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111. 发明专利

NO20064631A 未知
公开(公告)号：NO20064631A
公开(公告)日：2006-12-11
申请号：NO20064631
申请日：2006-10-10
申请人： FRESENIUS KABI DE GMBH
发明人： ZANDER NORBERT , FRANK RONALD , CONRADT HARALD S , EICHNER WOLFRAM , HACKET FRANK , LANGER KLAUS , ORLANDO MICHELE
IPC分类号： A61K47/48 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/38 , A61K38/42 , A61K38/44 , A61K38/48 , A61K38/55 , A61K51/06 , A61K51/08 , C07K14/00 , C08B31/00 , C08B31/18
CPC分类号： A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/202 , A61K38/212 , A61K38/215 , A61K38/37 , A61K38/42 , A61K38/446 , A61K38/4846 , A61K38/4866 , A61K38/55 , A61K47/61 , A61K51/065 , C08B31/00 , C08B31/006 , C08B31/12 , C08B31/185

113. 发明专利

NO20061121L 未知
公开(公告)号：NO20061121L
公开(公告)日：2006-05-05
申请号：NO20061121
申请日：2006-03-08
申请人： FRESENIUS KABI DE GMBH
发明人： EICHNER WOLFRAM , ZANDER NORBERT , FRANK RONALD , KNOLLER HELMUT , LUTTERBECK KATHARINA , SOMMERMEYER KLAUS , CONRADT HARALD S , GRABESHORST ECKART
IPC分类号： A61K47/48
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a granulocyte colony stimulating factor protein (G-CSF) wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the methods of producing these conjugates and the use of these conjugates.

114. 发明专利

AU2005226844A1 Conjugates of hydroxyalkyl starch and a protein 未知
公开(公告)号：AU2005226844A1
公开(公告)日：2005-10-06
申请号：AU2005226844
申请日：2005-03-11
申请人： FRESENIUS KABI DE GMBH
发明人： HACKET FRANK , FRANK RONALD , EICHNER WOLFRAM , CONRADT HARALD , LANGER KLAUS , SCHIMMEL MARTIN , ORLANDO MICHELE , SOMMERMEYER KLAUS , KRAUS ELMAR , ZANDER NORBERT
IPC分类号： A61K47/48
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a protein wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the method of producing these conjugates and the use of these conjugates.

115. 发明专利

NO20051427L 未知
公开(公告)号：NO20051427L
公开(公告)日：2005-05-31
申请号：NO20051427
申请日：2005-03-17
申请人： FRESENIUS KABI DE GMBH
发明人： ZANDER NORBERT
IPC分类号： A61K8/73 , A61K9/00 , A61K9/14 , A61K38/00 , A61K38/18 , A61K47/48 , C07K14/505 , C07K14/53 , C07K14/54 , C07K14/55 , C07K14/56 , C07K14/565 , C07K17/06 , C07K17/10 , C08B31/00 , C08B31/08 , C08B31/12 , C08B33/04 , C08B35/04 , C12N15/12
摘要： Preparation of hydroxyalkyl starch derivatives involves reaction of hydroxyalkyl starch at its reducing end with amino compound. The reducing end is not oxidized prior to the reaction. Preparation of hydroxyalkyl starch derivatives involves reaction of hydroxyalkyl starch of formula (I) at its reducing end with amino compound of formula R a-NH-R b (II). [Image] R 1-R 3H, linear or branched hydroxyalkyl; R aat least one functional group X capable of reacting with at least one other compound prior to or after the reaction; R ba functional group X or W; W : -NH-, -NH-C(=G)-, -NH-C(=G)-G-, -NH-S(O) 2- or -NH-C(=G)-NH-; X : -SH, -NH 2, -O-NH 2, -NH-O-alkyl, -C(=G)-NH-NH 2, -G-C(=G)-NH-NH 2, -NH-C(=G)-NH-NH 2 or -S(O) 2-NH-NH 2; and G : O or S. An independent claim is included for a pharmaceutical composition comprising the hydroxyalkyl starch derivative (where the reaction product of (I) with (II) is reacted via the functional group X in (II) with the further compound (III) or (II) is reacted via the functional group X with (III) prior to the reaction with (I), and the reaction product of (I) and (II) with the crosslinking compound is reacted with a polypeptide). ACTIVITY : Antianemic. Hydroxyethyl starch-erythropoietin (HES-EPO) was tested by the EPO-bioassay in normocythaemic mouse system and showed specific activity of 344000 U/mg, which was 3 fold higher than international BRP-erythropoietin reference standard preparation. MECHANISM OF ACTION : None given.

116. 发明专利

PL370779A1 STARCH DERIVATIVES, STARCH ACTIVE SUBSTANCE CONJUGATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS 未知
公开(公告)号：PL370779A1
公开(公告)日：2005-05-30
申请号：PL37077903
申请日：2003-02-20
申请人： FRESENIUS KABI DE GMBH
发明人： SOMMERMEYER KLAUS , ZANDER NORBERT , FRANK RONALD , CONRADT HARALD
IPC分类号： A61K45/00 , A61K47/48 , A61P5/00 , A61P31/00 , C08B31/00

117. 发明专利

CA2534418A1 CONJUGATES OF HYDROXYALKYL STARCH AND G-CSF 未知
公开(公告)号：CA2534418A1
公开(公告)日：2005-02-17
申请号：CA2534418
申请日：2004-08-06
申请人： FRESENIUS KABI DE GMBH
发明人： CONRADT HARALD S , GRABENHORST ECKART , SOMMERMEYER KLAUS , FRANK RONALD , ZANDER NORBERT , LUTTERBECK KATHARINA , EICHNER WOLFRAM , KNOLLER HELMUT
IPC分类号： A61K47/48
摘要： The present invention relates to conjugates of hydroxyalkyl starch and a granulocyte colony stimulating factor protein (G-CSF) wherein these conjugat es are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the methods of producing these conjugates and the use of the se conjugates.

118. 发明专利

DE02020425T1 未知
公开(公告)号：DE02020425T1
公开(公告)日：2004-07-15
申请号：DE02020425
申请日：2002-09-11
申请人： FRESENIUS KABI DE GMBH
发明人： CONRADT HARALD S , GRABENHORST ECKART , NIMTZ MANFRED , ZANDER NORBERT , FRANK RONALD , EICHNER WOLFRAM
IPC分类号： A61K8/73 , A61K9/00 , A61K9/14 , A61K38/00 , A61K38/18 , A61K47/48 , C07K14/505 , C07K14/53 , C07K14/54 , C07K14/55 , C07K14/56 , C07K14/565 , C07K17/06 , C07K17/10 , C08B31/00 , C08B31/08 , C08B31/12 , C08B33/04 , C08B35/04 , C12N15/12

119. 发明专利

AU2003255406A1 HYDROXYALKYL STARCH DERIVATIVES 未知
公开(公告)号：AU2003255406A1
公开(公告)日：2004-04-30
申请号：AU2003255406
申请日：2003-08-08
申请人： FRESENIUS KABI DE GMBH
发明人： ZANDER NORBERT
IPC分类号： A61K8/73 , A61K9/00 , A61K9/14 , A61K38/00 , A61K38/18 , A61K47/48 , C07K14/505 , C07K14/53 , C07K14/54 , C07K14/55 , C07K14/56 , C07K14/565 , C07K17/06 , C07K17/10 , C08B31/00 , C08B31/08 , C08B31/12 , C08B33/04 , C08B35/04 , C12N15/12
摘要： Preparation of hydroxyalkyl starch derivatives involves reaction of hydroxyalkyl starch at its reducing end with amino compound. The reducing end is not oxidized prior to the reaction. Preparation of hydroxyalkyl starch derivatives involves reaction of hydroxyalkyl starch of formula (I) at its reducing end with amino compound of formula R a-NH-R b (II). [Image] R 1-R 3H, linear or branched hydroxyalkyl; R aat least one functional group X capable of reacting with at least one other compound prior to or after the reaction; R ba functional group X or W; W : -NH-, -NH-C(=G)-, -NH-C(=G)-G-, -NH-S(O) 2- or -NH-C(=G)-NH-; X : -SH, -NH 2, -O-NH 2, -NH-O-alkyl, -C(=G)-NH-NH 2, -G-C(=G)-NH-NH 2, -NH-C(=G)-NH-NH 2 or -S(O) 2-NH-NH 2; and G : O or S. An independent claim is included for a pharmaceutical composition comprising the hydroxyalkyl starch derivative (where the reaction product of (I) with (II) is reacted via the functional group X in (II) with the further compound (III) or (II) is reacted via the functional group X with (III) prior to the reaction with (I), and the reaction product of (I) and (II) with the crosslinking compound is reacted with a polypeptide). ACTIVITY : Antianemic. Hydroxyethyl starch-erythropoietin (HES-EPO) was tested by the EPO-bioassay in normocythaemic mouse system and showed specific activity of 344000 U/mg, which was 3 fold higher than international BRP-erythropoietin reference standard preparation. MECHANISM OF ACTION : None given.

120. 发明专利

CA2496318A1 HYDROXYALKYL STARCH DERIVATIVES 未知
公开(公告)号：CA2496318A1
公开(公告)日：2004-03-25
申请号：CA2496318
申请日：2003-08-08
申请人： FRESENIUS KABI DE GMBH
发明人： ZANDER NORBERT
IPC分类号： A61K8/73 , A61K9/00 , A61K9/14 , A61K38/00 , A61K38/18 , A61K47/48 , C07K14/505 , C07K14/53 , C07K14/54 , C07K14/55 , C07K14/56 , C07K14/565 , C07K17/06 , C07K17/10 , C08B31/00 , C08B31/08 , C08B31/12 , C08B33/04 , C08B35/04 , C12N15/12
摘要： The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound o f formula (II) R'NH-R'' (II) wherein R1-R2 and R3 are independently hydrogen o r a linear or branched hydroxyalkyl group, and wherein either R' or R'' or R' and R'' comprise at least one functional group X capable of being reacted wi th at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.

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