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111. 发明申请

WO2010087975A1 TRANSAPICAL MINI-INTRODUCER HOMEOSTASIS VALVE AND PUNCH 审中-公开
标题翻译：透视微型引导器家用阀门和PUNCH
公开(公告)号：WO2010087975A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/000249
申请日：2010-01-29
申请人： ST. JUDE MEDICAL, INC. , CHALEKIAN, Aaron J.
发明人： CHALEKIAN, Aaron J.
IPC分类号： A61B17/34
CPC分类号： A61B17/3421 , A61B17/32053 , A61B17/3462 , A61B17/3498 , A61B2017/00243 , A61B2017/00247 , A61B2017/3425 , A61B2017/346 , A61B2017/3488
摘要： An introducer for providing access to the interior of the heart generally includes a valve, a shaft, and a piercing element. The valve has a substantially closed state in the absence of an instrument inside the valve and an open state in the presence of the instrument inside the valve. The shaft has first and second ends. The piercing element is located at the first end of the shaft. The shaft is removably positioned inside the valve in an assembled condition. The valve is dimensioned to receive the instrument therein upon removal of the shaft from the valve.
摘要翻译：用于提供进入心脏内部的导引器通常包括阀，轴和穿刺元件。阀门内没有仪器时，阀门具有基本上关闭的状态，阀门内存在仪器时打开状态。轴具有第一和第二端。穿刺元件位于轴的第一端。轴在组装状态下可拆卸地定位在阀的内部。该阀的尺寸设计成在从阀上取下轴时接收仪器。

112. 发明申请

WO2010008549A1 AXIALLY ANCHORING COLLAPSIBLE AND RE-EXPANDABLE PROSTHETIC HEART VALVES FOR VARIOUS DISEASE STATES 审中-公开
标题翻译：对各种疾病状态进行轴向锚定和可再膨胀的预防心脏瓣膜
公开(公告)号：WO2010008549A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/004095
申请日：2009-07-15
申请人： ST. JUDE MEDICAL, INC. , BRAIDO, Peter N. , NEUMAN, Julia A. , BENSON, Thomas M.
发明人： BRAIDO, Peter N. , NEUMAN, Julia A. , BENSON, Thomas M.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A stent (10) for use in a prosthetic heart valve has an annulus section (12) adapted for placement within the ' leaflets and annulus of the native heart valve. The annulus section has latch members (50) adapted to engage the leaflets of the native heart valve when prosthetic valve is implanted in the native valve. The latch members may hold the leaflets in engagement with the annulus section, and help to retain the prosthetic valve in position. The annulus section may have a non-circular cross-sectional shape.
摘要翻译：用于假体心脏瓣膜的支架（10）具有适于放置在天然心脏瓣膜的小叶和环形空间内的环形部分（12）。环形部分具有闩锁构件（50），当人工瓣膜植入天然瓣膜时，该构件适于接合天然心脏瓣膜的小叶。闩锁构件可以将小叶保持与环形部分接合，并且有助于将假体瓣保持在适当位置。环形部分可以具有非圆形横截面形状。

113. 发明申请

WO2008153872A2 DEVICES FOR TRANSCATHETER PROSTHETIC HEART VALVE IMPLANTATION AND ACCESS CLOSURE 审中-公开
标题翻译：用于运输系统前置心脏瓣膜植入和进入闭合的装置
公开(公告)号：WO2008153872A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/007012
申请日：2008-06-04
申请人： ST. JUDE MEDICAL, INC. , BRAIDO, Peter N.
发明人： BRAIDO, Peter N.
IPC分类号： A61B17/00 , A61B17/32
CPC分类号： A61B17/32 , A61B17/0057 , A61B17/32053 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/320064
摘要： Apparatus for use in conjunction with implanting a collapsible and re-expandable prosthetic heart valve in a patient by means that are less invasive than traditional open-chest, open-heart surgery. The apparatus may include a one-way valve for preventing blood from escaping from the patient's circulatory system when that system is entered in order to get the prosthetic heart valve into that system. The apparatus may include various forms of cutters for gaining access to the patient's circulatory system. The apparatus may include various forms of devices for quickly closing the access to the patient's circulatory system after the prosthetic heart valve has been implanted.
摘要翻译：通过与传统的开胸胸腔开放心脏手术相比侵入性较低的手段，与患者一起植入可塌陷和可再膨胀的假体心脏瓣膜的装置。该装置可以包括单向阀，用于当输入该系统时防止血液从患者的循环系统中逸出，以便将假体心脏瓣膜置于该系统中。该装置可以包括用于获得患者循环系统的各种形式的切割器。该装置可以包括各种形式的装置，用于在植入人造心脏瓣膜之后快速关闭对患者循环系统的接近。

114. 发明申请

WO2008112243A1 PROSTHETIC HEART VALVES WITH FLEXIBLE LEAFLETS 审中-公开
标题翻译：具有柔韧性叶片的前置心脏瓣膜
公开(公告)号：WO2008112243A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003252
申请日：2008-03-12
申请人： ST. JUDE MEDICAL, INC. , LI, Xuemei , WOO, Yi-ren
发明人： LI, Xuemei , WOO, Yi-ren
IPC分类号： A61F2/24
CPC分类号： A61F2/2415
摘要： A prosthetic heart valve (10) of the type that includes a hollow annular stent (20) and a plurality of flexible leaflets (30a, 30b, 30c) that are attached to the stent. One or more fixture structures (i.e. clips (10Oa)) are used to attach the leaflets to the stent so that sutures do not have to be used for that purpose. The fixture structures preferably extend annularly at least substantially all the way around the valve. Surfaces of the fixture structures that can come into contact with portions of the leaflets that move during use of the valve can be shaped to help beneficially shape those leaflet portions during their movements.
摘要翻译：一种假体心脏瓣膜（10），其包括中空的环形支架（20）和附接到支架的多个柔性小叶（30a，30b，30c）。使用一个或多个夹具结构（即夹子（100A））将传单附接到支架上，使得缝合线不必用于该目的。固定结构优选地至少基本上围绕阀全部地环向延伸。能够与使用阀门期间移动的小叶的部分接触的夹具结构的表面可以被成形为有助于在移动过程中有利地塑造这些叶片部分。

115. 发明申请

WO2006093970A1 TISSUE ANCHOR APPARATUS 审中-公开
标题翻译：组织锚固装置
公开(公告)号：WO2006093970A1
公开(公告)日：2006-09-08
申请号：PCT/US2006/007101
申请日：2006-02-28
申请人： ST. JUDE MEDICAL, INC. , BRENZEL, Michael P. , DALE, Theodore P. , COSTELLO, David M. , HINDRICHS, Paul J.
发明人： BRENZEL, Michael P. , DALE, Theodore P. , COSTELLO, David M. , HINDRICHS, Paul J.
IPC分类号： A61B17/00
CPC分类号： A61B19/54 , A61B17/32053 , A61B90/39 , A61B2017/00243 , A61B2017/00575 , A61B2017/00623 , A61B2017/00986
摘要： A structure that can be used to provide an anchor in or adjacent to a patient's soft body tissue (rather than bone) includes an annular array of flexible members that extend between two axially spaced but aligned tubular members. The space between the tubular members can be selectively changed to affect the amount by which portions of the flexible members between the tubular member project radially outward relative to the tubular members. When the flexible members project radially out, the structure resists axial movement relative to adjacent tissue and therefore acts as an anchor. When the flexible members do not project radially out, they permit axial movement of the structure through adjacent tissue.
摘要翻译：可以用于在患者的软体组织（而不是骨骼）中或邻近提供锚的结构包括在两个轴向间隔开但对准的管状构件之间延伸的柔性构件的环形阵列。可以选择性地改变管状构件之间的空间以影响管状构件之间的柔性构件的一部分相对于管状构件径向向外突出的量。当柔性构件径向突出时，结构抵抗相对于相邻组织的轴向运动，因此用作锚固件。当柔性构件不径向伸出时，它们允许结构体通过相邻组织的轴向运动。

116. 发明申请

WO2005122963A1 ANNULOPLASTY PROSTHESES WITH IMPROVED ANCHORING STRUCTURES, AND RELATED METHODS 审中-公开
标题翻译：具有改进的锚固结构的ANNOLOPLASTY前景和相关方法
公开(公告)号：WO2005122963A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020525
申请日：2005-06-10
申请人： St. Jude Medical, Inc. , LIM, Jyue Boon
发明人： LIM, Jyue Boon
IPC分类号： A61F2/24
CPC分类号： A61F2/2445
摘要： An annuloplasty prosthesis (10) is less than a complete ring (e.g., it may be C-shaped or U-shaped). The prosthesis has a structural member (20) that basically gives the prosthesis its shape. The structural member is provided with surface portions that are transverse (22a, 22b) to adjacent portions of the surface of the structural member. At least two of these transverse surface portions are spaced from one another and face toward one another along the length of the structural member. Sutures (30a1, 30a2, 30b1, 30b2) that are used to implant the prosthesis and that are respectively adjacent to these two transverse surface portions are thereby prevented from moving farther apart along the length of the prosthesis.
摘要翻译：瓣膜成形假体（10）小于完整的环（例如，其可以是C形或U形）。假体具有基本上给予假体其形状的结构构件（20）。结构构件设置有与结构构件的表面的相邻部分横向（22a，22b）的表面部分。这些横向表面部分中的至少两个彼此间隔开并且沿着结构构件的长度朝向彼此面对。用于植入假体并且分别邻近这两个横向表面部分的缝合线（30a1,30b2,301a，30b2）因此被防止沿着假体长度移动得更远。

117. 发明申请

WO2005112829A1 HEART VALVE ANNULOPLASTY SEWING CUFFS AND METHODS OF MAKING SAME 审中-公开
标题翻译：心脏瓣膜吻合缝及其制造方法
公开(公告)号：WO2005112829A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/016675
申请日：2005-05-12
申请人： ST. JUDE MEDICAL, INC. , LIM, Jyue Boon , MCCARTHY, Andrea L.
发明人： LIM, Jyue Boon , MCCARTHY, Andrea L.
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61F2/2409 , A61F2/2445 , A61F2/2448
摘要： An annuloplasty prosthesis (10) for a heart valve has a sewing cuff (50) added to the conventional structure. The sewing cuff is preferably an extension of the fabric cover (40) that is provided around the core (20) of the prosthesis. The sewing cuff preferably extends radially outwardly from cross sections of the remainder of the prosthesis. Methods of making such a sewing cuff are also disclosed.
摘要翻译：用于心脏瓣膜的瓣环成形假体（10）具有添加到常规结构的缝合箍（50）。缝合箍最好是设置在假体的芯部（20）周围的织物罩（40）的延伸部。缝合箍优选地从假体的其余部分的横截面径向向外延伸。还公开了制造这种缝合袖口的方法。

118. 发明申请

WO2003053490A1 COMPOSITE BIOCOMPATIBLE MATRICES COMPRISING COLLAGEN AND ELASTIN 审中-公开
标题翻译：包含COLLAGEN和ELASTIN的复合生物成像矩阵
公开(公告)号：WO2003053490A1
公开(公告)日：2003-07-03
申请号：PCT/US2002/041109
申请日：2002-12-19
申请人： ST. JUDE, MEDICAL, INC.
发明人： KELLY, Sheila, J. , OGLE, Matthew, F.
IPC分类号： A61L27/40
CPC分类号： A61L27/3843 , A61F2/2415 , A61L27/48 , A61L27/507
摘要： A composite matrix has a first layer and a second layer. The first layer includes at least about 5 dry weight percent flexibility modifying agent. The second layer includes at least about 5 dry weight percent less flexibility modifying agent than the first layer. A valved prosthesis with flexible leaflets supported by a wall can be formed from the composite materials. In some embodiments, the wall of the prosthesis includes a first layer with at least about 60 weight percent collagen and a second layer with at least about 25 weight percent collagen and at least about 5 weight percent elastin. The leaflets preferably include a first layer with at least about 60 weight percent collagen and a second layer with at least about 25 weight percent collagen and at least about 5 weight percent proteoglycans.
摘要翻译：复合矩阵具有第一层和第二层。第一层包括至少约5重量％的柔性改性剂。第二层包括比第一层少至少约5干重量％的柔性改性剂。可以由复合材料形成具有由壁支撑的柔性小叶的带瓣假体。在一些实施方案中，假体的壁包括具有至少约60重量％胶原的第一层和具有至少约25重量％胶原蛋白和至少约5重量％弹性蛋白的第二层。小叶优选包括具有至少约60重量％胶原的第一层和具有至少约25重量％胶原蛋白和至少约5重量％蛋白多糖的第二层。

119. 发明申请

WO2003024366A1 POLYMER LEAFLET DESIGNS FOR MEDICAL DEVICES 审中-公开
标题翻译：用于医疗器械的聚合物叶片设计
公开(公告)号：WO2003024366A1
公开(公告)日：2003-03-27
申请号：PCT/US2002/029786
申请日：2002-09-19
申请人： ST. JUDE MEDICAL, INC.
发明人： CAI, Chad, Q. , KRUSE, Stephen, D. , KURK, James, L. , WOO, Yi-Ren
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2250/0029
摘要： Valved prostheses include a support structure (108) and a plurality of flexible polymer leaflets (107, 104, 106) connected to the support structure, in which the leaflets have an improved structural design. The support structure has a plurality of commissure supports (114, 116, 118) and scallops (120, 122, 124) between the commissure supports. Generally, the flexible polymer leaflets project away from the support structure at an attachment edge (A) where the leaflets connect to the support structure. In particular embodiments, the leaflets at the attachment edge are at an angle from about 5 degrees to about 85 degrees relative to a plane normal to the valve axis. In some embodiments, the flexible polymer leaflets having a coaptation depth (D) from about 0.3 times the valve radius (R) to about 0.8 times the valve radius (R). In further embodiments, the flexible polymer leaflets form a valve with a valve height (H) from about one times the valve radius (R) to about 2 'times the valve radius (R) and have leaflet lengths (L) at least about 1 millimeter greater than the valve radius (R).
摘要翻译：带阀的假体包括支撑结构（108）和连接到支撑结构的多个柔性聚合物单张（107,104,106），其中传单具有改进的结构设计。支撑结构在连接支撑之间具有多个连合支撑（114,116,118）和扇贝（120,122,124）。一般来说，柔性聚合物传单在附件边缘（A）处远离支撑结构突出，其中传单连接到支撑结构。在特定实施例中，附接边缘处的小叶相对于垂直于阀轴线的平面为约5度至约85度的角度。在一些实施例中，柔性聚合物小叶具有约0.3倍阀半径（R）至约0.8倍阀半径（R）的接合深度（D）。在另外的实施方案中，柔性聚合物小叶形成阀，阀的高度（H）约为阀半径（R）的大约一倍，大约为阀门半径（R）的2倍，叶片长度（L）至少约为1 毫米比阀门半径（R）大。

120. 发明申请

WO1997027886A1 CALCIFICATION-RESISTANT BIOMATERIALS 审中-公开
标题翻译：耐辐射生物材料
公开(公告)号：WO1997027886A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001526
申请日：1997-02-05
申请人： ST. JUDE MEDICAL, INC.
发明人： ST. JUDE MEDICAL, INC. , SCHROEDER, Richard, F. , OGLE, Matthew, F.
IPC分类号： A61L27/00
CPC分类号： A61L27/3604 , A61L27/50 , A61L2400/02
摘要： The invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of calcification inhibitors releasably bound thereto. The storage structure can be a protein or a synthetic polymer. The calcification inhibitors include metal ions and phosphatase inhibitors generally. Bifunctional metal chelators can be bound to endogenous proteins to deliver metal ions.
摘要翻译：本发明的特征在于生物假体制品，其包括具有至少一种结合的外源储存结构的生物相容性材料，所述储存结构具有可释放地结合于其上的钙化抑制剂。储存结构可以是蛋白质或合成聚合物。钙化抑制剂通常包括金属离子和磷酸酶抑制剂。双功能金属螯合剂可以与内源蛋白结合以递送金属离子。

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