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131. 发明申请

WO2005010240A2 LOW TEMPERATURE METHODS FOR HERMETICALLY SEALING RESERVOIR DEVICES 审中-公开
标题翻译：用于人造密封储存器件的低温方法
公开(公告)号：WO2005010240A2
公开(公告)日：2005-02-03
申请号：PCT/US2004023137
申请日：2004-07-19
申请人： MICROCHIPS INC , COPPETA JONATHAN R , UHLAND SCOTT A , POLITO BENJAMIN F , SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SNELL DOUGLAS , SANTINI JOHN T JR
发明人： COPPETA JONATHAN R , UHLAND SCOTT A , POLITO BENJAMIN F , SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SNELL DOUGLAS , SANTINI JOHN T JR
IPC分类号： A61K9/00 , B01L3/00 , B65B7/28 , H01L21/50 , C25D5/10 , A61M5/14 , C25D5/54 , G02B6/38 , G02B6/42 , H01L23/06 , H01L23/10
CPC分类号： B01L3/5085 , A61K9/0009 , A61K9/0097 , B01L3/5027 , B01L2400/0677 , B81B2201/058 , B81C1/00269 , B81C2203/0145 , H01L21/50
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.
摘要翻译：提供了用于气密地密封容纳装置的储存器中的开口的方法。该方法包括将聚合物材料施加到容纳装置的储存器中的开口，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成临时印章并将气密密封材料粘附到聚合物材料上以气密地密封开口。储层可以是微储层。容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

132. 发明申请

WO2004022033A1 METHOD AND DEVICE FOR THE CONTROLLED DELIVERY OF PARATHYROID HORMONE 审中-公开
标题翻译：用于控制输送PARAMYROID HORMONE的方法和装置
公开(公告)号：WO2004022033A1
公开(公告)日：2004-03-18
申请号：PCT/US2003/027770
申请日：2003-09-04
申请人： MICROCHIPS, INC.
发明人： AUSIELLO, Dennis , SANTINI, John, T., Jr. , HERMAN, Stephen, J. , PRESCOTT, James, H.
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0036 , A61K9/0097 , A61K38/29 , A61K2300/00
摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a pluralityof reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
摘要翻译：提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。所述方法包括将医疗装置植入患者体内，所述医疗装置包括基底，所述基底中的多个储存器，包含在每个所述储存器中的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

133. 发明申请

WO2003032957A2 METHODS FOR HERMETICALLY SEALING MICROCHIP RESERVOIR DEVICES 审中-公开
标题翻译：密封微裂缝储层装置的方法
公开(公告)号：WO2003032957A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/020490
申请日：2002-06-28
申请人： MICROCHIPS, INC.
发明人： UHLAND, Scott, A. , POLITO, Benjamin, F. , HERMAN, Stephen, J. , SANTINI, John, T., Jr.
IPC分类号： A61K9/22
CPC分类号： A61K9/0097
摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.
摘要翻译：提供了用于气密密封微芯片装置的储存器并且用于将密封封装结构中的基板组件气密密封的方法。在一个实施方案中，该方法包括（1）提供具有前侧和后侧的主衬底，该衬底包括定位在前侧和后侧之间的多个储器，每个储器装载有分子或次级装置用于受控释放或暴露，所述储存器具有至少一个需要密封的开口，所述主要基底包括一种或多种气密密封材料; （2）提供具有由一种或多种气密密封材料构成的表面的气密密封基板; （3）将气密密封基板定位在储存器开口上并使主基板的气密密封材料与气密密封基板的气密密封材料接触; （4）对接触的密封材料施加能量或机械力，以有效地在气密密封基板和主基板之间形成气密密封，以气密地密封储液器开口。

134. 发明申请

WO2002096389A1 CONFORMAL COATED MICROCHIP RESERVOIR DEVICES 审中-公开
标题翻译：一致的涂层微型储存器件
公开(公告)号：WO2002096389A1
公开(公告)日：2002-12-05
申请号：PCT/US2002/017084
申请日：2002-05-30
申请人： MICROCHIPS, INC.
发明人： SHEPPARD, Norman, F., Jr. , FEAKES, Christina, M.
IPC分类号： A61K9/00
CPC分类号： A61K9/0009 , A61K9/0097 , Y10T29/49146 , Y10T29/49155
摘要： Microchip devices are provided with an inert and biocompatible conformal coating to mitigate adverse responses following device implantation in a patient, to contain and seal a drug or other material within the device, and/or to insulate the electrical connections to the device. The device can include: (1) a substrate having a plurality of reservoirs; (2) reservoir contents, such as a drug or biosensor, in the reservoirs; (3) reservoir caps covering the reservoirs to isolate the contents from environmental components outside the reservoirs; and (4) a conformal coating over the outer surface of at least a portion of the substrate other than the reservoir caps. The reservoir caps can be selectively disintegrated or permeabilized to expose the reservoir contents to environmental components. The conformal coating preferably comprises a vapor depositable polymeric material, such as parylene. Processes for controlling coating of the devices while facilitating reservoir cap exposure are provided.
摘要翻译： Microchip器件提供有惰性和生物相容的保形涂层，以减轻患者装置植入后的不良反应，以容纳和密封装置内的药物或其他材料，和/或使电气连接与设备绝缘。该装置可以包括：（1）具有多个储存器的基板; （2）储层内的储存物，如药物或生物传感器; （3）覆盖水库的水库盖，以将内容物与储存器外的环境成分隔离; 和（4）除了储存器盖之外的基底的至少一部分的外表面上的保形涂层。储存器盖可以选择性地分解或渗透以将储存器内容物暴露于环境组分。保形涂层优选包括可气相沉积的聚合物材料，例如聚对二甲苯。提供了用于控制装置的涂层同时促进储存器盖暴露的过程。

135. 发明申请

WO2012019083A3 BIOSENSOR MEMBRANE COMPOSITION, BIOSENSOR, AND METHODS FOR MAKING SAME 审中-公开
标题翻译：生物传感器膜组合物，生物传感器及其制备方法
公开(公告)号：WO2012019083A3
公开(公告)日：2012-04-12
申请号：PCT/US2011046714
申请日：2011-08-05
申请人： MICROCHIPS INC , ZHANG YANAN
发明人： ZHANG YANAN
IPC分类号： A61B5/00 , C12Q1/00
CPC分类号： G01N27/3335 , A61B5/14865 , B01D67/0088 , B01D69/144 , B01D71/54 , B01D71/70 , B01D2323/12 , B01D2323/16 , B01D2323/30 , B01D2325/36 , C12Q1/002 , C25B13/08 , G01N27/3271
摘要： Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked ed via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components. In another embodiment., the membrane includes a solvent cast film which includes a mixture of a first polyether-based thermoplastic polyurethane copolymer, a polyether-based polyurethane copolymer, and, optionally, a second polyether-based thermoplastic polyurethane copolymer.
摘要翻译：提供用于生物传感器的选择性渗透膜。在一个实施方案中，膜包括包含聚氨酯组分，硅氧烷组分和水凝胶组分的聚合物混合物，混合物中的组分的量为约60至约80重量％的聚氨酯，约10至约20重量％的硅氧烷，和约10至约20重量％的水凝胶。该膜具有重新形成为亲水性的表面，其中重组的表面通过至少一种聚氨酯，硅氧烷和水凝胶组分上的反应性端基进行交联。在另一个实施方案中，膜包括溶剂流延膜，其包括第一聚醚基热塑性聚氨酯共聚物，聚醚基聚氨酯共聚物和任选的第二聚醚基热塑性聚氨酯共聚物的混合物。

136. 发明申请

WO2011047271A1 MULTI-CHANNEL POTENTIOSTAT FOR BIOSENSOR ARRAYS 审中-公开
标题翻译：生物传感器阵列的多通道电位
公开(公告)号：WO2011047271A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052860
申请日：2010-10-15
申请人： MICROCHIPS, INC. , SHEPPARD, Jr., Norman, F.
发明人： SHEPPARD, Jr., Norman, F.
IPC分类号： G01N27/416 , G01N33/487
CPC分类号： G01N27/3273
摘要： Method of operating an array of biosensors comprising the steps of : (i) measuring a first and a second working current at a first and a second working electrode, respectively, by using a first reference electrode and a first control amplifier; (ii) measuring a third and a fourth working current at the first and the second working electrode, respectively, using a second reference electrode and a second control amplifier.
摘要翻译：操作生物传感器阵列的方法，包括以下步骤：（i）通过使用第一参考电极和第一控制放大器分别在第一和第二工作电极处测量第一和第二工作电流; （ii）使用第二参考电极和第二控制放大器分别在第一和第二工作电极处测量第三和第四工作电流。

137. 发明申请

WO2010068846A3 WIRELESS COMMUNICATION WITH A MEDICAL IMPLANT 审中-公开
标题翻译：无线通信与医疗植物
公开(公告)号：WO2010068846A3
公开(公告)日：2010-09-30
申请号：PCT/US2009067637
申请日：2009-12-11
申请人： MICROCHIPS INC , UTSI VINCENT , NORRIS MARK , RICHERD JEAN-DANIEL
发明人： UTSI VINCENT , NORRIS MARK , RICHERD JEAN-DANIEL
IPC分类号： H01Q1/27 , H01Q1/38 , H01Q5/00 , H01Q9/04
CPC分类号： A61N1/37223 , H01Q1/273 , H01Q1/38 , H01Q5/40 , H01Q9/0414 , H01Q21/30
摘要： An apparatus for providing transdermal wireless communication includes medical implant circuitry; a transceiver coupled to the medical implant circuitry; a first metal surface having an end portion and a base portion; a second metal surface parallel to the first metal surface and connected to the first metal surface by a conductor, the second metal surface being separated from the first metal surface by a dielectric layer; a first radiating element tuned to a first frequency and disposed within the dielectric layer between the first metal surface and second metal surface; and a feed structure in electrical communication with the transceiver and the first radiating strip. The first radiating element has a first reactive portion at a first end thereof, a second reactive portion at a second end thereof, and a first radiating strip extending between the first reactive portion and the second reactive portion.
摘要翻译：用于提供透皮无线通信的装置包括医疗植入电路; 耦合到所述医疗植入电路的收发器; 具有端部和基部的第一金属表面; 第二金属表面，平行于第一金属表面并通过导体连接到第一金属表面，第二金属表面通过介电层与第一金属表面分离; 调整到第一频率并且设置在第一金属表面和第二金属表面之间的电介质层内的第一辐射元件; 以及与收发器和第一辐射带电连通的馈送结构。第一辐射元件在其第一端处具有第一反作用部分，在其第二端处具有第二反作用部分，以及在第一反作用部分和第二反作用部分之间延伸的第一辐条。

138. 发明申请

WO2008008845A3 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或输送物质的多储层泵装置
公开(公告)号：WO2008008845A3
公开(公告)日：2008-04-10
申请号：PCT/US2007073271
申请日：2007-07-11
申请人： MICROCHIPS INC , SANTINI JOHN T , CIMA MICHAEL F , COPPETA JONATHAN R , PRESCOTT JAMES H , SBIAA ZOUHAIR , STAPLES MARK A
发明人： SANTINI JOHN T , CIMA MICHAEL F , COPPETA JONATHAN R , PRESCOTT JAMES H , SBIAA ZOUHAIR , STAPLES MARK A
IPC分类号： A61M37/00 , A61M5/14
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供泵补丁装置用于药物递送。该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

139. 发明申请

WO2007001624A3 MEDICAL AND DENTAL IMPLANT DEVICES FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物输送的医疗和牙科植入装置
公开(公告)号：WO2007001624A3
公开(公告)日：2007-04-12
申请号：PCT/US2006017062
申请日：2006-05-04
申请人： MICROCHIPS INC , SANTINI JOHN T JR , HUTCHINSON CHARLES E , PROOS ELIZABETH REES
发明人： SANTINI JOHN T JR , HUTCHINSON CHARLES E , PROOS ELIZABETH REES
IPC分类号： A61F2/30 , A61F2/28
CPC分类号： A61C8/0012 , A61C8/0016 , A61C19/063 , A61C2008/0046 , A61F2/30744 , A61F2/30756 , A61F2/30767 , A61F2/30771 , A61F2/36 , A61F2/3662 , A61F2/3676 , A61F2/38 , A61F2/446 , A61F2002/2817 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/30004 , A61F2002/30013 , A61F2002/30062 , A61F2002/30224 , A61F2002/30261 , A61F2002/30266 , A61F2002/30462 , A61F2002/30677 , A61F2002/30808 , A61F2002/3081 , A61F2002/30874 , A61F2002/30878 , A61F2002/30937 , A61F2002/3617 , A61F2002/4631 , A61F2002/4636 , A61F2002/482 , A61F2210/0004 , A61F2220/0075 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0024 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61K9/0024 , A61L15/585 , A61L24/043 , A61L27/54 , A61L27/56 , A61L28/0026 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2430/02 , C08L31/04
摘要： Implantable devices and methods for use in the treatment of osteonecrosisare provided. The device includes at least one implant device body adapted for insertion into one or more channels or voids in bone tissue,- a plurality of discrete reservoirs (14) , which may preferably be microreservoirs , located in the surface of the at least one implant device body; and at least one release system disposed in one or more of the plurality of reservoirs, wherein the release system includes at least one drug (15, 20) selected from the group consisting of bone growth promoters, angiogenesis promoters, analgesics, anesthetics, antibiotics, and combinations thereof . The device body may be formed of a bone graft material, a polymer, a metal, a ceramic, or a combination thereof . The device body may be a monolithic structure, such as one having a cylindrical shape, or it may be in the form of multiple units, such as a plurality of beads.
摘要翻译：提供了用于治疗骨坏死的植入式装置和方法。所述装置包括适于插入骨组织中的一个或多个通道或空隙中的至少一个植入物装置主体， - 多个离散储存器（14），其优选地可以是位于至少一个植入装置的表面中的微储层身体; 以及至少一个释放系统，其设置在所述多个储存器中的一个或多个储存器中，其中所述释放系统包括至少一种选自骨生长促进剂，血管生成促进剂，止痛剂，麻醉剂，抗生素的药物（15,20）及其组合。装置主体可以由骨移植材料，聚合物，金属，陶瓷或其组合形成。装置主体可以是诸如具有圆柱形形状的整体结构，或者其可以是多个单元的形式，例如多个珠。

140. 发明申请

WO2006085908A9 DEVICES AND METHODS FOR MEASURING AND ENHANCING DRUG OR ANALYTE TRANSPORT TO/FROM MEDICAL IMPLANT 审中-公开
标题翻译：用于测量和增强药物或分析物运输到/来自医学植入物的装置和方法
公开(公告)号：WO2006085908A9
公开(公告)日：2006-09-21
申请号：PCT/US2005019021
申请日：2005-06-01
申请人： MICROCHIPS INC , HERMAN STEPHEN J , KRIEGER TIMOTHY , SANTINI JOHN T JR , PRESCOTT JAMES H , STAPLES MARK ANDREW , LIPKA SARA A
发明人： HERMAN STEPHEN J , KRIEGER TIMOTHY , SANTINI JOHN T JR , PRESCOTT JAMES H , STAPLES MARK ANDREW , LIPKA SARA A
IPC分类号： A61M37/00 , A61B5/00 , A61B5/03 , A61B5/042 , A61B5/07 , A61K9/00 , A61K49/00 , A61M31/00 , A61N1/05 , A61N1/30
CPC分类号： A61K9/0009 , A61B5/03 , A61B5/04001 , A61B5/042 , A61B5/076 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/686 , A61K9/0024 , A61K9/0097 , A61M37/00 , A61N1/05 , A61N1/30 , A61N1/306
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要翻译：提供了用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织囊的物质运输的方法和装置。还提供了用于增强植入装置周围的血管形成的方法和装置，这也将有助于质量输送到装置或从装置输送。该装置优选包含多个储器，其含有（i）用于短期或长期受控药物递送的药物制剂，（ii）用于感测患者中分析物的传感器，或（iii）其组合。

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