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121. 发明申请

US20080015486A1 System and method for determining the hematocrit and/or blood volume 有权
标题翻译：用于确定血细胞比容和/或血液体积的系统和方法
公开(公告)号：US20080015486A1
公开(公告)日：2008-01-17
申请号：US11717812
申请日：2007-03-13
申请人： Wei Zhang , Helge Brauer , Reiner Spickermann , Carsten Muller
发明人： Wei Zhang , Helge Brauer , Reiner Spickermann , Carsten Muller
IPC分类号： A61M1/14
CPC分类号： A61M1/3639 , A61M1/16 , A61M1/1613 , A61M1/3659 , A61M2230/207
摘要： A method for determining the hematocrit and/or blood volume during an extracorporeal blood treatment with an extracorporeal blood circuit, in which blood is taken with a blood pump via an arterial cannula and an arterial flexible-tube line and blood is fed back via a venous flexible-tube line and a venous cannula. Pressure is measured in the extracorporeal blood circuit and a change in the hematocrit is determined from a change in the pressure. The respective relationship between hematocrit HKT or blood volume RBV and pressure P in the extracorporeal circuit is stored for various cannula diameters and various blood-flow values. The respective relationship for a given cannula diameter and blood flow is selected. The hematocrit and/or blood volume is determined taking account of the selected relationship.
摘要翻译：一种用体外血液回路确定体外血液处理过程中的血细胞比容和/或血液体积的方法，其中通过动脉插管和血液通过血泵将动脉血管与血液一起通过静脉柔性管线和静脉插管。在体外血液回路中测量压力，并且根据压力的变化确定血细胞比容的变化。针对各种插管直径和各种血流值，存储血细胞比容HKT或体积RBV与体外循环中的压力P之间的各自关系。选择给定插管直径和血流量的相应关系。考虑所选择的关系来确定血细胞比容和/或血容量。

122. 发明申请

US20070270486A1 Compositions and methods for high throughput screening of pharmacological chaperones 有权
标题翻译：用于高通量筛选药理学分子伴侣的组合物和方法
公开(公告)号：US20070270486A1
公开(公告)日：2007-11-22
申请号：US11698513
申请日：2007-01-26
申请人： Ron Kopito , Wei Zhang
发明人： Ron Kopito , Wei Zhang
IPC分类号： A61K31/352 , C12Q1/68
CPC分类号： G01N33/502 , G01N2500/10
摘要： Assays are provided for the screening and classification of biologically active agents that alter the conformation of conformationally defective proteins. The methods of the invention find use in the identification and classification of agents with chaperone activity, particularly the identification and classification of small molecule chemical and pharmacological chaperones. The agents thus identified find use altering the conformation of otherwise conformationally defective proteins.
摘要翻译：提供了用于筛选和分类改变构象缺陷型蛋白质构象的生物活性剂的试验。本发明的方法用于鉴定和分类具有伴侣活性的试剂，特别是鉴定和分类小分子化学和药理学分子伴侣。如此确定的试剂发现使用改变其它构象缺陷型蛋白质的构象。

123. 发明申请

US20070232026A1 Methods and materials useful for chip stacking, chip and wafer bonding 有权
标题翻译：用于芯片堆叠，芯片和晶片接合的方法和材料
公开(公告)号：US20070232026A1
公开(公告)日：2007-10-04
申请号：US11726354
申请日：2007-03-21
申请人： Chris Apanius , Robert Shick , Hendra Ng , Andrew Bell , Wei Zhang , Phil Neal
发明人： Chris Apanius , Robert Shick , Hendra Ng , Andrew Bell , Wei Zhang , Phil Neal
IPC分类号： H01L21/00
CPC分类号： H01L24/29 , C08F32/00 , C08G64/0208 , C09D145/00 , H01L24/13 , H01L24/73 , H01L24/81 , H01L24/83 , H01L25/0657 , H01L25/50 , H01L2224/05568 , H01L2224/05573 , H01L2224/131 , H01L2224/16145 , H01L2224/16225 , H01L2224/16227 , H01L2224/274 , H01L2224/29 , H01L2224/29101 , H01L2224/2919 , H01L2224/29298 , H01L2224/32145 , H01L2224/32225 , H01L2224/33181 , H01L2224/48091 , H01L2224/48227 , H01L2224/48472 , H01L2224/73103 , H01L2224/73203 , H01L2224/73204 , H01L2224/73265 , H01L2224/81191 , H01L2224/81903 , H01L2224/83191 , H01L2224/83193 , H01L2224/83203 , H01L2224/838 , H01L2225/0651 , H01L2225/06513 , H01L2225/06517 , H01L2225/06575 , H01L2924/00013 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01019 , H01L2924/01023 , H01L2924/01024 , H01L2924/01025 , H01L2924/01033 , H01L2924/01041 , H01L2924/01047 , H01L2924/01051 , H01L2924/01055 , H01L2924/01058 , H01L2924/01073 , H01L2924/01082 , H01L2924/014 , H01L2924/0665 , H01L2924/10253 , H01L2924/12041 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/19042 , H01L2924/00 , H01L2924/3512 , H01L2924/00012 , H01L2224/29099 , H01L2224/29199 , H01L2224/29299 , H01L2224/2929 , H01L2224/05599
摘要： Materials, and methods that use such materials, that are useful for forming chip stacks, chip and wafer bonding and wafer thinning are disclosed. Such methods and materials provide strong bonds while also being readily removed with little or no residues.
摘要翻译：公开了使用这种材料的材料和方法，其可用于形成芯片堆叠，芯片和晶片接合以及晶片薄化。这样的方法和材料提供强的键，同时也很少或没有残留物容易地除去。

124. 发明申请

US20070189501A1 Method for synchronizing contact information 审中-公开
标题翻译：联系信息同步方法
公开(公告)号：US20070189501A1
公开(公告)日：2007-08-16
申请号：US11653994
申请日：2007-01-17
申请人： Cheng-Shing Lai , Wei Zhang
发明人： Cheng-Shing Lai , Wei Zhang
IPC分类号： H04M1/00 , H04M3/00
CPC分类号： H04M1/274516
摘要： A method for synchronizing the contact information, which is applied in the synchronization between a wireless exchange device and a communication device. Both the wireless exchange devices and the communication devices have a synchronization software, respectively. The synchronization software allows the wireless exchange device and the communication device to be set as a transmitter or a receiver interchangeably, and it also allows a keyword searching, multiple entries, or the entire database of contact information to be sent from the transmitter to the receiver. In addition, the synchronization software also provides a verification process to ensure the contact information is only sent to the authorized device. Therefore, the receiver can obtain the contact information stored in a contact database of the transmitter, thus achieving the aim of updating the contact databases.
摘要翻译：一种用于同步在无线交换装置和通信装置之间的同步中应用的联系人信息的方法。无线交换设备和通信设备分别具有同步软件。同步软件允许无线交换设备和通信设备可互换地设置为发送器或接收器，并且还允许将关键字搜索，多个条目或整个联系人信息数据库从发送器发送到接收器。此外，同步软件还提供验证过程，以确保联系人信息仅发送到授权设备。因此，接收机可以获得存储在发射机的联系人数据库中的联系信息，从而达到更新联系人数据库的目的。

125. 发明申请

US20070185305A1 Oligomers and polymers containing sulfinate groups and method for the production thereof 审中-公开
标题翻译：含有亚磺酸盐基团的低聚物和聚合物及其制备方法
公开(公告)号：US20070185305A1
公开(公告)日：2007-08-09
申请号：US11602481
申请日：2006-11-20
申请人： Thomas Haring , Jochen Kerres , Wei Zhang
发明人： Thomas Haring , Jochen Kerres , Wei Zhang
IPC分类号： C08G75/00
CPC分类号： H01M6/181 , C08C19/02 , C08F8/04 , C08J5/2243 , C08J2381/00 , H01M8/1023 , H01M8/1025 , H01M8/1027 , H01M8/103 , H01M8/1032 , H01M8/1039 , H01M8/1072 , Y02P70/56
摘要： The invention relates to novel polymers or oligomers containing at least sulfonite groups (P—(SO2)nX, X=1−(n=1), 2−(n=2) or 3−(n=3) valent metal cation or H+ or ammonium ion NR4+ where R=alkyl, aryl, H), which are obtained by completely or partially reducing polymers or oligomers containing at least SO2Y-groups (Y═F, Cl, Br, I, OR, NR2 (R=alkyl and/or aryl and/or H), N-imidazolyl, N-pyrazolyl) by means of suitable reducing agents in a suspension or in a solution form. The invention also relates to polymers and polymer(blend) membranes which are obtained by further reacting the obtained sulfinated polymers, especially by alkylation of the sulfinate groups with mono- di- or oligo functional electrophiles. The invention further relates to methods for producing the sulfinated polymers and for further reacting the sulfinated polymers with electrophiles by S-alkylation.
摘要翻译：本发明涉及至少含有亚磺酸基团的新型聚合物或低聚物（X-1-（n = 1），2-（ n = 2）或3-（n = 3）价金属阳离子或H +或铵离子NR 4 +，其中R =烷基，芳基，H），其通过完全或部分还原含有至少SO 2 Y基（YF，Cl，Br，I，OR，NR 2）的聚合物或低聚物而获得（R =烷基和/或芳基和/或H），N-咪唑基，N-吡唑基），通过合适的还原剂以悬浮液或溶液形式。本发明还涉及聚合物和聚合物（共混物）膜，其通过进一步使得到的硫化聚合物反应而获得，特别是通过亚磺酸基团与单 - 或寡官能亲电体的烷基化。本发明还涉及用于生产硫化聚合物的方法，以及通过S-烷基化进一步使硫化聚合物与亲电体反应。

126. 发明申请

US20070165989A1 Method and systems for diffusion tensor imaging 审中-公开
标题翻译：扩散张量成像的方法和系统
公开(公告)号：US20070165989A1
公开(公告)日：2007-07-19
申请号：US11336269
申请日：2006-01-20
申请人： Luis Serra Del Molino , Wei Zhang , Ralf Kockro
发明人： Luis Serra Del Molino , Wei Zhang , Ralf Kockro
IPC分类号： G02B6/36
CPC分类号： G01R33/283 , G01R33/546 , G01R33/5608 , G01R33/56341
摘要： One embodiment of the present invention includes a system comprising an input interface having at least 3 degrees of spatial freedom for input control; and a diffusion tensor imaging (DTI) module operable with the input interface having at least 3 degrees of spatial freedom. In one embodiment, the DTI module is operable to compute fiber bundles. The module is further operable to identify one or more 3D regions of interests (ROIs) in a reference volume, and compute or identify the fiber bundles passing through one or more 3D ROIs. In one embodiment, the system support displaying a 3D stereoscopic image of the fiber bundles passing through a 3D ROI.
摘要翻译：本发明的一个实施例包括一种系统，其包括具有至少3度空间自由度用于输入控制的输入接口; 和具有至少3度空间自由度的输入接口可操作的扩散张量成像（DTI）模块。在一个实施例中，DTI模块可操作以计算光纤束。该模块还可操作以识别参考体积中的一个或多个感兴趣区域（ROI），并计算或识别通过一个或多个3D ROI的纤维束。在一个实施例中，系统支持显示穿过3D ROI的光纤束的3D立体图像。

127. 发明申请

US20070124117A1 Method and system for fiber tracking 有权
标题翻译：光纤跟踪方法及系统
公开(公告)号：US20070124117A1
公开(公告)日：2007-05-31
申请号：US11336376
申请日：2006-01-20
申请人： Wei Zhang
发明人： Wei Zhang
IPC分类号： G06F15/00
CPC分类号： G01R33/56341 , G01R33/546 , G01R33/5608
摘要： One embodiment of the present invention includes a system comprising to determine a direction of tracking a fiber based on a vector corresponding to a largest value of a set of values for a tensor, if an anisotropy value of the tensor is greater than or equal to a first threshold; and to apply a weighted function to the vector of the tensor to select the direction of tracking the fiber, if the anisotropy value of the tensor is less than or equal to the first threshold and larger than or equal to a second threshold. In one embodiment, the system is to generate the weighted function comprises a linear interpolation to be performed on the vector. In one embodiment, a weight of the linear interpolation is in part dependent on the anisotropy value of the tensor, wherein the weight corresponds to the anisotropy value relative to the first threshold. One embodiment of the invention is also executable as a method
摘要翻译：本发明的一个实施例包括一种系统，包括：如果张量的各向异性值大于或等于a，则确定基于与张量的一组值的最大值对应的矢量来跟踪光纤的方向第一门槛; 并且如果张量的各向异性值小于或等于第一阈值且大于或等于第二阈值，则将加权函数应用于张量的向量以选择跟踪光纤的方向。在一个实施例中，系统是生成加权函数，包括要对向量执行的线性内插。在一个实施例中，线性内插的权重部分地取决于张量的各向异性值，其中权重对应于相对于第一阈值的各向异性值。本发明的一个实施例也可以作为一种方法执行

128. 发明申请

US20070031402A1 Immunoconjugate formulations 有权
标题翻译：免疫缀合物制剂
公开(公告)号：US20070031402A1
公开(公告)日：2007-02-08
申请号：US11498139
申请日：2006-08-03
申请人： Wei Zhang , Michael Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
发明人： Wei Zhang , Michael Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K9/0019 , A61K47/10 , A61K47/26 , A61K47/40 , A61K47/6803 , A61K47/6849 , A61K47/6863
摘要： The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
摘要翻译：本发明提供了基本上不含颗粒的免疫偶联物制剂，所述免疫偶联物制剂包含：免疫偶联物和一种或多种选自以下的赋形剂：蔗糖，聚山梨醇酯20，聚山梨醇酯80，环糊精，右旋糖，甘油，聚乙二醇，甘露醇，氯化钠和氨基酸，其中所述制剂是pH为4.5至7.6的缓冲水溶液。本发明还提供了基本上不含聚集体的免疫缀合物制剂，免疫缀合物制剂包含：免疫偶联物和一种或多种选自组氨酸，蔗糖，甘氨酸和氯化钠的赋形剂，其中所述制剂是缓冲水溶液 pH为4.5至7.6。本发明还提供基本上不含颗粒和聚集体的免疫偶联物制剂。

129. 发明申请

US20070009540A1 Drug conjugate composition 有权
公开(公告)号：US20070009540A1
公开(公告)日：2007-01-11
申请号：US11521120
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

130. 发明授权

US07153628B2 Color-developing agent resin composition, emulsion thereof and method for preparing the same 有权
标题翻译：显色剂树脂组合物，其乳液及其制备方法
公开(公告)号：US07153628B2
公开(公告)日：2006-12-26
申请号：US10820605
申请日：2004-04-08
申请人： Zonglai Liu , Chunxuan Guo , Wei Zhang , Yuzhu Liu
发明人： Zonglai Liu , Chunxuan Guo , Wei Zhang , Yuzhu Liu
IPC分类号： G03C1/73 , G03F7/004
CPC分类号： B41M5/155 , B41M5/3335 , C08L61/06 , C08L61/14 , C08L2205/02 , Y10S430/163 , C08L2666/24 , C08L2666/16
摘要： The present invention relates to a color-developing agent resin composition, which contains: (1) a phenolic resin represented by formula I; and (2) a blend of graft copolymers of a phenolic resin and a multivalent metal salt polymer of a substituted aryl carboxylic acid, said graft copolymers are represented by (II) and (III). The present invention further relates to a resin emulsion containing the color-developing agent resin composition and a method for preparing the same. The color-developing agent resin composition and the color-developing agent resin emulsion of the present invention are used for no-carbon copying paper as special resin color-developing agents. They have advantages of not only fast developing at a low temperature and bright colors, but also heavy developing strength and good light-aging resistance of writing, and furthermore, their coatings are not easy to turn yellow when they are hold in the air, and the like.
摘要翻译：本发明涉及一种显色剂树脂组合物，其含有：（1）由式I表示的酚醛树脂; 和（2）酚醛树脂和取代的芳基羧酸的多价金属盐聚合物的接枝共聚物的共混物，所述接枝共聚物由（II）和（III）表示。本发明还涉及含有显色剂树脂组合物的树脂乳液及其制备方法。本发明的显色剂树脂组合物和显色剂树脂乳液用作无碳复印纸作为特殊树脂显色剂。它们具有不仅在低温快速发展和明亮的颜色，而且具有显着的强度和良好的耐光老化性能的优点，此外，它们的涂层在空气中保持不易变黄，并且类似。

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