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    • 113. 发明授权
    • Peptide-based peroxidase inhibitors and methods of using same
    • 基于肽的过氧化物酶抑制剂及其使用方法
    • US08937039B2
    • 2015-01-20
    • US14081695
    • 2013-11-15
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, Jr.
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, Jr.
    • A61K38/06A61P9/12A61P19/02C07K5/09
    • C07K5/0815A61K38/00C07K5/0821
    • The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
    • 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂,其中AA1为带正电荷的带负电荷或中性氨基酸,AA2为氧化还原活性氨基酸,AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂,其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化,增加SCD小鼠的血管舒张,抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积,抑制急性肺损伤,减少心脏缺血性损伤。
    • 115. 发明授权
    • Electronic device with isolated antennas
    • 具有隔离天线的电子设备
    • US08866692B2
    • 2014-10-21
    • US12340610
    • 2008-12-19
    • Enrique Ayala VazquezBing ChiangHao Xu
    • Enrique Ayala VazquezBing ChiangHao Xu
    • H01Q1/48H01Q1/24H01Q1/52H01Q21/00
    • H01Q1/521H01Q1/2291H01Q1/48
    • Antennas for electronic devices are provided. First and second antennas may be mounted within an electronic device. Free-space coupling between the first and second antennas may give rise to interference. The first and second antennas may be coupled to a global ground. The global ground may be formed using a conductive member in the electronic device such as a conductive frame member. Signals that pass between the antennas through the global ground may serve as canceling signals that reduce the magnitude of free-space interference signals and thereby improve antenna isolation. The antennas may be coupled to the global ground using electrical paths or through near-field electromagnetic coupling. Coupling efficiency to the global ground may be enhanced by configuring the conductive traces of one or both of the antennas to form a resonant circuit.
    • 提供电子设备天线。 第一和第二天线可以安装在电子设备内。 第一和第二天线之间的自由空间耦合可能会引起干扰。 第一和第二天线可以耦合到全球地面。 全球接地可以使用诸如导电框架构件的电子设备中的导电构件来形成。 通过全球地面通过天线之间的信号可以用作消除自由空间干扰信号幅度的抵消信号,从而改善天线隔离。 天线可以使用电路径或通过近场电磁耦合耦合到全局地面。 可以通过配置一个或两个天线的导电迹线来形成谐振电路来增强耦合效率到全局地。
    • 116. 发明申请
    • Peptide-Based Peroxidase Inhibitors and Methods of Using Same
    • 基于肽的过氧化物酶抑制剂及其使用方法
    • US20140194342A1
    • 2014-07-10
    • US14081695
    • 2013-11-15
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, JR.
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, JR.
    • C07K5/09
    • C07K5/0815A61K38/00C07K5/0821
    • The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
    • 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂,其中AA1为带正电荷的带负电荷或中性氨基酸,AA2为氧化还原活性氨基酸,AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂,其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化,增加SCD小鼠的血管舒张,抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积,抑制急性肺损伤,减少心脏缺血性损伤。
    • 117. 发明授权
    • Method and apparatus that facilitates interference cancellation for control channels in heterogenous networks
    • 促进异构网络中控制信道干扰消除的方法和装置
    • US08761094B2
    • 2014-06-24
    • US12838294
    • 2010-07-16
    • Renqiu WangHao Xu
    • Renqiu WangHao Xu
    • H04W4/00H04W72/00H04W28/04H04W72/12H04W72/04H04W84/04
    • H04W28/04H04W16/32H04W72/0413H04W72/1278H04W84/045
    • Aspects are described for reducing interference in wireless systems. In a first embodiment, an uplink acknowledgment region associated with a macro cell is determined, and an assignment of uplink control resources is restricted to a region within the uplink acknowledgment region. A control signal is then transmitted to user equipment via the assignment of uplink control resources. In another embodiment, control signals are received from wireless terminals, which include desired uplink control signals associated with an access point base station, as well as interfering uplink acknowledgement signals associated with macro cells. The control signals may then be regenerated by cancelling the set of interfering signals from the control signals. The desired uplink control signals are then decoded.
    • 描述了减少无线系统干扰的方面。 在第一实施例中,确定与宏小区相关联的上行链路确认区域,并且上行链路控制资源的分配被限制在上行链路确认区域内的区域。 然后通过上行链路控制资源的分配将控制信号发送到用户设备。 在另一个实施例中,从无线终端接收控制信号,无线终端包括与接入点基站相关联的期望的上行链路控制信号,以及与宏小区相关联的干扰上行链路确认信号。 然后可以通过从控制信号中消除一组干扰信号来再生控制信号。 然后解码所需的上行链路控制信号。
    • 118. 发明申请
    • METHOD AND DEVICE FOR ALLOCATING UPLINK SHARED CHANNEL RESOURCE, AND COMMUNICATION SYSTEM
    • 用于分配UPLINK共享信道资源的方法和设备,以及通信系统
    • US20130294280A1
    • 2013-11-07
    • US13979446
    • 2012-01-11
    • Hao XuJian HeZhiqiu Zhu
    • Hao XuJian HeZhiqiu Zhu
    • H04W72/04
    • H04W72/04H04W72/0486H04W72/085
    • The present invention provides a method and device for allocating uplink shared channel resource, and a communication system, for solving the problem of the overall performance of the communication system being reduced in an existing allocating method. The method comprises: acquiring the volume of data-to-be-transmitted and an uplink channel quality indication; on the basis of the volume of data-to-be-transmitted acquired, determining at least one set of resource profile of the uplink channel quality indication and a resource number; judging of whether or not the uplink channel quality indication comprised within the at least one set of resource profile is identical to the uplink channel quality indication acquired, if identical, using a corresponding set of resource profile as a final resource profile; and if different, combining an uplink transmission power with the corresponding set of resource profile to determine the final resource profile. Under the premise of ensuring QoS, the present invention allows for minimization of transmission power of each terminal, thus reducing inter-system interference, allowing system performance to be further improved.
    • 本发明提供一种用于分配上行链路共享信道资源的方法和装置,以及用于解决在现有分配方法中减少通信系统的整体性能问题的通信系统。 该方法包括:获取要发送的数据的数量和上行链路信道质量指示; 基于所获取的要发送的数据量的量,确定上行链路信道质量指示和资源号码的至少一组资源简档; 判定包含在所述至少一组资源简档内的所述上行链路信道质量指示是否与所获取的所述上行链路信道质量指示相同,如果相同,则使用对应的一组资源简档作为最终资源简档; 并且如果不同,则将上行链路传输功率与相应的一组资源简档组合以确定最终资源简档。 在确保QoS的前提下,本发明允许最小化每个终端的传输功率,从而减少系统间干扰,从而进一步提高系统性能。