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11. 发明申请

WO0141037B1 CARDIOVASCULAR HEALTHCARE MANAGEMENT SYSTEM AND METHOD 审中-公开
标题翻译：心血管健康管理系统与方法
公开(公告)号：WO0141037B1
公开(公告)日：2002-03-07
申请号：PCT/US0032833
申请日：2000-12-01
申请人： BERKELEY HEARTLAB INC , RUDERMAN FRANK R , SHEWMAKE DAVID T
发明人： RUDERMAN FRANK R , SHEWMAKE DAVID T
IPC分类号： G06F19/00 , G06Q50/22 , G06Q50/24 , G06F17/00
CPC分类号： G06F19/3456 , G06F19/325 , G06F19/326 , G06F19/3418 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S706/924
摘要： The invention relates to a cardiovascular healthcare management system which as an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular educational materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and/or patient treatment plan compliance data.
摘要翻译：心血管保健管理系统本发明涉及一种心血管保健管理系统，其作为具有与诸如年龄，血压，LDL，HDL及其子分类之类的心血管疾病风险因素有关的信息的数据库以及诸如饮食，运动，药物和心血管的心血管疾病管理教育资料。医生可以通过电子方式与信息中心站点进行交流，以获取患者检测结果，并根据饮食，运动和药物数据制定患者治疗计划。医生可以通过信息中心记录以电子方式向患者传达治疗计划。患者可以通过患者记录以电子方式将依从性信息传达给医生。信息中心站点还可以提供个案管理者以向医生提供初始治疗计划草案，收集患者历史数据和/或患者治疗计划合规性数据。

12. 发明申请

WO0141037A3 CARDIOVASCULAR HEALTHCARE MANAGEMENT SYSTEM AND METHOD 审中-公开
标题翻译：心血管健康管理系统与方法
公开(公告)号：WO0141037A3
公开(公告)日：2002-02-07
申请号：PCT/US0032833
申请日：2000-12-01
申请人： BERKELEY HEARTLAB INC , RUDERMAN FRANK R , SHEWMAKE DAVID T
发明人： RUDERMAN FRANK R , SHEWMAKE DAVID T
IPC分类号： G06F19/00 , G06Q50/22 , G06Q50/24 , G06F17/00
CPC分类号： G06F19/3456 , G06F19/325 , G06F19/326 , G06F19/3418 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S706/924
摘要： The invention relates to a cardiovascular healthcare management system which as an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular educational materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and/or patient treatment plan compliance data.
摘要翻译：本发明涉及一种心血管保健管理系统，其作为具有与心血管疾病危险因素（例如年龄，血压，LDL，HDL及其分数）有关的信息的数据库的信息网站以及心血管疾病管理如饮食，运动，药物和心血管教材。医师可以与信息网站进行电子通信，以获得患者测试结果，并从饮食，运动和药物数据中制定患者治疗计划。医生可以通过信息网站的记录将治疗计划电子化地传达给病人。患者可以通过患者记录将合规信息以电子方式传达给医师。信息网站还可以提供病例管理者向医师提供初始治疗计划草案，收集患者病史数据和/或患者治疗计划合规性数据。

13. 发明授权

US07842506B2 Apolipoprotein E genotyping and accompanying internet-based health management system 有权
标题翻译：载脂蛋白E基因分型和伴随的基于互联网的健康管理系统
公开(公告)号：US07842506B2
公开(公告)日：2010-11-30
申请号：US11702961
申请日：2007-02-06
申请人： Christopher Hall , Vance Lanier, Jr. , David T. Shewmake
发明人： Christopher Hall , Vance Lanier, Jr. , David T. Shewmake
IPC分类号： G01N33/92
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N33/92 , G06F19/00 , G06F19/18 , G06Q50/24
摘要： The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.
摘要翻译：本发明提供一种用于监测患者的系统，其包括：1）测量来自患者的Apo E基因型或其衍生物的血液检测以产生Apo B信息; 2）接收并存储患者Apo E信息的数据库; 以及3）基于因特网的系统，其连接到所述数据库并被配置为利用所述算法处理所述Apo E信息，所述算法作为响应，为所述患者产生饮食和治疗计划。

14. 发明申请

US20090188796A1 Method For Identifying At Risk Cardiovascular Disease Patients 审中-公开
标题翻译：识别风险心血管疾病患者的方法
公开(公告)号：US20090188796A1
公开(公告)日：2009-07-30
申请号：US12197694
申请日：2008-08-25
申请人： David Shewmake , Frank Ruderman , Christopher Boggess , Faith Clendenen
发明人： David Shewmake , Frank Ruderman , Christopher Boggess , Faith Clendenen
IPC分类号： G01N27/447
CPC分类号： G01N33/92 , C25B1/285 , G01N2800/32 , G01N2800/52 , Y10T436/104165
摘要： The invention provides a data base of LDL, I, IIa, IIb, IIIa, IIb, IVa, IVb and HDL2a, HDL2b, HDL 3a, HDL 3b and HDL 3c together with patient data such as HDL-C, LDL-C, Apo A, ApoB, Lp(a) and patient personal data useful for treatment, diagnosing, and monitoring cardiovascular disease. The data base contains the LDL and HDL subfraction data in quantitative mg/dl values and permits deriving relationship amongst the LDL and HDL values and cardiovascular disease. Quantitative data permits more effective treatment and monitoring of cardiovascular disease. For example, quantitative differences in LDL and HDL subclass levels can determine the need for more or less aggressive treatment. The data base which includes patient events, procedures, interventions which is correlated to LDL and HDl quantitative subclass data permits development of personalized patient treatment plans and monitoring the effectiveness of such treatment. Thus, LDL and HDL quantitative subfraction data can be used to more effectively treat and monitor cardiovascular disease.The invention, for example, provides a method for identifying patients with normal NCEP lipid levels who are in need of treatment for cardiovascular disease comprising measuring one or more LDL or HDL particle subclass levels and identifying abnormal LDL or HDL subclass levels. LDL III a & b and HDL 2b are preferred subclasses.
摘要翻译：本发明提供LDL，I，IIa，IIb，IIIa，IIb，IVa，IVb和HDL2a，HDL2b，HDL 3a，HDL 3b和HDL 3c的数据库以及患者数据如HDL-C，LDL-C，Apo A，ApoB，Lp（a）和患者个人资料可用于治疗，诊断和监测心血管疾病。数据库包含定量mg / dl值中的LDL和HDL次级分数据，并允许LDL和HDL值与心血管疾病之间的关系。定量数据可以更有效地治疗和监测心血管疾病。例如，LDL和HDL亚类水平的定量差异可以确定对或多或少积极治疗的需要。包括与LDL和HDI定量亚类数据相关的患者事件，程序，干预措施的数据库允许开发个性化的患者治疗计划并监测此类治疗的有效性。因此，LDL和HDL定量分数据可用于更有效地治疗和监测心血管疾病。例如，本发明提供了一种用于鉴定需要治疗心血管疾病的正常NCEP脂质水平的患者的方法，包括测量一种或多种LDL或HDL颗粒亚类水平并鉴定异常的LDL或HDL亚类水平。 LDL III a＆b和HDL 2b是优选的亚类。

15. 发明授权

US07416895B2 Method for identifying at risk cardiovascular disease patients 有权
标题翻译：识别危险心血管疾病患者的方法
公开(公告)号：US07416895B2
公开(公告)日：2008-08-26
申请号：US10412838
申请日：2003-04-12
申请人： David Shewmake , Frank Ruderman , Christopher Boggess , Faith Clendenen
发明人： David Shewmake , Frank Ruderman , Christopher Boggess , Faith Clendenen
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C25B1/285 , G01N2800/32 , G01N2800/52 , Y10T436/104165
摘要： This invention is directed to a data base which contains data for HDL2b, LDL IIIa & LDL IIIb and LDL IVb subclasses all in mg/Dl and which is correlated to cardiovascular disease.
摘要翻译：本发明涉及一种数据库，其中包含HDL2b，LDL IIIa和LDL IIIb和LDL IVb亚类的数据，全部以mg / dl表示，并与心血管疾病相关。

16. 发明申请

US20070224619A1 Apolipoprotein E genotyping and accompanying internet-based health management system 有权
标题翻译：载脂蛋白E基因分型和伴随的基于互联网的健康管理系统
公开(公告)号：US20070224619A1
公开(公告)日：2007-09-27
申请号：US11702961
申请日：2007-02-06
申请人： Matthew Banet , Randon Schultz , Marshal Dhillon , Adam Fleming , Henk Visser , Christopher Hall , Vance Lanier
发明人： Matthew Banet , Randon Schultz , Marshal Dhillon , Adam Fleming , Henk Visser , Christopher Hall , Vance Lanier
IPC分类号： C12Q1/68 , C12Q1/60
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N33/92 , G06F19/00 , G06F19/18 , G06Q50/24
摘要： The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.
摘要翻译：本发明提供一种用于监测患者的系统，其包括：1）测量来自患者的Apo E基因型或其衍生物的血液检测以产生Apo B信息; 2）接收并存储患者Apo E信息的数据库; 以及3）基于因特网的系统，其连接到所述数据库并被配置为利用所述算法处理所述Apo E信息，所述算法作为响应，为所述患者产生饮食和治疗计划。

17. 发明申请

US20070072302A1 Method for quantitatively determining the LDL particle number in a distribution of LDL cholesterol subfractions 审中-公开
$Method for quantitatively determining the LDL particle number in a distribution of LDL cholesterol subfractions$
标题翻译：定量测定低密度脂蛋白胆固醇分数分布中LDL粒子数的方法
公开(公告)号：US20070072302A1
公开(公告)日：2007-03-29
申请号：US11522591
申请日：2006-09-18
申请人： Faith Clendenen , Christopher Boggess , Frank Ruderman
发明人： Faith Clendenen , Christopher Boggess , Frank Ruderman
IPC分类号： G01N33/92
CPC分类号： G01N33/92
摘要： The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a LDL subfraction. The method features the steps of: 1) measuring an initial distribution of LDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of LDL particles with a mathematical model to determine a modified distribution of LDL particles (e.g., a relative particle distribution); 3) determining a total LDL particle number value from a blood sample; and 4) analyzing both the modified distribution of particles and the total LDL particle number value to calculate the particle number value in an LDL subfraction.
摘要翻译：本发明提供了一种用于计算LDL子分数中的粒子数量的方法（例如，计算机算法）。该方法的特征在于：1）测量来自血液样本的LDL颗粒的初始分布（例如相对质量分布）; 2）用数学模型处理LDL颗粒的初始分布，以确定LDL颗粒的修饰分布（例如，相对颗粒分布）; 3）从血液样品中确定总LDL颗粒数值; 和4）分析改性粒子分布和总LDL粒子数值，以计算LDL亚分数中的粒子数值。

18. 发明申请

US20070073558A1 Internet based patient-monitoring system featuring interactive messaging engine 审中-公开
标题翻译：基于互联网的患者监测系统，具有交互式消息传递引擎
公开(公告)号：US20070073558A1
公开(公告)日：2007-03-29
申请号：US11522562
申请日：2006-09-18
申请人： Christopher Hall , Vance Lanier , Matthew Banet , Randon Schultz , Marshal Dhillon , Adam Fleming , Henk Visser
发明人： Christopher Hall , Vance Lanier , Matthew Banet , Randon Schultz , Marshal Dhillon , Adam Fleming , Henk Visser
IPC分类号： G06Q10/00 , A61B5/00
CPC分类号： G06F19/3418 , G06Q50/22
摘要： The invention provides: 1) a monitoring device featuring systems that monitor the patient's vital sign and exercise information; 2) an Internet-based system configured to receive, store, and display vital sign and exercise from the monitoring device, and blood test information from an external blood test; and 3) a messaging system configured to process the vital sign, exercise, and blood test information, and in response send a personalized message to the patient.
摘要翻译：本发明提供：1）监测装置，其特征在于监测患者生命体征和运动信息的系统; 2）基于互联网的系统，被配置为从监测装置接收，存储和显示生命体征和运动，以及来自外部血液测试的血液测试信息; 以及3）被配置为处理所述生命体征，运动和血液测试信息的消息系统，并且作为响应向所述患者发送个性化消息。

19. 发明申请

US20070073178A1 Monitoring device for measuring calorie expenditure 审中-公开
标题翻译：用于测量卡路里消耗的监测装置
公开(公告)号：US20070073178A1
公开(公告)日：2007-03-29
申请号：US11522565
申请日：2006-09-18
申请人： Ray Browning , Christopher Hall , Matthew Banet
发明人： Ray Browning , Christopher Hall , Matthew Banet
IPC分类号： A61B5/04
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/024 , A61B5/11 , G16H40/67
摘要： The invention provides a monitoring device that features: 1) a cardiac sensor component with at least one light-emitting diode and a photodetector; 2) a pedometer component with at least one motion-sensing component (e.g., an accelerometer); and 3) a wireless component with a wireless interface that communicates with an external weight scale. The device also features a microprocessor in electrical communication with the cardiac sensor, pedometer, and wireless components and configured to analyze: 1) a signal from the cardiac sensor component to generate heart rate information; 2) a signal from the pedometer component to generate exercise information; 3) heart rate and exercise information to generate calorie information; and 4) a signal from the external weight scale to calculate weight information (e.g., weight and percent body fat).
摘要翻译：本发明提供了一种监测装置，其特征在于：1）具有至少一个发光二极管和光电检测器的心脏传感器部件; 2）具有至少一个运动感测部件（例如，加速度计）的计步器部件; 以及3）具有与外部重量秤通信的无线接口的无线部件。该装置还具有与心脏传感器，计步器和无线部件电通信的微处理器，并且被配置为分析：1）来自心脏传感器部件的信号以产生心率信息; 2）来自计步器组件的信号以产生运动信息; 3）心率和运动信息产生卡路里信息; 和4）来自外部重量级的信号以计算重量信息（例如体重和身体脂肪百分比）。

20. 发明申请

US20040043496A1 Method for identifying patients who will require multiple invasive cardiovascular procedures 审中-公开
标题翻译：确定需要多次侵入性心血管手术的患者的方法
公开(公告)号：US20040043496A1
公开(公告)日：2004-03-04
申请号：US10463664
申请日：2003-06-16
申请人： Berkeley HeartLab, Inc.
发明人： H. Robert Superko
IPC分类号： G01N033/92
CPC分类号： G01N33/92 , G01N2800/52
摘要： The invention provides a method for identifying patients who will require multiple invasive cardiac procedures comprising measuring elevated LDL IVb levels in patients who have had or will have invasive heart surgery.
摘要翻译：本发明提供了一种用于鉴定需要多次侵入性心脏手术的患者的方法，包括测量已经或将要进行侵入性心脏手术的患者的升高的LDL IVb水平。

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