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111. 发明申请

US20110028837A1 Photodynamic-based myocardial mapping device and method 审中-公开
标题翻译：基于光动力学的心肌贴壁装置及方法
公开(公告)号：US20110028837A1
公开(公告)日：2011-02-03
申请号：US12934601
申请日：2009-04-02
申请人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
发明人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
IPC分类号： A61B6/00 , A61B1/07 , A61B1/04
CPC分类号： A61B5/6859 , A61B1/07 , A61B5/0044 , A61B5/0071 , A61B5/0084 , A61B5/4839 , A61B5/6858 , A61B5/7278 , A61B2562/0233 , A61B2562/046 , A61B2576/023 , A61M5/007 , A61M25/007 , A61M25/0147
摘要： A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances.
摘要翻译：光动力测绘装置包括具有近端和远端的轴，在轴的远端处的至少一个光电极和位于轴内部的至少一个光纤。在实施例中，至少一个光纤从轴的远端延伸并且耦合到设置在设备的外表面处或周围的至少一个光电极。在一个实施例中，至少一个光纤在轴的近端处或周围耦合到耦合的光源和光学传感器。分析仪可以耦合到光学传感器。这种装置的实施例可以被配置为递送物质，例如光动力学治疗物质。

112. 发明申请

US20090171331A1 SYSTEMS AND METHODS OF PHOTODYNAMIC-BASED CARDIAC ABLATION VIA THE ESOPHAGUS 失效
标题翻译：以ESOPHAGUS为基础的基于光化学的心脏病患者的系统和方法
公开(公告)号：US20090171331A1
公开(公告)日：2009-07-02
申请号：US12345569
申请日：2008-12-29
申请人： Saurav Paul , Isreal A. Byrd
发明人： Saurav Paul , Isreal A. Byrd
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B90/39 , A61B2017/00084 , A61B2018/2272 , A61B2090/065 , A61B2090/3954 , A61N5/0601 , A61N5/062
摘要： Systems and methods for photodynamic ablation of cardiac tissue via an esophagus are disclosed. An exemplary system includes an ablation catheter having an expandable distal end for securing the ablation catheter in the esophagus. The distal end of the ablation catheter contains at least one light source operable to activate a photodynamic substance delivered to the target area of the cardiac tissue to be ablated and form a lesion. The system also includes at least one feedback device contained in the distal end of the ablation catheter. The at least one feedback device provides feedback for at least one of: positioning a distal end of an ablation catheter in a desired position in the esophagus adjacent a target area of the cardiac tissue to be ablated, forming an adequate lesion, and assessing lesion formation.
摘要翻译：公开了通过食道对心脏组织的光动力消融的系统和方法。示例性系统包括具有用于将消融导管固定在食道中的可扩展远端的消融导管。消融导管的远端包含至少一个光源，其可操作以激活被输送到待烧蚀的心脏组织的靶区域并形成病变的光动力物质。该系统还包括包含在消融导管的远端中的至少一个反馈装置。所述至少一个反馈装置为以下中的至少一个提供反馈：将消融导管的远端定位在邻近被切除的心脏组织的靶区域的食道中的期望位置，形成足够的损伤，以及评估损伤形成。

113. 发明申请

US20090158852A1 Contact Sensing Flexible Conductive Polymer Electrode 有权
标题翻译：接触感应柔性导电聚合物电极
公开(公告)号：US20090158852A1
公开(公告)日：2009-06-25
申请号：US11963321
申请日：2007-12-21
申请人： Saurav Paul , Chou Thao , Troy T. Tegg
发明人： Saurav Paul , Chou Thao , Troy T. Tegg
IPC分类号： G01L9/00 , H01S4/00
CPC分类号： G01L1/16 , A61B5/042 , A61B5/6885 , G01L5/0038 , Y10T29/49002
摘要： A contact sensing catheter system includes a catheter shaft having a distal end; a flexible conductive polymer electrode located at the distal end of the shaft; and an electromechanical contact sensor positioned at least partially within the electrode. The sensor outputs an electrical signal in response to a mechanical force acting thereon. The sensor may be a piezoelectric sensor, a strain gauge, a fiber optic sensor, or another suitable electromechanical contact sensor. The electrical signal output by the sensor typically varies in response to variations in the mechanical force acting on the sensor. An output device may receive the signal output by the contact sensor and present to a user of the system an indicator of contact between the electrode and a tissue by assessing, for example, the amplitude or periodicity of the signal.
摘要翻译：接触感测导管系统包括具有远端的导管轴; 位于所述轴的远端的柔性导电聚合物电极; 以及至少部分地位于电极内的机电接触传感器。传感器响应于作用在其上的机械力而输出电信号。传感器可以是压电传感器，应变计，光纤传感器或另一适合的机电接触传感器。由传感器输出的电信号通常响应于作用在传感器上的机械力的变化而变化。输出装置可以接收由接触传感器输出的信号，并通过评估例如信号的幅度或周期性向系统的用户呈现电极和组织之间的接触的指示。

114. 发明申请

US20080161786A1 Pressure-sensitive conductive composite contact sensor and method for contact sensing 有权
标题翻译：压敏导电复合接触传感器和接触感应方法
公开(公告)号：US20080161786A1
公开(公告)日：2008-07-03
申请号：US11647314
申请日：2006-12-29
申请人： Kedar Ravindra Belhe , Saurav Paul
发明人： Kedar Ravindra Belhe , Saurav Paul
IPC分类号： A61B18/08
CPC分类号： A61B18/1492 , A61B5/6885 , A61B2018/00083 , A61B2018/00577 , A61B2018/00875 , A61B2018/00988 , A61B2090/064 , A61B2090/065 , A61B2562/0209 , A61M25/00 , A61M2025/0002 , G01L1/20
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

115. 发明授权

US08672936B2 Systems and methods for assessing tissue contact 有权
标题翻译：用于评估组织接触的系统和方法
公开(公告)号：US08672936B2
公开(公告)日：2014-03-18
申请号：US11617364
申请日：2006-12-28
申请人： Chou Thao , Saurav Paul
发明人： Chou Thao , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B5/4848 , A61B18/14 , A61B18/1492 , A61B2018/00351 , A61B2018/00577 , A61B2018/0066 , A61B2018/00839 , A61B2018/143 , A61B2090/065
摘要： Systems and methods are disclosed for assessing tissue contact, e.g., for mapping tissue ablation or other procedures. An exemplary tissue contact sensing system comprises a flexible tip device. At least one piezoelectric sensor is housed within the flexible tip device. The at least one piezoelectric sensor is responsive to contact stress of the flexible tip device by generating electrical signals corresponding to the amount of contact stress. An output device is electrically connected to the at least one piezoelectric sensor. The output device receives the electrical signals for assessing tissue contact by the flexible tip device. Methods for assembling and using the flexible tip device are also disclosed.
摘要翻译：公开了用于评估组织接触的系统和方法，例如用于映射组织消融或其它过程。示例性组织接触感测系统包括柔性尖端装置。至少一个压电传感器容纳在柔性尖端装置内。至少一个压电传感器通过产生对应于接触应力量的电信号来响应柔性尖端装置的接触应力。输出装置电连接到至少一个压电传感器。输出装置接收用于评估柔性尖端装置的组织接触的电信号。还公开了用于组装和使用柔性末端装置的方法。

116. 发明授权

US08577447B2 Optic-based contact sensing assembly and system 有权
标题翻译：基于光学的接触感测组件和系统
公开(公告)号：US08577447B2
公开(公告)日：2013-11-05
申请号：US11941073
申请日：2007-11-15
申请人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
发明人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B5/6885 , A61B5/0084 , A61B5/6852 , A61B5/6886 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0002
摘要： The invention relates to an optic-based sensing assembly and a system incorporating the assembly and related use of the assembly. In particular, the invention relates to an optic-based catheter assembly and related system used to determine contact between a catheter and surrounding proximate environment, such as tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
摘要翻译：本发明涉及一种基于光学的感测组件以及结合该组件的组件和该组件的相关使用的系统。特别地，本发明涉及一种基于光学的导管组件和相关系统，其用于确定导管和周围的近处环境（例如组织）之间的接触。这种系统的实施例可以例如用于组织和/或周围区域的可视化，映射，消融或其它诊断和治疗方法。

117. 发明授权

US08500731B2 Adjustable length flexible polymer electrode catheter and method for ablation 有权
标题翻译：可调长度柔性聚合物电极导管和消融方法
公开(公告)号：US08500731B2
公开(公告)日：2013-08-06
申请号：US12347097
申请日：2008-12-31
申请人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
发明人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1815
摘要： An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
摘要翻译：消融导管包括在其远端具有柔性电极的柔性细长轴。柔性电极包括内部柔性导电元件和与内部柔性导电元件电接触的外部柔性导电聚合物层。所述导管还包括围绕所述柔性电极的至少一部分的电绝缘护套和能够调节所述电绝缘护套和所述柔性电极中的至少一个的线性位移机构，以改变在所述远端暴露的所述柔性电极的长度的轴。还公开了可调节长度的消融电极和消融组织的方法。

118. 发明授权

US07996078B2 Systems and methods of photodynamic-based cardiac ablation via the esophagus 失效
标题翻译：通过食道的基于光动力的心脏消融的系统和方法
公开(公告)号：US07996078B2
公开(公告)日：2011-08-09
申请号：US12345569
申请日：2008-12-29
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61N1/30
CPC分类号： A61B18/24 , A61B90/39 , A61B2017/00084 , A61B2018/2272 , A61B2090/065 , A61B2090/3954 , A61N5/0601 , A61N5/062
摘要： Systems and methods for photodynamic ablation of cardiac tissue via an esophagus are disclosed. An exemplary system includes an ablation catheter having an expandable distal end for securing the ablation catheter in the esophagus. The distal end of the ablation catheter contains at least one light source operable to activate a photodynamic substance delivered to the target area of the cardiac tissue to be ablated and form a lesion. The system also includes at least one feedback device contained in the distal end of the ablation catheter. The at least one feedback device provides feedback for at least one of: positioning a distal end of an ablation catheter in a desired position in the esophagus adjacent a target area of the cardiac tissue to be ablated, forming an adequate lesion, and assessing lesion formation.
摘要翻译：公开了通过食道对心脏组织的光动力消融的系统和方法。示例性系统包括具有用于将消融导管固定在食道中的可扩展远端的消融导管。消融导管的远端包含至少一个光源，其可操作以激活被输送到待烧蚀的心脏组织的靶区域并形成病变的光动力物质。该系统还包括包含在消融导管的远端中的至少一个反馈装置。所述至少一个反馈装置为以下中的至少一个提供反馈：将消融导管的远端定位在邻近被切除的心脏组织的靶区域的食道中的期望位置，形成足够的损伤，以及评估损伤形成。

119. 发明授权

US07879030B2 Multipolar, virtual-electrode catheter with at least one surface electrode and method for ablation 有权
标题翻译：具有至少一个表面电极的多极虚拟电极导管和消融方法
公开(公告)号：US07879030B2
公开(公告)日：2011-02-01
申请号：US11190560
申请日：2005-07-27
申请人： Saurav Paul , Kedar Ravindra Belhe
发明人： Saurav Paul , Kedar Ravindra Belhe
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/1472
摘要： Virtual-electrode catheters and methods for using such virtual-electrode catheters are disclosed. For example, bipolar and multipolar, virtual-electrode catheters having at least one internal electrode and at least one surface electrode, and methods of using these catheters for treatment of cardiac arrhythmias via, for example, radiofrequency (RF) ablation are disclosed. The catheters may comprise a catheter body with an internal lumen extending within it and adapted to flowingly receive a conductive fluid. An exit feature defining a flow path from the internal lumen to the catheter's outer surface may exist through a sidewall of the catheter body. A conductor is mounted within the internal lumen adjacent to the exit feature and is adapted to deliver treatment energy to the tissue via the conductive fluid in the internal lumen. At least one surface electrode is mounted on the outer surface of the catheter body adjacent to the exit feature.
摘要翻译：公开了虚拟电极导管和使用这种虚拟电极导管的方法。例如，公开了具有至少一个内部电极和至少一个表面电极的双极和多极虚拟电极导管，以及通过例如射频（RF）消融来治疗心律失常的这些导管的方法。导管可以包括具有在其内延伸并适于流动地接收导电流体的内腔的导管体。限定从内腔到导管的外表面的流动路径的出口特征可以通过导管主体的侧壁而存在。导体被安装在与出口特征相邻的内腔中，并且适于经由内腔中的导电流体将治疗能量递送至组织。至少一个表面电极安装在导管主体的与出口部件相邻的外表面上。

120. 发明申请

US20100286530A1 Photodynamic-based tissue sensing device and method 审中-公开
标题翻译：基于光动力学的组织感测装置及方法
公开(公告)号：US20100286530A1
公开(公告)日：2010-11-11
申请号：US12744201
申请日：2008-12-18
申请人： Saurav Paul , Israel Byrd
发明人： Saurav Paul , Israel Byrd
IPC分类号： A61B6/00
CPC分类号： A61N5/062 , A61B5/0084 , A61N5/0601
摘要： A system and method for diagnosis or treatment of tissue is provided. One or more optic fibers are disposed within a deformable, tubular body. An electronic control unit activates an electromagnetic radiation source to direct a first set of electromagnetic radiation through a first optic fiber to the tissue. The unit also receives a signal generated by an electromagnetic radiation sensor in response to a second set of electromagnetic radiation received through the first optic or a second fiber. The second set of electromagnetic radiation originates from the tissue in response to the first set of electromagnetic radiation and may be reflected or emitted by a substance contained in the tissue that alters radiation characteristics of the tissue. Finally, the unit is configured to determine a characteristic of the tissue (e.g. the distance from the tissue to the tubular body) responsive to the signal.
摘要翻译：提供了用于诊断或治疗组织的系统和方法。一个或多个光纤设置在可变形的管状体内。电子控制单元激活电磁辐射源以将第一组电磁辐射通过第一光纤引导到组织。该单元还响应于通过第一光学器件或第二光纤接收的第二组电磁辐射，接收由电磁辐射传感器产生的信号。第二组电磁辐射响应于第一组电磁辐射来自组织，并且可以被包含在组织中的物质反射或发射，从而改变组织的辐射特性。最后，单元被配置成响应于该信号来确定组织的特征（例如，从组织到管状体的距离）。

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