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161. 发明授权

US06518038B1 Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction 失效
标题翻译：使用空间定位的分析物繁殖来检测和定量样品中一种或多种目标分析物
公开(公告)号：US06518038B1
公开(公告)日：2003-02-11
申请号：US09728826
申请日：2000-11-28
申请人： Stephen C. Wardlaw , Stephen C. Edberg
发明人： Stephen C. Wardlaw , Stephen C. Edberg
IPC分类号： C12Q104
CPC分类号： G01N33/569 , Y02A50/59
摘要： The presence or absence of one or more target microbial analytes in a substance, such as a biological or environmental substance, is assayed by inoculating a growth medium with a sample of the substance. The medium may be combined with a labeled analyte-specific material (LASM) which can migrate through the substrate and which is homogeneously distributed throughout the medium. The LASM may be premixed with the medium, or may be added to the medium after inoculation with the substance. The nature of the medium is such that it will support target analyte reproduction so as to form target analyte colonies in or on the medium, and it will not allow the target analyte colonies to migrate on or within the medium. After the sample to be assayed is added to the medium, growth of the target analyte colonies in the sample will bind increasing quantities of the LASM, thereby creating localized intensely labeled areas in the medium which can be visually or photometrically detected. As the target analyte colonies grow on or in the medium they attract increasing quantities of the LASM which diffuses to the colonies through the medium causing the local target analyte colonies to become intensely labeled, which renders the colonies readily detectable. Each of the intensely labeled target analyte colonies in the medium may also be surrounded by areas of lower intensity due to local depletion of the LASM in the regions of colony growth. The number of intensely labeled target analyte colonies in the medium will be proportional to the concentration of the target analyte present in the sample. In the event that the target analyte is absent from the sample, then there will be no localized labeled microbe colonies in the medium.
摘要翻译：通过用物质样品接种生长培养基来测定物质如生物或环境物质中的一种或多种目标微生物分析物的存在或不存在。介质可以与标记的分析物特异性材料（LASM）组合，其可以迁移穿过基底并且均匀分布在整个介质中。 LASM可以与培养基预混合，或者可以在接种物质后添加到培养基中。培养基的性质使得其将支持靶分析物繁殖，以便在培养基中或培养基上形成靶分析物菌落，并且不允许靶分析物菌落在培养基上或培养基内迁移。将待测定样品加入到培养基中后，样品中目标分析物菌落的生长将结合增加量的LASM，从而在培养基中产生局部强烈标记的区域，可以在视觉上或光度上检测。当目标分析物菌落在培养基上或培养基中生长时，它们吸引越来越多的LASM，其通过培养基扩散到菌落，导致局部目标分析物菌落变得强烈标记，这使得菌落易于检测。由于LASM在集落生长区域局部消耗，所以介质中每个强烈标记的目标分析物菌落也可能被较低强度的区域包围。培养基中强烈标记的目标分析物菌落的数量将与样品中存在的目标分析物的浓度成比例。在样品中不存在目标分析物的情况下，培养基中不存在局部标记的微生物菌落。

162. 发明授权

US06384906B1 Method and apparatus for timing intermittent illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube-imaging system 有权
公开(公告)号：US06384906B1
公开(公告)日：2002-05-07
申请号：US09962022
申请日：2001-09-24
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： G01N3348
摘要： Centrifuged material layer volumes are measured and quantified during centrifugation of the material layers contained in a sample tube in a centrifuge assembly, which sample tube is disposed on a centrifuge platen. The material layers in the sample tube are periodically illuminated during centrifugation by a pulsed light source which differentially excites one or more fluorescent dyes or stains which are admixed with the sample being analyzed. This kinetic procedure is particularly useful in performing differential blood cell and platelet counts. A fluorscent target reference device is positioned on the centrifuge platen along with a detectable platen position sensor. The centrifuge assembly includes a processor controller which receives information from the platen position sensor, and from the target reference device, and which controls operation of the light source.

163. 发明授权

US5753456A Method for quantification of biological material in a liquid sample 失效
标题翻译：液体样品中生物材料定量方法
公开(公告)号：US5753456A
公开(公告)日：1998-05-19
申请号：US394315
申请日：1995-02-22
申请人： Ali Naqui , Mark W. Pierson , Thomas R. Weschler , Stephen C. Wardlaw , Michael P. Finnerty , Charles R. Carpenter
发明人： Ali Naqui , Mark W. Pierson , Thomas R. Weschler , Stephen C. Wardlaw , Michael P. Finnerty , Charles R. Carpenter
IPC分类号： G01N33/487 , B01L3/00 , B65D75/32 , B65D75/34 , B65D75/36 , B65D75/40 , C12M1/34 , C12Q1/04 , C12Q1/02
CPC分类号： B01L3/5085 , B01L3/505 , B65D75/324 , C12Q1/04 , G01N2333/245 , Y10S435/81 , Y10S435/975
摘要： An article adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet and a lower surface sheet enclosing a volume therebetween. The bag has an upper opening through which the liquid sample can be poured into the volume in the bag. The bag also has a plurality of partitions configured to separate one or more portions of adequate sample in the bag. Also provided is a passage through which a liquid sample can be distributed throughout the volume in the bag. The bag is made of material which can be caused to form discreet non-permeable compartments for holding separate aliquots of the liquid sample.
摘要翻译：一种用于容纳用于定量液体样品中的生物材料的液体样品的制品。该物品包括具有上表面片和在其间包围体积的下表面片的袋。该袋具有上部开口，液体样品可以通过该上部开口倒入袋中的体积中。该袋还具有多个分隔件，其被配置为分离袋中足够样品的一个或多个部分。还提供了一种通道，液体样品可通过该通道分布在袋中的整个体积中。该袋由材料制成，其可以形成离散的非渗透性隔室，用于保持液体样品的单独等分试样。

164. 发明授权

US4325913A Reagent probe and method for fabrication thereof 失效
标题翻译：试剂探头及其制造方法
公开(公告)号：US4325913A
公开(公告)日：1982-04-20
申请号：US198523
申请日：1980-10-20
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： B01L3/02
CPC分类号： B01L3/0275
摘要： A probe for aspirating and dispensing fluids is provided with a concave arcuate termination of the tubular bodywall forming a terminal orifice, in which the tip of the arcuate termination projects inwardly toward the tubular axis; the projection of the tip extends to a position at a distance in the range of approximately 1/4 to about 3/4 of the distance perpendicularly across the outside diameter of the bodywall.
摘要翻译：用于吸入和分配流体的探针设置有形成终端孔的管状壁板的凹弧形终端，其中弓形端接件的尖端朝向管状轴线向内突出; 尖端的突起延伸到垂直于主体壁的外径的距离的大约1/4至大约3/4范围内的距离处的位置。

165. 发明授权

US09322835B2 Method and apparatus for selectively admixing reagents in a substantially undiluted biologic fluid sample analysis 有权
标题翻译：在基本未稀释的生物液体样品分析中选择性混合试剂的方法和装置
公开(公告)号：US09322835B2
公开(公告)日：2016-04-26
申请号：US13077251
申请日：2011-03-31
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： G01N1/10 , G01N31/00 , G01N35/02 , G01N1/14 , G01N35/00
CPC分类号： G01N35/025 , G01N1/14 , G01N35/00584 , G01N35/026 , Y10T436/2575
摘要： A biologic fluid sample analysis method and system is provided that includes a reagent depository, and analysis chamber, a biologic fluid transfer system, and a programmable analyzer. The reagent depository has a plurality of reagent deposits, and each reagent deposit located at a position within the depository independent of the other reagent deposits. The analysis chamber is adapted to quiescently hold a biologic fluid sample and one or more reagents during analysis. The biologic fluid transfer system has at least one fluid transfer device. The programmable analyzer is adapted to control the biologic fluid transfer system to acquire a volume of sample from a sample reservoir, dispense a volume of the sample into the reagent depository, acquire a volume of sample and reagent from the reagent depository, and to transfer the sample and reagent to the analysis chamber, and to analyze the combined sample and reagent.
摘要翻译：提供了一种生物液体样品分析方法和系统，其包括试剂库和分析室，生物流体转移系统和可编程分析仪。试剂库具有多个试剂沉积物，每个试剂沉积物位于存储体内的位置，而与其它试剂沉积物无关。分析室适于在分析期间静止地保持生物流体样品和一种或多种试剂。生物液体输送系统具有至少一个流体转移装置。可编程分析仪适用于控制生物流体转移系统，以从样品储存器获取一定体积的样品，将样品的体积分配到试剂储存器中，从试剂库获取一定体积的样品和试剂，并将样品和试剂分析到分析室，并分析组合的样品和试剂。

166. 发明授权

US09084995B2 Disposable chamber for analyzing biologic fluids 有权
标题翻译：一次性分析生物液体室
公开(公告)号：US09084995B2
公开(公告)日：2015-07-21
申请号：US12774445
申请日：2010-05-05
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： B01L3/00 , G01N1/00 , G01N1/28 , G01N21/03 , G01N1/31 , G01N35/00 , G01N15/00 , G01N15/10 , G01N15/14
CPC分类号： G01N33/48764 , B01L3/5027 , B01L3/502738 , B01L2200/025 , B01L2200/12 , B01L2300/0877 , B01L2300/0887 , B01L2400/0406 , G01N1/2813 , G01N1/312 , G01N21/03 , G01N33/492 , G01N35/00009 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2021/0346 , G01N2021/0364 , Y10T436/101666 , Y10T436/25375
摘要： An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At least one of the members or separators is sufficiently flexible to permit the chamber height to approximate the mean size of the separators. During use, the biologic fluid to be analyzed is disposed within the chamber.
摘要翻译：提供一种用于分析生物流体的装置，其包括第一平面构件，第二平面构件和至少三个分隔件。平面构件中的至少一个是透明的。分离器设置在构件之间，并且分离构件以形成具有高度的室。构件或分隔件中的至少一个具有足够的柔性，以允许室的高度接近分隔件的平均尺寸。在使用过程中，待分析的生物流体设置在室内。

167. 发明申请

US20130209332A1 CONTAINER FOR HOLDING BIOLOGIC FLUID FOR ANALYSIS 审中-公开
标题翻译：用于分析用于控制生物流体的容器
公开(公告)号：US20130209332A1
公开(公告)日：2013-08-15
申请号：US13727151
申请日：2012-12-26
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： B01L3/00
CPC分类号： B01L3/50 , B01L3/502738 , B01L3/502746 , B01L3/545 , B01L9/56 , B01L2300/089 , B01L2400/0406 , B01L2400/0633 , B01L2400/086 , G01N35/00029 , G01N35/00732 , G01N2001/282 , G01N2035/00851
摘要： A container for holding a biologic fluid sample for analysis is provided which includes a chamber and a label. The chamber includes a first wall, a transparent second wall, and a plurality of features including features spatially located within the chamber. The transparent second wall permits a fluid sample quiescently residing within the chamber to be imaged through the second wall. The plurality of features, including those spatially located within the chamber, are operable to enable the analysis of the biologic fluid. The label directly or indirectly contains information regarding the features and the spatial location of the features within the chamber. The sample is analyzed by an analytical device that utilizes the information communicated through the label.
摘要翻译：提供用于容纳用于分析的生物流体样品的容器，其包括室和标签。腔室包括第一壁，透明第二壁和包括空间上位于腔室内的特征的多个特征。透明的第二壁允许静止在腔室内的流体样品通过第二壁成像。多个特征，包括在空间上位于腔室内的特征，可操作以使得能够分析生物流体。标签直接或间接包含关于室内特征和空间位置的信息。样品通过利用通过标签传递的信息的分析装置进行分析。

168. 发明授权

US08415169B2 Buffy coat separator float system and method 失效
公开(公告)号：US08415169B2
公开(公告)日：2013-04-09
申请号：US13371761
申请日：2012-02-13
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48 , C12M1/34
CPC分类号： B01L3/50215 , Y10T436/111666 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.

169. 发明申请

US20120164683A1 BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD 失效
标题翻译： BUFFY COAT SEPATATOR FLOAT SYSTEM AND METHOD
公开(公告)号：US20120164683A1
公开(公告)日：2012-06-28
申请号：US13371761
申请日：2012-02-13
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： C12Q1/04 , B29C45/00 , C12M1/34
CPC分类号： B01L3/50215 , Y10T436/111666 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

170. 发明申请

US20110171680A1 BUFFY COAT TUBE AND FLOAT SYSTEM AND METHOD 有权
公开(公告)号：US20110171680A1
公开(公告)日：2011-07-14
申请号：US13052151
申请日：2011-03-21
申请人： Thomas Haubert , Stephen C. Wardlaw
发明人： Thomas Haubert , Stephen C. Wardlaw
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： B01L3/505 , B01L3/50215 , B01L2400/0409 , G01N33/49 , Y10S435/81 , Y10S436/81
摘要： A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an elongated sidewall having a first cross-sectional inner diameter. The float consists of a main body portion and one or more support members protruding from the main body portion to engage and support the sidewall of the sample tube. The main body portion and the support members of the float have a cross-sectional diameter less than that of the first cross-sectional inner diameter of the tube when the sample tube is expanded, such as by centrifugation. The main body portion of the float together with an axially aligned portion of the sidewall define an annular volume therebetween. The support members protruding from the main body portion of the float traverse said annular volume to produce one or more analysis areas. During centrifugation, the centrifugal force enlarges the diameter of the tube to permit density-based axial movement of the float in the tube. Thereafter, the centrifugal force is reduced to cause the tube sidewall to return to its first diameter, thereby capturing the float and trapping the buffy coat constituents in the analysis area. The bully coat constituents can then be evaluated or measured.
摘要翻译：提供了用于分离和轴向膨胀血沉棕黄层的管和浮子系统。该系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。样品管具有具有第一横截面内径的细长侧壁。浮子包括主体部分和从主体部分突出的一个或多个支撑构件，以接合和支撑样品管的侧壁。例如通过离心，浮体的主体部分和支撑构件的横截面直径小于管的第一截面内径的横截面直径。浮子的主体部分与侧壁的轴向对准部分在其间限定了环形体积。从浮子的主体部分突出的支撑构件穿过所述环形体积以产生一个或多个分析区域。在离心过程中，离心力扩大了管的直径，以允许管中的浮子的基于密度的轴向运动。此后，减小离心力使管侧壁回到其第一直径，从而捕获浮子并将分析区域中的血沉棕黄层成分捕获。然后可以评估或测量欺负涂层成分。

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