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111. 发明授权

EP0216867B1 N-ALKYL AND N-BENZYL ADRIAMYCIN DERIVATIVES 失效
标题翻译： N-烷基和N-苄基腺嘌呤衍生物
公开(公告)号：EP0216867B1
公开(公告)日：1990-08-08
申请号：EP86902258.2
申请日：1986-04-04
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： ISRAEL, Mervyn , SESHADRI, Ramakrishnan
IPC分类号： A61K31/71 , C07H15/24
CPC分类号： C07H15/252
摘要： Compounds having the structure (I), in which A is alkanoate having from 4 to 10 carbon atoms, hemiadipate, or hemiglutarate, and R1 and R2 are n-propyl, or n-butyl, or R1 is hydrogen, n-propyl or n-butyl and R2 is benzyl, and their corresponding non-toxic pharmacologically acceptable acid salts. The compounds are useful as active agents in therapeutic compositions having antitumor activity.

112. 发明公开

EP0277776A2 Solid core liposomes 失效
标题翻译： Liposome mit harten Kernen。
公开(公告)号：EP0277776A2
公开(公告)日：1988-08-10
申请号：EP88300750.2
申请日：1988-01-28
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： Huang, Leaf
IPC分类号： A61K9/50
CPC分类号： B82Y30/00 , A61K9/1277 , Y10S436/829 , Y10S514/963 , Y10T428/2984
摘要： Preferred solid core liposomes are prepared in four major steps:

(1) Preparation of prevesicles with encapsulated solid cores of agarose-gelatin by emulsification of agarose-gelatin sol in organic solvent containing emulsifiers followed by cooling;
(2) Extraction of lipophilic components from prevesicles to obtain microspherules of agarose - gelatin;
(3) In an optional step, colloidal gold particles are introduced into the microspherules, which are then coated with a protein or peptide molecule layer;
(4) Encapsulation of the microspherules is conducted using a modified organic solvent spherule evaporation method for the formation of the liposomes.

Electron micrographs indicate that if liposomes are prepared by using a lipid mixture containing dioleoyl phosphatidyl choline, cholesterol, dioleoylphosphatidylglycerol, and triolein (molar ratio 4.5:4.5:1:1), there is only a single continuous bilayer membrane for each solid core liposome.
摘要翻译：优选的固体核脂质体以四个主要步骤制备：（1）通过在含有乳化剂的有机溶剂中乳化琼脂糖凝胶溶胶随后冷却来制备具有封装的琼脂糖凝胶固体核心的前囊泡; （2）从前囊中提取亲脂性成分，得到琼脂糖凝胶微珠; （3）在任选的步骤中，将胶体金颗粒引入微球体中，然后用蛋白质或肽分子层包被; （4）使用用于形成脂质体的改性有机溶剂微球蒸发法进行微球的封装。电子显微照片表明，如果通过使用含有二油酰磷脂酰胆碱，胆固醇，二油酰磷脂酰甘油和三油酸甘油酯（摩尔比为4.5:4.5:1:1）的脂质混合物制备脂质体，则每个固体核脂质体仅存在单个连续双层膜。

113. 发明公开

EP0259457A1 MONOCLONAL ANTIBODIES TO LEGIONELLA 失效
标题翻译：对军团菌的单克隆抗体。
公开(公告)号：EP0259457A1
公开(公告)日：1988-03-16
申请号：EP87901984.0
申请日：1987-03-11
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HOFFMAN, Paul, S.
IPC分类号： C07K16
CPC分类号： C07K16/126
摘要： Des anticorps monoclonaux ayant une réactivité à des épitopes spécifiques au genre présents sur des protéines de la membrane externe de bactéries du genre Légionella ainsi que des hybridomes de sécrétion des anticorps sont décrits.

114. 发明公开

EP0185738A1 IMMUNOLIPOSOME ASSAY - METHODS AND PRODUCTS 失效
标题翻译：免疫脂质体测试方法和产品。
公开(公告)号：EP0185738A1
公开(公告)日：1986-07-02
申请号：EP85903151.0
申请日：1985-06-11
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HUANG, Leaf , HO, Rodney, Jin, Yong
IPC分类号： G01N33
CPC分类号： G01N33/532 , G01N33/586 , Y10S435/966 , Y10S435/967 , Y10S435/975 , Y10S436/815 , Y10S436/829
摘要： Nouvel essai immunologique par lyse de membrane. Dans un mode de réalisation de cet essai, un antigène est d'abord couplé de façon covalente à des lipides, et ce composé antigène-lipide est mélangé à un lipide formant une phase hexagonale pour obtenir des vésicules de liposome à double couche contenant en outre un colorant fluorescent auto-inhibiteur. Lorsque ce liposome contenant des antigènes est mis en contact avec une surface solide enduite de molécules anticorps, une liaison se produit entre l'antigène et l'anticorps, faisant éclater le liposome et libérant le colorant. Afin de tester la présence d'antigènes libres dans un fluide biologique, le fluide est premièrement mis en contact avec le composé surface solide-anticorps, afin de saturer l'anticorps lié. Il en résulte la limitation de la liaison par les liposomes, ce qui réduit la libération de colorant. En comparant la libération de colorant avec une courbe standard de libération de colorant par rapport à des concentrations connues d'antigènes, il est possible de déterminer rapidement la concentration inconnue d'antigènes dans le fluide biologique. De même, il est possible de vérifier la présence d'anticorps et d'autres entités, par exemple, d'enzymes, de médicaments, etc ... en utilisant des versions légèrement modifiées de cet essai.

115. 发明公开

EP0179126A1 FUSED LIPOSOME AND ACID INDUCED METHOD FOR LIPOSOME FUSION 失效
标题翻译：融化的脂质体和酸致PROCESS FOR LIPOSOMSCHMELZE。
公开(公告)号：EP0179126A1
公开(公告)日：1986-04-30
申请号：EP85902244.0
申请日：1985-04-09
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HUANG, Leaf , CONNOR, Jerome
IPC分类号： A01H1 , A01H5 , A61K9 , B01J13 , C12N5 , C12N15
CPC分类号： A61K9/127 , A61K9/1272 , C12N15/88 , Y10T428/2984
摘要： Des liposomes contenant de la phosphatidyléthanolamine, de la palmitoyl homocystéine ou de l'acide oléique ou de l'acide palmitique, fusionnent rapidement lorsque le pH du milieu est réduit en dessous de 7. On a mesuré la fusion des liposomes par a) mélange des lipides liposomiques comme cela est illustré par le transfert d'énergie de résonance, b) filtration par gel et c) microscopie électronique. La présence de phosphatidyléthanolamine ou d'esters d'addition d'acide de celle-ci dans les liposomes favorise considérablement la fusion, tandis que la présence de phosphatidylcholine inhibe la fusion des liposomes. Pendant la fusion de liposomes contenant phosphatidyléthanolamine: palmitoyl homocystéine (8:2), presque toute la calcéine encapsulée est libérée. L'inclusion de cholestérol (40%) dans les liposomes diminue sensiblement les fuites sans nuire à la fusion. Ces liposomes sensibles au pH sont fusionnés pour fournir des molécules biologiquement actives telles que l'ADN dans des cellules vivantes.

116. 发明公开

EP2277514A1 A method for chemoprevention of prostate cancer 审中-公开
标题翻译： Methode zur Vorbeugung von Prostatakrebs
公开(公告)号：EP2277514A1
公开(公告)日：2011-01-26
申请号：EP10012242.3
申请日：1999-05-07
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： Steiner, Mitchell S. , Raghow, Sharon
IPC分类号： A61K31/135 , A61K31/138
CPC分类号： A61K31/138
摘要： The invention relates to the chemoprevention of prostate cancer and, more particularly, provides a chemopreventive agent, e.g. toremifene citrate, for use in treating prostate intraepithelial neoplasia (PIN), especially high grade prostate intraepithelial neoplasia (HGPIN).
摘要翻译：本发明涉及前列腺癌的化学预防，更具体地说，涉及化学预防剂，例如化学预防剂。托伐米芬柠檬酸盐，用于治疗前列腺上皮内瘤变（PIN），特别是高级前列腺上皮内瘤变（HGPIN）。

117. 发明公开

EP1678096A2 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE 失效转让
标题翻译： LPA受体激动剂和拮抗剂及使用方法
公开(公告)号：EP1678096A2
公开(公告)日：2006-07-12
申请号：EP04809934.5
申请日：2004-10-12
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： MILLER, Duane, D. , TIGYI, Gabor , DURGAM, Gangadhar, G. , VIRAG, Tamas , WALKER, Michelle, D. , TSUKAHARA, Ryoko
IPC分类号： C03C27/02
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or ogan, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
摘要翻译：本发明涉及如本文所公开的根据式（I）的化合物以及包含那些化合物的药物组合物。还公开了使用这种化合物的方法，所述化合物具有作为LPA受体的激动剂或拮抗剂的活性; 所述方法包括抑制LPA受体上的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗细胞凋亡或保留或恢复细胞，组织或细胞中的功能，培养细胞，保存器官或组织功能，并治疗皮肤病。

118. 发明公开

EP1487780A1 HALOACETAMIDE AND AZIDE SUBSTITUTED COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：卤乙酰胺和AZIDSUBSTITUIERTE化合物和申请流程。
公开(公告)号：EP1487780A1
公开(公告)日：2004-12-22
申请号：EP03713345.1
申请日：2003-02-24
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： DALTON, James , MILLER, Duane, D.
IPC分类号： C07C231/00 , C07C233/05 , C07C247/00 , C07C255/00 , A61K31/165 , A61K31/215 , A61K31/275 , A61K31/655
CPC分类号： A61K31/165 , A61K31/215 , A61K31/275 , A61K31/655 , C07C235/16 , C07C235/24 , C07C247/16 , C07F9/46 , C07F9/5004 , C07F9/5022 , C07F9/52
摘要： The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents. These agents which define a new subclass of compounds, namely selective androgen receptor modulators (SARMs) which, either alone or in a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell.

119. 发明授权

EP1003496B1 MEDICAMENT FOR TREATING PROSTATE INTRAEPITHELIAL NEOPLASIA 有权
标题翻译：药物治疗前列腺上皮内
公开(公告)号：EP1003496B1
公开(公告)日：2004-11-24
申请号：EP99924157.3
申请日：1999-05-07
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： STEINER, Mitchell, S. , RAGHOW, Sharon
IPC分类号： A61K31/135 , A61P35/00 , A61P13/08
CPC分类号： A61K31/138
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of administering to a subject an effective dose of a chemopreventive agent, toremifene and analogs or metabolites thereof, to prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having an elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

120. 发明公开

EP1264220A2 PATTERNING METHODS AND SYSTEMS USING REFLECTED INTERFERENCE PATTERNS 审中-公开
标题翻译：方法研究系统泽西埃尔克斯特氏菌麻醉剂干燥素
公开(公告)号：EP1264220A2
公开(公告)日：2002-12-11
申请号：EP01912902.2
申请日：2001-02-22
申请人： Semiconductor Research Corporation , THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HERR, Daniel, J.C. , JOY, David, Charles
IPC分类号： G03H5/00 , G03F7/20 , H01J37/317
CPC分类号： G03H1/04 , B82Y10/00 , B82Y40/00 , G03F7/2002 , G03F7/2049 , G03F7/70408 , G03H1/02 , G03H1/0402 , G03H1/0866 , G03H5/00 , G03H2001/0038 , G03H2001/0094 , G03H2001/0204 , G03H2001/0456 , G03H2001/0469 , G03H2210/30 , G03H2222/34 , G03H2260/14 , G03H2260/62 , G03H2260/63 , H01J37/3174
摘要： A method for patterning a layer on a substrate can include projecting coherent radiation toward a reflector surface so that the coherent radiation is reflected off the reflector surface to provide a holographic projection of a desired image wherein the reflector surface includes information that corresponds to an inverse of the holographic projection of the desired image. The substrate including the layer can be maintained in the path of the reflected radiation so that the holographic projection is projected onto the layer. Related systems are also discussed.
摘要翻译：用于图案化衬底上的层的方法可以包括将相干辐射投射到反射器表面，使得相干辐射从反射器表面反射以提供期望图像的全息投影，其中反射器表面包括对应于所需图像的全息投影。包括该层的衬底可以保持在反射辐射的路径中，使得全息投影投影到该层上。还讨论了相关系统。

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