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121. 发明授权

US07756646B2 Method for predicting peptide detection in mass spectrometry 失效
标题翻译：用于预测质谱中肽检测的方法
公开(公告)号：US07756646B2
公开(公告)日：2010-07-13
申请号：US11394839
申请日：2006-03-31
申请人： Lars Kangas , Richard D. Smith , Konstantinos Petritis
发明人： Lars Kangas , Richard D. Smith , Konstantinos Petritis
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N33/6848
摘要： A method of predicting whether a peptide present in a biological sample will be detected by analysis with a mass spectrometer. The method uses at least one mass spectrometer to perform repeated analysis of a sample containing peptides from proteins with known amino acids. The method then generates a data set of peptides identified as contained within the sample by the repeated analysis. The method then calculates the probability that a specific peptide in the data set was detected in the repeated analysis. The method then creates a plurality of vectors, where each vector has a plurality of dimensions, and each dimension represents a property of one or more of the amino acids present in each peptide and adjacent peptides in the data set. Using these vectors, the method then generates an algorithm from the plurality of vectors and the calculated probabilities that specific peptides in the data set were detected in the repeated analysis. The algorithm is thus capable of calculating the probability that a hypothetical peptide represented as a vector will be detected by a mass spectrometry based proteomic platform, given that the peptide is present in a sample introduced into a mass spectrometer.
摘要翻译：通过用质谱仪分析来检测存在于生物样品中的肽的方法。该方法使用至少一种质谱仪对含有已知氨基酸的蛋白质的含有肽的样品进行重复分析。然后，该方法通过重复分析产生被鉴定为包含在样品内的肽的数据集。然后，该方法计算在重复分析中检测到数据集中的特定肽的概率。该方法然后创建多个向量，其中每个载体具有多个维度，并且每个维度表示存在于每个肽中的一个或多个氨基酸和数据集中的相邻肽的性质。使用这些向量，该方法然后从多个向量生成算法，并且在重复分析中检测出数据集中的特定肽的计算概率。因此，鉴于该肽存在于引入质谱仪的样品中，该算法因此能够计算出通过基于质谱的蛋白质组学平台检测表示为载体的假定肽的概率。

122. 发明申请

US20100156150A1 FOLDING AND STACKING MESH CHAIR SYSTEM 有权
标题翻译：折叠和堆叠会议椅系统
公开(公告)号：US20100156150A1
公开(公告)日：2010-06-24
申请号：US12422811
申请日：2009-04-13
申请人： Richard D. Smith , Orrin C. Farnsworth
发明人： Richard D. Smith , Orrin C. Farnsworth
IPC分类号： A47C4/28
CPC分类号： A47C4/44 , A47C3/04 , A47C4/28 , A47C4/38 , A47C5/06 , A47C7/002 , A47C7/282
摘要： A folding and stacking chair system includes a plurality of folding and stacking chairs having an unfolded seating position in which the chairs are configured for sitting upon, and a folded and stacked position in which the chairs are folded and stacked together. Each chair has a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. The seat and the backrest each have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held between the backrest supports of the frame sides.
摘要翻译：折叠和折叠椅系统包括多个折叠和堆叠椅子，其具有展开的就座位置，其中椅子被配置为坐在其上，并且折叠和堆叠的位置，椅子被折叠并堆叠在一起。每个椅子都有一个座位和一个靠在相对的框架侧面之间的靠背，每个座椅都有靠背支撑件，前腿和后腿。座椅和靠背各自具有连续的柔性和弹性网状片材或者被保持在框架侧面的靠背支架之间的图案化的开放纹理塑料。

123. 发明申请

US20100156149A1 COMFORTABLE MESH FOLDING CHAIR 有权
标题翻译：舒适的MESH折叠椅
公开(公告)号：US20100156149A1
公开(公告)日：2010-06-24
申请号：US12422801
申请日：2009-04-13
申请人： Richard D. Smith , Orrin C. Farnsworth , Spencer Posey
发明人： Richard D. Smith , Orrin C. Farnsworth , Spencer Posey
IPC分类号： A47C4/28
CPC分类号： A47C4/44 , A47C3/04 , A47C4/28 , A47C4/38 , A47C5/06 , A47C7/002 , A47C7/282
摘要： A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides.
摘要翻译：折叠网椅包括座位和靠在相对的框架侧之间的靠背。椅子具有展开的就座位置，其中座椅枢转以从框架侧面延伸，前后腿的底部移动分开，并且座椅朝向框架侧部枢转并且前后腿部一起移动的折叠位置。座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。

124. 发明申请

US20090294662A1 Ion funnel ion trap and process 有权
标题翻译：离子漏斗离子阱和工艺
公开(公告)号：US20090294662A1
公开(公告)日：2009-12-03
申请号：US12156360
申请日：2008-05-30
申请人： Mikhail E. Belov , Yehia M. Ibrahim , Brian H. Clowers , David C. Prior , Richard D. Smith
发明人： Mikhail E. Belov , Yehia M. Ibrahim , Brian H. Clowers , David C. Prior , Richard D. Smith
IPC分类号： H01J49/00
CPC分类号： H01J49/4235 , H01J49/066
摘要： An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 μs, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
摘要翻译：描述了一种离子漏斗阱，其包括入口部分，捕获部分和出口部分，其在正常操作中与离子漏斗相连。离子阱在约1托的压力下有效地工作，并提供：1）去除低质量（m / z）离子物质，2）离子累积效率高达80％，3）充电容量〜10,000,000个基本费用，4）离子喷射时间为40至200微米，以及5）优化的可变离子积聚时间。具有低浓度肽混合物的离子累积显示出30倍的分析物信噪比（SNR）的增加，以及多次充电分析物的SNR的提高大于10倍。

125. 发明申请

US20090286324A1 SERUM MARKERS FOR TYPE II DIABETES MELLITUS 有权
标题翻译： II型糖尿病血清标记物
公开(公告)号：US20090286324A1
公开(公告)日：2009-11-19
申请号：US12120043
申请日：2008-05-13
申请人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
发明人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/042
摘要： A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.
摘要翻译：一种利用以下描述的选择的生物标志物来单独或组合地鉴定发生2型糖尿病风险增加的人的方法。本发明允许广泛的，可靠的筛选大量人口基础，并提供其他优点，包括在不同条件下制定表征，归档和对比来自多种样品类型的数据的有效策略。

126. 发明授权

US07552968B2 Feet for stacking chair 有权
标题翻译：堆叠椅脚
公开(公告)号：US07552968B2
公开(公告)日：2009-06-30
申请号：US11411572
申请日：2006-04-25
申请人： Richard D. Smith , David J. Laws
发明人： Richard D. Smith , David J. Laws
IPC分类号： A47C3/04
CPC分类号： A47C3/04
摘要： A chair foot device for a wire frame chair stackable with other wire frame chairs includes a lower surface disposable on a support surface. An upper surface, opposite the lower surface is sized and shaped to carry the lower surface of an adjacent foot from an adjacently stacked upper chair. The chair foot also includes an alignment protrusion disposed on one of the lower and upper surfaces and an alignment indentation disposed on the other of the lower and upper surfaces. The alignment protrusion is sized and shaped to be receivable within an alignment indentation of a corresponding foot from an adjacently stacked chair. The foot is sized and shaped to carry an applied load from an adjacently stacked upper foot and to transfer the applied load to an adjacent load bearing surface. The foot is also sized and shaped to protect the wire frame chair from damage during stacking.
摘要翻译：用于与其他线框架椅子可堆叠的线框架椅子的椅子脚装置包括可在支撑表面上一次性的下表面。尺寸和形状相对的下表面的上表面承载相邻脚的下表面从相邻层叠的上椅子。椅脚还包括设置在下表面和上表面中的一个上的对准突起和设置在下表面和上表面中的另一个上的对准凹口。对准突起的尺寸和形状被设计成能够接收在相邻的脚的相对堆叠的椅子的对准凹槽内。脚的尺寸和形状适于承载来自相邻堆叠的上脚的施加的负载并且将施加的负载传递到相邻的承载表面。脚也具有尺寸和形状，以保护线框椅子在堆叠期间免受损坏。

127. 发明申请

US20090048797A1 METHODS FOR RECALIBRATION OF MASS SPECTROMETRY DATA 失效
标题翻译：用于测量质谱数据的方法
公开(公告)号：US20090048797A1
公开(公告)日：2009-02-19
申请号：US11524028
申请日：2006-09-19
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： G06F19/00
CPC分类号： H01J49/0009
摘要： Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.
摘要翻译：公开了重新校准质谱数据的方法，其通过调整对质量测量精度具有实质性影响的参数的实验方差来提高质量精度和精度。使用通过匹配集合的测量和推定质量值编译的相关质量值对来确定最优系数，从而使总体有效质量误差和质量误差扩展最小化。随后使用系数来校正在测量数据集中检测到的峰的质量值，从而提供其重新校准。在重新校准后，在复杂的真菌蛋白质组上已经证明了亚ppm质量测量精度，为肽鉴定提供了改进的置信度。

128. 发明申请

US20080185513A1 Method of multiplexed analysis using ion mobility spectrometer 有权
标题翻译：使用离子迁移谱仪的多重分析方法
公开(公告)号：US20080185513A1
公开(公告)日：2008-08-07
申请号：US11701752
申请日：2007-02-01
申请人： Mikhail E. Belov , Richard D. Smith
发明人： Mikhail E. Belov , Richard D. Smith
IPC分类号： H01J49/04
CPC分类号： H01J49/0031 , G01N27/622
摘要： A method for analyzing analytes from a sample introduced into a Spectrometer by generating a pseudo random sequence of a modulation bins, organizing each modulation bin as a series of submodulation bins, thereby forming an extended pseudo random sequence of submodulation bins, releasing the analytes in a series of analyte packets into a Spectrometer, thereby generating an unknown original ion signal vector, detecting the analytes at a detector, and characterizing the sample using the plurality of analyte signal subvectors. The method is advantageously applied to an Ion Mobility Spectrometer, and an Ion Mobility Spectrometer interfaced with a Time of Flight Mass Spectrometer.
摘要翻译：一种用于通过产生调制箱的伪随机序列来分析从引入到光谱仪中的样品的分析物的方法，将每个调制箱组织成一系列的子调制箱，由此形成扩频的伪随机序列的子调制箱，将分析物在一系列分析物分组进入光谱仪，从而产生未知的原始离子信号矢量，检测检测器处的分析物，并使用多个分析物信号子矢量表征样品。该方法有利地应用于离子移动光谱仪和与飞行时间质谱仪接口的离子迁移光谱仪。

129. 发明申请

US20080054178A1 ION FUNNEL WITH EXTENDED MASS RANGE AND REDUCED CONDUCTANCE LIMIT APERTURE 失效
标题翻译：具有扩展质量范围和减少导线限制光圈的离子风机
公开(公告)号：US20080054178A1
公开(公告)日：2008-03-06
申请号：US11251528
申请日：2005-09-30
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： H01J49/42
CPC分类号： H01J49/067 , H01J49/066
摘要： An improved ion funnel design is disclosed that decreases the axial RF (parasite) fields at the ion funnel exit. This is achieved by addition of one or more compensation electrodes after the conductance limit electrode. Various RF voltage profiles may be applied to the various electrodes minimizing the parasite axial potential wells. The smallest RF aperture that serves as the conductance limiting electrode is further reduced over standard designs. Overall, the ion funnel improves transmission ranges of both low m/z and high m/z ions, reducing RF activation of ions and decreasing the gas load to subsequent differential pumping stages.
摘要翻译：公开了一种改进的离子漏斗设计，其减少了离子漏斗出口处的轴向RF（寄生）场。这是通过在电导限制电极之后添加一个或多个补偿电极来实现的。各种RF电压分布可以被施加到使寄生虫轴向势阱最小化的各种电极。用作电导限制电极的最小RF孔径比标准设计进一步降低。总的来说，离子漏斗改善了低m / z和高m / z离子的透射范围，减少了离子的RF激发，并将气体负载降低到随后的差动泵送阶段。

130. 发明授权

US06803565B2 Ionization source utilizing a multi-capillary inlet and method of operation 有权
标题翻译：电离源采用多毛细管入口和操作方法
公开(公告)号：US06803565B2
公开(公告)日：2004-10-12
申请号：US09860727
申请日：2001-05-18
申请人： Richard D. Smith , Taeman Kim , Harold R. Udseth
发明人： Richard D. Smith , Taeman Kim , Harold R. Udseth
IPC分类号： H01J4904
CPC分类号： H01J49/0404 , H01J49/066 , H01J49/165
摘要： A multi-capillary inlet to focus ions and other charged particles generated at or near atmospheric pressure into a relatively low pressure region, which allows increased conductance of ions and other charged particles. The multi-capillary inlet is juxtaposed between an ion source and the interior of an instrument maintained at near atmospheric pressure, it finds particular advantages when deployed to improve the ion transmission between an electrospray ionization source and the first vacuum stage of a mass spectrometer, and finds its greatest advantages when deployed in conjunction with an electrodynamic (RF) ion funnel deployed within the interior of the mass spectrometer, particularly an ion funnel equipped with a jet disturber.
摘要翻译：将多个毛细管入口聚焦在大气压下或接近大气压下产生的离子和其他带电粒子到相对较低的压力区域，这样可以增加离子和其他带电粒子的电导率。多毛细管入口与离子源和维持在接近大气压的仪器的内部并置，当部署以改善电喷雾离子源和质谱仪的第一真空级之间的离子传递时，它具有特别的优点，以及与部署在质谱仪内部的电动（RF）离子漏斗配合使用时，具有最大的优势，特别是配备有喷射干燥器的离子漏斗。

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