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101. 发明授权

US4139637A Quinone derivatives useful as medicaments 失效
标题翻译：喹诺酮衍生物作为药物有用
公开(公告)号：US4139637A
公开(公告)日：1979-02-13
申请号：US694491
申请日：1976-06-09
申请人： Maurice Rouchy
发明人： Maurice Rouchy
IPC分类号： C07C281/18 , A61K31/175 , A61K31/445 , A61K31/535 , A61K31/555
CPC分类号： C07C281/18 , Y10S514/889
摘要： The present invention relates to new chemical compounds which are useful in particular as medicaments. The compounds are derivatives of a quinone endowed with physiological and particularly vitamin activity and of a substituted hydrazine; they correspond to the following general formulas: ##STR1## R.sub.1 and R.sub.2 are identical or different and correspond to the general formula: ##STR2## X represents S, Se, O or NH; R.sub.a, R.sub.b are identical or different and are either H, or a branched or unbranched alkyl radical, or the radical --CH.sub.2 NR.sub.4 R.sub.5 ; in this case R.sub.4 and R.sub.5 are lower alkyl radicals or else form either a morpholine ring or a methylated piperazine ring,R.sub.6 and R.sub.7 may be hydrogen, methyl, allyl, phytyl, farnesyl, geranyl, linayl. R.sub.6 is different from R.sub.7 and one of the two is either hydrogen, methyl or allyl,R.sub.8 and R.sub.9 are identical or different and are --H, --CH.sub.3 or --OCH.sub.3, or form the two together a benzene ring.The compounds in accordance with the invention are endowed with antiviral and vitamin properties and can be administered in therapeutically active doses intravenously, intramuscularly or orally.
摘要翻译：本发明涉及特别用作药物的新化合物。所述化合物是具有生理特别是维生素活性的醌的取代的肼的衍生物; 它们对应于以下通式： R 1和R 2相同或不同，并且对应于通式：其中X表示S，Se，O或NH; R a，R b相同或不同，为H或支链或非支链烷基，或基团-CH 2 NR 4 R 5; 在这种情况下，R4和R5是低级烷基，或者形成吗啉环或甲基化哌嗪环，R6和R7可以是氢，甲基，烯丙基，植酰基，法呢基，香叶基，亚麻基。 R6不同于R7，二者之一是氢，甲基或烯丙基，R8和R9相同或不同，为-H，-CH3或-OCH3，或两者一起形成苯环。

102. 发明授权

US4112120A Methods and compositions for use in animal husbandry 失效
标题翻译：用于畜牧业的方法和组合物
公开(公告)号：US4112120A
公开(公告)日：1978-09-05
申请号：US667440
申请日：1976-03-16
申请人： Michael James Smithers
发明人： Michael James Smithers
IPC分类号： A23K1/16 , A23K1/18 , C07C67/00 , C07C239/00 , C07C271/08 , C07C281/18 , C07C325/00 , C07C337/08 , C07D233/52 , A61K31/175 , A61K31/155 , A61K31/17 , A61K31/415
CPC分类号： C07C281/18 , A23K20/111 , A23K20/137 , A23K50/30 , C07C337/08 , C07D233/52 , Y10S514/889
摘要： The disclosure relates to method for use in the husbandry of meat-producing domestic animals which comprises the oral administration to the animals of a p-benzoquinonedi-imide derivative, or a dihydro derivative or a salt thereof, and to compositions suitable for direct feeding to animals, in the method of the invention, or suitable for dilution with an animal foodstuff to give a supplemented foodstuff suitable for direct feeding to animals in the method of the invention; also to certain of the p-benzoquinonedi-imide derivatives which are novel compounds, and a process for their manufacture.
摘要翻译：本公开涉及用于养殖生肉的家畜的方法，其包括向动物口服给予对苯醌二酰亚胺衍生物或其二氢衍生物或其盐，以及适于直接进食的组合物动物，或者适合于用动物食品稀释以在本发明的方法中给予适于直接喂养动物的补充食品; 也是某些作为新化合物的对苯醌二酰亚胺衍生物及其制备方法。

103. 发明授权

US4021551A 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof 失效
标题翻译： 3,6-双 - （杂环氨酰基 - 氨基） - 吖啶及其盐
公开(公告)号：US4021551A
公开(公告)日：1977-05-03
申请号：US600434
申请日：1975-07-30
申请人： Ernest Cullen , Peter Meindl , Hans Tuppy , Gerhard Bodo
发明人： Ernest Cullen , Peter Meindl , Hans Tuppy , Gerhard Bodo
IPC分类号： C07D219/08 , C07D401/12 , A61K31/54 , C07D413/12 , C07D417/12
CPC分类号： C07D219/08 , Y10S514/889
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3, together with each other and the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring system which may optionally contain one or more additional heteroatoms, andA is lower alkylene or aryl-lower alkylene, and nontoxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as inducers of the formation of interferon.
摘要翻译：其中R 1是氢或甲基，R 2和R 3彼此以及与它们相连的氮原子形成饱和或不饱和杂环体系，其可以任选地含有一个或多个另外的杂原子，和A是低级亚烷基或芳基 - 低级亚烷基，和无毒的药学上可接受的酸加成盐; 化合物及其盐可用作干扰素形成的诱导剂。

104. 发明授权

US3948886A 6-Substituted purine 3',5'-cyclic nucleotides 失效
标题翻译： 6-取代嘌呤3 {40,5 {40-环核苷酸
公开(公告)号：US3948886A
公开(公告)日：1976-04-06
申请号：US368323
申请日：1973-06-08
申请人： Dennis A. Shuman , Rich B. Meyer, Jr. , Roland K. Robins
发明人： Dennis A. Shuman , Rich B. Meyer, Jr. , Roland K. Robins
IPC分类号： C07H19/20
CPC分类号： C07H19/20 , Y10S514/889 , Y10S526/923
摘要： Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon potentiation, antiviral activity, and the ability to activate adenosine 3',5'-cyclic phosphate-dependent protein kinase while enjoying resistance to phosphodiesterase hydrolysis superior to that of its naturally occuring analog. The compounds are obtained by alkylation of the corresponding 6-thio nucleotide, which is in turn provided by a novel synthetic route.
摘要翻译：本文描述了新颖的6-烷硫基和6-芳基烷硫基嘌呤3'，5'环核苷酸，其各不相同地显示腺苷酸环化酶和（在动物研究中）肿瘤抑制性质，干扰素增强，抗病毒活性和激活腺苷3'，5' 环磷酸依赖性蛋白激酶，同时享受抗磷酸二酯酶水解优于其天然存在的类似物。通过相应的6-硫代核苷酸的烷基化获得化合物，其又由新的合成途径提供。

105. 发明授权

US3843629A Complexs of polyriboinosinic acid and polyribo-2-thiocytidylic acid 失效
标题翻译：聚氨基磷酸和聚二氧杂环戊二烯酸的复合物
公开(公告)号：US3843629A
公开(公告)日：1974-10-22
申请号：US26367772
申请日：1972-06-16
申请人： MERCK PATENT GMBH
发明人： SCHEIT K , SAIKO O , FAERBER P , REUSS K
IPC分类号： C07H21/00 , C07D51/52 , C07D51/54
CPC分类号： C07H21/00 , Y10S514/889
摘要： Two-component complexes consisting of a polyriboinosinic acid of the formula
WHEREIN M IS AN INTEGER FROM 1 TO 3, INCLUSIVE; AND N IS AN INTEGER FROM 1 TO 2,000, INCLUSIVE; AND THE METAL AND AMMONIUM SALTS THEREOF, EXHIBIT ANTIMICROBIAL, IN PARTICULAR ANTIVIRAL, ACTIVITY.

WHEREIN K IS AN INTEGER FROM 1 TO 3, INCLUSIVE; AND B IS AN INTEGER FROM 1 TO 2,000, INCLUSIVE; AND THE METAL AND AMMONIUM SALTS THEREOF, AND A POLYRIBO-2-THIOCYTIDYLIC ACID OF THE FORMULA

106. 发明授权

US3819482A Method of preparing high yields of double-stranded ribonucleic acid 失效
标题翻译：制备双链抗坏血酸的方法
公开(公告)号：US3819482A
公开(公告)日：1974-06-25
申请号：US25125772
申请日：1972-05-08
申请人： SEMANCIK J , ETTEN J VAN , VIDAVER A
发明人： VIDAVER A , VAN ETTEN J , SEMANCIK J
IPC分类号： C07H21/00 , C12N7/00 , C12P19/34 , C12D13/06
CPC分类号： C07H21/00 , C12N7/00 , C12N2795/14251 , C12P19/34 , Y10S435/803 , Y10S435/874 , Y10S514/889
摘要： An unusual bacteriophage phi 6, ATCC No. 21781-B, containing a lipid coat and double-stranded ribonucleic acid has been isolated for the plant pathogenic bacterium Pseudomonas phaseolicola ATCC No. 21781. High yields of double-stranded ribonucleic acid may be obtained rapidly and expediently by cultivating a host bacterium for the bacteriophage, infecting the host bacteria with the bacteriophage to provide a lysate and recovering double-stranded ribonucleic acid from the separated bacteriophage. The intact or whole bacteriophage, the bacteriophage with its lipid coat removed, and the isolated nucleic acid have all been found to be effective interferon inducers.
摘要翻译：已经分离了含有脂质外壳和双链核糖核酸的不寻常的噬菌体phi 6，ATCC 21781-B，用于植物致病菌Pseudomonas phaseolicola ATCC No.21781。可以快速获得高产量的双链核糖核酸通过培养用于噬菌体的宿主细菌，用噬菌体感染宿主细菌以提供裂解物并从分离的噬菌体中回收双链核糖核酸。

107. 发明授权

EP0942724B1 GEL FORMULATIONS FOR TOPICAL DRUG DELIVERY 失效
标题翻译：凝胶制剂外用药品供应
公开(公告)号：EP0942724B1
公开(公告)日：2003-07-23
申请号：EP97950772.0
申请日：1997-12-01
申请人： MINNESOTA MINING AND MANUFACTURING COMPANY
发明人： BEAURLINE, Joseph, M. , RODDY, Patrick, J. , TOMAI, Mark, A.
IPC分类号： A61K31/4745 , A61K47/02 , A61K47/10 , A61K47/14
CPC分类号： A61K9/0014 , A61K31/4745 , A61K47/02 , A61K47/10 , A61K47/14 , Y10S514/889 , Y10S514/934 , Y10S514/944
摘要： Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug 4-amino-2-ethoxymethyl- alpha , alpha -dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol, which when applied topically induces cytokines, such as interferon and tumor necrosis factor, locally in the skin or mucous membranes of a mammal. The gel formulations are also well suited for topical delivery of drugs for treatment of diseases involving skin and/or mucosal lesions because the gel formulations do not need to include irritating components.

108. 发明授权

EP0828727B1 CYCLOHEXYLDIHYDROBENZOFURANE 失效
公开(公告)号：EP0828727B1
公开(公告)日：2003-01-02
申请号：EP96914207.4
申请日：1996-05-14
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BÄR, Thomas , FLOCKERZI, Dieter , SCHMID, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , ULRICH, Wolf-Rüdiger , MARTIN, Thomas
IPC分类号： C07D307/94 , C07D307/86 , A61K31/34
CPC分类号： C07D307/94 , C07D307/86 , Y10S514/826 , Y10S514/886 , Y10S514/889 , Y10S514/914
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and R5 have the meanings given in the description, are new powerful PDE inhibitors.

109. 发明公开

EP1219630A1 IMMUNOPOTENTIATING COMPOSITIONS 有权
标题翻译：不锈钢VERBINDUNGEN
公开(公告)号：EP1219630A1
公开(公告)日：2002-07-03
申请号：EP00954940.3
申请日：2000-08-24
申请人： OTSUKA PHARMACEUTICAL CO., LTD.
发明人： KUMEMURA, Megumi , DOI, Tatsuya , SAITO, Takao , NODA, Tsuneyuki , OKAMATSU, Hiroshi
IPC分类号： C07H3/06 , A61K31/702 , A61P37/04 , A61P43/00 , A61P31/04 , A61P1/00
CPC分类号： C07H3/06 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/702 , Y10S514/885 , Y10S514/889 , A23V2250/712 , A23V2250/032 , A23V2250/606 , A23V2250/708 , A23V2250/24 , A23V2250/211 , A23V2250/28
摘要： The invention provides an immunopotentiating composition and to a composition accelerating the production of interferon-γ, both comprising lactosuclose as an active ingredient. In particular, the invention provides such compositions in the form of a foodstuff. Oral administration or ingestion of the compositions enhances biophylaxis mechanism (immunological function) in the digestive tract, thus achieving significant treating and preventing effects on intestinal infections and like diseases.
摘要翻译：本发明提供一种免疫增强组合物和加速生产干扰素-γ的组合物，两者都包含乳糖基糖苷作为活性成分。特别地，本发明提供了食品形式的这种组合物。口服给药或摄入组合物增强消化道中的生物防治机制（免疫功能），从而实现对肠道感染等疾病的显着治疗和预防作用。

110. 发明授权

EP0771191B1 IMMUNOLOGICAL ACTIVITY OF RHAMNOLIPIDS 失效
标题翻译：鼠李糖脂免疫活性
公开(公告)号：EP0771191B1
公开(公告)日：2002-04-10
申请号：EP95927153.7
申请日：1995-07-20
申请人： Piljac, Goran , Piljac, Visnja
发明人： Piljac, Goran , Piljac, Visnja
IPC分类号： A61K31/70 , C12P19/04
CPC分类号： A61K31/7028 , A61K8/602 , A61K31/70 , A61Q19/00 , C12P19/44 , Y10S514/814 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/878 , Y10S514/883 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/889 , Y10S514/903 , Y10S514/908
摘要： Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) wherein R1 is H or α-L-rhamnopyranosyl; R2 is H or -CH(R4)-CH2-COOH; R3 is (C¿5?-C20)-saturated, mono or polyunsaturated hydrocarbyl and R?4¿ is (C¿5?-C20)-saturated, mono or polyunsaturated hydrocarbyl; are provided.

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