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    • 115. 发明公开
    • Heterocyclic amides
    • 杂环酰胺。
    • EP0190685A2
    • 1986-08-13
    • EP86101300.1
    • 1986-01-31
    • G.D. Searle & Co.
    • Mueller, Richard AugustPartis, Richard Allen
    • C07D295/18C07D207/16
    • C07D295/185C07C319/02C07C331/10C07D207/16C07C323/20C07C323/52
    • The compounds of this invention are heterocyclic amides represented by the formula:
      wherein: R 1 and R 2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a
      group wherein q, r and t are independently an integer of from 1 to 8 provided that q + r + t is equal to or less than 10; Y is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene, and R 3 is a heterocyclic amine represented by the formula
      wherein R 4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl; X is selected from the group consisting of N-R 4 , 0 and CH 2 ; m is 2 or 3; n is 2 or 3 when X is O or N-R 4 , and n is 1 to 3 when X is CH 2 ; p is 0 to 2; and the pharmaceutically acceptable salts thereof. The compounds are anti-inflammatory and anti-allergy agents.
    • 本发明的化合物是由下式表示的杂环酰胺:其中:R1和R2是卤素,苯基,取代的苯基和基团中相同或不同的成员,其中q,r和t 独立地为1〜8的整数,条件是q + r + t等于或小于10; Y是硫代,亚磺酰基或磺酰基; Alk是直链或支链低级亚烷基,R3是由式CHEM表示的杂环胺,其中R4选自氢,低级烷基,苯基,取代的苯基,苄基,取代的苄基,羧基或羧基低级烷基; X选自N-R 4,O和CH 2; m为2或3; 当X为O或N-R 4时,n为2或3,当X为CH 2时,n为1至3; p为0〜2; 及其药学上可接受的盐。 这些化合物是抗炎和抗过敏剂。