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131. 发明申请

WO1996032883A1 METHOD AND APPARATUS FOR NONINVASIVELY DETERMINING HEMATOCRIT 审中-公开
标题翻译：用于非确定性测定HEMATOCRIT的方法和装置
公开(公告)号：WO1996032883A1
公开(公告)日：1996-10-24
申请号：PCT/US1996004547
申请日：1996-04-03
申请人： MICROCOR, INC.
发明人： MICROCOR, INC. , RUBEN, Paul, W. , KAMINSKY, Allan, L.
IPC分类号： A61B05/02
CPC分类号： G01N33/49 , A61B5/14535 , A61B5/4869 , A61B5/7264
摘要： This invention is a method and apparatus for non-invasiveness in determining hematocrit, utilizing the frequency dependent electrical impedance characteristics of whole blood by electrically stimulating a patient body portion containing a vascular compartment with a current source over a range of frequencies. A hematocrit measurement system includes a signal generator and demodulator [SGD] (34) that sends an applied signal to an electrode pod (36) that applies a current to a limb of a patient. The electrode pod (36) receives resulting measured voltage signals and provides them to the SGD. The SGD provides to a personal computer [PC] (42) signals indicative of the current passing through the limb of the patient and the resulting voltage. The voltage and current may be measured for various frequencies over, for example, a range from about 10 kHz to about 10 MHz. The electrical impedance from the blood alone is isolated from the total limb impedance from the blood, tissue, bone, etc. by determining the difference between measurement at different blood volumes. The hematocrit is determined by the PC based on inphase and quadrature data provided by the SGD. A neural network (52) may be useful in determining the hematocrit from the blood impedance patterns.
摘要翻译：本发明是一种用于在确定血细胞比容方面非侵入性的方法和装置，利用全血的频率依赖性电阻抗特性，通过在一个频率范围内用电流源电流刺激包含血管隔室的患者体部分。血细胞比容测量系统包括信号发生器和解调器（SGD）（34），其将施加的信号发送到向患者的肢体施加电流的电极盒（36）。电极盒（36）接收得到的测量电压信号并将其提供给SGD。 SGD向个人计算机提供指示通过患者肢体的电流和所产生的电压的信号（42）。可以在例如约10kHz至约10MHz的范围内针对各种频率测量电压和电流。通过确定不同血容量的测量值之差，血液中单独血液的电阻抗与血液，组织，骨骼等的总肢体阻抗隔离。基于由SGD提供的同相和正交数据由PC确定血细胞比容。神经网络（52）可用于从血液阻抗模式确定血细胞比容。

132. 发明申请

WO1996022050A1 BLOOD PRESSURE MONITOR 审中-公开
标题翻译：血压监测仪
公开(公告)号：WO1996022050A1
公开(公告)日：1996-07-25
申请号：PCT/JP1996000039
申请日：1996-01-12
申请人： COLIN CORPORATION , SHINODA, Masayuki , INUKAI, Hidekatsu , SAKAI, Hiroshi
发明人： COLIN CORPORATION
IPC分类号： A61B05/02
CPC分类号： A61B5/14551 , A61B5/02116 , A61B5/02125 , A61B5/022 , A61B5/7239
摘要： The sphygmomanometry using sphygmomanometric means (72) is terminated with sphygmomanometry terminating means (84), when the value of |DM - DCP|/DCP is within the range of a preset reference value alpha for judgment, the DM representing a phase difference provided based on a monitoring blood value MBP determined with monitoring blood pressure value determining means (76) from a phase difference/blood pressure relationship in the step of initiating sphygmomanometry with the sphygmomanometric means (72) while the DCP representing an actual phase difference determined with phase difference computing means (80). Therefore, when a deviation of the pressure pulse wave/blood pressure relationship is not significant, the execution of unnecessary sphygmomanometry for redertermining the pressure pulse wave/blood pressure relationship can be dispensed with, thus reducing the frequency of sphygmomanometry using a cuff, which in turn reduces the burden on the living body.
摘要翻译：使用血压测量装置（72）的血压计用血压计终止装置（84）终止，当| DM-DCP | / DCP的值在用于判断的预设参考值α的范围内时，DM表示基于相位差在通过血压测量装置（72）开始血压测量的步骤中通过监测血压值确定装置（76）从监测血压值确定装置（76）确定的监测血值MBP，而表示由相位差确定的实际相位差的DCP 计算装置（80）。因此，当压力脉搏波/血压关系的偏差不显着时，可以省略对压力脉搏波/血压关系进行重新起动的不必要的血压测量的执行，从而降低使用袖带的血压测量的频率，减轻生物体的负担。

133. 发明申请

WO1996011628A1 OSCILLOMETRIC METHOD OF DETERMINING BASIC HAEMODYNAMIC PARAMETERS IN A PATIENT'S ARTERIAL CIRCULATION AND A MEASURING SYSTEM FOR CARRYING OUT SAID METHOD 审中-公开
标题翻译：确定患者ARTERIAL循环中的基本动脉瘤参数的振动方法和实施方法的测量系统
公开(公告)号：WO1996011628A1
公开(公告)日：1996-04-25
申请号：PCT/RU1995000112
申请日：1995-05-29
申请人： TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU "e;RUSSKY TSENTR PERSPEKTIVNYKH TEKHNOLOGY"e; (RUSSINTSENTR"e; , RAGOZIN, Vyacheslav Nikolaevich , DEGTYAROV, Vladimir Alexandrovich , BABIN, Dmitry Vladimirovich , VISHNYAKOV, Igor Dmitrievich , SAVCHENCKO, Vladimir Alexandrovich
发明人： TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU "e;RUSSKY TSENTR PERSPEKTIVNYKH TEKHNOLOGY"e; (RUSSINTSENTR"e;
IPC分类号： A61B05/02
CPC分类号： A61B5/022
摘要： Disclosed is an oscillometric method of determining basic haemodynamic parameters in a patient's arterial circulation. According to the proposed method, the parameters in question are determined from characteristic points (9, 10) of a recorded oscillometric signal (5) of the patient's arterial pulsogramme and the simultaneously recorded pressure fluctuation signal (4) from the measurement cuff (2). Also disclosed is a measurement system (3) for carrying out this method, comprising a unit to form the frequency characteristics of the arterial pulsogramme oscillometric signal or a device for calculating the continuous component of that signal.
摘要翻译：公开了一种确定患者动脉循环中基本血液动力学参数的示波法。根据所提出的方法，根据患者动脉脉搏计的记录示波信号（5）的特征点（9,10）和来自测量袖带（2）的同时记录的压力波动信号（4）确定所讨论的参数，。还公开了一种用于执行该方法的测量系统（3），包括形成动脉脉搏计示波器信号的频率特性的单元或用于计算该信号的连续分量的装置。

134. 发明申请

WO1996003914A1 CALIBRATION OF SEGMENTAL BLOOD VOLUME CHANGES IN ARTERIES AND VEINS FOR PULSE VOLUME RECORDERS 审中-公开
标题翻译：脉冲体积记录仪的动脉和血管内分泌血液体积变化的校正
公开(公告)号：WO1996003914A1
公开(公告)日：1996-02-15
申请号：PCT/US1995009725
申请日：1995-08-02
申请人： VASOCOR, INC.
发明人： VASOCOR, INC. , RAINES, Jeffrey, K. , SNYDER, Leon, T. , HOFFMAN, John
IPC分类号： A61B05/02
CPC分类号： A61B5/02141 , A61B5/022 , A61B5/742 , A61B2560/0223
摘要： The calibration device includes a controllable pneumatic pump (44), a pressure sensor (48), a computerized device (72) for determining when a representative number of blood volume change signals are substantially similar and thereafter generating a calibration signal. The calibration system also includes a device which changes the volume in the closed peumatic system by a predetermined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves (V1, V2) coupled by a chamber (50) having a known volumetric size or a positive displacement pump driven by a stepper motor. The calibration system also includes a computerized device for correcting representative blood volume change signals based on the pressure signals at each discrete level of cuff pressure as corrected by the calibration signals represented by detected pressure signals obtained substantially simultaneously with the change of the volume at each discrete level of cuff pressure.
摘要翻译：校准装置包括可控气动泵（44），压力传感器（48），计算机化装置（72），用于确定代表数量的血容量变化信号何时基本相似，然后产生校准信号。校准系统还包括一种在存在校准触发信号的情况下将闭合的皮肤系统中的体积改变预定校准量的装置。该体积改变装置可以是由具有已知体积尺寸的室（50）和由步进电动机驱动的容积式泵耦合的一系列阀（V1，V2）。该校准系统还包括一个计算机化装置，用于根据每个离散级别的袖带压力下的压力信号来校正代表性的血容量变化信号，所述压力信号由校准信号校正，所述校准信号由检测到的压力信号表示，袖带压力水平。

135. 发明申请

WO1994000049A1 CARDIAC ABLATION CATHETER HAVING RESISTIVE MAPPING ELECTRODES 审中-公开
标题翻译：具有电阻映射电极的心脏吸引管
公开(公告)号：WO1994000049A1
公开(公告)日：1994-01-06
申请号：PCT/US1993005752
申请日：1993-06-16
申请人： AMERICAN CARDIAC ABLATION CO., INC.
发明人： AMERICAN CARDIAC ABLATION CO., INC. , NARDELLA, Paul, C.
IPC分类号： A61B05/02
CPC分类号： A61N1/06 , A61B5/0422 , A61B18/1233 , A61B18/1492 , A61B2017/00292 , A61B2562/0209 , A61B2562/043
摘要： A cardiac ablation catheter (10) includes a distal, energy delivering electrode (14) and at least one sensing electrode (16) proximal to the energy delivering electrode (14). The catheter communicates with an electrosurgical generator (22) which provides electrical energy, such as a radio frequency energy, to the distal energy (14). The sensing electrodes (16) communicate with a monitor (24) for recording electrical signals within the heart. One or more resistors (30) is positioned adjacent each sensing electrode (16), and in series with a conductor (20) associated with the sensing electrode (16), to reduce or eliminate any current tending to be emitted through the sensing electrodes (16) as a result of delivery of electrical current through the distal electrode (14).
摘要翻译：心脏消融导管（10）包括远端能量输送电极（14）和靠近能量输送电极（14）的至少一个感测电极（16）。该导管与向远端能量（14）提供诸如射频能量的电能的电外科发生器（22）连通。感测电极（16）与用于在心脏内记录电信号的监视器（24）通信。一个或多个电阻器（30）位于每个感测电极（16）附近并且与与感测电极（16）相关联的导体（20）串联，以减少或消除倾向于通过感测电极发射的任何电流（作为通过远端电极（14）的电流传递的结果的结果。

136. 发明申请

WO1993009712A1 PORTABLE NON-INVASIVE TESTING APPARATUS 审中-公开
标题翻译：便携式非入网测试设备
公开(公告)号：WO1993009712A1
公开(公告)日：1993-05-27
申请号：PCT/US1992009501
申请日：1992-11-13
申请人： TELMED, INC.
发明人： TELMED, INC. , RAPOPORT, Issac
IPC分类号： A61B05/02
CPC分类号： A61B8/02 , A61B5/4356 , A61B8/0866 , Y10S128/904
摘要： A portable apparatus for the non-invasive, simultaneous, self-testing of fetal and maternal signals which comprises: a user display means (19) to indicate that the device is operational, an ultrasonic means (1) to detect fetal heart rate connected to the device, a detection means (15) for detecting a maternal input signal connected to the device, wherein the device has signal processing means (25) for simultaneously processing fetal heart rate and maternal input signals, and also has a communication linking means (27) for the simultaneous transmission of fetal heart rate and maternal input data to a remote output device.

137. 发明申请

WO1992018052A2 BLOOD PRESSURE MONITORING IN NOISY ENVIRONMENTS 审中-公开
标题翻译：血压监测在噪声环境中
公开(公告)号：WO1992018052A2
公开(公告)日：1992-10-29
申请号：PCT/US1992002641
申请日：1992-03-31
申请人： CARDIODYNE, INC.
发明人： CARDIODYNE, INC. , PHILLIPPS, Patrick, G. , EPSTEIN, Paul , TWEED, David, G.
IPC分类号： A61B05/02
CPC分类号： A61B5/02208 , A61B5/02
摘要： Several techniques are provided for aiding in the discrimination of detected bilogical signals indicative of blood pressure from detected signals not indicative of blood pressure (e.g., noise). A threshold, based predominantly on a level of noise, is developed and used in the discrimination. A second threshold, based predominantly on levels of previously detected biological signals, is developed and additionally used to help discriminate the biological signals from noise. The biological signals are detected during a selected portion of a cardiac cycle, and additional signals detected outside of the selected portion of the cycle are applied to the detected signals. Another threshold may be developed based predominantly on a level of signals sensed by a transducer positioned to preferentially sense noise; the transducer is positioned so that the noise that it detects is related to noise that is detected during the detection of the bilogical signals. Blood pressure is measured during periodically scheduled measurement cycles, and a measurement cycle is suspended if noise exceeds a predeteremined level. The times at which the detected signals (i.e., the signals indicative of blood pressure and the signals not indicative of blood pressure) are processed during a given cardiac cycle are selected based at least in part on the pressure of the cuff. The biological signals indicative of blood pressure that are detected during a current measurement cycle are used to at least in part determine the times at which the detected signals will be processed during a succeeding measurement cycle.
摘要翻译：提供了几种技术，用于帮助鉴别来自未指示血压（例如噪声）的检测信号指示血压的检测到的生物信号。基于噪声水平的阈值主要用于歧视。开发了主要基于先前检测到的生物信号的水平的第二阈值，并且另外用于帮助区分生物信号与噪声。在心脏周期的选定部分期间检测生物信号，并且在周期的选定部分之外检测到的附加信号被应用于检测到的信号。可以主要基于被定位成优先感测噪声的换能器感测的信号的水平来开发另一个阈值; 换能器被定位成使得其检测到的噪声与在检测生物信号期间检测到的噪声相关。在周期性调度的测量周期内测量血压，如果噪声超过预定水平，则测量周期将被暂停。至少部分地基于袖带的压力选择在给定的心动周期期间处理检测到的信号（即，指示血压的信号和不指示血压的信号）的时间。指示在当前测量周期期间检测到的血压的生物信号用于至少部分地确定在随后的测量周期期间检测到的信号将被处理的时间。

138. 发明申请

WO1992003966A1 METHOD AND APPARATUS FOR DETERMINING BLOOD PRESSURE 审中-公开
标题翻译：用于测定血压的方法和装置
公开(公告)号：WO1992003966A1
公开(公告)日：1992-03-19
申请号：PCT/US1991006191
申请日：1991-08-29
申请人： UNIVERSITY OF UTAH
发明人： UNIVERSITY OF UTAH , BAKER, Phillip, D. , ORR, Joseph, A. , WESTENSKOW, Dwayne, R. , EGBERT, Timothy, P.
IPC分类号： A61B05/02
CPC分类号： A61B5/02225 , A61B5/02156 , A61B5/022 , A61B5/7221 , A61B5/7239 , A61B5/7267
摘要： A method and device for indirect, quantitative estimation of blood pressure attributes and similar variable physiological parameters utilizing noninvasive, indirect techniques. The method of practice includes (i) generating a sequence of signals which are quantitative dependent upon the variable parameter, (ii) transmitting and processing the signals within a computer system and associated neural network capable of generating a single output signal for the combined input signals, (ii) invasively determining an actual value for the parameter concurrent with the noninvasive generation of signals of the previous steps, (iv) applying weighting factors within the neural network at interconnecting nodes to force the output signal of the neural network to match the true value of the parameter as determined invasively, (v) recording the input signals, weighting factors and true value as training data within memory of the computer, and (vi) repeating the previous steps to develop sufficient training data to enable the neural network to accurately estimate parameter value upon future receipt of on-line input signals. Procedures are also described for preclassification of signals and artifact rejection. Following training of the neural network, further invasive measurement is unnecessary and the system is ready for diagnostic application and noninvasive estimation of parameter values.
摘要翻译：使用非侵入性间接技术间接，定量估计血压属性和类似可变生理参数的方法和装置。实践方法包括：（i）产生定量依赖于可变参数的信号序列，（ii）在计算机系统内发送和处理能够产生用于组合输入信号的单个输出信号的相关联的神经网络的信号（ii）与先前步骤的信号的非侵入式生成同时入侵地确定参数的实际值;（iv）在互连节点处在神经网络内应用加权因子以迫使神经网络的输出信号与真实的（v）将输入信号，加权因子和真实值作为训练数据记录在计算机的存储器内，以及（vi）重复先前的步骤以开发足够的训练数据以使得神经网络能够准确地在将来接收在线输入信号时估计参数值。还描述了信号的预分类和伪像抑制的程序。在神经网络训练之后，进一步的侵入式测量是不必要的，系统已准备好进行诊断应用和无创估计参数值。

139. 发明申请

WO1991019451A1 DEVICE FOR MEASURING BLOOD FLOW VELOCITY AND QUANTITY IN AORTA 审中-公开
标题翻译：用于测量AORTA血液流速和数量的装置
公开(公告)号：WO1991019451A1
公开(公告)日：1991-12-26
申请号：PCT/JP1990000813
申请日：1990-06-19
申请人： TOMITA, Mitsuei
IPC分类号： A61B05/02
CPC分类号： A61B5/02208 , A61B5/0225 , A61B5/0285 , A61B5/029
摘要： The blood flow in the upper arm is obstructed by a blood flow obstruction bag (220) in a cuff (200) applied to the upper arm. The flow obstruction bag is provided with a front detecting bag (210) and rear one (230) on the up- and down-stream sides thereof, respectively, and a front sensor (110) and rear one (120) are provided for detecting pressure in respective detecting bags. Each sensor detects front pulse waves (Wf) and rear ones (Wb) respectively. Standard internal pressure in the cuff is controlled by a pneumatic pump (140) and a leak valve (150) controlled by the CPU (130). With every pulse wave monitored, the internal standard pressure in the cuff can be maintained at systolic phase pressure SP or diastolic phase pressure DP. A propagation speed of the pulse wave passing beneath the cuff whose internal pressure is maintained at the systolic phase pressure SP can be found from the time of delay SPdt of the rear pulse wave from the front pulse wave and is approximate to a blood flow velocity VH when the aorta is at high pressure. A blood flow velocity VL when the aorta is at low pressure is found when dividing the blood flow velocity VH by a given coefficient R. The rear pulse wave obtained when the standard internal pressure is maintained at the diastolic phase pressure DP becomes an approximate aortic wave. On the basis of the waveform of this approximate aortic wave, effective cross-sectional areas SH and SL of the blood flow are found and a blood flow quantity per unit pulse is calculated by multiplying the cross-sectional area by the blood flow velocity.
摘要翻译：上臂中的血液流动被施加到上臂的袖带（200）中的血流阻塞袋（220）阻挡。流动阻塞袋分别在其上游侧和下游侧设置有前检测袋（210）和后检测袋（230），并且设置有前传感器（110）和后传感器（120），用于检测相应检测袋中的压力。每个传感器分别检测前脉冲波（Wf）和后脉冲波（Wb）。通过由CPU（130）控制的气动泵（140）和泄漏阀（150）来控制袖带中的标准内部压力。在监测每个脉搏波的情况下，可以将袖带内的内标压力保持在收缩期相压SP或舒张期相压DP。脉搏波的传播速度可以从内侧压力保持在收缩期相位压力SP的袖带下方传播，可以从前脉冲波的后脉搏波的延迟时间SPdt开始，并且接近血流速度VH 当主动脉处于高压时。当将血流速度V H除以给定系数R时，发现当主动脉处于低压时的血流速度VL。当标准内压保持在舒张期相位压力DP时获得的后脉搏波变为近似的主动脉波。基于该近似主动脉波的波形，发现血流的有效截面积SH和SL，并且通过将横截面积乘以血流速度来计算每单位脉冲的血流量。

140. 发明申请

WO1991006243A1 NONINVASIVE DIAGNOSTIC SYSTEM FOR CORONARY ARTERY DISEASE 审中-公开
标题翻译：用于冠状动脉疾病的非侵入性诊断系统
公开(公告)号：WO1991006243A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006180
申请日：1990-10-26
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ...
发明人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ... , SEMMLOW, John, L. , WELKOWITZ, Walter , AKAY, Metin , KOSTIS, John, B.
IPC分类号： A61B05/02
CPC分类号： G01P15/0922 , A61B5/024 , A61B5/0285 , A61B7/04 , G01P2015/0831
摘要： A method and system for analyzing diastolic heart sounds detected rom a patient's chest cavity during the diastolic portion of the heart cycle in order to identify a low level auditory component associated with turbulent blood flow in partially occluded coronary arteries. The system includes an acoustic transducer (1) coupled against the chest cavity of a patient using an ultrasonic acoustic gel and a pulse sensor device and a signal processor (7) and a diagnostic display (14). Heart sounds detected by the acoustic transducer (1) are amplified by a conventional low noise audio amplifier (2), resulting in an electrical heart sound signal (3). Electro-optical pulse detector and associated amplifier (4) provide an output signal based on occurrence of the patient's pulse. The signal is processed through threshold detector (5) to provide a timing reference signal (6) indicative of the occurence of each pulse.

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