic agent will in most cases be testosterone or a pharmaceutically acceptable derivative thereof, administered alone or in combination with an estrogen and/or progestogen.
摘要翻译：提供用于经皮给药雄激素剂的药物递送系统和方法。该系统通常是在药物储存器内含有药物制剂的层压复合材料，其中雄激素剂以等于或高于饱和浓度存在于制剂中。复合材料还具有粘附于皮肤或粘膜组织的装置。储存器通常由“高容量”材料组成，例如聚氨酯水凝胶或超吸收材料。雄激素剂在大多数情况下是单独施用或与雌激素和/或孕激素组合施用的睾酮或其药学上可接受的衍生物。

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