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111. 发明授权

US09802061B2 Apparatus for particle therapy verification comprising a collimator with multiple openings 有权
公开(公告)号：US09802061B2
公开(公告)日：2017-10-31
申请号：US14707828
申请日：2015-05-08
申请人： ION BEAM APPLICATIONS S.A. , Université Claude Bernard Lyon 1 , Institut National des Science Appliquées de Lyon , Centre National de Recherche Scientifique (CNRS)
发明人： Nicolas Freud , Frauke Roellinghoff , Etienne Testa , Marco Pinto , Julien Smeets
IPC分类号： A61N5/10 , A61B6/00 , G01T1/29
CPC分类号： A61N5/1071 , A61B6/4216 , A61B6/4258 , A61B6/4291 , A61N5/1031 , A61N5/1043 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087 , G01T1/29
摘要： The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera.

112. 发明申请

US20170304652A1 Systems and Methods for the Verification of Source Placement for Brachytherapy Radiation Procedures Using Real Time Radiation Detectors 审中-公开
公开(公告)号：US20170304652A1
公开(公告)日：2017-10-26
申请号：US15517624
申请日：2015-10-09
申请人： Duke University
发明人： Matthew D. Belley , Michael J. Therein , Ian N. Stanton , Terry T. Yoshizumi , Brian W. Langloss , Oana I. Craciunescu , Junzo P. Chino
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61N5/1001 , A61N5/1075 , A61N2005/1076
摘要： The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to provide real-time information indicative of ionizing radiation emitted by a radiation source. A controller may perform operations including receiving, from the radiation detector, real-time information indicative of at least one of: a particle flux rate, an energy fluence, or an absorbed dose of ionizing radiation emitted from the radiation source. The operations may also include determining, based on the received information, at least one of: a location of the radiation source or a dwell time of the radiation source.

113. 发明授权

US09789339B2 System design and method for verifying 3D dosimetric imaging of charged particles in media 有权
公开(公告)号：US09789339B2
公开(公告)日：2017-10-17
申请号：US15370022
申请日：2016-12-06
申请人： Purdue Research Foundation , St. Jude Children's Research Hospital, Inc.
发明人： Vadim Moskvin , Keith Michael Stantz
IPC分类号： A61N5/10 , A61B8/08
CPC分类号： A61N5/1071 , A61B8/08 , A61B8/0833 , A61B8/483 , A61B2019/524 , A61N5/1031 , A61N5/1039 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087
摘要： A method of verifying therapeutic proton beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) proton dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam.

114. 发明授权

US09707411B2 Hadron radiation installation and verification method 有权
公开(公告)号：US09707411B2
公开(公告)日：2017-07-18
申请号：US14351391
申请日：2012-10-12
申请人： Technische Universiteit Delft
发明人： Frederik Johannes Beekman , Victor Robert Bom
IPC分类号： A61N5/10 , G01T1/29
CPC分类号： A61N5/1067 , A61N5/1043 , A61N5/1048 , A61N5/1071 , A61N5/1075 , A61N5/1084 , A61N2005/1052 , A61N2005/1076 , A61N2005/1087 , G01T1/2935
摘要： A hadron radiation installation adapted to subject a target to irradiation by a hadron radiation beam includes a target support configured to support, preferably immobilize, a target; a hadron radiation apparatus adapted to emit a hadron radiation beam along a beam axis to irradiate the target supported by the target support, the radiation beam penetrating into the target. The radiation apparatus has a control system at least comprising a beam penetration depth control allowing at least to control and vary the penetration depth of the radiation beam into the target. The installation has a radiation beam range sensor device adapted to determine the penetration depth of said radiation beam into the target, where the range sensor device includes a gamma camera responsive to prompt gamma rays that are emitted while the hadron radiation beam penetrates into the target.

115. 发明申请

US20170165502A1 PARTICLE THERAPY SYSTEM AND METHOD WITH PARALLEL CONTROL OF ENERGY VARIATION AND BEAM POSITION VARIATION 有权
公开(公告)号：US20170165502A1
公开(公告)日：2017-06-15
申请号：US15375259
申请日：2016-12-12
申请人： Ion Beam Applications
发明人： Yves Claereboudt , Damien Prieels
IPC分类号： A61N5/10 , H05H7/04
CPC分类号： A61N5/1043 , A61N5/103 , A61N5/107 , A61N5/1081 , A61N2005/1076 , A61N2005/1087 , H05H7/04 , H05H13/005 , H05H13/02 , H05H13/04 , H05H2007/048 , H05H2245/122
摘要： The present disclosure relates to a particle therapy system for irradiating a target with a scanning beam technique. In one implementation, the system includes an irradiation planning device with a planning algorithm configured to associate a particle beam energy E(i) to each spot of the irradiation plan and organize the spots in a sequence of spots according to energy. The system may further include a control system configured for controlling in parallel, from spot to spot, a variation of an output energy of a beam generator, a variation of a magnetic field of one or more electromagnets of a beam transport system and a variation of a magnetic field of the scanning magnet.

116. 发明授权

US09643029B2 Dosimetric end-to-end verification devices, systems, and methods 有权
公开(公告)号：US09643029B2
公开(公告)日：2017-05-09
申请号：US14038595
申请日：2013-09-26
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： Stefan Scheib
IPC分类号： A61N5/10 , A61B6/00
CPC分类号： A61N5/1075 , A61N5/1049 , A61N5/1071 , A61N2005/1052 , A61N2005/1055 , A61N2005/1058 , A61N2005/1061 , A61N2005/1076
摘要： Dosimetrical end-to-end quality assurance devices, systems, and methods for radiation devices using X-ray imaging, optical surface imaging, and electromagnetic navigational systems to position the quality assurance device either absolute or relative in space.

117. 发明授权

US09586060B2 Method and system for calorimetry probe 有权
标题翻译：量热探针的方法和系统
公开(公告)号：US09586060B2
公开(公告)日：2017-03-07
申请号：US14403416
申请日：2013-05-29
申请人： The Royal Institution for the Advancement of Learning / McGill University
发明人： Jan Seuntjens , Arman Sarfehnia , James Renaud
IPC分类号： G01T1/12 , A61N5/10 , G01K17/00
CPC分类号： A61N5/1071 , A61N5/1075 , A61N2005/1076 , G01K17/003 , G01T1/12
摘要： Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner. According to embodiments of the invention novel compact graphite probe calorimeters are provided.
摘要翻译：放射治疗是癌症最有效的治疗方法之一，其成功主要取决于准确的靶向和正确辐射剂量的传播。因此，准确的剂量测定对于维持和改善患者的存活率至关重要。然而，目前尺寸和长时间的等待时间目前将水和石墨基热量计限于标准实验室，将基于现场的剂量测定法取决于参考场规定校准因子的电离室测量。因此，为放射治疗设备操作者提供临床参考剂量测定法的直接方法将是有益的，其中剂量计提供增加的剂量，剂量率，辐射能量和能量类型的独立性等。将这种新型临床剂量计作为紧凑，作为常规用于测量的二级标准，并允许直接和绝对地测量放射治疗剂量。根据本发明的实施例，提供了新颖的小型石墨探针量热计。

118. 发明授权

US09545527B2 System design and method for verifying 3D dosimetric imaging of charged particles in media 有权
标题翻译：用于验证介质中带电粒子的3D剂量测量成像的系统设计和方法
公开(公告)号：US09545527B2
公开(公告)日：2017-01-17
申请号：US14888363
申请日：2014-04-30
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , PURDUE RESEARCH FOUNDATION
发明人： Vadim Moskvin , Keith Michael Stantz
IPC分类号： A61N5/00 , A61N5/10 , A61B8/08 , A61B19/00
CPC分类号： A61N5/1071 , A61B8/08 , A61B8/0833 , A61B8/483 , A61B2019/524 , A61N5/1031 , A61N5/1039 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087
摘要： A method of verifying therapeutic beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam.
摘要翻译：一种通过超声断层成像来验证治疗束传递精度的方法，通过从质子束检测电离辐射引起的热声信号来映射三维（3D）剂量。

119. 发明申请

US20160279445A1 METHOD, APPARATUS, AND SYSTEM FOR MANUFACTURING PHANTOM CUSTOMIZED TO PATIENT 审中-公开
标题翻译：用于制造定制患者的方法，装置和系统
公开(公告)号：US20160279445A1
公开(公告)日：2016-09-29
申请号：US14778515
申请日：2014-03-18
申请人： SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： Sang Gyu JU
IPC分类号： A61N5/10 , B29C67/00 , G06F19/00
CPC分类号： A61N5/1075 , A61B6/583 , A61N5/1039 , A61N5/1045 , A61N5/1071 , A61N2005/1074 , A61N2005/1076 , B29C64/386 , B29L2031/753 , G09B23/286 , G09B23/30 , G16H50/50
摘要： An apparatus and method for generating print data about a phantom customized to a patent, the apparatus receive medical images including anatomical information of a patient's body and treatment plan information about a dose distribution of a radiation to be irradiated to a treatment area, reconstructs a three-dimensional phantom image in which internal and external structures of the patient's body are modeled which are based on the anatomical information and in which a space for a dosimeter is modeled which is to be inserted into the internal and external structures so as to verify the dose distribution according to the treatment plan information, and generates print data for three-dimensional printing, which is used for manufacturing the phantom customized to the patient on the basis of the reconstructed three-dimensional phantom image.
摘要翻译：用于产生关于专利定制的幻影的打印数据的装置和方法，该装置接收包括患者身体的解剖信息的医学图像和关于待照射到治疗区域的辐射的剂量分布的治疗计划信息，重建三个其中建模患者身体的内部和外部结构是基于解剖学信息并且其中用于剂量计的空间被建模以插入到内部和外部结构中以便验证剂量的维度幻影图像根据处理计划信息分配，并且基于重建的三维幻影图像生成用于制造针对患者定制的体模的三维打印用打印数据。

120. 发明申请

US20160199667A1 METHOD AND SYSTEM FOR DYNAMICALLY-TRIMMED SPOT SCANNING FOR ION THERAPY 审中-公开
标题翻译：用于离子治疗的动态斑点扫描的方法和系统
公开(公告)号：US20160199667A1
公开(公告)日：2016-07-14
申请号：US14897077
申请日：2014-07-03
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： Ryan Flynn , Daniel HYER , Dongxu WANG , Patrick HILL , Yves CLAEREBOUDT
IPC分类号： A61N5/10
CPC分类号： A61N5/1043 , A61N5/103 , A61N2005/1076 , A61N2005/1087 , A61N2005/1095 , G21K1/04 , G21K1/10
摘要： A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.
摘要翻译：一种点扫（SS）离子治疗系统，配置用于动态修整离子粒子笔束以减少靶边界外的辐射剂量。

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