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101. 发明申请

WO1995031463A1 NEW ANTAGONIST COMPOUNDS 审中-公开
标题翻译：新的ANTAGONIST化合物
公开(公告)号：WO1995031463A1
公开(公告)日：1995-11-23
申请号：PCT/SE1995000503
申请日：1995-05-09
申请人： ASTRA AKTIEBOLAG , SCHMIDHAMMER, Helmut
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07D489/09
CPC分类号： C07D491/18
摘要： New morphinane derivatives of formula (I), their pharmaceutically acceptable salts, a process for their preparation and their use in the manufacture of pharmaceutical preparations.
摘要翻译：式（I）的新的吗啡衍生物，其药学上可接受的盐，其制备方法及其在制备药物制剂中的用途。

102. 发明申请

WO1995022365A1 INHALATION DEVICE WITH ELECTRONICALLY READABLE IDENTIFICATION MEANS 审中-公开
标题翻译：具有电子可读性识别手段的吸入装置
公开(公告)号：WO1995022365A1
公开(公告)日：1995-08-24
申请号：PCT/SE1995000157
申请日：1995-02-15
申请人： ASTRA AKTIEBOLAG , MARNFELDT, Nils, Göran , WALDECK, Johan, Mats, Bertil
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61J7/0418 , A61M15/00 , A61M15/0066 , A61M15/008 , A61M15/0083 , A61M2202/064 , A61M2205/52 , A61M2205/60
摘要： An inhalation device comprises at least one inhaler for dispensing a dose of a drug to a user inhaling through the inhaler. The inhaler, which contains a supply of drug, has means (21-23) for detecting the dispensation of a dose and means (21-23; 38) for measuring a specific feature of the disease being treated with the drug, e.g. the inhalation air flow of an asthmatic. A processing unit (30), which is integrated in the inhaler or provided as a separate unit, has storage means (34) for storing the specific feature from a plurality of measurements as well as the time of each detected dispensation of a dose. To improve the reliability of information recorded in the processing device (30), the inhalation device further comprises electronically readable identification means (27), which are arranged inseparably from the supply of drug and which contain information enabling identification of at least the kind of drug in the supply and the size of the dose dispensed when a user inhales through the inhaler, and means for delivering said information to the processing unit.
摘要翻译：吸入装置包括至少一个吸入器，用于向通过吸入器吸入的使用者分配一定剂量的药物。含有药物供应的吸入器具有用于检测剂量分配的装置（21-23）和用于测量用药物治疗的疾病的特定特征的装置（21-23; 38）。哮喘的吸入气流。集成在吸入器中或作为单独单元提供的处理单元（30）具有用于从多个测量值以及每个检测到的剂量分配的时间存储特定特征的存储装置（34）。为了提高记录在处理装置（30）中的信息的可靠性，吸入装置还包括电子可读识别装置（27），它们与药物供应不可分离地布置并且包含至少能够鉴别药物的信息的信息在用户通过吸入器吸入时分配的剂量的供给和尺寸以及用于将所述信息传送到处理单元的装置。

103. 发明申请

WO1995020414A1 AN INHALATION CHAMBER FOR CHILDREN FOR USE IN CONJUNCTION WITH A METERED DOSE INHALER 审中-公开
标题翻译：儿童吸入室用于与计量剂量吸入器相连
公开(公告)号：WO1995020414A1
公开(公告)日：1995-08-03
申请号：PCT/SE1995000058
申请日：1995-01-23
申请人： ASTRA AKTIEBOLAG , BERG, Elna, Birgitta , NILSSON, Hans, Jörgen
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M15/009 , A61M2205/0233
摘要： The present invention relates to a spacer for children primarily intended to be used in conjunction with a metered dose inhaler (MDI), said spacer having a generally oblong shape and being rotationally symmetrical around a central, longitudinal axis and being provided with an opening at each end located centrally in said axis for connection of a metered dose inhaler respectively of a mouth-piece or similar. The spacer has a small total volume which is in the range between 50 and 400 ml, and the material in the spacer has a surface resistivity which is lower than 10 Ohm, preferably lower than 10 Ohm.
摘要翻译：本发明涉及一种主要用于与计量剂量吸入器（MDI）结合使用的儿童间隔物，所述间隔物具有大体上长圆形的形状并且围绕中心纵向轴线旋转对称并且在每个位置设置有开口端部位于所述轴线的中心，用于分别连接口器或类似物的计量吸入器。间隔物的总体积小，为50-400ml，间隔物中的材料的表面电阻率低于10欧姆，优选低于10 6欧姆。

104. 发明申请

WO1995017189A1 NEW USE OF 'delta'-OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：三磷酸酯受体拮抗剂的新用途
公开(公告)号：WO1995017189A1
公开(公告)日：1995-06-29
申请号：PCT/SE1994001210
申请日：1994-12-16
申请人： ASTRA AKTIEBOLAG , DALSGAARD, Carl-Johan
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： Use of delta -opioid receptor antagonists or a pharmaceutically acceptable salt thereof, for the manufacture of a pharmaceutical preparation with antirheumatic effect.
摘要翻译： δ-阿片受体拮抗剂或其药学上可接受的盐在制备具有抗风湿作用的药物制剂中的用途。

105. 发明申请

WO1995012424A1 DEVICE FOR MIXING A PHARMACEUTICAL COMPOSITIION WITH ANOTHER AGENT 审中-公开
标题翻译：用于与其他药剂混合药物组合物的装置
公开(公告)号：WO1995012424A1
公开(公告)日：1995-05-11
申请号：PCT/SE1994000996
申请日：1994-10-24
申请人： ASTRA AKTIEBOLAG , GLAD, Lars, Håkan, Christer , KERS, Anders, Tore , RUDÉN, Mats, Anders
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61M05/178
CPC分类号： A61M5/284 , A61J1/2044 , A61J1/2096 , A61M5/3134 , A61M5/31596 , A61M2005/3104 , A61M2005/3106 , A61M2005/312 , A61M2005/3128
摘要： Device for mixing a pharmaceutical composition stored in a chamber (44) in said device with an agent to be added shortly before administration to form a preparation to be administered. The device should be capable of being shaken without leaking. It comprises a hollow body (2) having an outlet (4) sealed by a removable closure (12) and a plunger (6), which is slidable therein in sealing contact with the inner wall of the hollow body (2). The plunger (6), the hollow body (2) and the removable closure (12) define said chamber (44). An actuating means (22) is connected to the plunger (6) for displacing the same in the hollow body (2). A filling conduit (19) for said agent is connected to the chamber (44). A check valve (30) is associated with the conduit (19) and the chamber (44), which prevents flow from the chamber (44) but permits flow into said chamber through said conduit (19). A process for preparing a pharmaceutical preparation and a method for administration of said preparation with the device are also disclosed.
摘要翻译：用于将存储在所述装置中的室（44）中的药物组合物与施用前不久添加的试剂混合以形成待施用的制剂的装置。该设备应能够被摇动而不会泄漏。它包括一个具有出口（4）的中空体（2），该出口（4）由可拆卸的封闭件（12）和一个柱塞（6）密封，柱塞可在其中与中空体（2）的内壁密封接触。柱塞（6），中空体（2）和可移除的封闭件（12）限定所述腔室（44）。致动装置（22）连接到柱塞（6），用于将其移动到中空体（2）中。用于所述试剂的填充导管（19）连接到所述腔室（44）。止回阀（30）与导管（19）和腔室（44）相关联，其防止从腔室（44）流出，但允许通过所述导管（19）流入所述腔室。还公开了制备药物制剂的方法和用所述装置给药所述制剂的方法。

106. 发明申请

WO1995011891A1 NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES 审中-公开
标题翻译： 5-巯基-3-氟-N，N-脱氨基 - 氨基-3,4-二氢-2H-苯并二氮杂
公开(公告)号：WO1995011891A1
公开(公告)日：1995-05-04
申请号：PCT/SE1994001010
申请日：1994-10-26
申请人： ASTRA AKTIEBOLAG , EVENDEN, John, Leslie , HAMMARBERG, Eva, Maria , HANSSON, Hans, Sverker , HELLBERG, Sven, Erik , JOHANSSON, Lars, George , LUNDKVIST, Johan, Rune, Michael , ROSS, Svante, Bertil , SOHN, Daniel, Dungan , THORBERG, Seth, Olov
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07D311/58
CPC分类号： C07D311/58 , A61K31/353 , C07D335/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要： Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
摘要翻译：通式（I）的化合物，其中R 1是正丙基或环丁基; R2是异丙基，叔丁基，环丁基，环戊基或环己基; R3是氢; R4是氢或甲基; 作为（R） - 对映异构体并以其游离碱或其药学上可接受的盐的形式，其制备方法，药物组合物，使用和CNS治疗疾病的方法。

107. 发明申请

WO1995009835A1 NOVEL PHENYLETHYL AND PHENYLPROPYLAMINES 审中-公开
标题翻译：新型苯乙烯和苯丙氨酸
公开(公告)号：WO1995009835A1
公开(公告)日：1995-04-13
申请号：PCT/SE1994000860
申请日：1994-09-16
申请人： ASTRA AKTIEBOLAG , BENGTSSON, Stefan , HELLBERG, Sven , MOHELL, Nina , ZHANG, Lian , HALLNEMO, Gerd , JACKSON, David , ULFF, Bengt
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07C233/62
CPC分类号： C07D207/408 , C07C233/62 , C07C237/06 , C07C255/58 , C07C2601/02 , C07C2601/14 , C07C2602/44 , C07C2603/74 , C07D209/48 , C07D221/20 , C07D223/10
摘要： Compounds of general formula (I) wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group, R2, R3 and R13 are selected from the following groups: H, OH, OR14, halogen, CO2R9, CN, CF3, NO2, NH2, COCH3, OSO2CF3, OSO2CH3, CONR10R11 and OCOR12, R is (1), (2), (3) or (4) wherein R4, R5, R6, R7, R8, W, n3 and n4 have the definitions of the claims, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment of psychiatric disorders.
摘要翻译：通式（I）的化合物，其中Z为饱和或不饱和的3至6个碳链，m为2或3，R 1为氢原子，或选择直链或支链C 1-4烷基，R 2，R 3和R 13 （1），（2），（3）或（4）可以由下列各组组成：H，OH，OR14，卤素，CO 2 R 9，CN，CF 3，NO 2，NH 2，COCH 3，OSO 2 CF 3，OSO 2 CH 3，CONR 10 R 11和OCOR 12，其中R4，R5，R6，R7，R8，W，n3和n4具有权利要求书的定义，其制备方法，含有它们的药物制剂以及该化合物在治疗精神疾病中的用途。

108. 发明申请

WO1995009616A1 PROCESS II 审中-公开
标题翻译：程序二
公开(公告)号：WO1995009616A1
公开(公告)日：1995-04-13
申请号：PCT/SE1994000897
申请日：1994-09-29
申请人： ASTRA AKTIEBOLAG , TROFAST, Eva , OLSSON, Magnus , AHLNECK, Claes
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K09/16
CPC分类号： A61K9/1688 , B01J2/20 , Y10T428/2982
摘要： According to the invention there is provided a method of treatment of a finely divided powdered medicament having a particle size smaller than 10 mu m and poor flowing properties to form, in a controlled manner, agglomerates or pellets which are free flowing and which are capable of breaking down to provide the finely divided medicament, comprising the steps of agglomerating the powdered medicament having a particle size being smaller than 10 mu m by feeding the material to a sieve, causing the finely divided powdered medicament to pass through the apertures of the sieve thereby obtaining agglomerates, spheronizing the resulting agglomerates in order to provide agglomerates which are more spherical, more dense and more compact than the agglomerates resulting from the agglomeration process in the sieve, and sizing the agglomerates to obtain a uniform size of the final product. According to the invention there is also provided an apparatus for carrying out the method.
摘要翻译：根据本发明，提供了一种处理粒度小于10μm的细碎粉末状药物的方法，并且流动性差，以可控方式形成自由流动的凝聚体或丸粒，并且能够破碎以提供细碎的药物，包括通过将材料进料到筛上而使具有小于10μm的粒度的粉末状药物附聚的步骤，使细碎的粉末药物通过筛子的孔，由此获得附聚物，使所得附聚物成球，以提供比由筛子中的附聚过程产生的附聚物更球形，更致密和更致密的附聚物，以及对附聚物进行定型以获得最终产品的均匀尺寸。根据本发明，还提供了一种用于执行该方法的装置。

109. 发明申请

WO1994029335A1 NEW PEPTIDES DERIVATIVES 审中-公开
标题翻译：新型肽衍生物
公开(公告)号：WO1994029335A1
公开(公告)日：1994-12-22
申请号：PCT/SE1994000534
申请日：1994-06-02
申请人： ASTRA AKTIEBOLAG , ANTONSSON, Karl, Thomas , BYLUND, Ruth
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07K05/06
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/06078
摘要： A compound of the general formula (I): A - A -NH-(CH2)n - NH-C(NH)-NH2, wherein n is an integer 2, 3, 4, 5, or 6; preferably 3 or 4; A represents a structural fragment of formulae (IIa), (IIb), (IIc), (IId) or (IIe); A represents a structural fragment (a), as well as processes for the preparation thereof, the use and the pharmaceutical formulations.
摘要翻译：通式（I）的化合物：A 1 -A 2 -NH-（CH 2）n -NH-C（NH）-NH 2，其中n是整数2,3,4,5或 6; 优选3或4; A 1表示式（IIa），（IIb），（IIc），（IId）或（IIe）的结构片段。 A 2表示结构片段（a），以及其制备方法，用途和药物制剂。

110. 发明申请

WO1998028009A1 PHARMACEUTICAL COMPOSITIONS FOR FREEZE DRYING 审中-公开
标题翻译：用于冻干的药物组合物
公开(公告)号：WO1998028009A1
公开(公告)日：1998-07-02
申请号：PCT/SE1997002068
申请日：1997-12-11
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BLAND, Chris , STEELE, Gerald
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： A61K47/26
CPC分类号： A61K31/7076 , A61K9/0019 , A61K9/19 , A61K31/704 , A61K47/02 , A61K47/26 , Y10S514/951
摘要： A pharmaceutical composition comprising a nucleotide analogue, mannitol and a modifying additve which is sodium chloride or a polyol which is suitable for freeze drying.
摘要翻译：一种药物组合物，其包含核苷酸类似物，甘露糖醇和改性添加剂，其是适合于冷冻干燥的氯化钠或多元醇。

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