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1. 发明授权

US09023793B2 Intranasal carbetocin formulations and methods for the treatment of autism 有权
标题翻译：鼻内卡贝缩胆制剂和治疗自闭症的方法
公开(公告)号：US09023793B2
公开(公告)日：2015-05-05
申请号：US13204485
申请日：2011-08-05
申请人： Alexis Kays Leonard , Joshua Orion Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty , Steven C. Quay
发明人： Alexis Kays Leonard , Joshua Orion Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty , Steven C. Quay
IPC分类号： A61K38/11 , A61P5/10 , A61K9/00 , A61K45/06 , A61K31/337 , A61K9/08
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/337 , A61K45/06 , A61K2300/00
摘要： Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
摘要翻译：提供含有催产素或催产素类似物（例如卡贝缩略）的方法和组合物用于预防和治疗自闭症谱系障碍，相关疾病和此类病症的症状。本公开的方法和组成有效地用于治疗社会戒断，避免眼睛接触，重复行为，焦虑，注意力缺陷，多动，抑郁，言语失调，口头沟通困难，厌恶触觉，视力困难，理解困难，声光灵敏度。提供了额外的组合物和方法，其使用催产素或催产素类似物与次要或辅助治疗剂组合以产生针对孤独症谱系障碍和相关病症的更有效的治疗工具。

2. 发明授权

US08486891B2 Nasal calcitonin formulations containing chlorobutanol 有权
标题翻译：包含氯丁醇的鼻降钙素制剂
公开(公告)号：US08486891B2
公开(公告)日：2013-07-16
申请号：US13371037
申请日：2012-02-10
申请人： Steven C. Quay , Jorge C. de Meireles , Arati Deshpande , Zenaida O. Go , Anthony P. Sileno
发明人： Steven C. Quay , Jorge C. de Meireles , Arati Deshpande , Zenaida O. Go , Anthony P. Sileno
IPC分类号： A61K38/23 , C07K14/585
CPC分类号： A61K9/0043 , A61K38/23
摘要： An aqueous solution of calcitonin suitable for intranasal administration comprised of calcitonin, chlorobutanol at a concentration of less than 0.4% weight/weight, and water and having a pH of less than 4 with the proviso that benzalkonium chloride is not present in the solution. The aqueous solution of calcitonin can be used to treat osteoporosis, Paget's bone disease and hypercalcemia.
摘要翻译：适于鼻内给药的降钙素水溶液包含浓度小于0.4重量％的降钙素，氯丁醇和水，pH小于4，条件是溶液中不存在苯扎氯铵。降钙素水溶液可用于治疗骨质疏松症，佩吉特骨病和高钙血症。

3. 发明申请

US20110009321A1 NASAL CALCITONIN FORMULATIONS CONTAINING CHLOROBUTANOL 有权
标题翻译：包含氯丁醇的纳卡尔钙钙配方
公开(公告)号：US20110009321A1
公开(公告)日：2011-01-13
申请号：US12878936
申请日：2010-09-09
申请人： Steven C. Quay , Jorge C. de Meireles , Arati A. Deshpande , Zenaida O. Go , Anthony P. Sileno
发明人： Steven C. Quay , Jorge C. de Meireles , Arati A. Deshpande , Zenaida O. Go , Anthony P. Sileno
IPC分类号： A61K38/23 , A61P19/10 , A61P19/08 , A61P3/00
CPC分类号： A61K9/0043 , A61K38/23
摘要： An aqueous solution of calcitonin suitable for intranasal administration comprised of calcitonin, chlorobutanol at a concentration of less than 0.4% weight/weight, and water and having a pH of less than 4 with the proviso that benzalkonium chloride is not present in the solution. The aqueous solution of calcitonin can be used to treat osteoporosis, Paget's bone disease and hypercalcemia.
摘要翻译：适于鼻内给药的降钙素水溶液包含浓度小于0.4重量％的降钙素，氯丁醇和水，pH小于4，条件是溶液中不存在苯扎氯铵。降钙素水溶液可用于治疗骨质疏松症，佩吉特骨病和高钙血症。

4. 发明授权

US07812120B2 Nasal calcitonin formulations containing chlorobutanol 有权
标题翻译：包含氯丁醇的鼻降钙素制剂
公开(公告)号：US07812120B2
公开(公告)日：2010-10-12
申请号：US10805788
申请日：2004-03-22
申请人： Steven C. Quay , Jorge C. de Meireles , Arati A. Deshpande , Zenaida O. Go , Anthony P. Sileno
发明人： Steven C. Quay , Jorge C. de Meireles , Arati A. Deshpande , Zenaida O. Go , Anthony P. Sileno
IPC分类号： A61K38/00
CPC分类号： A61K9/0043 , A61K38/23
摘要： Compositions suitable for intranasal administration containing calcitonin, chlorobutanol, a pH of about 3.5, and sodium chloride, and an intranasal spray and a pharmaceutical delivery device thereof.
摘要翻译：适合鼻内给药的组合物含有降钙素，氯丁醇，pH值约为3.5，氯化钠，鼻内喷雾剂及药物输送装置。

5. 发明申请

US20100210506A1 INTRANASAL ADMINISTRATION OF RAPID ACTING INSULIN 审中-公开
标题翻译：快速行动胰岛素的管理管理
公开(公告)号：US20100210506A1
公开(公告)日：2010-08-19
申请号：US12672478
申请日：2006-10-20
申请人： Steven C. Quay , Annemarie Stoudt Cohen , Henry R. Costantino , Shu-Chih Chen Quay , Anthony P. Sileno , Mary S. Kleppe
发明人： Steven C. Quay , Annemarie Stoudt Cohen , Henry R. Costantino , Shu-Chih Chen Quay , Anthony P. Sileno , Mary S. Kleppe
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K9/0043 , A61K38/28 , A61K47/40
摘要： What is described are pharmaceutical compositions, formulations, and uses thereof, for medicaments for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, and a surface active agent, wherein the human insulin may be rapid actin insulin.
摘要翻译：所描述的是药物组合物，制剂及其用途，用于向患者鼻内递送胰岛素的药物，包括人胰岛素的水性混合物，增溶剂和表面活性剂，其中人胰岛素可以是快速肌动蛋白胰岛素。

6. 发明申请

US20100209487A1 NICKED OR GAPPED NUCLEIC ACID MOLECULES AND USES THEREOF 有权
标题翻译：粘结或加入的核酸分子及其用途
公开(公告)号：US20100209487A1
公开(公告)日：2010-08-19
申请号：US12445868
申请日：2007-10-18
申请人： Steven C. Quay , James Mcswiggen , Narendra K. Vaish , Mohammad Ahmadian
发明人： Steven C. Quay , James Mcswiggen , Narendra K. Vaish , Mohammad Ahmadian
IPC分类号： A61K31/713 , C07H21/02 , A61K9/127 , A61K9/51 , C12N5/071 , A61P35/00 , A61P29/00 , A61P31/00
CPC分类号： A61K31/713 , A61K38/00 , A61K47/645 , A61K47/66 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3513 , C12N2310/533 , C12N2320/30 , C12N2320/51 , C12N2330/30 , C12N2310/3521
摘要： The present disclosure provides meroduplex (nicked or gapped) ribonucleic acid molecules (mdRNA) that decreases or silences target gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a target gene RNA. In addition, the meroduplex may have one or more modifications or substitutions, such as nucleotide base, sugar, terminal cap structure, internucleotide linkage, or any combination of such modifications. Also provided are methods of decreasing expression of a target gene in a cell or in a subject to treat a disease related to altered expression of a target gene.
摘要翻译：本公开提供降低或沉默靶基因表达的meroduplex（切口或间隙）核糖核酸分子（mdRNA）。本公开的mdRNA包含至少三条链，其组合形成由切口或间隙分开的至少两个非重叠的双链区域，其中一条链与靶基因RNA互补。此外，meroduplex可以具有一个或多个修饰或取代，例如核苷酸碱基，糖，末端帽结构，核苷酸间连接，或这些修饰的任何组合。还提供减少细胞或受试者中靶基因表达以治疗与靶基因表达改变相关的疾病的方法。

7. 发明申请

US20100184688A1 COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE 审中-公开
标题翻译：组合物和方法，用于增强间皮瘤的输送
公开(公告)号：US20100184688A1
公开(公告)日：2010-07-22
申请号：US12726308
申请日：2010-03-17
申请人： Steven C. Quay , Henry R. Costantino , Mary S. Kleppe , Ching-Yuan Li
发明人： Steven C. Quay , Henry R. Costantino , Mary S. Kleppe , Ching-Yuan Li
IPC分类号： A61K38/17 , A61P19/08 , A61P19/10
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
摘要翻译：描述的药物组合物和方法包括至少一种甲状旁腺激素肽（PTH），优选PTH1-34和一种或多种用于增强鼻粘膜递送PTH的粘膜递送增强剂，用于治疗或预防哺乳动物受试者中的骨质疏松症或骨质减少，优选地一个人。

8. 发明申请

US20090018097A1 MODIFICATION OF DOUBLE-STRANDED RIBONUCLEIC ACID MOLECULES 审中-公开
标题翻译：双链抗坏血酸分子的修饰
公开(公告)号：US20090018097A1
公开(公告)日：2009-01-15
申请号：US12065604
申请日：2006-05-25
申请人： Steven C. Quay , Kunyuan Cui , Paul H. Johnson , Lishan Chen , Mohammad Ahmadian
发明人： Steven C. Quay , Kunyuan Cui , Paul H. Johnson , Lishan Chen , Mohammad Ahmadian
IPC分类号： A61K31/713 , C07H21/02 , C12N5/10 , A61P35/00
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2320/50 , C12N2320/51 , C12N2310/3521
摘要： A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5′-methyl-pyrimidine and/or at least one 2′-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.
摘要翻译：包含约15个碱基对和约40个碱基对的双链RNA（dsRNA）分子，其中dsRNA的至少一个核糖核苷酸是5'-甲基 - 嘧啶和/或至少一个2'-O-甲基核糖核苷酸，以及使用这种dsRNA，提高核糖核酸酶稳定性，降低双链siRNA分子的脱靶效应或降低双链siRNA分子的干扰素反应性的方法。

9. 发明申请

US20080286866A1 NUCLEIC ACID COMPOUNDS FOR INHIBITING VEGF GENE EXPRESSION AND USES THEREOF 审中-公开
标题翻译：用于抑制VEGF基因表达的核酸化合物及其用途
公开(公告)号：US20080286866A1
公开(公告)日：2008-11-20
申请号：US12039650
申请日：2008-02-28
申请人： Steven C. Quay , James McSwiggen , Narendra K. Vaish , Mohammad Ahmadian
发明人： Steven C. Quay , James McSwiggen , Narendra K. Vaish , Mohammad Ahmadian
IPC分类号： C12N5/06 , C07H21/02
CPC分类号： C12N15/1136 , C12N2310/14
摘要： The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing VEGFA, VEGFB, VEGFC, FIGF, or PGF gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a VEGF mRNA. In addition, the meroduplex may have at least one 5-methyluridine, locked nucleic acid, 2′-O-methyl, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a VEGF gene in a cell or in a subject to treat a VEGF-related disease.
摘要翻译：本公开提供能够降低或沉默VEGFA，VEGFB，VEGFC，FIGF或PGF基因表达的meroduplex核糖核酸分子（mdRNA）。本公开的mdRNA包含至少三条链，其组合形成由切口或间隙隔开的至少两个不重叠的双链区域，其中一条链与VEGF mRNA互补。此外，meroduplex可以具有至少一个5-甲基尿苷，锁定核酸，2'-O-甲基或任选的其它修饰及其任何组合。还提供减少细胞或受试者中VEGF基因表达以治疗VEGF相关疾病的方法。

10. 发明申请

US20080182817A1 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 有权
标题翻译：用于鼻内给药的氰钴胺素低粘度含水制剂
公开(公告)号：US20080182817A1
公开(公告)日：2008-07-31
申请号：US12079875
申请日：2008-03-27
申请人： Steven C. Quay , Peter C. Aprile , Zenaida O. Go , Anthony P. Sileno
发明人： Steven C. Quay , Peter C. Aprile , Zenaida O. Go , Anthony P. Sileno
IPC分类号： A61K31/7056 , A61P43/00
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/7056 , A61K31/714 , A61K47/10 , A61K47/12 , A61K47/186
摘要： A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
摘要翻译：一种由氰钴胺素和水组成的稳定的药用无汞水溶液，其中所述氰钴胺溶液适合于鼻内给药，其粘度小于约1000cPs，其中所述氰钴胺溶液在鼻内给药时具有氰钴胺素的生物利用度相对于肌内注射氰钴胺素至少约7％，条件是溶液基本上不含汞和含汞化合物。本发明还涉及提高脑脊髓液（CSF）中维生素B12水平的方法，其包括向鼻内施用足够量的无汞氰钴胺溶液，以增加CSF中维生素B12的平均比例在血清中（B12 CSF / B12 Serumx100）至少约1.1，包括鼻内施用氰钴胺水溶液，其中所述氰钴胺溶液相对于肌内注射氰钴胺素具有至少7％的生物利用度。

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