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111. 发明授权

US08060186B2 System and method for intraoperative guidance of stent placement during endovascular interventions 有权
标题翻译：血管内介入治疗支架植入术的指导系统及方法
公开(公告)号：US08060186B2
公开(公告)日：2011-11-15
申请号：US12031787
申请日：2008-02-15
申请人： Ashraf Mohamed , Chenyang Xu , Frank Sauer , Marcus Pfister , Andrew F Hall , Klaus Klingenbeck-Regn
发明人： Ashraf Mohamed , Chenyang Xu , Frank Sauer , Marcus Pfister , Andrew F Hall , Klaus Klingenbeck-Regn
IPC分类号： A61B5/05
CPC分类号： G06T19/006 , A61B6/4423 , A61B6/487 , A61B6/504 , A61B34/10 , A61B2034/102 , A61B2034/108 , A61B2090/365 , A61F2/91 , A61F2250/0067 , A61F2310/0097 , G06T7/344 , G06T7/38 , G06T2207/10121 , G06T2207/30101 , G06T2207/30204
摘要： A method for guiding stent deployment during an endovascular procedure includes providing a virtual stent model of a real stent that specifies a length, diameter, shape, and placement of the real stent. The method further includes projecting the virtual stent model onto a 2-dimensional (2D) DSA image of a target lesion, manipulating a stent deployment mechanism to navigate the stent to the target lesion while simultaneously acquiring real-time 2D fluoroscopic images of the stent navigation, and overlaying each fluoroscopic image on the 2D DSA image having the projected virtual stent model image, where the 2D fluoroscopic images are acquired from a C-arm mounted X-ray apparatus, and updating the projection of the virtual stent model onto the fluoroscopic images whenever a new fluoroscopic image is acquired or whenever the C-arm is moved, where the stent is aligned with the virtual stent model by aligning stent end markers with virtual end markers.
摘要翻译：用于在血管内手术期间引导支架展开的方法包括提供实际支架的虚拟支架模型，其指定真实支架的长度，直径，形状和位置。该方法还包括将虚拟支架模型投影到目标损伤的二维（2D）DSA图像上，操纵支架展开机构以将支架导航到目标病变，同时获取支架导航的实时2D透视图像并且将每个透视图像叠加在具有投射的虚拟支架模型图像的2D DSA图像上，其中从C臂安装的X射线装置获取2D透视图像，并且将虚拟支架模型的投影更新到荧光图像上每当获取新的荧光透视图像或每当C形臂移动时，通过将支架终点标记与虚拟末端标记对齐，支架与虚拟支架模型对准。

112. 发明申请

US20110210534A1 AIR BAG MODULE FOR A VEHICLE OCCUPANT RESTRAINT SYSTEM 有权
标题翻译：用于车辆职业限制系统的气囊模块
公开(公告)号：US20110210534A1
公开(公告)日：2011-09-01
申请号：US13102982
申请日：2011-05-06
申请人： Frank Sauer , Steffen Weigand
发明人： Frank Sauer , Steffen Weigand
IPC分类号： B60R21/215
CPC分类号： B60R21/2035 , B60R21/215 , B60R21/21656 , B60R2021/21543
摘要： An airbag module for a vehicle occupant restraint system is provided. The airbag module comprising an airbag, a gas generator and an gas generator support and comprises a visible surface facing the vehicle interior in the installed state formed by different segments of the airbag module. At least two of the segments comprise optically and/or haptically different surfaces and are mechanically connected to each other by means of mechanical interfaces such that the mechanical connection between the segments is at least partially released when triggered by opening the interfaces so that an opening is formed in the visible surface through which the airbag can exit the airbag module. All segments contributing to the formation of an opening for the airbag by opening an interface when triggered are thereby directly fastened to the gas generator support.
摘要翻译：提供一种用于车辆乘员约束系统的安全气囊模块。气囊模块包括气囊，气体发生器和气体发生器支撑件，并且包括在由安全气囊模块的不同段形成的安装状态下面向车辆内部的可见表面。至少两个片段包括光学和/或高度不同的表面，并且通过机械接口彼此机械连接，使得当通过打开界面触发时，片段之间的机械连接至少部分地被释放，使得开口是形成在可见表面中，安全气囊可以穿过该表面从气囊组件中排出。通过在触发时打开界面而有助于形成气囊开口的所有部分由此直接固定在气体发生器支架上。

113. 发明申请

US20100293824A1 Film plate for an airbag cover 有权
标题翻译：安全气囊盖板
公开(公告)号：US20100293824A1
公开(公告)日：2010-11-25
申请号：US12585122
申请日：2009-09-03
申请人： Steffen Weigand , Frank Sauer
发明人： Steffen Weigand , Frank Sauer
IPC分类号： B60R21/215 , G09F3/08 , B32B3/06
CPC分类号： B60R13/005 , B60R2021/21543 , Y10T428/24008 , Y10T428/24017
摘要： A film plate for an airbag cover is provided. The film plate is pre-formed by deep-drawing or embossing and is directly without reinforcing elements attachable to the airbag cover by mechanical connecting elements. The airbag cover has at the location of the film plate at least a partial support for the film plate and the film plate has an embossed structure on its lower side, which is visible on the upper side.
摘要翻译：提供了一种用于安全气囊盖的胶片板。薄膜板通过深冲压或压花预成形，并且直接没有通过机械连接元件附接到安全气囊盖的增强元件。安全气囊盖在薄膜板的位置处至少具有用于薄膜板的部分支撑，并且薄膜板的下侧具有压花结构，其在上侧是可见的。

114. 发明申请

US20090141968A1 CORONARY RECONSTRUCTION FROM ROTATIONAL X-RAY PROJECTION SEQUENCE 失效
标题翻译：旋转X射线投影序列的冠状重建
公开(公告)号：US20090141968A1
公开(公告)日：2009-06-04
申请号：US12275714
申请日：2008-11-21
申请人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
发明人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
IPC分类号： G06K9/00
CPC分类号： G06T7/55 , G06T7/136 , G06T2207/10116 , G06T2207/20044 , G06T2207/30101 , G06T2207/30172
摘要： A method for three-dimensional reconstruction of a branched object from a rotational sequence of images of the branched object includes segmenting the branched object from each image of the sequence, extracting centerlines of the branched object, performing symbolic reconstruction via a stereo correspondence matching between the centerlines from different views of the sequence of images using a graph cut-based optimization, and creating a three-dimensional tomographic reconstruction of the branched object compensated for motion of the branched object between the images of the sequence.
摘要翻译：从分支对象的图像的旋转顺序对分支对象进行三维重建的方法包括从分支对象的每个图像分割分支对象，提取分支对象的中心线，通过在对象之间的立体对应匹配进行符号重建使用基于图切割优化的图像序列的不同视图的中心线，以及创建分支对象的三维断层重建，以补偿分支对象在序列图像之间的运动。

115. 发明授权

US07398997B2 Steering wheel arrangement for motor vehicles 失效
标题翻译：机动车辆的方向盘布置
公开(公告)号：US07398997B2
公开(公告)日：2008-07-15
申请号：US11065797
申请日：2005-02-25
申请人： Frank Sauer , Oliver Bauer
发明人： Frank Sauer , Oliver Bauer
IPC分类号： B62D1/011
CPC分类号： B62D1/11 , B60R21/05 , Y10T74/20834 , Y10T74/20864
摘要： The invention relates to a steering wheel arrangement for motor vehicles, in which the risk of injury is reduced, should a driver impact against the steering wheel in the event of a crash. According to the invention the skeleton of the steering wheel arrangement has a compact body of deformable, energy absorbing material, in which the spokes of the steering wheel are fixed.
摘要翻译：本发明涉及一种用于机动车辆的方向盘装置，其中如果驾驶员在发生碰撞的情况下对方向盘造成撞击，则会损害其风险。根据本发明，方向盘装置的骨架具有可变形能量吸收材料的紧凑体，其中方向盘的轮辐固定在其中。

116. 发明授权

US07369101B2 Calibrating real and virtual views 有权
标题翻译：校准真实视图和虚拟视图
公开(公告)号：US07369101B2
公开(公告)日：2008-05-06
申请号：US10863414
申请日：2004-06-08
申请人： Frank Sauer , Yakup Genc , Nassir Navab
发明人： Frank Sauer , Yakup Genc , Nassir Navab
IPC分类号： G09G5/00
CPC分类号： G06F3/012 , G02B27/0101 , G02B27/0189 , G02B2027/0138 , G02B2027/0187
摘要： A method for calibrating real and virtual views includes tracking a calibration screen, wherein a real reference point, generated by a real reference point generator, is projected on the calibration screen, aligning a view of a virtual reference point to a view of the real reference point in a display, wherein the real reference point generator and the display have a fixed relative position, determining a point correspondence between the virtual reference point and the real reference point, and determining one or more parameters for rendering a virtual object in the real scene.
摘要翻译：用于校准实际和虚拟视图的方法包括跟踪校准屏幕，其中由实际参考点发生器生成的实际参考点被投影在校准屏幕上，将虚拟参考点的视图与真实参考图像的视图对准指向显示器，其中所述实际参考点发生器和所述显示器具有固定的相对位置，确定所述虚拟参考点和所述实际参考点之间的点对应，以及确定用于在所述真实场景中呈现虚拟对象的一个或多个参数。

117. 发明申请

US20070179817A1 System and method for per-patient licensing of interventional imaging software 失效
标题翻译：介入成像软件每个患者许可的系统和方法
公开(公告)号：US20070179817A1
公开(公告)日：2007-08-02
申请号：US11643284
申请日：2006-12-21
申请人： Frank Sauer , Norbert Rahn , Chenyang Xu , James Williams
发明人： Frank Sauer , Norbert Rahn , Chenyang Xu , James Williams
IPC分类号： G06Q40/00
CPC分类号： G06F21/10 , G06F2221/2135 , G06Q30/04 , G06Q40/08
摘要： A method for implementing per-use licensing for image processing software includes acquiring image data from an image scanner. Processed image data is calculated from the image data using an image processing module. The processed image data is exported. The use of the image processing module is logged in an accounting database when the processed data are exported. Access to the accounting database is provided for account settlement.
摘要翻译：用于实现图像处理软件的使用许可的方法包括从图像扫描器获取图像数据。使用图像处理模块从图像数据计算处理的图像数据。已处理的图像数据被导出。当处理的数据被导出时，图像处理模块的使用将记录在会计数据库中。提供会计数据库的访问用于结算帐户。

118. 发明授权

US07239330B2 Augmented reality guided instrument positioning with guiding graphics 有权
标题翻译：增强现实引导仪器定位与指导图形
公开(公告)号：US07239330B2
公开(公告)日：2007-07-03
申请号：US10963852
申请日：2004-10-13
申请人： Frank Sauer , Ali Bani-Hashemi
发明人： Frank Sauer , Ali Bani-Hashemi
IPC分类号： G09G5/00
CPC分类号： G06T19/003 , G06T19/006 , G06T2210/41
摘要： There is provided a method for augmented reality guided instrument positioning. A graphics guide is determined for positioning an instrument that provides a substantially unobstructed view of the instrument during the positioning. The graphics guide is rendered in alignment with a predetermined path to be traversed during the positioning of the instrument.
摘要翻译：提供了一种增强现实引导仪器定位的方法。确定用于定位在定位期间提供仪器的基本无障碍视图的仪器的图形引导件。图形引导件与在仪器定位期间要穿过的预定路径相对准。

119. 发明授权

US07176936B2 Augmented reality guided instrument positioning with modulated guiding graphics 有权
标题翻译：增强现实引导仪器定位与调制指导图形
公开(公告)号：US07176936B2
公开(公告)日：2007-02-13
申请号：US09818388
申请日：2001-03-27
申请人： Frank Sauer , Ali Bani-Hashemi
发明人： Frank Sauer , Ali Bani-Hashemi
IPC分类号： G09G5/00 , G09G5/02 , A61B6/00
CPC分类号： G06F3/011 , G06F3/0304 , H04N13/339
摘要： There is provided a method for augmented reality guided instrument positioning. A graphics guide is determined for positioning an instrument. The graphics guide is rendered such that an appearance of at least one portion of the graphics guide is modulated with respect to at least one of space and time.
摘要翻译：提供了一种增强现实引导仪器定位的方法。确定用于定位仪器的图形指南。呈现图形指南，使得图形指南的至少一部分的外观相对于空间和时间中的至少一个进行调制。

120. 发明申请

US20060115482A1 Modifications of histone proteins as indicators of cell proliferation and differentiation 审中-公开
标题翻译：组蛋白蛋白的修饰作为细胞增殖和分化的指标
公开(公告)号：US20060115482A1
公开(公告)日：2006-06-01
申请号：US11116142
申请日：2005-04-26
申请人： Frank Sauer , David Wassarman , Tobias Maile
发明人： Frank Sauer , David Wassarman , Tobias Maile
IPC分类号： G01N33/574 , C07H21/04 , A61K39/395 , C12N5/06
CPC分类号： C07K14/4702 , C07K16/18 , C07K16/44 , G01N33/6875 , G01N2500/00
摘要： The invention provides a method of a method of characterizing the proliferative state of cells in a biological sample based on detecting transcription factor-mediated phosphorylation of histone H2B (H2B) at residue 36 (numbered according to human H2B). This method optionally includes detection of transcription factor-mediated acetylation of histone H3 (H3) at residue 14 and/or acetylation of histone H4, which also provides an indication of cell proliferation. The invention also provides antibodies specific for H2B phosphorylated at H2B; transcription factor and H2B derivatives and related polynucleotides, vectors, host cells, recombinant production methods and compositions; and screening methods for modulators of H2B phosphorylation at residue 36.
摘要翻译：本发明提供了一种基于在残基36（根据人H2B编号）检测组蛋白H2B（H2B）的转录因子介导的磷酸化来鉴定生物样品中细胞增殖状态的方法的方法。该方法任选地包括在残基14处检测转录因子介导的组蛋白H3（H3）的乙酰化和/或组蛋白H4的乙酰化，这也提供细胞增殖的指示。本发明还提供对H2B磷酸化的H2B特异的抗体; 转录因子和H2B衍生物和相关多核苷酸，载体，宿主细胞，重组生产方法和组合物; 以及在残基36处H2B磷酸化调节剂的筛选方法。

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