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121. 发明公开

EP2428220A1 Dengue vaccine, pharmaceutical composition comprising the same, and nucleotide molecule 审中-公开
标题翻译：登革热疫苗
公开(公告)号：EP2428220A1
公开(公告)日：2012-03-14
申请号：EP11180973.7
申请日：2011-09-12
申请人： National Cheng Kung University
发明人： Lin, Yee-Shin
IPC分类号： A61K39/12 , C07K14/18 , A61P31/14
CPC分类号： A61K39/12 , C07K14/005 , C12N2770/24111 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： The present invention relates to a dengue vaccine, a pharmaceutical composition including the same, and a nucleotide molecule. The dengue vaccine includes N and C termini-deleted nonstructural protein ΔNC NS1 with a peptide fragment from amino acids 36 to 270, which is derived from dengue virus nonstructural protein 1 (DV NS1) with deletions of N-terminal region from amino acids 1 to 35 and C-terminal region from amino acids 271 to 352. The dengue vaccine of the present invention is depleted of cross-reactivity with endothelial cells and platelets, and can shorten the bleeding time.
摘要翻译：本发明涉及登革热疫苗，含有该登革热疫苗的药物组合物和核苷酸分子。登革热疫苗包括N和C末端缺失的非结构蛋白“NC NS1，其具有来自氨基酸36至270的肽片段，其衍生自具有来自氨基酸1的N-末端区域的登革热病毒非结构蛋白1（DV NS1）至35和C末端区域。本发明的登革热疫苗耗尽与内皮细胞和血小板的交叉反应性，并且可以缩短出血时间。

122. 发明公开

EP2422936A1 Magnetic-controlled actuator with auto-locking function for joints of manipulation arm 有权
标题翻译：磁致动器控制的具有自锁功能，用于操纵臂的关节
公开(公告)号：EP2422936A1
公开(公告)日：2012-02-29
申请号：EP10008821.0
申请日：2010-08-24
申请人： Delta Electronics, Inc. , National Cheng Kung University
发明人： Hsu, Liang-Yi , Wang, Po-Kung , Tsai, Mi-Ching , Cheng, Ming-Yang , Huang, Chien-Chin , Tsai, Ching-Shiong , Sheu, Hong-Cheng
IPC分类号： B25J9/12
CPC分类号： B25J9/126 , H02K7/106
摘要： A magnetic-controlled actuator (100) with an auto-locking function for joints of a manipulation arm mainly includes an inner-layer stator (10), an inner-layer mover (20), an outer-layer mover (30), an outer-layer stator (40), and a fixing shaft (50). The inner-layer mover (20), the outer-layer mover (30), and the outer-layer stator (40) have a plurality of permanent magnets, respectively. The fixed shaft (50) simultaneously penetrates through the inner-layer stator (10), the inner-layer mover (20), the outer-layer mover (30), and the outer-layer stator (40) forming a coaxial arrangement. The inner-layer mover (20) rotates relatively to the inner-layer stator (10) to output power from the actuator (100). Therefore, a cogging effect, which is produced due to interaction of the permanent magnets between the outer-layer mover (30) and the outer-layer stator (40), is automatically produces a high cogging torque for the actuator (100). Thus the actuator (100) provides a sufficient locking force to lock the non-stationary inner-layer mover (20) when a power failure occurs.
摘要翻译：磁控制的致动器（100），其具有自动锁定功能的操作臂的关节主要包括层内的定子（10），在层内移动器（20）外层动机（30），以外层定子（40），以及一固定轴（50）。内层动机（20），所述外层移动器（30），和所述外层定子（40）具有永久磁铁的复数，分别。在固定轴（50）同时通过内层定子（10）穿过，所述内层动机（20），所述外层移动器（30）;以及形成一同轴布置外层定子（40）。内层动机（20）旋转相对于内层定子（10），以输出功率从所述致动器（100）。因此，这是产生由于外层动机（30）和所述外层定子（40）之间的永磁体相互作用的齿槽效应，所有是自动产生高的齿槽转矩的致动器（100）。因此，致动器（100）提供了足够的锁定力。当电源故障的发生以锁定非固定内层动机（20）。

123. 发明公开

EP2410239A2 Method for manufacturing a flexible optical plate, product and backlight module made therewith 有权
标题翻译：一种用于制造柔性光盘，产品的方法，和由此制得的背光模组
公开(公告)号：EP2410239A2
公开(公告)日：2012-01-25
申请号：EP11005881.5
申请日：2011-07-18
申请人： National Cheng Kung University
发明人： Chung, Chen-Kuei , Cheng, Chih-Ching , Lin, Shih-Lung , Syu, Yuan-Jie , Sher, Kun-Lin
IPC分类号： F21V8/00 , G02B6/00
CPC分类号： G02B6/0036 , B29C2059/023 , B29D11/00326 , B29D11/00663 , B29D11/00798 , G02B6/0053 , G02B6/0065 , Y10T428/24355
摘要： A method for manufacturing a flexible optical plate includes steps of: (A) positioning a metallic mask on a surface of a mother substrate; (B) irradiating a carbon dioxide laser beam through the metallic mask to form cavities on the surface of the mother substrate; (C) coating a polymer material on the surface of the mother substrate to fill the cavities; and (D) drying the coated polymer material to form the flexible optical plate, the flexible optical plate having a substrate on the surface of the mother substrate and microstructures protruding from the substrate and each corresponding to one of the cavities.

124. 发明公开

EP2241934A2 Fast photovoltachromic device and the application thereof 有权
标题翻译： Schnelle photovoltachromische Vorrichtung und deren Anwendung
公开(公告)号：EP2241934A2
公开(公告)日：2010-10-20
申请号：EP10159522.1
申请日：2010-04-09
申请人： National Cheng Kung University
发明人： Wu, Jih-Jen , Hsieh, Min-Da , Liao, Wen-Pin , Wu, Wei-Ting , Chen, Jen-Sue , Huang, Jow-Lay
IPC分类号： G02F1/155 , G02F1/163 , E06B9/24 , H01M14/00
CPC分类号： G02F1/155 , B82Y20/00 , G02F1/1523 , G02F1/163 , G02F2001/13324 , G02F2202/36 , H01G9/2022 , H01M4/9016 , H01M4/92 , H01M14/005
摘要： A photovoltachromic device (600) includes a photoelectrode, a counter electrode electrically connected to the photoelectrode, and an electrolyte layer (660) disposed between the photoelectrode and the counter electrode. The photoelectrode includes a first transparent electrode (610) supported by the first transparent substrate (612), an electron-transport layer (630) disposed on the first transparent electrode, and a sensitizing layer (632) disposed on the electron-transport layer. The counter electrode includes a second transparent electrode (620) supported by the second transparent substrate (622) and an electrochromic layer (640) disposed on the second transparent electrode and an auxiliary conductive catalyst layer (650) disposed on the second transparent electrode. The auxiliary conductive catalyst layer contacts both the electrolyte layer (660) and the electrochromic layer (640) thereby accelerating the response times for coloring and bleaching the photovoltachromic device. For achieving a lower transmittance of the photovoltachromic device in colored state the thickness of the electrochromic layer (660) can be increased. The photovoltachromic device (600) may include a switch (670) and a variable resistor (680) instead of an electrical connection between the two transparent electrodes such that the transmittance can be variable by adjusting the resistance.
摘要翻译：光电装置（600）包括光电极，与光电极电连接的对电极，以及设置在光电极和对电极之间的电解质层（660）。光电极包括由第一透明基板（612）支撑的第一透明电极（610），设置在第一透明电极上的电子传输层（630）和设置在电子传输层上的敏化层（632）。对电极包括由第二透明基板（622）支撑的第二透明电极（620）和设置在第二透明电极上的电致变色层（640）和设置在第二透明电极上的辅助导电催化剂层（650）。辅助导电催化剂层与电解质层（660）和电致变色层（640）接触，从而加快色素和漂白光电装置的响应时间。为了在有色状态下实现光电变装置的较低透射率，可以增加电致变色层（660）的厚度。光电装置（600）可以包括开关（670）和可变电阻器（680），而不是两个透明电极之间的电连接，使得透射率可以通过调节电阻而变化。

125. 发明公开

EP2170950A1 ANTI-IL-20 ANTIBODY AND ITS USE IN TREATING IL-20 ASSOCIATED INFLAMMATORY DISEASES 审中-公开
标题翻译：抗IL-20抗体及其USE IN与IL-20相关的炎性疾病治疗的
公开(公告)号：EP2170950A1
公开(公告)日：2010-04-07
申请号：EP08770662.8
申请日：2008-06-11
申请人： National Cheng Kung University
发明人： CHANG, Ming-shi
IPC分类号： C07K16/00 , C07K16/24 , C12P21/04 , A61K51/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要： This invention features an antibody specifically binding to human IL-20 (e.g., mAb 7E and a equivalent thereof) and its use in treating an IL-20 associated inflammatory disease, such as atherosclerosis, RA, psoriasis, psoriatic arthritis, bacteria-induced gastric ulcer, and acute renal failure.

126. 发明申请

WO2019094732A1 INHIBITORS OF CYCLIC-AMP RESPONSE ELEMENT-BINDING PROTEIN 审中-公开
公开(公告)号：WO2019094732A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/060048
申请日：2018-11-09
申请人： ACADEMIA SINICA , NATIONAL CHENG KUNG UNIVERSITY , CHEN, Ching-Shih , WU, Chia-Hsien , HSIEH, I-Shan , HUANG, Po-Hsien
发明人： CHEN, Ching-Shih , WU, Chia-Hsien , HSIEH, I-Shan , HUANG, Po-Hsien
IPC分类号： C07D207/34 , C07D213/75 , C07D237/20 , C07D241/20 , C07D265/12 , C07D291/08 , C07D295/104 , C07D471/04 , C07C235/56 , C07C309/76
摘要： The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating diseases associated with the binding of CREB to CREB-binding protein (CBP) and/or the CREB-CBP pathway, ( e.g ., proliferative diseases, for example, cancer ( e.g ., lung cancer or breast cancer), and inflammatory disease ( e.g. , pancreatic fibrosis or liver fibrosis)). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

127. 发明申请

WO2015153582A1 TREATMENT OF INFLAMMATORY PAIN USING IL-20 ANTAGONISTS 审中-公开
标题翻译：使用IL-20拮抗剂治疗炎症性疼痛
公开(公告)号：WO2015153582A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/023548
申请日：2015-03-31
申请人： NATIONAL CHENG KUNG UNIVERSITY , CHANG, Ming-Shi , LIU, Yen-Chen , SHEN, Meng-Ru
发明人： CHANG, Ming-Shi , LIU, Yen-Chen , SHEN, Meng-Ru
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/76
摘要： Reducing inflammatory pain in a subject having or being suspected of having an inflammatory pain using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.
摘要翻译：使用IL-20拮抗剂减轻患有或怀疑患有炎性疼痛的受试者的炎性疼痛，IL-20拮抗剂可以是阻断由IL-20介导的信号传导途径的抗体。这些抗体包括特异性阻断IL-20信号通路的抗IL-20抗体和抗IL-20R抗体。

128. 发明申请

WO2012018801A2 SUPPRESSING BONE LOSS WITH ANTI-IL-19 ANTIBODY 审中-公开
标题翻译：用抗IL-19抗体抑制骨质疏松
公开(公告)号：WO2012018801A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046248
申请日：2011-08-02
申请人： NATIONAL CHENG KUNG UNIVERSITY , CHANG, Ming-Shi
发明人： CHANG, Ming-Shi
IPC分类号： A61K39/395 , C07K16/24 , A61P19/08 , A61P35/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/73
摘要： A method of suppressing bone loss with an anti-IL-19 antibody, optionally in combination with an anti-IL-20 antibody or an anti-RANKL antibody.
摘要翻译：用抗IL-19抗体抑制骨丢失的方法，任选与抗IL-20抗体或抗RANKL抗体组合。

129. 发明申请

WO2011163223A1 METHOD OF ANALYZING INTRINSIC PARALLELISM OF ALGORITHM 审中-公开
标题翻译：分析算法的内部并行性的方法
公开(公告)号：WO2011163223A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041243
申请日：2011-06-21
申请人： LEE, Gwo-Giun , LIN, He-Yuan , NATIONAL CHENG KUNG UNIVERSITY
发明人： LEE, Gwo-Giun , LIN, He-Yuan
IPC分类号： G06F9/45
CPC分类号： G06F17/10 , G06F8/456
摘要： A method of analyzing intrinsic parallelism of an algorithm, comprising: generating a dataflow graph which is composed of vertexes representing computation and directed edges denoting the dependency and flow of data from the algorithm; building a matrix representing the dataflow graph; and quantifying the intrinsic parallelism based on rank and dimension of the matrix representing the generated dataflow graph.
摘要翻译：一种分析算法的本征并行性的方法，包括：生成由表示计算的顶点和表示来自算法的数据的依赖性和流动的有向边组成的数据流图; 构建表示数据流图的矩阵; 并且基于表示生成的数据流图的矩阵的等级和维度量化本征并行度。

130. 发明申请

WO2011014155A1 PREPARATION OF HIGH PURITY COLLAGEN 审中-公开
标题翻译：高纯度胶原蛋白的制备
公开(公告)号：WO2011014155A1
公开(公告)日：2011-02-03
申请号：PCT/US2009/051827
申请日：2009-07-27
申请人： NATIONAL CHENG KUNG UNIVERSITY , LIFE FUSION, LLC. , HUANG, Lynn, L.H.
发明人： HUANG, Lynn, L.H.
IPC分类号： A23L1/0562 , A23L1/015
CPC分类号： A23J1/10 , A23J3/342 , A23L29/284 , A23L33/28
摘要： A method of preparing collagen by first producing a collagen matrix and then extracting collagen from the matrix.
摘要翻译：通过首先产生胶原基质，然后从基质中提取胶原蛋白来制备胶原蛋白的方法。

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