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    • 102. 发明申请
    • INCREASED AMORPHOUS STABILITY OF POORLY WATER SOLUBLE DRUGS BY NANOSIZING
    • 纳米化增加水溶性难溶性药物的非晶形稳定性
    • WO2008002485A2
    • 2008-01-03
    • PCT/US2007014585
    • 2007-06-22
    • ALZA CORPWEI MINXU SHUQIANLAM ANDREW C
    • WEI MINXU SHUQIANLAM ANDREW C
    • A61K9/14A61K31/00
    • A61K9/145A61K9/146
    • Disclosed is a population of nanoparticles, together with methods of making a population of nanoparticles, wherein wherein one or more of the nanoparticles includes: an amorphous drug core having an effective diameter less than or equal to about 2.0 microns, wherein the amorphous drug core is substantially free of dopant, and wherein the amorphous drug core comprises a drug with properties that satisfy the following relationships: a glass transition temperature greater than or equal to about 30 Deg. C; and water solubility at 25 Deg. C less than or equal to about 1 mg/ml; and at least one stabilizer adsorbed on a surface of the amorphous drug core; and wherein the at least one stabilizer is present in an amount effective to provide an amorphous stability of the population of nanoparticles that is approximately equal to or greater than an amorphous stability of an amorphous bulk drug substance comprising the drug, as measured over a period of at least four months.
    • 公开了纳米颗粒群,以及制备纳米颗粒群的方法,其中一个或多个纳米颗粒包括:具有小于或等于约2.0微米的有效直径的无定形药物核,其中无定形药物核是 基本上不含掺杂剂,并且其中所述无定形药心包含具有满足以下关系的性质的药物:玻璃化转变温度大于或等于约30℃。 C; 和在25℃下的水溶性。 C小于或等于约1mg / ml; 和至少一种吸附在无定形药心表面上的稳定剂; 并且其中所述至少一种稳定剂以有效提供所述纳米颗粒群的无定形稳定性的量存在,所述无定形稳定性近似等于或大于包含所述药物的无定形原料药的无定形稳定性, 至少四个月。
    • 105. 发明申请
    • MEDICATION DELIVERY DEVICE
    • 药物递送装置
    • WO2015160600A1
    • 2015-10-22
    • PCT/US2015/024998
    • 2015-04-08
    • WEI, Min
    • WEI, Min
    • A61M5/20
    • A61M5/31515A61M5/2033A61M5/3137A61M5/31501A61M5/3204A61M2005/206A61M2005/3139A61M2005/31508
    • A mechanical device for assisting medication injection is provided herein comprising a connector having a distal end and a proximal end; a piston rod locked in said connector before medication injection; a spring configured to bias said piston rod distally; a releasable restraining means configured to releasably restrain said piston rod in a locked state against said biasing of said spring, wherein, upon release of said releasable restraining means, said piston rod moves distally under force of said spring; an activation means configured to release said releasable restraining means; and a mounting means for mounting a syringe at said distal end of said connector.
    • 本发明提供了一种用于辅助药物注射的机械装置,其包括具有远端和近端的连接器; 在注射药物之前锁定在所述连接器中的活塞杆; 配置成向远端偏压所述活塞杆的弹簧; 可释放限制装置,被配置为将所述活塞杆可释放地限制在锁定状态,抵抗所述弹簧的所述偏置,其中,在释放所述可释放限制装置时,所述活塞杆在所述弹簧的作用下向远侧移动; 激活装置,被配置为释放所述可释放限制装置; 以及用于将注射器安装在所述连接器的所述远端处的安装装置。