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101. 发明授权

US5877500A Multichannel infrared detector with optical concentrators for each channel 失效
标题翻译：多通道红外探测器，每个通道带有光集中器
公开(公告)号：US5877500A
公开(公告)日：1999-03-02
申请号：US816088
申请日：1997-03-13
申请人： James R. Braig , Arthur M. Shulenberger
发明人： James R. Braig , Arthur M. Shulenberger
IPC分类号： G01J1/02 , G01J1/04 , G01J5/04 , G01J5/08 , G01J5/02
CPC分类号： G01J5/061 , G01J5/04 , G01J5/045 , G01J5/06 , G01J5/08 , G01J5/0815 , G01J5/0862 , G01J5/0881 , G01J5/0893 , G01J5/0205
摘要： The present invention comprises a system and method for detecting multiple wavelength bands of infrared radiation. The present invention incorporates an optical concentrator or "optical funnel" to increase the energy density on the detection elements and discrete filters mounted in the funnels and a mounting structure for individual detector elements. An apparatus in accordance with the present invention is an advance over conventional infrared detector assemblies in several areas. The apparatus in accordance with the present invention provides a unified means for mounting detectors, optical concentrators and infrared filters. It also provides an efficient means for electrical connection to the detector elements. The present invention provides a mounting structure for the detectors bonding them directly to the body of the optical funnel and passing light into them from the "backside" of the detector elements. The present invention prevents cross talk by mounting the detector elements at the focused end of individual optical concentrators.
摘要翻译：本发明包括用于检测红外辐射的多个波长带的系统和方法。本发明包括光集中器或“光漏斗”，以增加安装在漏斗中的检测元件和分立滤光片上的能量密度和用于各个检测器元件的安装结构。根据本发明的装置是在几个领域中超过常规红外探测器组件的进步。根据本发明的装置提供了用于安装检测器，光集中器和红外滤光器的统一装置。它还提供了用于与检测器元件电连接的有效手段。本发明提供了一种用于检测器的安装结构，它们将它们直接连接到光漏斗的主体并将光从检测器元件的“背面”传送到它们中。本发明通过将检测器元件安装在各个聚光器的聚焦端处来防止串扰。

102. 发明申请

US20130165900A1 FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20130165900A1
公开(公告)日：2013-06-27
申请号：US13619825
申请日：2012-09-14
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

103. 发明申请

US20110313318A1 SYSTEMS AND METHODS TO REDUCE FLUID CONTAMINATION 有权
标题翻译：减少流体污染的系统和方法
公开(公告)号：US20110313318A1
公开(公告)日：2011-12-22
申请号：US13162315
申请日：2011-06-16
申请人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
IPC分类号： A61B5/15
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/6866 , A61M5/1415 , A61M5/1452 , A61M5/1723 , A61M2005/14208 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2230/201
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.
摘要翻译：描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。分析物监测系统可以包括自动采血系统，其被配置为以低压和/或撤出速率从患者的脉管系统中提取血液，以便减少或防止从输注流体中排出的流体的污染。

104. 发明申请

US20110190606A1 FLUID HANDLING CASSETTE 有权
标题翻译：流体处理CASSETTE
公开(公告)号：US20110190606A1
公开(公告)日：2011-08-04
申请号：US13046611
申请日：2011-03-11
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/157
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

105. 发明申请

US20110111449A1 IN VITRO DETERMINATION OF ANALYTE LEVELS WITHIN BODY FLUIDS 有权
标题翻译：在身体液体中分析水平的体外测定
公开(公告)号：US20110111449A1
公开(公告)日：2011-05-12
申请号：US13007502
申请日：2011-01-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

106. 发明申请

US20110011167A1 FLUID HANDLING CASSETTE WITH A FLUID CONTROL INTERFACE AND SAMPLE SEPARATOR 有权
标题翻译：具有流体控制界面和样品分离器的流体处理箱
公开(公告)号：US20110011167A1
公开(公告)日：2011-01-20
申请号：US11316676
申请日：2005-12-21
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01N1/10
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

107. 发明申请

US20100331754A1 Method and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements 审中-公开
标题翻译：使用中央静脉压测量控制超滤的方法和系统
公开(公告)号：US20100331754A1
公开(公告)日：2010-12-30
申请号：US12875888
申请日：2010-09-03
申请人： Barry N. Fulkerson , James R. Braig , Victor Gura
发明人： Barry N. Fulkerson , James R. Braig , Victor Gura
IPC分类号： A61M1/16
CPC分类号： A61M1/3653 , A61B5/02152 , A61B5/412 , A61M1/3659 , A61M1/3661 , A61M2230/30 , B01D61/22 , B01D61/32
摘要： The volume of fluid removed from a patient during ultrafiltration is controlled automatically on the basis of central venous pressure (CVP) measurements. In one embodiment, a central venous catheter (CVC) is used for accessing blood during dialysis. A sensor located at the tip of the catheter or inside the dialysis machine is used to periodically measure CVP. CVP feedback data helps prevent the excessive removal of fluids from the patient.
摘要翻译：基于中心静脉压（CVP）测量自动控制在超滤期间从患者移除的流体体积。在一个实施例中，中心静脉导管（CVC）用于在透析期间接近血液。位于导管尖端或透析机内部的传感器用于定期测量CVP。 CVP反馈数据有助于防止患者过度去除液体。

108. 发明申请

US20100234703A1 METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的方法和装置
公开(公告)号：US20100234703A1
公开(公告)日：2010-09-16
申请号：US12786244
申请日：2010-05-24
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jenifer H. Gable
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jenifer H. Gable
IPC分类号： A61B5/1455
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： In some embodiments, an apparatus analyzes the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：在一些实施例中，装置分析体液的组成。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

109. 发明授权

US07738085B2 Device and method for in vitro determination of analyte concentration within body fluids 有权
标题翻译：用于体外测定体液中分析物浓度的装置和方法
公开(公告)号：US07738085B2
公开(公告)日：2010-06-15
申请号：US12343218
申请日：2008-12-23
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

110. 发明授权

US07722537B2 Method and apparatus for detection of multiple analytes 有权
标题翻译：检测多种分析物的方法和装置
公开(公告)号：US07722537B2
公开(公告)日：2010-05-25
申请号：US11314173
申请日：2005-12-21
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jennifer H. Gable
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jennifer H. Gable
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

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