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131. 发明授权

US07763007B2 Diagnostic methods for branching catheter systems 有权
标题翻译：分支导管系统的诊断方法
公开(公告)号：US07763007B2
公开(公告)日：2010-07-27
申请号：US11112078
申请日：2005-04-22
申请人： Keith A. Miesel , Justin A. Blanco
发明人： Keith A. Miesel , Justin A. Blanco
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
摘要： Branching catheter systems with diagnostic components for detecting and isolating fluid flow problems (e.g., leaks, occlusions, etc.) and methods for detecting and isolating fluid flow problems are disclosed. Among the fluid flow problems that may potentially be detected are leaks in the branching catheter systems (e.g., cuts, disconnected components, etc.). Another fluid flow problem that may be detected using the diagnostic systems of the present invention is the presence of occlusions or other blockages that prevent fluid flow within the catheter systems. In addition to identifying that a problem exists, the diagnostic components may preferably also be used to identify the location of the fluid flow problem as discussed herein. Connectors for use in the branching catheter systems are also disclosed. Among the diagnostic components that may be used in branching catheter systems of the present are valves to control fluid flow through the various sections of the branching catheter system, fluid flow detectors to detect flow through the one or more sections of the branching catheter system and a control system for operating the diagnostic components.
摘要翻译：公开了具有用于检测和分离流体流动问题（例如泄漏，闭塞等）的诊断部件的分支导管系统以及用于检测和分离流体流动问题的方法。在可能潜在检测的流体流动问题中，分支导管系统中的泄漏（例如，切割，断开的部件等）。可以使用本发明的诊断系统检测的另一个流体流动问题是存在妨碍导管系统内的流体流动的闭塞或其它阻塞物。除了确定存在问题之外，诊断部件还可以优选地用于识别本文所讨论的流体流动问题的位置。还公开了用于分支导管系统的连接器。在本发明的分支导管系统中可以使用的诊断部件中的阀是用于控制通过分支导管系统的各个部分的流体流动的流体流动检测器，用于检测通过分支导管系统的一个或多个部分的流动，以及用于操作诊断部件的控制系统。

132. 发明申请

US20100121214A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于内分泌压力和患者运动的癫痫病症评估
公开(公告)号：US20100121214A1
公开(公告)日：2010-05-13
申请号：US12359055
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0476 , A61B5/03 , A61B5/11 , A61B5/053
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压，以评估癫痫发作障碍。在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间发生癫痫发作。除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

133. 发明授权

US07491181B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US07491181B2
公开(公告)日：2009-02-17
申请号：US10825955
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/103 , A61B5/117 , A61N1/00
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/4519 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61N1/36135 , A61N1/36542
摘要： A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.
摘要翻译：诸如可植入医疗装置（IMD）或编程装置之类的装置确定患者何时试图睡觉。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于所确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

134. 发明申请

US20080177355A1 COLLECTING ACTIVITY INFORMATION TO EVALUATE THERAPY 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US20080177355A1
公开(公告)日：2008-07-24
申请号：US12017918
申请日：2008-01-22
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/08
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

135. 发明申请

US20080081958A1 Implantable medical device with sensor self-test feature 审中-公开
标题翻译：具有传感器自检功能的植入式医疗设备
公开(公告)号：US20080081958A1
公开(公告)日：2008-04-03
申请号：US11789438
申请日：2007-04-24
申请人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
发明人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
IPC分类号： A61B5/00
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

136. 发明申请

US20070225674A1 Method and Apparatus for the Treatment of Movement Disorders 有权
标题翻译：用于治疗运动障碍的方法和装置
公开(公告)号：US20070225674A1
公开(公告)日：2007-09-27
申请号：US11565268
申请日：2006-11-30
申请人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
发明人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
IPC分类号： A61N1/00 , A61M31/00 , A61B5/00 , A61B5/04
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A method, apparatus, and system for treating patients suffering from movement disorders having the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.
摘要翻译：用于治疗患有运动障碍的患者的方法，装置和系统，其具有确定指示疾病状态的一种或多种生物标志物的能力。在一些实施方案中，生物标志物可以用作闭环反馈信号以控制治疗的递送（例如电刺激或药物治疗），并且其也可以用作治疗有效性的指示。一个实施例使用放置在脑中的电极来测量EEG或局部场电位（LFP）信号，从该信号可以确定一个或多个生物标志物。

137. 发明授权

US6162180A Non-invasive cardiac monitoring system and method with communications interface 失效
标题翻译：非侵入性心脏监测系统及方法与通讯接口
公开(公告)号：US6162180A
公开(公告)日：2000-12-19
申请号：US221038
申请日：1998-12-28
申请人： Keith A. Miesel , Lee Stylos
发明人： Keith A. Miesel , Lee Stylos
IPC分类号： A61B5/083 , A61N1/365 , A61B5/08 , A61B5/02
CPC分类号： A61B5/083 , A61N1/36557
摘要： A system and method for determining a patient's cardiac output in a non-invasive manner and transmitting cardiac output data to a remote host processor, a communications system, or a local output device is disclosed. A non-invasive cardiac monitoring approach utilizes an implantable medical device coupled to an oxygen sensor. The oxygen sensor provides venous oxygen saturation data to the implantable medical device. An oxygen consumption unit produces oxygen consumption data using air exhaled by a patient. A processing unit calculates a cardiac output result in real-time using the venous oxygen saturation data, the oxygen consumption data, and arterial oxygen saturation data assumed to be about 100% or acquired using a sensor external to the patient. The implantable medical device may transmit the venous oxygen saturation data to the processing unit using electromagnetic signals or acoustic signals. The implantable medical device may be a pacemaker, a pacemaker/cardioverter/defibrillator (PCD), an oxygen sensing device, or an implantable hemodynamic monitor. The processing unit may store the cardiac output data/result for a period of time and/or communicate the cardiac output result to the remote host processor substantially in real-time via a communications interface. The interface may include a modem, a computer interface, a network interface, or a communications system interface, for example. The processing unit may communicate the cardiac output result to the remote host processor in an analog, digital or optical form.
摘要翻译：公开了一种用于以非侵入性方式确定患者心输出量并将心输出量数据传送到远程主机处理器，通信系统或本地输出设备的系统和方法。非侵入式心脏监测方法利用耦合到氧传感器的可植入医疗装置。氧传感器向可植入医疗装置提供静脉氧饱和度数据。耗氧单元使用患者呼出的空气产生氧气消耗数据。处理单元使用假定为约100％的静脉血氧饱和度数据，氧耗数据和动脉血氧饱和度数据，使用患者外部的传感器获取，来实时计算心输出量结果。可植入医疗装置可以使用电磁信号或声信号将静脉氧饱和度数据传送到处理单元。可植入医疗装置可以是起搏器，起搏器/心律转复器/除颤器（PCD），氧气感测装置或可植入血液动力学监测器。处理单元可以将心输出数据/结果存储一段时间和/或通过通信接口实时地将心输出结果传送到远程主机处理器。该接口可以包括例如调制解调器，计算机接口，网络接口或通信系统接口。处理单元可以以模拟，数字或光学形式将心输出结果传送到远程主机处理器。

138. 发明授权

US5919221A Method and apparatus for calibrating pacemaker pressure sensor lead prior to chronic implant 失效
标题翻译：在慢性植入前校准起搏器压力传感器导线的方法和装置
公开(公告)号：US5919221A
公开(公告)日：1999-07-06
申请号：US837674
申请日：1997-04-22
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61B5/0215 , A61N1/05 , A61N1/08 , A61N1/04
CPC分类号： A61N1/08 , A61N1/05 , A61B2560/0257 , A61B5/02156
摘要： The present invention provides apparatus, systems, and methods for accurately calibrating a pressure sensor which is incorporated into a lead, e.g., a pacemaker lead, prior to implant into a patient. A calibration vessel is provided which has a housing which forms a reservoir for containing the portion of the lead having the pressure sensor. The vessel also has a connector for receiving a reference pressure into the reservoir, and a sealable opening for receiving the distal end of the lead that carries the pressure sensor. The calibration vessel can be used in a system comprising an electronic display module and an external pressure reference, for establishing an accurate sensor baseline for zero pressure; and can also be used in a system comprising an electronic display module, a reference pressure input source, and a manometer for establishing an accurate scale factor for the lead pressure sensor.
摘要翻译：本发明提供了用于在植入患者体内之前精确地校准被结合到引线例如起搏器引线中的压力传感器的装置，系统和方法。提供了一种校准容器，其具有形成用于容纳具有压力传感器的引线部分的容器的壳体。容器还具有用于接收储存器中的参考压力的连接器，以及用于接收承载压力传感器的引线的远端的可密封开口。校准容器可以用于包括电子显示模块和外部压力参考的系统中，用于为零压力建立精确的传感器基线; 并且还可以用于包括电子显示模块，参考压力输入源和压力计的系统，用于为铅压传感器建立准确的比例因子。

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