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131. 发明申请

US20180224409A1 FLOW PATH STRUCTURE AND MEASURING DEVICE FOR LIQUID TO BE MEASURED 审中-公开
公开(公告)号：US20180224409A1
公开(公告)日：2018-08-09
申请号：US15939880
申请日：2018-03-29
申请人： ALPS ELECTRIC CO., LTD.
发明人： Kenichiro SAMESHIMA
IPC分类号： G01N30/74 , G01N30/46 , B01D15/18 , G01N27/447
CPC分类号： G01N30/74 , B01D15/18 , B01L3/502738 , B01L2300/0681 , B01L2400/0644 , B01L2400/065 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N30/20 , G01N30/468 , G01N30/6095 , G01N2030/027 , G01N2030/202 , G01N2030/204 , G01N2030/207 , G01N2030/8881
摘要： A flow path structure incorporated into a measuring device that facilitates maintenance, includes a base, and a flow path switch member provided in a flow path switch member accommodation part and measures a liquid to be measured. The base includes a separation element accommodation part to accommodate a separation element that separates a plurality of components included in the liquid to be measured, and the flow path switch member accommodation part provided at an intermediate part of a flow path that guides the liquid to be measured. The flow path switch member measures the liquid to be measured, and switches a state of a flow path inside the base between a first flow path state in which the liquid to be measured is guided outside the separation element accommodation part, and a second flow path state in which the measured liquid is guided inside the separation element accommodation part.

132. 发明申请

US20180149625A1 AUTOMATED SAMPLING AND REACTION SYSTEM FOR HIGH PRESSURE LIQUID CHROMATOGRAPHY AND OTHER TYPES OF DETECTION 审中-公开
公开(公告)号：US20180149625A1
公开(公告)日：2018-05-31
申请号：US15851101
申请日：2017-12-21
申请人： Waters Technologies Corporation
发明人： Hillary B. Hewitson , Sylvain G. Cormier , Charles H. Phoebe, JR. , Aaron D. Phoebe
IPC分类号： G01N30/20 , G01N30/24 , G01N30/06 , G01N35/10 , G01N35/00
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.

133. 发明申请

US20180080908A1 INJECTION VALVE ASSEMBLY WITH LOOPING INTERNAL SAMPLE LOOP 审中-公开
公开(公告)号：US20180080908A1
公开(公告)日：2018-03-22
申请号：US15496956
申请日：2017-04-25
申请人： Neil R. Picha
发明人： Neil R. Picha
IPC分类号： G01N30/20 , F16K31/04
CPC分类号： G01N30/20 , F16K11/076 , F16K31/041 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： An injection valve assembly with looping internal sample loop works to inject discrete fluid samples into analytical instrumentation. The assembly provides an internal sample loop that carries the fluid sample follows an outwardly looping path. This looping deposition enables internal sample loop to have a uniform cross section and a larger sample volume of fluid; thereby creating enhanced peak shape in chromatography readings. The assembly provides a stator defined by stator openings, and a rotor defined by rotor grooves. The rotor grooves are arranged to form a rotor circumference. A stator face engages the stator to maintain operational engagement between the stator and the rotor. Internal sample loop is defined by a generally looped shape and an inner tube diameter. Internal sample loop follows a path at least partially outside the rotor circumference; whereby more than half of the length of internal sample loop is outside the rotor circumference.

134. 发明授权

US09884266B2 Fluoropolymer pneumatically/hydraulically actuated liquid chromatographic system for use with harsh reagents 有权
公开(公告)号：US09884266B2
公开(公告)日：2018-02-06
申请号：US14326191
申请日：2014-07-08
申请人： ORLAB CHROMATOGRAPHY, LLC
发明人： Nicolas Dauphas , Francois L. H. Tissot , Reika Yokochi , Thomas J. Ireland , Jingya Hu
IPC分类号： B01D15/10 , B01D15/22 , B01D15/18 , G01N30/60 , G01N30/38 , G01N30/44 , G01N30/82 , B01D15/24 , B01D15/42 , G01N30/34 , G01N30/04 , G01N30/84 , G01N30/20 , G01N30/88
CPC分类号： B01D15/1814 , B01D15/247 , B01D15/426 , G01N30/34 , G01N30/84 , G01N2030/207 , G01N2030/347 , G01N2030/8809
摘要： The invention provides a high-performance liquid chromatography system, said system is controlled in temperature by running a fluid in sleeves that surround the different parts of the system. All parts in contact with the fluid are made in fluoropolymer, carbon-filled fluoropolymer, or carbon-fiber fluoropolymer. The system comprises at least one reagent reservoir; at least one mixing chamber, wherein the contents of the at least one reagent reservoir are combined; at least one pump that transfers the contents of the at least one reservoir to the mixing chamber; and at least one modular elution column, wherein the at least one modular elution column contains a temperature control means; a sample injection system connected to an injection loop or 3-way valve to inject the sample solutions in the modular elution columns, at least one manifold or X-Y moving stage to distribute the eluted volumes in different receptacles; at least one return line to automatically reinject selected elution fractions at the top of the column; wherein all moving components of the said system are fluid actuated.

135. 发明授权

US09841406B2 Switching valve for flow type analysis apparatus 有权
公开(公告)号：US09841406B2
公开(公告)日：2017-12-12
申请号：US14786397
申请日：2014-04-22
申请人： Sekisui Medical Co., Ltd.
发明人： Takuya Yotani , Hiroaki Taira , Takayuki Oka , Hideki Muraki
IPC分类号： G01N30/20 , G01N35/10 , G01N33/49
CPC分类号： G01N30/20 , G01N33/491 , G01N35/1097 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.

136. 发明授权

US09643104B2 Liquid chromatography device, liquid chromatography analysis process, and non-transitory computer-readable medium for liquid chromotography analysis 有权
公开(公告)号：US09643104B2
公开(公告)日：2017-05-09
申请号：US14453400
申请日：2014-08-06
申请人： ARKRAY, Inc.
发明人： Takeshi Matsubara
IPC分类号： B01D15/42 , B01D15/26 , G01N30/24 , G01N30/88 , B01D15/16 , G01N30/34 , G01N30/02 , B01D19/00 , G01N30/20
CPC分类号： B01D15/424 , B01D15/166 , B01D15/265 , B01D19/00 , G01N30/24 , G01N30/34 , G01N30/88 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/207 , G01N2030/8804 , G01N2030/8822
摘要： A liquid chromatography device includes an adsorption portion that adsorbs one or more analysis components in a specimen, an analysis device that analyzes an analysis component eluted by an eluent, a main feeding device that feeds a first eluent to the adsorption portion, the first eluent eluting an analysis component, a feeding channel in fluid communication with the main feeding device and the adsorption portion, a first retention channel that retains a second eluent, the second eluent differing from the first eluent, an auxiliary feeding device that feeds the second eluent to the first retention channel, and a first switching device that switches the feeding channel to either a first channel or a second channel, the first channel allowing the first eluent to flow from the main feeding device to the adsorption portion, and the second channel allowing the second eluent to flow from the first retention channel to the adsorption portion.

137. 发明申请

US20150226711A1 Volumetric Flow Regulation in Multi-Dimensional Liquid Analysis Systems 有权
标题翻译：多维液体分析系统中的体积流量调节
公开(公告)号：US20150226711A1
公开(公告)日：2015-08-13
申请号：US14620924
申请日：2015-02-12
申请人： IDEX Health & Science LLC
发明人： Carl Sims
IPC分类号： G01N30/32 , B01D15/42 , B01D15/08
CPC分类号： G01N30/32 , B01D15/08 , B01D15/1878 , B01D15/22 , B01D15/424 , G01N30/20 , G01N30/465 , G01N2030/027 , G01N2030/207 , G01N2030/208 , G01N2030/324
摘要： A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.
摘要翻译：多维液体分析系统包括第一尺寸系统和第二尺寸系统，其中来自第一尺寸系统的流出在受控条件下在分流器处分离。流量分配器将第一尺寸流出物分离成第一和第二分流出口流，其中一个分流出口流量被计量到指定的流速，流量计量装置设置在分流器的下游。流量计量装置选择性地关闭或打开出口流动路径以限定沿出口流动路径的体积流量，从而相应地控制其它分流出口流。

138. 发明申请

US20130304393A1 IMPROVED METHOD OF ANALYSING GAS CHROMATOGRAPHY DATA 有权
标题翻译：分析气相色谱数据的改进方法
公开(公告)号：US20130304393A1
公开(公告)日：2013-11-14
申请号：US13854264
申请日：2013-04-01
申请人： I-VIGILANT TECHNOLOGIES LIMITED
发明人： Anwar SUTAN
IPC分类号： G01N30/86
CPC分类号： G01N30/8665 , G01N30/8675 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： A method of analysing gas chromatography data is described. The method, a first response factor data set acquired from a gas chromatograph (GC) apparatus during a procedure on a calibration or reference gas sample at a first time is received. One or more additional response factor data sets acquired from the gas chromatograph apparatus during a procedure on a calibration or reference gas sample from one or more later times are received. The method comprises calculating a measure of uncertainty for at least one compound of the reference gas sample from the first and additional response factor data sets. The one or more later times are during an operational period of the gas chromatograph apparatus. The measure of uncertainty may be used to, for example, identify the necessity to perform a maintenance action in the GC or to assess whether the GC is in a healthy or unhealthy condition.
摘要翻译：描述了分析气相色谱数据的方法。该方法是在第一次在校准或参考气体样品的程序期间从气相色谱仪（GC）装置获取的第一响应因子数据集。接收在一个或更多次的校准或参考气体样品的过程中从气相色谱仪装置获取的一个或多个附加响应因子数据集。该方法包括从第一和另外的响应因子数据集计算参考气体样本的至少一种化合物的不确定度的量度。一个或多个以后的时间是在气相色谱仪的操作期间。例如，可能会使用不确定性的措施来确定在GC中执行维护行动的必要性，或者评估GC是否处于健康或不健康的状况。

139. 发明授权

US08539982B2 Flow through isolation valve for high pressure fluid 有权
标题翻译：流通隔离阀用于高压流体
公开(公告)号：US08539982B2
公开(公告)日：2013-09-24
申请号：US10598072
申请日：2005-03-02
申请人： Russell Keene , David R. Friswell
发明人： Russell Keene , David R. Friswell
IPC分类号： F16K11/085
CPC分类号： F16K11/0853 , F16K5/0428 , F16K11/076 , G01N30/28 , G01N2030/207 , G01N2030/328 , Y10T137/86863 , Y10T137/86871 , Y10T137/87161
摘要： A flow through isolation valve having a stationary member; a movable member, with a surface of the stationary member interfacing with a surface of the movable member; and at least one pin isolation valve. The pin isolation valve has a flow through internal conduit and is movable so that the internal conduit can fluidically communicate with at least one blank opening in the movable member and with a flow through internal conduit in the movable member. Movement is by rotation, linear or curvilinear translation. At least one pin isolation valve is fluidically coupled typically to a sample loop of a face seal valve, or to a pump supplying high pressure liquid to or to a column discharging liquid from a face seal valve of a high pressure liquid chromatography (HPLC) system or directly to the face seal valve.
摘要翻译：具有静止构件的通过隔离阀的流动; 可动构件，其中所述固定构件的表面与所述可动构件的表面相接合; 和至少一个针式隔离阀。销隔离阀具有通过内部导管的流动并且可移动，使得内部导管可与可移动构件中的至少一个毛坯开口流动连通，并且流过可移动构件中的内部导管。运动是通过旋转，线性或曲线翻译。至少一个针式隔离阀通常流体耦合到面密封阀的样品回路，或者向从高压液相色谱（HPLC）系统的面密封阀排出液体的柱提供高压液体的泵或直接到面密封阀。

140. 发明授权

US08522628B2 Liquid sample analyzing apparatus and liquid sample introducing apparatus 失效
标题翻译：液体样品分析装置和液体样品引入装置
公开(公告)号：US08522628B2
公开(公告)日：2013-09-03
申请号：US13503694
申请日：2010-10-20
申请人： Yoshiaki Seki , Kimihiko Ishii , Mitsuhiko Ueda , Katsutoshi Shimizu , Hiroshi Suzuki
发明人： Yoshiaki Seki , Kimihiko Ishii , Mitsuhiko Ueda , Katsutoshi Shimizu , Hiroshi Suzuki
IPC分类号： G01N35/10
CPC分类号： G01N30/16 , G01N30/20 , G01N30/24 , G01N2030/207
摘要： A liquid sample introducing apparatus capable of executing a process with high reliability and high speed is realized. An injection valve includes a sample storage loop connected to a mobile phase flow passage for supplying a sample to a detector of a liquid chromatograph apparatus. A sample is sucked in a needle through a valve and a pipe by a syringe, being introduced to the sample storage loop, being supplied to the mobile phase flow passage. A washing solution from a washing solution bottle is supplied to the needle by a washing unit through the valve and the pipe to wash the inner wall of the needle. The washing solution from the washing solution bottle is supplied to a washing tank by the washing unit through the valve and a pipe to wash the external wall of the needle in the washing tank.
摘要翻译：实现能够执行高可靠性和高速度的处理的液体样品引入装置。注射阀包括连接到流动相流动通道的样本储存环，用于将样品供应到液相色谱仪的检测器。将样品通过注射器通过阀和管吸入针中，并被引入到样品储存环中，供给流动相流动通道。来自洗涤溶液瓶的洗涤液通过洗涤单元通过阀和管道供应到针中以洗涤针的内壁。来自洗涤溶液瓶的洗涤溶液通过洗涤单元通过阀门和洗涤槽中的针的外壁来洗涤的洗涤槽。

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