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101. 发明授权

US5618831A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。（I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

102. 发明授权

US4939066A Color diffusion transfer photographic element 失效
标题翻译：彩色扩散转印照相材料
公开(公告)号：US4939066A
公开(公告)日：1990-07-03
申请号：US115070
申请日：1987-10-30
申请人： Masaharu Toriuchi , Keizo Koya
发明人： Masaharu Toriuchi , Keizo Koya
IPC分类号： C07D261/12 , C07D413/12 , G03C7/00 , G03C7/305 , G03C8/08 , G03C8/40
CPC分类号： C07D413/12 , C07D261/12 , G03C7/30594 , G03C8/08 , Y10S430/158
摘要： A color diffusion transfer photographic material comprises a base having thereon at least one silver halide emulsion layer and a dye image-receiving layer, at least one layer thereof containing a dye-releasing redox compound and at least one layer thereof containing a development inhibitor-releasing compound represented by the following general formula (I):A--Time).sub.t DIG (I)wherein A represents ##STR1## linked to --Time).sub.t DIG through at least one of R.sup.1, R.sup.2 and EAG; R.sup.1 and R.sup.2, which may be the same or different, each represents a single bond or a substituent other than a hydrogen atom, provided that R.sup.1 and R.sup.2 may be linked to form a ring; EAG represents an electron-accepting group; Time represents a group capable of releasing DIG after EAG accepts an electron; DIG represents a development inhibitor precursor; and t is an integer of 0 or 1.
摘要翻译：彩色扩散转印照相材料包括其上具有至少一个卤化银乳剂层和染料影像接收层的基底，其至少一层含有释放染料的氧化还原化合物和至少一层含有显影抑制剂释放通过R1，R2和EAG中的至少一个，由以下通式（I）代表的化合物：A-time）tDIG（I）其中A表示与-Time连接的时间）tDIG; R 1和R 2可以相同或不同，各自表示单键或除氢原子以外的取代基，条件是R 1和R 2可以连接形成环; EAG代表电子接受基团; 时间表示EAG接受电子后能释放DIG的组; DIG代表发育抑制剂前体; t为0或1的整数。

103. 发明授权

US5424442A Water-soluble methine compounds useful in photographic silver halide emulsion containing the same 失效
标题翻译：水溶性次甲基化合物可用于含有相同的照相卤化银乳剂
公开(公告)号：US5424442A
公开(公告)日：1995-06-13
申请号：US078110
申请日：1993-06-18
申请人： Keizo Koya , Toshinao Ukai , Haruo Takei
发明人： Keizo Koya , Toshinao Ukai , Haruo Takei
IPC分类号： G03C1/12 , C09B23/00 , C09B23/01 , C09B69/06 , G03C1/26 , G03C1/40 , C07D277/62
CPC分类号： C09B69/06 , C09B23/0075 , G03C1/26
摘要： A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.
摘要翻译：由以下通式（I）表示的水溶性次甲基化合物：其中Z1和Z2可以相同或不同，分别表示形成一个或多个所需的非金属原子团 5元或6元含氮杂环; R 1和R 2可以相同或不同，各自表示烷基; Q1和Q2各自表示组合形成4-噻唑烷酮环，5-噻唑烷酮环，4-咪唑啉酮环，4-恶唑烷酮环，5-恶唑烷酮环，5-咪唑啉酮环所需的原子团或4-二硫戊环酮环; L1，L2，L3，L4和L5可以相同或不同，表示次甲基; R表示氢原子，烷基，芳基或杂环基; m表示1或2; i和h各自表示0或1; l表示1或2; 并且j和k各自表示0,1,2或3.还公开了含有以水溶液形式加入的次甲基化合物的照相卤化银乳剂。

104. 发明授权

US5096801A Color image recording method 失效
标题翻译：彩色图像记录方法
公开(公告)号：US5096801A
公开(公告)日：1992-03-17
申请号：US503643
申请日：1990-04-03
申请人： Keizo Koya , Kozo Sato , Yoshiharu Yabuki , Hiroshi Hara
发明人： Keizo Koya , Kozo Sato , Yoshiharu Yabuki , Hiroshi Hara
IPC分类号： G02F1/1335 , G03F1/56 , G03F7/00 , G03F7/028
CPC分类号： G03F1/56 , G02F1/133516 , G03F7/0007 , G03F7/028
摘要： A novel color image recording method is provided, which comprises exposing to light a light-sensitive material obtained by dispersing a composition containing at least a photopolymerization initiator, a color image-forming substance and a polymerizable compound in a hydrophilic binder and then coating said dispersion on a support, subjecting said polymerizable compound in the exposed portions to polymerization, and then (a) eluting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions with an alkaline aqueous solution or (b) subjecting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions to chemical change so that it is discolored, thereby forming dye images.
摘要翻译：提供一种新颖的彩色图像记录方法，其包括通过将含有至少一种光聚合引发剂，彩色成像物质和可聚合化合物的组合物分散在亲水性粘合剂中而获得的感光材料曝光，然后涂布所述分散体在支持体上使暴露部分中的所述可聚合化合物进行聚合，然后（a）用碱性水溶液洗脱未曝光部分中包含的未聚合的可聚合化合物中的所述彩色图像形成物质，或（b）使所述彩色图像包含在未曝光部分中的未聚合的可聚合化合物中的化合物质化学变化，使其变色，从而形成染料图像。

105. 发明授权

US5073473A Method of forming an image by silver salt diffusion transfer 失效
标题翻译：通过银盐扩散转移形成图像的方法
公开(公告)号：US5073473A
公开(公告)日：1991-12-17
申请号：US467292
申请日：1990-01-16
申请人： Keizo Koya , Yoshio Idota
发明人： Keizo Koya , Yoshio Idota
IPC分类号： G03C8/06
CPC分类号： G03C8/06 , Y10S430/156
摘要： A method for forming an image by silver salt diffusion transfer is described, comprises processing an imagewise exposed photosensitive element provided with a layer of photosensitive silver halide emulsion on a support, and an image-receiving element provided with an image-receiving layer containing a silver-precipitating agent on a support, with an alkali processing composition in the presence of a silver halide solvent, to convert at least part of the unexposed silver halide in the emulsion layer into a transferable silver complex salt, to transfer at least part of said complex salt into the image-receiving layer, and to form an image in the image-receiving layer; the processing being carried out in the presence of at least one compound as described.
摘要翻译：描述了通过银盐扩散转移形成图像的方法，包括在载体上处理具有感光卤化银乳剂层的图像曝光感光元件，以及设置有包含银的图像接收层的图像接收元件在载体上，在卤化银溶剂存在下用碱处理组合物将所述乳液层中的至少部分未曝光的卤化银转化为可转移的银络合盐，以将至少部分所述复合物盐进入图像接收层，并在图像接收层中形成图像; 该处理在至少一种所述化合物存在下进行。

106. 发明授权

US5071729A Silver halide color photographic material 失效
标题翻译：卤化银彩色照相材料
公开(公告)号：US5071729A
公开(公告)日：1991-12-10
申请号：US188778
申请日：1988-04-29
申请人： Keizo Koya , Shigeru Ohno , Yoshisada Nakamura
发明人： Keizo Koya , Shigeru Ohno , Yoshisada Nakamura
IPC分类号： G03C7/26 , C07D231/20 , C07D231/56 , C07D413/14 , C07F1/08 , C07F15/00 , C07F15/04 , C07F15/06 , G03C7/305 , G03C7/32
CPC分类号： G03C7/30541 , Y10S430/156
摘要： A silver halide photographic material comprising a support having provided thereon at least one silver halide emulsion layer, wherein the silver halide photographic material contains a compound having discoloration inhibitory activity represented by formula (I):PWR--Time).sub.t MCAP (I)wherein PWR represents a group capable of releasing (Time).sub.t -MCAP upon being reduced; Time represents a group which is released from PWR in the form of (Time).sub.t -MCAP and then releases MCAP through a subsequent reaction; t represents 0 or 1; and MCAP represents a group having discoloration inhibitory activity.
摘要翻译：一种卤化银照相材料，包括在其上提供有至少一个卤化银乳剂层的载体，其中所述卤化银照相材料含有由式（I）表示的具有变色抑制活性的化合物：PWR-Time）tMCAP（I）其中PWR表示一个能够在减少时释放（时间）t-MCAP的组; 时间表示从PWR以（时间）t-MCAP的形式释放的组，然后通过随后的反应释放MCAP; t表示0或1; 并且MCAP表示具有变色抑制活性的基团。

107. 发明授权

US4957848A Heat developable color light-sensitive material with dye developers 失效
标题翻译：具有染色显影剂的可开发的彩色感光材料
公开(公告)号：US4957848A
公开(公告)日：1990-09-18
申请号：US192097
申请日：1988-05-10
申请人： Osamu Takahashi , Koichi Koyama , Keizo Koya
发明人： Osamu Takahashi , Koichi Koyama , Keizo Koya
IPC分类号： G03C8/18 , G03C8/40
CPC分类号： G03C8/18 , G03C8/4033 , G03C8/408
摘要： A heat-developable color light-sensitive material is disclosed, comprising a support having thereon at least one layer containing a light-sensitive silver halide, a binder, a compound containing a color moiety represented by formula (A), and a compound or a precursor thereof which reacts with an oxidized compound formed from the compound of formula (A), thereby converting the oxidized compound into a nondiffusible form, said compound of formula (A) being represented by ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an acylamino group, an alkylthio group, an arylthio group, or a halogen atom, provided that at least one of R.sub.1, R.sub.2, and R.sub.3 represents a hydrogen atom; X represents a chemical bond or a divalent linking group; Dye represents an image-forming dye moiety; and G represents a hydroxyl group or a group capable of forming a hydroxyl group upon heating and/or by the action of a base.The material provides an image having a low minimum density in highlight areas, and excellent color separation and image preservability.

108. 依法登记的发明

USH817H Photographic light-sensitive material 失效
标题翻译：摄影感光材料
公开(公告)号：USH817H
公开(公告)日：1990-09-04
申请号：US188576
申请日：1988-04-29
申请人： Masaharu Toriuchi , Keizo Koya
发明人： Masaharu Toriuchi , Keizo Koya
IPC分类号： G03C7/26 , C07D231/20 , C07D231/56 , C07D233/42 , C07D233/72 , C07D249/12 , C07D249/14 , C07D257/04 , C07D261/12 , C07D261/14 , C07D261/20 , C07D265/02 , C07D275/00 , C07D285/16 , C07D291/00 , C07D521/00 , G03C1/06 , G03C7/30 , G03C7/305
CPC分类号： G03C7/3003 , G03C7/30541
摘要： A photographic light-sensitive material comprising a support having provided thereon at least one silver halide emulsion layer, wherein said light-sensitive material contains:(1) a compound represented by formula (I):PWR--Time--.sub.t PUG (I) wherein PWR represents a group capable of releasing (Time--.sub.t PUG upon being reduced; PUG represents a photographically useful group; Time represents a group capable of releasing PUG through a reaction subsequent to the release from PWR in the form of --Time--.sub.t PUG; and t represents 0 or 1, and(2) a polymer comprising at least 10 repeating units derived from the same monomer and having a molecular weight of 1000 or more. The photographic light-sensitive material exhibits both high activity of a compound capable of releasing a photographically useful group during development processing and preservation stability before development processing.

109. 发明授权

US08815945B2 Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers 有权
标题翻译：使用双[硫代酰肼]化合物如elesclomol用于治疗癌症
公开(公告)号：US08815945B2
公开(公告)日：2014-08-26
申请号：US13642275
申请日：2011-04-20
申请人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
发明人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
IPC分类号： A61K45/06 , A61K31/19 , A61K31/337
CPC分类号： A61K31/30 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/28 , A61K31/337 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments.
摘要翻译：改进的双[硫代酰肼]化合物如elesclomol的癌症治疗，特别是用于鉴定将受益于这种治疗的患者群体。

110. 发明申请

US20110245577A1 COMBINATION WITH BIS (THIOHYDRAZIDE AMIDES) FOR TREATING CANCER 审中-公开
标题翻译：与BIS（THIOHYDRAZIDE AMIDES）联合治疗癌症
公开(公告)号：US20110245577A1
公开(公告)日：2011-10-06
申请号：US13078573
申请日：2011-04-01
申请人： Keizo Koya
发明人： Keizo Koya
IPC分类号： A61M36/00
CPC分类号： A61K31/16 , A61K31/165 , A61K31/337 , A61K41/0052 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.
摘要翻译：本文公开了与双热（硫代酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药，与热疗治疗结合治疗增殖性疾病如癌症的方法。还公开了与放射治疗组合的双（硫代 - 酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药治疗增殖性疾病如癌症的方法。

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