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101. 发明授权

US06569404B1 Phase shift colloids as ultrasound contrast agents 失效
标题翻译：相移胶体作为超声造影剂
公开(公告)号：US06569404B1
公开(公告)日：2003-05-27
申请号：US08465922
申请日：1995-06-06
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61B800
CPC分类号： A61K49/223 , A61K49/226
摘要： Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
摘要翻译：用于增强诊断超声程序中的对比度的试剂包括液体 - 液体类型的胶体分散体，即乳液或微乳液，其中分散液相是沸点低于待成像动物温度的液体因此，在施用于动物后，其从分散的液体经历相变到高回声分散的气态泡沫或kugelschaum。分散相的液体状态允许制造粒度通常低于1000nm的非常稳定的药学上可接受的乳液。在体温下的气态产生高度回声的微泡，通常在直径小于10,000nm的范围内，其作为超声造影剂是有效的。描述了静脉内，动脉内，口服，腹膜内和子宫内剂型，给药方法和成像技术。

102. 发明授权

US06274713B1 Polychelants 失效
标题翻译：聚合物
公开(公告)号：US06274713B1
公开(公告)日：2001-08-14
申请号：US08473573
申请日：1995-06-07
申请人： Paul F. Sieving , Alan David Watson , Steven C. Quay , Scott Michael Rocklage
发明人： Paul F. Sieving , Alan David Watson , Steven C. Quay , Scott Michael Rocklage
IPC分类号： C07K100
CPC分类号： A61K49/146 , A61K49/085 , A61K49/128 , A61K49/143 , A61K51/0491 , A61K51/065 , A61K51/081 , A61K51/088 , C08G69/48
摘要： Invention is directed to polychelants and their metal chelates which are useful in diagnostic imaging. The polychelants comprise a plurality of macrocyclic chelant moieties, eg. DOTA residues, conjugated by thiourea, urea or glycinamide linkages to a backbone moiety through a donor atom.
摘要翻译：本发明涉及可用于诊断成像的多元醇及其金属螯合物。多元醇包含多个大环螯合剂部分，例如。 DOTA残基，由硫脲缀合，尿素或甘氨酰胺键通过供体原子连接到骨架部分。

103. 发明授权

US06245319B1 Colloidal dispersions of perfluoropentane 失效
标题翻译：全氟戊烷的胶体分散体
公开(公告)号：US06245319B1
公开(公告)日：2001-06-12
申请号：US09535165
申请日：2000-03-24
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61B813
CPC分类号： A61K49/223 , A61K49/226
摘要： Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
摘要翻译：用于增强诊断超声程序中的对比度的试剂包括液体 - 液体类型的胶体分散体，即乳液或微乳液，其中分散液相是沸点低于待成像动物温度的液体因此，在施用于动物后，其从分散的液体经历相变到高回声分散的气态泡沫或kugelschaum。分散相的液体状态允许制造粒度通常低于1000nm的非常稳定的药学上可接受的乳液。在体温下的气态产生高度回声的微泡，通常在直径小于10,000nm的范围内，其作为超声造影剂是有效的。描述了静脉内，动脉内，口服，腹膜内和子宫内剂型，给药方法和成像技术。

104. 发明授权

US6156292A Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media 失效
公开(公告)号：US6156292A
公开(公告)日：2000-12-05
申请号：US770522
申请日：1996-12-20
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61B8/08 , A61B8/14 , A61K9/133 , A61K49/00 , A61K49/22 , A61B5/055
CPC分类号： A61K49/223
摘要： Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.

105. 发明授权

US5707607A Phase shift colloids as ultrasound contrast agents 失效
标题翻译：相移胶体作为超声造影剂
公开(公告)号：US5707607A
公开(公告)日：1998-01-13
申请号：US469472
申请日：1995-06-06
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61K49/00 , A61K9/127 , A61K49/22 , A61B8/13
CPC分类号： A61K49/226 , A61K49/223
摘要： Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
摘要翻译：用于增强诊断超声程序中的对比度的试剂包括液体 - 液体类型的胶体分散体，即乳液或微乳液，其中分散的液相是高分子液体化合物，其经历从分散液体到相变在向生物体施用后，高度回声的分散的气态泡沫或k。。。分散相的液体状态允许制造粒度通常低于1000nm的非常稳定的药学上可接受的乳液。在体温下的气态产生高度回声的微泡，通常在直径小于10,000nm的范围内，其作为超声造影剂是有效的。描述了静脉内，动脉内，口服，腹膜内和子宫内剂型，给药方法和成像技术。

106. 发明授权

US5558855A Phase shift colloids as ultrasound contrast agents 失效
标题翻译：相移胶体作为超声造影剂
公开(公告)号：US5558855A
公开(公告)日：1996-09-24
申请号：US8172
申请日：1993-01-25
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61K49/22 , A61N7/00 , A61K49/00
CPC分类号： A61K49/226 , A61K49/223
摘要： Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling point at or below the body temperature of the organism to be studied and thus undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
摘要翻译：本文公开了用于增强诊断超声程序中的对比度的试剂。这些试剂包括液体液体类型的胶体分散体，即乳液或微乳液，其中分散的液相的沸点在待研究的生物体的体温或以下，因此经历相变在向生物体施用后，将分散的液体分散到高度回声的分散的气态泡沫或密封胶。分散相的液体状态允许制造粒度通常低于1000nm的非常稳定的药学上可接受的乳液。在体温下的气态产生高度回声的微泡，通常在直径小于10,000nm的范围内，其作为超声造影剂是有效的。描述了静脉内，动脉内，口服，腹膜内和子宫内剂型，给药方法和成像技术。

107. 发明授权

US5393524A Methods for selecting and using gases as ultrasound contrast media 失效
标题翻译：选择和使用气体作为超声波造影剂的方法
公开(公告)号：US5393524A
公开(公告)日：1995-02-28
申请号：US71377
申请日：1993-06-04
申请人： Steven C. Quay
发明人： Steven C. Quay
IPC分类号： A61K49/00 , A61K49/22 , A61K49/02
CPC分类号： A61K49/223
摘要： Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of a microbubble comprised of the gas.
摘要翻译：本文公开了用于增强超声图像中的对比度的试剂。这些试剂是非常小的气泡，或由特殊选择的气体组成的“微泡”。本文描述的微泡在溶液中显示出长寿命，并且可以以足够小的尺寸产生穿过肺，从而能够改善心血管系统和其他重要器官的超声成像。本文还公开了用于选择可以从其中产生造影剂的气体的方法。该方法基于使用气体的固有物理性质的计算，并且描述了将气体的性质与由气体组成的微气泡溶解的时间相关联的手段。

108. 发明授权

US5039512A NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes 失效
标题翻译：聚（亚烷基 - 氨基） - 烷烃的顺磁多价金属盐的NMR成像
公开(公告)号：US5039512A
公开(公告)日：1991-08-13
申请号：US057709
申请日：1987-06-15
申请人： Karl F. Kraft , Steven C. Quay , Scott M. Rocklage , Dilip Worah
发明人： Karl F. Kraft , Steven C. Quay , Scott M. Rocklage , Dilip Worah
IPC分类号： A61K49/06 , C07D259/00 , C07F5/00 , C07F9/38 , C07F13/00 , G01R33/28
CPC分类号： G01R33/5601 , A61K49/06 , C07D259/00 , C07F13/005 , C07F5/003 , C07F9/3817 , Y10S424/90 , Y10T436/24
摘要： In a method of imaging body tissue in a patient, comprising administering to the patient an effective amount of a pharmaceutical agent for effecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to effect such relaxation times, of a paramagnetic, physiologically compatible salt of a physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 57-70, or of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier, and subjecting the patient to NMR tomography, the improvement wherein said salt of said chelate complex is the calcium or magnesium salt. Such salts are new as are some of the complexing chelates.
摘要翻译：在患者体内成像身体组织的方法中，包括向患者施用有效量的用于进行经历核磁共振诊断的身体组织中的原子的松弛时间的药剂，由此增强图像对比度，所述药剂包含有效量实现这样的松弛时间，原子序数为57-70的镧系元素离子的生理上相容的螯合络合物的顺磁性生理上相容的盐或原子序数21-29,42或44的过渡金属; 和药学上可接受的载体，并对患者进行NMR层析成像，其中所述螯合络合物的所述盐是钙盐或镁盐。这些盐是一些新的络合螯合物。

109. 发明授权

US5039511A Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor 失效
标题翻译：淀粉样变性和阿尔茨海默病诊断测定及其试剂
公开(公告)号：US5039511A
公开(公告)日：1991-08-13
申请号：US582152
申请日：1990-09-14
申请人： Steven C. Quay , Scott M. Rocklage , Warren K. Miller
发明人： Steven C. Quay , Scott M. Rocklage , Warren K. Miller
IPC分类号： A61K51/04 , C07C309/47 , C07C309/50 , C07D277/66 , C09B29/01 , C09B29/30 , C09B35/08 , C09B35/16 , C09B35/20 , C09B43/40 , G01N33/68
CPC分类号： G01N33/6896 , A61K51/0453 , C07C309/47 , C07C309/50 , C07D277/66 , C09B29/0003 , C09B29/0011 , C09B29/30 , C09B35/08 , C09B35/16 , C09B35/20 , C09B43/40 , A61K2123/00 , G01N2800/2821
摘要： The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects of the invention
摘要翻译：淀粉样蛋白沉积物在患者的器官或身体区域中的存在和位置通过向患者静脉内施用新的放射性碘标记的淀粉样蛋白结合化合物和优选123I标记的化合物来实现，并感测从器官或身体区域发射的辐射。易于碘化的新型非放射性碘取代的淀粉样蛋白结合化合物和淀粉样蛋白结合化合物是本发明的另外的方面

110. 发明授权

US4992555A Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates 失效
标题翻译：能够形成金属离子螯合物的某些二吡啶磷酸盐螯合化合物
公开(公告)号：US4992555A
公开(公告)日：1991-02-12
申请号：US370428
申请日：1989-06-23
申请人： Scott M. Rocklage , Steven C. Quay
发明人： Scott M. Rocklage , Steven C. Quay
IPC分类号： A61K49/06 , C07F9/58 , C07F13/00 , G01R33/28
CPC分类号： C07F13/005 , A61K49/06 , C07F9/582 , G01R33/5601
摘要： N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N'-bis-(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N'-diacetic acid, and the soluble calcium salts thereof.Novel intermediates for forming these compounds are N,N'-bis(pyridoxal-5-phosphate)alkylenediimines, N,N'-bis(pyridoxal-5-phosphate)alkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-arylenediamines, and the corresponding monophosphate compounds.
摘要翻译： N，N'-二 - （吡哆醛-5-磷酸） - 亚烷基二胺-N，N'-二乙酸，N，N'-双 - （吡哆醛-5-磷酸酯）-1,2-环烷二胺-N，N' - 二乙酸和N，N'-二 - （吡哆醛-5-磷酸）-1,2-芳基二胺-N，N'-二乙酸，相应的单磷酸酯化合物和单乙酸化合物，其盐和酯形成稳定，具有顺磁金属离子的高度可溶性螯合物，是高效的NMRI造影剂。优选的造影剂是N，N'-双 - （吡哆醛-5-磷酸）乙二胺-N，N'-二乙酸，N，N'-双 - （吡哆醛-5-磷酸）反式-1的顺磁离子螯合物， 2-环己二胺-N，N'-二乙酸，N，N'-双 - （吡哆醛-5-磷酸）反式-1,2-芳基二胺-N，N'-二乙酸及其可溶性钙盐。用于形成这些化合物的新型中间体是N，N'-双（吡哆醛-5-磷酸）亚烷基二亚胺，N，N'-双（吡哆醛-5-磷酸）亚烷基二胺，N，N'-双（吡哆醛-5-磷酸酯） 1,2-环烷基二亚胺，N，N'-双（吡哆醛-5-磷酸）-1,2-环烷基二胺，N，N'-双（吡哆醛-5-磷酸）-1,2-亚芳基二胺，和相应的单磷酸盐化合物。

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