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111. 发明申请

US20090234406A1 SYSTEMS, DEVICES AND METHODS FOR MODULATING AUTONOMIC TONE 有权
标题翻译：用于调制自动音调的系统，设备和方法
公开(公告)号：US20090234406A1
公开(公告)日：2009-09-17
申请号：US12397464
申请日：2009-03-04
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Bruce H. KenKnight , Douglas R. Daum
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Bruce H. KenKnight , Douglas R. Daum
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： Various system embodiments comprise means for intermittently delivering a sympathetic stimulus, including means for delivering a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further includes means for delivering neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.
摘要翻译：各种系统实施例包括用于间歇地递送交感刺激的装置，包括用于递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列的装置。应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。该实施方案还包括用于递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感反应或交感反应的装置。神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

112. 发明授权

US07587238B2 Combined neural stimulation and cardiac resynchronization therapy 有权
标题翻译：组合神经刺激和心脏再同步治疗
公开(公告)号：US07587238B2
公开(公告)日：2009-09-08
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译：提供了向患者输送心脏治疗的方法和装置。各种可植入装置实施例包括多个引线和控制器。引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART）与RCT结合抑制交感神经活动。本文提供了其他实施例。

113. 发明授权

US07493162B2 Pulmonary vein stent for treating atrial fibrillation 失效
标题翻译：肺静脉支架用于治疗房颤
公开(公告)号：US07493162B2
公开(公告)日：2009-02-17
申请号：US10160269
申请日：2002-05-31
申请人： Steven D. Girouard , Bruce H. KenKnight , David S. Wood
发明人： Steven D. Girouard , Bruce H. KenKnight , David S. Wood
IPC分类号： A61N1/00
CPC分类号： A61F2/958 , A61B18/1492 , A61B2018/00375 , A61N5/1002
摘要： An apparatus and method for treating atrial fibrillation is described that uses a vascular stent deployed within the pulmonary veins of the left atrium. The stent may be used alone or in combination with chemical, thermal, electrical, or radioactive energy sources to ablate myocardial tissue residing in the pulmonary veins. The targeted myocardial tissue in the pulmonary veins will have been identified as the source of initiation and/or sustenance of atrial fibrillation. Ablation therapy using the pulmonary venous stent stops discharges from ectopic foci in the vein or alternatively stops impulses from reaching the left atrium. The deployed stent can then be left in place to prevent stenosis of the vein.
摘要翻译：描述了一种用于治疗房颤的装置和方法，其使用部署在左心房的肺静脉内的血管支架。支架可以单独使用或与化学，热，电或放射能源组合使用，以消融存在于肺静脉中的心肌组织。肺静脉中的靶向心肌组织将被确定为心房颤动的起始和/或维持的来源。使用肺静脉支架的消融治疗可以阻止静脉中异位灶的排出，或者停止脉冲到达左心房。然后将部署的支架置于适当位置以防止静脉狭窄。

114. 发明授权

US07346392B2 Method and apparatus for the monitoring and treatment of spontaneous cardiac arrhythmias 失效
标题翻译：用于监测和治疗自发性心律失常的方法和装置
公开(公告)号：US07346392B2
公开(公告)日：2008-03-18
申请号：US10355857
申请日：2003-01-31
申请人： Bruce H. KenKnight
发明人： Bruce H. KenKnight
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/3956
摘要： An implantable apparatus for the detection and monitoring of spontaneous cardiac electrogram features in a comprises a cardiac monitoring device and a plurality of subcutaneous cardiac sensing electrodes electrically connected to the monitoring device. The sensing electrodes are configured for sensing cardiac electrogram features when implanted in spatially separate locations in a patient. A storage device contained within the monitoring device is operably associated with the subcutaneous electrodes and stores the cardiac electrogram features. Preferably, the plurality of subcutaneous electrodes are carried by a single elongate lead. A downloading device such as telemetry apparatus or transcutaneous electrical connectors may be provided so that the stored information can be downloaded to a separate apparatus external to the patient. In a preferred embodiment, the apparataus is a defibrillator. Methods of using such apparatus are also disclosed.
摘要翻译：用于检测和监测自发性心电图特征的可植入装置包括心电监测装置和电连接到监测装置的多个皮下心脏感测电极。感测电极被配置用于当植入在患者的空间上分离的位置时感测心脏电图特征。包含在监视装置内的存储装置可操作地与皮下电极相关联并存储心电图特征。优选地，多个皮下电极由单个细长引线承载。可以提供诸如遥测装置或经皮电连接器的下载装置，使得存储的信息可以被下载到患者外部的单独装置。在优选的实施方案中，食物是除颤器。还公开了使用这种装置的方法。

115. 发明授权

US07127290B2 Cardiac rhythm management systems and methods predicting congestive heart failure status 有权
公开(公告)号：US07127290B2
公开(公告)日：2006-10-24
申请号：US10213268
申请日：2002-08-06
申请人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
发明人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/4842
摘要： This document describes, among other things, systems, devices, and methods for predicting how the status of the patient's congestive heart failure (CHF) condition will progress in the future. In one example, a therapy is provided or adjusted at least in part in response to the prediction.

116. 发明授权

US06999814B2 Implantable intravenous cardiac stimulation system with pulse generator housing serving as optional additional electrode 失效
公开(公告)号：US06999814B2
公开(公告)日：2006-02-14
申请号：US09884862
申请日：2001-06-19
申请人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
发明人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
IPC分类号： A61N1/39
CPC分类号： A61N1/056 , A61N1/05 , A61N1/368 , A61N1/375 , A61N1/3756
摘要： A pulse generator housing for enclosing and containing pulse generator defibrillation circuitry. The housing is formed entirely of electrically conductive metal defining an electrically conductive outer surface which is connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The pulse generator housing is implanted in the pectoral region proximate the heart with the conductive surface facing the heart. Regions of the conductive outer surface may be electrically isolated and dedicated for separately sensing and shocking. The outer surface may be coated with platinum. Additional coiled segment electrodes may extend from the housing and be electrically connected to the conductive outer surface so as to increase the effective conductive surface area. A sensor is provided to determine whether the housing is inside or outside a body of a patient to disconnect the pulse generator housing conductive surface from the pulse generator circuitry when the unit is outside the body of a patient.

117. 发明授权

US06952611B2 Method for assessing cardiac functional status 有权
标题翻译：评估心脏功能状态的方法
公开(公告)号：US06952611B2
公开(公告)日：2005-10-04
申请号：US10136910
申请日：2002-04-30
申请人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
发明人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.
摘要翻译：一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。

118. 发明授权

US06939345B2 Method for reducing restenosis in the presence of an intravascular stent 失效
标题翻译：在血管内支架存在下减少再狭窄的方法
公开(公告)号：US06939345B2
公开(公告)日：2005-09-06
申请号：US10397623
申请日：2003-03-26
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B18/14 , A61B18/04
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译：第一电极位于植入的血管内支架附近的动脉内。第二电极相对于第一电极的位置定位在单独的位置。然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间心动周期。

119. 发明授权

US06873873B2 System for treating supraventricular tachyarrhythmias 有权
标题翻译：治疗室上性快速性心律失常的系统
公开(公告)号：US06873873B2
公开(公告)日：2005-03-29
申请号：US10444466
申请日：2003-05-22
申请人： William Hsu , Bruce H. KenKnight
发明人： William Hsu , Bruce H. KenKnight
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A system and method for treating atrial fibrillation using atrial pacing pulses to convert an atrial fibrillation to non-fibrillation atrial arrhythmia prior to delivering a low energy cardioversion/defibrillation shock. The system and method treats atrial fibrillations by first applying a plurality of pacing pulses to the atria which converts the atrial fibrillation to non-fibrillation atrial arrhythmia. Ventricular intervals are concurrently sensed and analyzed while the plurality of electrical pacing pulses are being applied. Upon detecting a period of stable ventricular intervals, the system then proceeds to deliver a low-energy cardioverting/defibrillating pulse of electrical energy across the atria of the heart.
摘要翻译：一种用于在递送低能量心律转复/除颤休克之前使用心房起搏脉冲来治疗心房颤动以将心房颤动转换为非纤维性心房心律失常的系统和方法。该系统和方法通过首先将多次起搏脉冲施加到将心房颤动转变为非纤维性心房心律不齐的心房来治疗房颤。在施加多个起搏脉冲的同时，同时感测和分析心室间隔。在检测到稳定的心室间隔的时间段时，系统然后继续在心脏的心房上提供电能的低能量心律转复/除颤脉冲。

120. 发明授权

US06801806B2 Adaptive anti-tachycardia therapy apparatus and method 失效
标题翻译：适应性抗心动过速治疗仪及方法
公开(公告)号：US06801806B2
公开(公告)日：2004-10-05
申请号：US10037622
申请日：2002-01-02
申请人： Weimin Sun , Bruce H. KenKnight , Martin Tze , Yatheendhar Manicka
发明人： Weimin Sun , Bruce H. KenKnight , Martin Tze , Yatheendhar Manicka
IPC分类号： A61N1362
CPC分类号： A61N1/3962
摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.
摘要翻译：公开了以自适应方式递送抗心动过速起搏的方法和装置。具有抗心动过速起搏能力的心脏节律管理装置，例如可植入心脏起搏器，在检测到可终止的心律失常时，根据选定的起搏方案提供抗心动过速起搏治疗。协议从可用协议库中选择。在用于选择协议的结果表中保留了每种可用协议在转换快速性心律失常方面的成功和失败的记录。

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