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141. 发明申请

US20100298356A1 SATURATED AND INSATURATED BI- OR TRICYCLIC ARYLOXYACETAMINE DERIVATIVES AND THEIR USE AS FUNGICIDES 失效
标题翻译：饱和和分离的二元或三聚氰胺乙酰胺衍生物及其作为杀真菌剂的用途
公开(公告)号：US20100298356A1
公开(公告)日：2010-11-25
申请号：US12676374
申请日：2008-09-03
申请人： Fiona Kessabi Murphy , Hans-Georg Brunner , Renaud Beaudegnies , Laura Quaranta , Frederik Cederbaum , Jayant Umarye
发明人： Fiona Kessabi Murphy , Hans-Georg Brunner , Renaud Beaudegnies , Laura Quaranta , Frederik Cederbaum , Jayant Umarye
IPC分类号： A01N43/54 , C07D215/48 , C07D239/72 , C07C235/32 , C07D333/64 , C07D307/83 , C07D277/68 , C07C255/38 , A01N43/42 , A01N37/18 , A01N43/12 , A01N43/78 , A01N37/34 , A01P3/00
CPC分类号： C07D215/20 , A01N39/04 , A01N43/16 , A01N43/18 , A01N43/42 , A01N43/54 , A01N43/78 , C07D239/74 , C07D277/62 , C07D277/64 , C07D307/79 , C07D333/54
摘要： Compounds of the general formula (I), wherein the substituents are as defined in claim 1, are useful as fungicides.
摘要翻译：通式（I）的化合物，其中取代基如权利要求1中所定义，可用作杀真菌剂。

142. 发明申请

US20070021634A1 SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS 审中-公开
标题翻译：治疗二苯醚的合成
公开(公告)号：US20070021634A1
公开(公告)日：2007-01-25
申请号：US11458035
申请日：2006-07-17
申请人： Yong Tao , Daniel Widlicka
发明人： Yong Tao , Daniel Widlicka
IPC分类号： C07C209/44 , C07C235/32
CPC分类号： C07C217/58 , C07C213/02 , C07C233/65 , C07C235/60
摘要： This invention is directed to a method of synthesizing compounds of Formula I and to intermediates useful in the synthesis of compounds of Formula I wherein X, Y, R1, R2, R3, and R4 are as defined herein above.
摘要翻译：本发明涉及一种合成式I化合物的方法和用于合成式I化合物的中间体，其中X，Y，R 1，R 2， R 3和R 4如上文所定义。

143. 发明申请

US20060276667A1 N-substituted p-menthane carboxamides 有权
标题翻译： N-取代的对薄荷烷甲酰胺
公开(公告)号：US20060276667A1
公开(公告)日：2006-12-07
申请号：US11437294
申请日：2006-05-19
申请人： Christophe Galopin , Pablo Krawec , Jay Slack , Lori Tigani
发明人： Christophe Galopin , Pablo Krawec , Jay Slack , Lori Tigani
IPC分类号： C07C255/20 , C07C235/32
CPC分类号： C07C255/60 , A61K8/42 , A61K2800/244 , A61Q11/00 , A61Q19/00 , C07C233/60 , C07C233/61 , C07C255/42 , C07C255/44 , C07C311/46 , C07C2601/14
摘要： Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is (CH2)n—R, where n is 0 or 1 and R is a group with non-bonding electrons, with the provisos that: (a) when Y and Z are H, X is not F, OH, MeO or NO2 in the 4-position and is not OH in the 2 or 6-position (b) when Y or Z is H then X, Y and Z are such that (i) the groups in the 3- and 4-positions are not both OMe, (ii) the groups in the 4- and 5-positions are not both OMe, (iii) the groups in 3- and 5-positions are not OMe if the group in the 4-position is OH, and (iv) the groups in the 3- and 5-positions are not OH if the group in the 4-position is methyl.
摘要翻译：提供具有下式的冷却化合物：其中m为0或1，Y和Z独立地选自H，OH，C 1 -C 4直链或支链烷基和C 1 -C 4直链或支链烷氧基，X 其中n为0或1，R为具有非键合电子的基团，前提条件是：（a）当Y（Y）为（CH 2）并且Z是H，X不是4位的F，OH，MeO或NO 2 2，并且在Y或Z是H时不在2或6位（b）中的OH，则X ，Y和Z为（i）3-和4-位的基团不同时为OMe，（ii）4-和5-位的基团不同时为OMe，（iii）3 - 和5-位不是OMe，如果4位的基团是OH，和（iv）如果4位的基团是甲基，那么3-和5-位的基团不是OH。

144. 发明授权

US07022880B2 Piperidine derivatives and process for their production 失效
标题翻译：哌啶衍生物及其生产工艺
公开(公告)号：US07022880B2
公开(公告)日：2006-04-04
申请号：US10918247
申请日：2004-08-13
申请人： Thomas E. D'Ambra
发明人： Thomas E. D'Ambra
IPC分类号： C07C235/32
CPC分类号： C07D211/22
摘要： The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings, each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
摘要翻译：本发明涉及下列基本上纯的哌啶衍生物化合物：其中R 1是氢或羟基; R 2是氢; 或R 1和R 2一起形成带有R 1和R 2的碳原子之间的第二个键， ; R 3是-COOH或-COOR 4; R 4具有1至6个碳原子; A，B和D是它们各自的取代基，其各自可以不同或相同，并且是氢，卤素，烷基，羟基，烷氧基或其它取代基。还公开了以基本上纯的形式制备这种哌啶衍生物化合物的方法。

145. 发明申请

US20050014950A1 Process for the preparation of alpha hydroxycarboxylic acid amides 有权
标题翻译： α-羟基羧酸酰胺的制备方法
公开(公告)号：US20050014950A1
公开(公告)日：2005-01-20
申请号：US10495257
申请日：2002-11-15
申请人： Martin Zeller , Dominik Faber , Thomas Vettiger , Clemens Lamberth
发明人： Martin Zeller , Dominik Faber , Thomas Vettiger , Clemens Lamberth
IPC分类号： C07C231/02 , C07C213/02 , C07C231/00 , C07C233/00 , C07C235/08 , C07C235/32 , C07C235/34 , C07D213/56
CPC分类号： C07C233/22
摘要： The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a α-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.
摘要翻译：本发明涉及制备式（I）的2-苯基-2-羟基-N- [2-（3-烷氧基-4-羟基苯基） - 乙基] - 乙酰胺的新方法，其中R1是烷基，R2 和R 3各自独立地为氢或烷基，R 4为任选取代的芳基或任选取代的杂芳基，该方法包括使式（II）的2-（3-烷氧基-4-羟基苯基） - 乙胺反应，其中R1R2和R3 （III）的α-羟基羧酸酯或式（III）a的二氧戊环酮，其中R 4如上所定义，R 5，R 6和R 7彼此独立地为低级烷基。式（I）化合物是衍生自扁桃酸酰胺的新型杀真菌剂组的重要中间体。

146. 发明申请

US20040092600A1 Novel sphingolipid synthesis inhibitor 失效
标题翻译：新型鞘脂合成抑制剂
公开(公告)号：US20040092600A1
公开(公告)日：2004-05-13
申请号：US10472379
申请日：2003-09-23
发明人： Shu Kobayashi , Kentaro Hanada
IPC分类号： A61K031/16 , C07C235/32
CPC分类号： C07C233/18 , A61K31/165
摘要： A inhibitor of sphingolipids synthesis comprising a compound represented by general formula A. Desirably, a novel inhibitor of sphingolipids synthesis comprising (1R, 3R) N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) alkaneamide, wherein carbon number of alkanoyl group is 8-16. 1 (in the formula, X is an aliphatic alkyl group, desirably is an aliphatic alkyl group having 7 to 15 carbon atoms).
摘要翻译：含有由通式A表示的化合物的鞘脂合成抑制剂。理想地，包含（1R，3R）N-（3-羟基-1-羟甲基-3-苯基丙基）烷酰胺的新型鞘脂合成抑制剂，其中烷酰基组是8-16。（式中，X为脂肪族烷基，优选为碳原子数7〜15的脂肪族烷基）。

147. 发明授权

US6083982A Natriuretic compounds 失效
标题翻译：利尿钠化合物
公开(公告)号：US6083982A
公开(公告)日：2000-07-04
申请号：US57731
申请日：1998-04-09
申请人： William J. Wechter , David E. Murray , Darko Kantoci , Barry H. Levine , Elaine J. Benaksas
发明人： William J. Wechter , David E. Murray , Darko Kantoci , Barry H. Levine , Elaine J. Benaksas
IPC分类号： C07D333/58 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/39 , A61P7/10 , B01J31/02 , C07B61/00 , C07C51/09 , C07C59/52 , C07C59/84 , C07C59/90 , C07C61/29 , C07C61/39 , C07C61/40 , C07C62/32 , C07C62/34 , C07C67/343 , C07C69/732 , C07C69/738 , C07C69/76 , C07C211/26 , C07C211/29 , C07C211/34 , C07C211/37 , C07C211/44 , C07C231/24 , C07C233/11 , C07C235/32 , C07C235/78 , C07C317/32 , C07C317/44 , C07D307/33 , C07D311/58 , C07D311/72 , C07D333/60 , C07D333/64 , C07D335/06 , C07D337/08 , C07D337/16 , C07D493/04 , G11C11/407 , G11C16/02 , G11C29/14 , A61K31/215 , A61K31/19 , A61K31/235
CPC分类号： C07D307/33 , A61K31/353 , A61K31/365 , C07C59/90 , C07C69/732 , C07C69/738 , C07D311/72 , C07D493/04
摘要： Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provided. The natriuretic compounds are capable of inducing sodium excretion in a mammal without inducing corresponding prolonged potassium excretion.
摘要翻译：化合物，方法和组合物用于在哺乳动物中诱导利尿。还提供了分离和合成利尿钠化合物的方法。还提供了使用利尿钠化合物的治疗方法。利钠化合物能够在哺乳动物中诱导钠排泄，而不引起相应的延长的钾排泄。

148. 发明授权

US5573999A .beta.-substituted cinnamic acid derivative 失效
标题翻译： β-取代肉桂酸衍生物
公开(公告)号：US5573999A
公开(公告)日：1996-11-12
申请号：US441639
申请日：1995-05-15
申请人： Hubert Sauter , Herbert Bayer , Klaus Oberdorf , Horst Wingert , Wolfgang von Deyn , Wassilios Grammenos , Hartmann Koenig , Harald Rang , Franz Roehl , Gisela Lorenz , Eberhard Ammermann
发明人： Hubert Sauter , Herbert Bayer , Klaus Oberdorf , Horst Wingert , Wolfgang von Deyn , Wassilios Grammenos , Hartmann Koenig , Harald Rang , Franz Roehl , Gisela Lorenz , Eberhard Ammermann
IPC分类号： C07C69/618 , A01N37/36 , A01N37/38 , A01N37/44 , A01N37/48 , A01N43/08 , A01N43/10 , A01N43/36 , A01N43/56 , A01N43/74 , A01N43/78 , A01N43/80 , A01N43/82 , A61K31/21 , A61K31/40 , A61K31/505 , C07C67/343 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , C07C69/75 , C07C69/76 , C07C69/84 , C07C69/86 , C07C69/92 , C07C69/94 , C07C205/34 , C07C205/38 , C07C205/56 , C07C229/40 , C07C229/44 , C07C233/11 , C07C235/32 , C07C235/34 , C07C251/38 , C07C251/48 , C07C251/52 , C07C251/60 , C07C251/66 , C07C255/57 , C07C255/64 , C07C275/64 , C07C309/66 , C07C309/73 , C07C311/09 , C07C311/21 , C07C311/29 , C07C313/04 , C07C313/06 , C07C317/44 , C07C317/46 , C07C323/56 , C07C323/62 , C07C327/22 , C07C327/48 , C07D207/32 , C07D207/335 , C07D207/337 , C07D213/53 , C07D213/64 , C07D213/643 , C07D213/66 , C07D213/68 , C07D213/70 , C07D215/22 , C07D215/227 , C07D215/233 , C07D215/36 , C07D231/12 , C07D233/84 , C07D235/28 , C07D239/52 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/32 , C07D263/34 , C07D263/58 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/68 , C07D277/74 , C07D285/12 , C07D285/125 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/06 , C07D333/24 , C07D409/04 , C07D413/04 , C07D513/04 , C07D521/00 , C07F7/08 , A01N37/10
CPC分类号： C07D207/335 , A01N37/36 , A01N37/38 , A01N37/48 , A01N43/08 , A01N43/10 , A01N43/36 , A01N43/56 , A01N43/74 , A01N43/80 , A01N43/82 , C07C205/34 , C07C205/38 , C07C205/56 , C07C229/44 , C07C251/48 , C07C251/52 , C07C251/60 , C07C255/64 , C07C275/64 , C07C309/66 , C07C309/73 , C07C311/09 , C07C311/21 , C07C311/29 , C07C313/04 , C07C313/06 , C07C317/46 , C07C323/56 , C07C323/62 , C07C327/22 , C07C327/48 , C07C69/734 , C07C69/736 , C07D207/337 , C07D213/53 , C07D213/643 , C07D213/66 , C07D213/68 , C07D213/70 , C07D215/227 , C07D215/233 , C07D215/36 , C07D231/12 , C07D233/56 , C07D233/84 , C07D235/28 , C07D239/52 , C07D249/08 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/32 , C07D263/34 , C07D263/58 , C07D271/06 , C07D271/113 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/74 , C07D285/12 , C07D285/125 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/06 , C07D333/24 , C07D409/04 , C07D413/04 , C07D513/04 , C07F7/0818 , C07C2101/14 , C07C2102/08
摘要： .beta.-Substituted cinnamic acid derivatives of the formula 1, ##STR1## where R.sup.1 is alkyl, chlorine or bromine, --X-- is --O--, --S--, ##STR2## m is 0 or 1, --Y is --OR.sup.4, --O--N.dbd.CR.sup.5 R.sup.6, --NR.sup.7 R.sup.8, --N(OR.sup.9)R.sup.10 or --SR.sup.11, where the above-mentioned substituents R.sup.2 to R.sup.11 are alkyl, and R.sup.2, and R.sup.3 and R.sup.5 to R.sup.11 can also be hydrogen,Z is halogen, nitro, cyano, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, arylthioalkyl, hetarylalkyl, hetaryloxyalkyl, hetarylthioalkyl, alkenyl, aralkenyl, aryloxyalkenyl, arylthioalkenyl, hetarylalkenyl, hetaryloxyalkenyl, hetarylthioalkenyl, alkynyl, arylalkynyl, hetarylalkynyl, aryl, hetaryl, arylazo, acylamino, --OR.sup.12, --SR.sup.13, --SOR.sup.14, --SO.sub.2 R.sup.15, --COOR.sup.16, --CONR.sup.17 R.sup.18, --COR.sup.19, --CR.sup.20 .dbd.NR.sup.21, --N.dbd.CR.sup.22, R.sup.23, --CR.sup.24 .dbd.N--OR.sup.25, --CR.sup.25 R.sup.26 --O--, N.dbd.CR.sup.27 R.sup.28, --CH.sub.2 --OCOR.sup.39 or --NR.sup.37 R.sup.38, where R.sup.2 and R.sup.38 and R.sup.39 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, hetaryl, aralkyl, hetarylalkyl, aryloxyalkyl, arylthioalkyl, hetaryloxyalkyl or hetarylthioalkyl, and r.sup.37 is hydrogen or C.sub.1 -C.sub.4 -alkyl, are useful as fungicides and insecticides.
摘要翻译：其中R1是烷基，氯或溴，-X-是-O-，-S-，m是0或1，-Y是-OR4，其中R1是烷基，氯或溴， -ON = CR5R6，-NR7R8，-N（OR9）R10或-SR11，其中上述取代基R2至R11是烷基，R2和R3和R5至R11也可以是氢，Z是卤素，硝基，氰基，烷基，环烷基，芳烷基，芳氧基烷基，芳硫基烷基，杂芳基烷基，杂芳基烷基，杂芳基硫代烷基，烯基，芳烯基，芳氧基烯基，芳硫基烯基，杂芳基烯基，环硫基烯基，杂芳基硫代烯基，炔基，芳基炔基，杂芳基炔基，芳基，杂芳基，芳基偶氮，酰氨基，-OR12， SR13，-SOR14，-SO2R15，-COOR16，-CONR17R18，-COR19，-CR20 = NR21，-N = CR22，R23，-CR24 = N-OR25，-CR25R26-O-，N = CR27R28，-CH2-OCOR39 或-NR37R38，其中R2和R38和R39是氢，烷基，烯基，炔基，环烷基，环烷基烷基，芳基，杂芳基，芳烷基，杂芳基烷基，芳氧基烷基，芳硫基烷基，芳基氧基烷基或杂芳硫基烷基，r37是氢或C1-C 4-烷基，可用作杀真菌剂和杀虫剂。

149. 发明授权

US5334747A Method of preparing substituted malonic ester anilides and malonic acid mono-anilides 失效
标题翻译：取代丙二酸酯和丙二酸单脒的制备方法
公开(公告)号：US5334747A
公开(公告)日：1994-08-02
申请号：US864740
申请日：1992-04-07
申请人： Klaus-Dieter Steffen
发明人： Klaus-Dieter Steffen
IPC分类号： C07C211/52 , C07C231/02 , C07C233/07 , C07C233/15 , C07C233/25 , C07C233/43 , C07C233/59 , C07C235/16 , C07C235/32 , C07C229/40
CPC分类号： C07C211/52 , C07C231/02 , C07C233/15 , C07C233/59 , C07C2101/02
摘要： Malonic mono-ester mono-anilides and malonic acid mono-anilides and bis-anilides are produced by reaction of malonic acid di-alkyl esters with an aniline in the presence of a stoichiometric amount, based on the aniline, of an alkali alcoholate, accompanied by the initial formation of alkali salts of mono-ester mono-anilides or malonic-acid bis-anilides. Neutralization results in the formation of free malonic mono-ester mono-anilide or malonic-acid bis-anilide and saponification forms the malonic acid mono-anilide. Chloro-substituted anilides of cyclopropyl-1,1-dicarboxylic acid and their mono-esters are preferred.
摘要翻译：马来酸单酯单酰苯胺和丙二酸单酰苯胺和双酰苯胺通过丙二酸二烷基酯与苯胺在基于苯胺的碱金属醇化合物的存在下反应而产生，伴随着通过初始形成单酯单酰苯胺或丙二酸双脒的碱金属盐。中和导致游离丙二酸单酯单酰苯胺或丙二酸双酰苯胺的形成，皂化形成丙二酸单苯胺。环丙基-1,1-二羧酸及其单酯的氯取代苯乙烯是优选的。

150. 发明授权

US5284963A Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines 失效
标题翻译： 7-（取代的）-9 - [（取代的甘氨酰） - 氨基] -6-脱甲基-6-脱氧四环素的制备方法
公开(公告)号：US5284963A
公开(公告)日：1994-02-08
申请号：US928588
申请日：1992-08-13
申请人： Phaik-Eng Sum , Ving J. Lee
发明人： Phaik-Eng Sum , Ving J. Lee
IPC分类号： A61K31/65 , A61K31/165 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/02 , C07C231/12 , C07C237/26 , C07D203/08 , C07D205/04 , C07D207/06 , C07D233/56 , C07D249/04 , C07D249/08 , C07D295/14 , C07D295/15 , C07D521/00 , C07C233/64 , C07C235/32
CPC分类号： C07D295/15 , C07C231/12 , C07C237/26 , C07D231/12 , C07D233/56 , C07D249/08 , C07C2103/46
摘要： The invention provides a novel method for producing compounds of the formula I: ##STR1## wherein X and R are defined in the specifications. The invention also provides a method for making intermediates useful to produce the compounds of formula I. Utilizing a common intermediate, the novel method efficiently produces compounds of the formula I.
摘要翻译：本发明提供了一种制备式I化合物的新方法：（*化学结构*）I其中X和R在说明书中定义。本发明还提供了制备用于制备式I化合物的中间体的方法。利用常用中间体，该新方法有效地产生式I化合物。

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