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    • 103. 发明申请
    • APPLICATION OF PUERARIN IN THE PREPARATION OF P2X3 MEDIATED DRUGS FOR PAIN/NERVOUS SYSTEM DISEASES
    • 在制备P2X3介导的药物用于疼痛/神经系统疾病中应用PUERARIN
    • US20110152205A1
    • 2011-06-23
    • US12922245
    • 2010-06-29
    • Shangdong LiangChangshui XuYun GaoGuilin LiJiari LinShuangmei LiuHan LiuJun ZhangXin Li
    • Shangdong LiangChangshui XuYun GaoGuilin LiJiari LinShuangmei LiuHan LiuJun ZhangXin Li
    • A61K31/7034A61P25/00A61P29/00
    • A61K31/352
    • The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
    • 本发明涉及葛根素在药物领域的新用途,换句话说,涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。 实验表明,葛根素可以抑制疼痛相关的行为反应,随后免疫组化分析,原位杂交,RT-PCR,蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用 的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型,通过使用全细胞膜片钳技术发现,葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流 神经性疼痛大鼠根神经节。 实验证明,葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。 本发明提供了一种预防和治疗急性和慢性疼痛的新方法,也表明葛根素可以作为P2X3受体的拮抗剂,有利于药物在P2X3的预防和治疗中的应用 受体涉及神经系统疾病。
    • 107. 发明授权
    • Adjustment method for control threshold of terminal forward transmission power in a mobile communication system
    • 移动通信系统终端正向传输功率控制阈值调整方法
    • US07783319B2
    • 2010-08-24
    • US11792164
    • 2004-12-02
    • Xuemin LiuXin LiXiaohan Liu
    • Xuemin LiuXin LiXiaohan Liu
    • H04B7/00H04Q7/20
    • H04W52/143H04W52/367
    • The present invention relates to a method for adjusting forward transmission power control threshold of a terminal in a mobile communication system, including the following steps of setting in advance at a base station side a forward pilot threshold and a lower bound, an upper bound of a forward transmission power control threshold as well as adjustment ranges of said lower bound and upper bound; obtaining the current forward pilot energy measured and reported by the terminal; judging whether the forward pilot energy exceeds said forward pilot threshold; and adjusting the forward transmission power control threshold of the terminal. In the invention, the forward pilot energy reported by the terminal is judged and adjusted through the pre-set parameters above, so as to dynamically adjust the forward transmission power control threshold of the terminal in the sector, reduce call drop rate, and promote the communication quality of a CDMA mobile communication system.
    • 本发明涉及一种用于调整移动通信系统中的终端的前向传输功率控制阈值的方法,包括以下步骤:在基站侧预先设置前向导频阈值和下限, 前向传输功率控制阈值以及所述下限和上限的调整范围; 获得终端测量和报告的当前前进导频能量; 判断前向导频能量是否超过所述前向导频阈值; 并调整终端的正向传输功率控制阈值。 在本发明中,由终端报告的前向导频能量通过上述预设参数进行判断和调整,动态调整终端在该扇区中的前向传输功率控制阈值,降低呼叫丢弃率,促进 CDMA移动通信系统的通信质量。
    • 109. 发明授权
    • Analog and radio frequency (RF) system-level simulation using frequency relaxation
    • 使用频率弛豫的模拟和射频(RF)系统级仿真
    • US07653524B2
    • 2010-01-26
    • US11208844
    • 2005-08-22
    • Xin LiYang XuPeng LiLawrence Piileggi
    • Xin LiYang XuPeng LiLawrence Piileggi
    • G06F17/50
    • G06F17/5036
    • Analog and radio frequency system-level simulation using frequency relaxation. Embodiments of the invention use a frequency relaxation approach for analog/RF system-level simulation that accommodates both large system size and complex signal space. The simulator can determine an output response for a system by partitioning the system into blocks and simulating the propagation of an input signal through the blocks. The input signal can take various forms, including a multi-tone sinusoidal signal, a continuous spectra signal, and/or a stochastic signal. Frequency relaxation is applied to produce individual responses. The output response can be computed based on obtaining convergence of the individual responses. The input to embodiments of the simulator can be a circuit netlist, or a block-level macromodel.
    • 模拟和射频系统级仿真使用频率弛豫。 本发明的实施例使用容纳大系统尺寸和复杂信号空间的模拟/ RF系统级仿真的频率松弛方法。 模拟器可以通过将系统划分成块并且模拟通过块的输入信号的传播来确定系统的输出响应。 输入信号可以采取各种形式,包括多音频正弦信号,连续频谱信号和/或随机信号。 应用频率弛豫来产生个体反应。 可以基于获得各个响应的收敛来计算输出响应。 模拟器的实施例的输入可以是电路网表或块级宏模型。
    • 110. 发明申请
    • USING HANDWRITING RECOGNITION IN COMPUTER ALGEBRA
    • 在计算机代码中使用手写识别
    • US20090052777A1
    • 2009-02-26
    • US11843645
    • 2007-08-22
    • Jinsong YuSeth AtkinsonXin LiLuke KellyLarry Israel
    • Jinsong YuSeth AtkinsonXin LiLuke KellyLarry Israel
    • G06K9/00
    • G06K9/00436
    • Systems and methods for use in handwriting recognition in computer algebra are provided. One disclosed method includes receiving handwriting input from a user via a handwriting input device, the handwriting input representing a mathematical expression. The method further includes, at a recognizer, processing the handwriting input to recognize a plurality of candidates and ranking the plurality of candidates to form initial candidate data. The method may further include, at an application program, scanning the plurality of candidates for segments that match application-level criteria, and adjusting a rank of one or more of the plurality of candidates based on the matching, to form a processed candidate list. The method may further include displaying the processed candidate list via a graphical user interface.
    • 提供了在计算机代数中用于手写识别的系统和方法。 一种公开的方法包括经由手写输入装置接收来自用户的手写输入,所述手写输入表示数学表达式。 该方法还包括在识别器处理手写输入以识别多个候选并对多个候选进行排序以形成初始候选数据。 该方法还可以包括:在应用程序中,扫描与候选标准匹配的段的多个候选者,以及基于匹配来调整多个候选中的一个或多个的等级,以形成处理的候选列表。 该方法还可以包括经由图形用户界面显示所处理的候选列表。