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141. 发明公开

EP1493754A1 POLYSACCHARIDE CONTAINING PHOSPHORYLCHOLINE GROUP AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：根据上述制造磷酸胆碱和过程的多糖
公开(公告)号：EP1493754A1
公开(公告)日：2005-01-05
申请号：EP03715780.7
申请日：2003-04-08
申请人： SHISEIDO COMPANY, LTD.
发明人： MIYAZAWA, Kazuyuki, SHISEIDO RESEARCH CENTER , YANAKI, Toshio, SHISEIDO RESEARCH CENTER , WINNIK, Francoise M.
IPC分类号： C08B15/00 , C07B37/00 , C07B37/02 , C07B37/08 , A61K47/36 , A61K7/00
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method.
The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it.
The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.

142. 发明授权

EP0970131B1 PARTICULATE DRUG CARRIERS 失效
标题翻译：颗粒药物载体
公开(公告)号：EP0970131B1
公开(公告)日：2004-01-02
申请号：EP98912633.9
申请日：1998-03-25
申请人： UNIVERSITY OF STRATHCLYDE
发明人： UCHEGBU, Ijeoma, Florence
IPC分类号： C08B37/08 , A61K9/127
CPC分类号： A61K9/5123 , A61K9/1272 , A61K9/5161 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is directed to particulate drug carriers, such as vesicles, formed from polysaccharide derivatives. A polysaccharide bearing at least one non-ionic hydrophilic group attached to an individual monosaccharide unit is hydrophobised to form a derivative bearing at least one long chain alkyl residue. Particle formation is then induced in the presence of cholesterol. The particles are suited for entrapment or conjugation of pharmaceutically active ingredients.

143. 发明公开

EP0586034A3 High pullulan content product, and its preparation and uses 失效
标题翻译：高支链淀粉含量产品及其制备和用途
公开(公告)号：EP0586034A3
公开(公告)日：1994-12-14
申请号：EP93301615.6
申请日：1993-03-03
申请人： KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
发明人： Ozaki, Yoshihide , Nomura, Tatsuo , Miyake, Toshio
IPC分类号： C12P19/10 , C08B37/00
CPC分类号： A23G3/343 , A21D2/181 , A23C9/137 , A23G3/346 , A23G2200/06 , A23L19/20 , A23L29/274 , A23P20/105 , A24B15/30 , A61K8/0212 , A61K8/73 , A61K9/0014 , A61K9/0019 , A61K9/286 , A61K9/4816 , A61K47/36 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/02 , C05G3/0052 , C08B37/0018 , C12P19/10 , D21H13/10
摘要： Disclosed is a novel high pullulan content product containing pullulan having an average molecular weight less than 250,000, said product being prepared by continuously cultivating a microorganism capable of producing pullulan in a nutrient culture medium containing a 10-20 w/v % saccharide while controlling the viscosity of the nutrient culture medium to a level below 30cp. The product can be advantageously used in a variety of fields such as a viscosity-imparting agent, coating agent, adhesive, formed product, food product, cosmetic, pharmaceutical, and material for agriculture, forestry, stock raising and paper processings, as well as for mining and manufacturing industries.
摘要翻译：公开了一种新型高支链淀粉含量产品，其含有平均分子量小于250,000的支链淀粉，所述产品通过在含有10-20w / v％糖的营养培养基中连续培养能够产生支链淀粉的微生物而制备，营养培养基的粘度降至30cp以下。该产品可以有利地用于各种领域，例如粘度赋予剂，涂布剂，粘合剂，成型产品，食品，化妆品，药物和用于农业，林业，畜牧业和纸加工的材料，以及用于采矿和制造业。

144. 发明公开

EP0370810A1 Fatty emulsion stabilized by a polysaccharide derivative 失效
标题翻译： Fettige乳液，稳定剂Hilfe von Polysaccharidverbindungen。
公开(公告)号：EP0370810A1
公开(公告)日：1990-05-30
申请号：EP89312173.1
申请日：1989-11-23
申请人： NIPPON OIL AND FATS COMPANY, LIMITED
发明人： Yamaguchi, Shigehiko , Sunamoto, Junzo
IPC分类号： B01F17/00 , C08B37/00 , A61K9/10
CPC分类号： C08B37/0018 , A23L29/274 , A61K47/36 , B01F17/0028 , Y10S514/937 , Y10S514/938 , Y10S514/943
摘要： The invention is a fatty emulsion stabilized by a polysaccharide derivative, characterized in that the fatty emulsion contains a polysaccharide derivative which is substituted by a fatty acid or cholesterol at a proportion of 0.5-5 per 100 sugar units.
摘要翻译：本发明是一种由多糖衍生物稳定的脂肪乳剂，其特征在于脂肪乳剂含有多糖衍生物，它以脂肪酸或胆固醇的比例以0.5-5 / 100糖单位代替。

145. 发明公开

EP0270682A1 NOVEL COMPLEXES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL USE OF THEM 失效
标题翻译： NEUE KOMPLEXE DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL。
公开(公告)号：EP0270682A1
公开(公告)日：1988-06-15
申请号：EP87903416.3
申请日：1987-05-20
申请人： KURARAY CO., LTD.
发明人： MORI, Fumio , OKADA, Masafumi , MIKI, Shuji , EBASHI, Iwao , NISHIDA, Takashi , KAWAI, Kouichiro , TASHIRO, Tazuko , TSUKAGOSHI, Shigeru
IPC分类号： A61K31/725 , C08B37/00
CPC分类号： C08B37/0018
摘要： Pullulans having active sites formed by sulfation, phosPhorylation, sulfonation or carboxylation or their pharmacologically acceptable salts, wherein one hydrogen atom of the active sites represented by formula (I), partially sub- stituted by a group represented by the general formula (II), (wherein L 1 and L 2 each represents amine or unidentate amine or when taken together, represent bidentate amine. and Y represents an anionic ligand) and/or two hydrogen atoms or the active sites represented by formula (III) or of two formula (IV) groups bound to the same carbon atom or adjacent carbon atoms are partially substituted by a group represented by the formula (V), (wherein L' and L 2 are the name as defined above). These compounds have an onco- static activity and are useful as oncostatic agents. Process for their preparation and their medicinal use are also dis- closed
摘要翻译：支链淀粉铂络合物是新的，其中支链淀粉具有式（Ia），（Ib），（Ic）或（Id）的活性位点：这些活性位点中的一些或全部的一个氢原子被一组式（IIa）或（IIb）：（其中L1和L2各自为氨或异齿胺，或一起为二齿胺; Y为阴离子配体）; 或在（Ic）的情况下，两个氢原子可以被式（IV）的基团取代; 或两个相邻（Id）的氢原子可以被（IV）代替。制备是通过支链淀粉的硫酸化，磺化，磷酸化或羧化，随后与式（III）的铂化合物反应：（其中X 1和X 2是硝基，或一个是硝基，另一个是羟基或硫酸根）。

146. 发明公开

EP0267788A2 Complex of pullulan and polyethylene glycol 失效
标题翻译： Komplex von Pullulan undPolyäthylenglykol。
公开(公告)号：EP0267788A2
公开(公告)日：1988-05-18
申请号：EP87309970.9
申请日：1987-11-11
申请人： KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
发明人： Hijiya, Hiromi , Miyake, Toshio
IPC分类号： C08L5/00
CPC分类号： A61K9/0014 , A61K8/73 , A61K8/86 , A61K9/205 , A61K47/36 , A61K2800/56 , A61K2800/594 , A61Q11/00 , C08B37/0018 , C08L5/00 , Y10S514/947 , Y10S514/953 , Y10S514/963 , Y10S514/964 , Y10S514/965 , C08L2666/02
摘要： An association complex, comprising pullulan and polyethylene glycol. The association complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association complex reduces or even eliminates the excessively high water-solubility, threading and stickiness of pullulan so that this extends the uses of pullulan and PEG such as those in gradually disintegrable- and sustained release-shaped articles for consumer's products, toiletries, cosmetics, pharmaceuticals and feeds.
摘要翻译：结合复合物，包括支链淀粉和聚乙二醇。缔合复合物以及其支链淀粉和PEG组分在水中的溶解度降低。缔合复合物减少或甚至消除了支链淀粉的过高的水溶性，螺纹和粘性，从而延长了支链淀粉和PEG的用途，例如消费品，化妆品，化妆品，化妆品，药品和饲料。

147. 发明公开

KR1020100120971A 가돌리늄 착물, 그 제조방법, 및 그것을 포함하는 ＭＲＩ 조영제 有权
标题翻译： GADOLINIUM复合物，其制备方法和包括其的MRI对比剂
公开(公告)号：KR1020100120971A
公开(公告)日：2010-11-17
申请号：KR1020090039883
申请日：2009-05-07
申请人： 가톨릭대학교 산학협력단
发明人： 나건 , 임현아
IPC分类号： C07F5/00 , A61K49/06
CPC分类号： A61K49/128 , C08B37/0018
摘要： PURPOSE: A gadolinium complex and MRI contrast medium composition containing the same are provided to ensure low toxicity and long half-life. CONSTITUTION: A gadolinium complex is formed by coordinate bond of gadolinium to pullulan-DTPA formed by ester bond pullulan and DTPA(diethylene triamine pentacetic acid dianhydride). A method for preparing the gadolinium complex comprises: a step of dissolving pullulan and DTPA in an organic solvent to obtaining pullulan-DTPA assembly by ester bond; a step of mixing the solution of pullulan-DTPA assembly; and a step of adjusting pH concentration by 5-7. An MRI contrast agent composition contains the gadolinium complex.
摘要翻译：目的：提供含有钆络合物和MRI造影剂组合物以确保低毒性和长半衰期。构成：钆络合物通过咔唑的配位键与由酯键支链淀粉和DTPA（二亚乙基三胺五乙酸二酐）形成的支链淀粉-DTPA形成。制备钆络合物的方法包括：将支链淀粉和DTPA溶解在有机溶剂中以通过酯键获得支链淀粉-DTPA组装的步骤; 混合支链淀粉-DTPA组合物的一个步骤; 以及将pH浓度调节5-7的步骤。 MRI造影剂组合物含有钆络合物。

148. 发明授权

KR100977788B1 포스포릴콜린기 함유 다당류 및 그 제조 방법 失效
标题翻译：含有磷杂环戊烷的多糖和其生产方法
公开(公告)号：KR100977788B1
公开(公告)日：2010-08-24
申请号：KR1020047013002
申请日：2003-04-08
申请人： 가부시키가이샤 시세이도
发明人： 미야자와가즈유키 , 야나키도시오 , 위닉프란코이즈엠.
IPC分类号： C08B15/00 , C08B37/00
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： 본 발명은, 글리세로포스포릴콜린의 산화적 개열반응에 의해 얻어진 알데히드체 함유 화합물을, 아미노기를 함유하는 다당류에 부가하는 것을 특징으로 하는 포스포릴콜린기 함유 다당류의 제조 방법, 및 본 제조 방법에 의해 얻어지는 포스포릴콜린기를 갖는 신규한 다당류이다.
본 발명의 목적은, 생체적합성, 보습성이 우수하고, 의료용 고분자 재료로서 유용한, 포스포릴콜린기를 갖는 신규한 다당류 및 그 간편한 제조 방법을 제공하는 것이다.
본 발명의 다당류는, 예를 들면 인공 장기, 생체막, 의료용구의 코팅제, 약물 송달, 화장료 배합 성분으로서 이용된다.
글리세로포스포릴콜린, 알데히드, 아미노기, 다당류, 포스포릴콜린.

149. 发明公开

KR1020100080924A 조직공학, 세포 배양 및 세포 운반용 다공성 스캐폴드의 제조방법 有权
标题翻译：制备用于组织工程，细胞培养和细胞递送的多孔切片的方法
公开(公告)号：KR1020100080924A
公开(公告)日：2010-07-13
申请号：KR1020107009937
申请日：2008-10-10
申请人： 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) , 유니베르시떼 파리스 7- 데니스 디데롯
发明人： 르비쟈쥐,까뜨린느 , 르뚜르너르,디디에
IPC分类号： A61L27/52 , A61L27/20 , A61L27/56 , C12N5/07
CPC分类号： A61L27/20 , A61L27/3804 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/507 , A61L27/52 , A61L27/54 , A61L27/56 , C08B37/0018 , C08B37/0021 , C08B37/003 , C08B37/0039 , C08B37/0054 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08J9/08 , C08J9/28 , C08J9/283 , C08J2201/026 , C08J2201/0484 , C08J2201/0504 , C08J2205/022 , C08J2207/10 , C08J2305/00 , C08J2305/02 , C08J2305/04 , C08J2305/08 , C08J2305/10 , C08J2305/12 , C12N5/0068 , C12N2533/70 , C12N2533/72 , C12N2533/74
摘要： The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).
摘要翻译：本发明涉及一种用于组织工程的多孔支架的制备方法。本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。本发明的方法包括以下步骤：a）制备包含一定量的多糖，一定量的交联剂和一定量的致孔剂的碱性水溶液b）将溶液转化成水凝胶通过将所述溶液置于约4℃至约80℃的温度下足够的时间以允许所述量的多糖的交联，和c）将所述水凝胶浸入水溶液中d）洗涤在步骤c）。

150. 发明授权

KR100261881B1 풀룰란고함유물과 그 제조방법 및 용도 失效
标题翻译：高尔兰内容产品及其制备和使用
公开(公告)号：KR100261881B1
公开(公告)日：2000-07-15
申请号：KR1019930003190
申请日：1993-03-04
申请人： 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조
发明人： 오자끼요시히데 , 노무라다쓰오 , 미야께도시오
IPC分类号： C12P19/10
CPC分类号： A23G3/343 , A21D2/181 , A23C9/137 , A23G3/346 , A23G2200/06 , A23L19/20 , A23L29/274 , A23P20/105 , A24B15/30 , A61K8/0212 , A61K8/73 , A61K9/0014 , A61K9/0019 , A61K9/286 , A61K9/4816 , A61K47/36 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/02 , C05G3/0052 , C08B37/0018 , C12P19/10 , D21H13/10
摘要： PURPOSE: To produce a pullulan concentrate industrially advantageously at a high productivity by continuously culturing a culture medium having a high sugar content while keeping the viscosity of the medium at a specified low value, and to establish the use of the concentrate. CONSTITUTION: A microorganism capable of producing pullulan is continuously cultured in a culture medium contg. 10-20w/v% sugar with the viscosity of the medium kept at 30 cP, giving a concentrate of pullulan having an average mol.wt. lower than 250,000. The concentrate is used as a thickener, a coating material, an adhesive, a molded article, etc., in the fields of food and beverage, cosmetics, medicines, materials for agriculture and stock raising, materials for paper manufacture, materials for mining industry, etc.
摘要翻译：目的：通过连续培养具有高糖含量的培养基，同时将培养基的粘度保持在规定的低值，以高生产率生产优质支链淀粉，并建立浓缩物的使用。构成：能够在培养基中持续培养能够生产支链淀粉的微生物。 10-20w / v％糖，培养基的粘度保持在30cP，得到具有平均重量百分比的支链淀粉的浓缩物。低于25万。浓缩物用作食品和饮料，化妆品，药物，农业和饲料用材料，造纸用材料，采矿业材料中的增稠剂，涂料，粘合剂，成型品等。等等

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