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111. 发明申请

WO0155441A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155441A8
公开(公告)日：2001-09-07
申请号：PCT/US0101320
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07K14/47 , C12N1/21 , C12P21/06 , C07H21/04 , C07K1/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47

112. 发明申请

WO0155440A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155440A8
公开(公告)日：2001-09-07
申请号：PCT/US0101318
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/12 , C12N15/66 , C12P15/00 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： A61K38/17 , A61G17/06 , A61G2203/90 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/66 , C12P15/00 , C12P21/06 , C12Q1/68 , G01N33/566
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells,and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

113. 发明申请

WO0155327A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155327A8
公开(公告)日：2001-09-07
申请号：PCT/US0101352
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel pancreatic related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic antigens", and the use of such pancreatic antigens for detecting disorders of the pancreas, particularly the presence of pancreatic cancer and pancreatic cancer metastases. More specifically, isolated pancreatic associated nucleic acid molecules are provided encoding novel pancreatic associated polypeptides. Novel pancreatic polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human pancreatic associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型胰腺相关多核苷酸和由这些多核苷酸编码的多肽，这些多肽在本文统称为“胰腺抗原”，以及使用这种胰腺抗原来检测胰腺疾病，特别是胰腺癌和胰腺癌转移的存在。更具体地，提供编码新胰腺相关多肽的分离的胰腺相关核酸分子。提供了与这些多肽结合的新型胰腺多肽和抗体。还提供了用于产生人胰腺相关多核苷酸和/或多肽的载体，宿主细胞和重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与胰腺相关的疾病（包括胰腺癌）的诊断和治疗方法以及用于治疗这些疾病的治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

114. 发明申请

WO0155326A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155326A8
公开(公告)日：2001-09-07
申请号：PCT/US0101347
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6424 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

115. 发明申请

WO0155322A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155322A8
公开(公告)日：2001-09-07
申请号：PCT/US0101341
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

116. 发明申请

WO0155321A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155321A8
公开(公告)日：2001-09-07
申请号：PCT/US0101340
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel cardiovascular system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "cardiovascular system antigens", and the use of such cardiovascular system antigens for detecting disorders of the cardiovascular system, particularly the presence of cancer of cardiovascular system tissues and cancer metastases. More specifically, isolated cardiovascular system associated nucleic acid molecules are provided encoding novel cardiovascular system associated polypeptides. Novel cardiovascular system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human cardiovascular system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the cardiovascular system, including cancer of cardiovascular system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的心血管系统相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“心血管系统抗原”，以及使用这种心血管系统抗原来检测心血管系统疾病，特别是心血管系统癌症的存在系统组织和癌症转移。更具体地，提供编码新的心血管系统相关多肽的分离的心血管系统相关核酸分子。提供了与这些多肽结合的新型心血管系统多肽和抗体。还提供载体，宿主细胞，以及用于产生人类心血管系统相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与心血管系统相关的疾病（包括心血管系统组织的癌症）以及治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

117. 发明申请

WO0155306A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155306A8
公开(公告)日：2001-09-07
申请号：PCT/US0101304
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07K11/00 , C07K14/00 , C12N20060101 , C12N5/00 , C12N5/06 , C12N15/00 , C12N15/63 , C12P21/04 , C12P21/06 , C12N
CPC分类号： C07K11/00 , C07K14/00 , C12N1/00 , C12N5/00 , C12N5/06 , C12N15/00 , C12N15/63 , C12P21/06
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

118. 发明申请

WO0155302A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155302A8
公开(公告)日：2001-09-07
申请号：PCT/US0101240
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel colon related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "colon antigens", and the use of such colon antigens for detecting disorders of the colon, particularly the presence of colon cancer and colon cancer metastases. More specifically, isolated colon associated nucleic acid molecules are provided encoding novel colon associated polypeptides. Novel colon polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human colon associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新颖的结肠相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“结肠抗原”，以及这种结肠抗原用于检测结肠疾病，特别是结肠癌和结肠癌转移的存在。更具体地，提供编码新的结肠相关多肽的分离的结肠相关核酸分子。提供结合这些多肽的新型结肠多肽和抗体。还提供了用于产生人结肠相关多核苷酸和/或多肽的载体，宿主细胞和重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与结肠相关的疾病（包括结肠癌）以及用于治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

119. 发明申请

WO0155208A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155208A8
公开(公告)日：2001-09-07
申请号：PCT/US0101357
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N5/10 , C12N5/16 , C12N15/63 , C12N15/64
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

120. 发明申请

WO0155200A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155200A8
公开(公告)日：2001-09-07
申请号：PCT/US0101313
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , A61K38/17
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

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