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91. 发明授权

US3636076A N - fluorodichloromethylmercapto - n - trifluoromethyl - amino -benzoic acid phenyl esters 失效
标题翻译： N-氟二氯三氟甲磺酰胺-N-三氟甲基 - 氨基苯甲酸苯酯
公开(公告)号：US3636076A
公开(公告)日：1972-01-18
申请号：US3636076D
申请日：1970-03-24
申请人： BAYER AG
发明人： KUHLE ENGELBERT , KLAUKE ERICH , HAMBURGER BRIGITTE , STEINFATT FRITZ
IPC分类号： A01N47/04 , A01N47/08 , A61K31/18 , C02F1/50 , C07C67/00 , C07C69/90 , C07C313/00 , C07C313/08 , C07C313/18 , C07C313/20 , C11D1/00 , C07C149/20
CPC分类号： C10M1/08 , A01N47/04 , C10M2201/02 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2219/00 , C10M2219/085 , C10N2240/62
摘要： N - TRIHALOGENMETHYLMERCAPTO - N TRIFLUOROMETHYLAMINO-BENZOIC ACID PHENYL ESTERS, I.E. (OPTIONALLY METHYL, (TRIFLUOROMETHYL, METHOXY, CHLORO OR NITRO - SUBSITUTED)(N - TRIHALOGENMETHYLMERCAPTO-N-TRIFLUOROMETHYL-AMINO)BENZOIC ACID (CARBOXY AND ALKOXYCARBONYL-SUBSITUTED)PHENYL ESTERS, WHICH POSSESS PESTICIDAL, ESPECIALLY ANTIMICROBIAL, PROPERTIES AND WHICH MAY BE PRODUCED BY CONVENTIONAL METHODS.

92. 发明授权

US3312695A Isophthalic acid derivatives 失效
标题翻译：间苯二甲酸衍生物
公开(公告)号：US3312695A
公开(公告)日：1967-04-04
申请号：US39177564
申请日：1964-08-24
申请人： SCHWEIZERHALL CHEM FAB
发明人： HERBERT MUHLE
IPC分类号： A61K31/19 , C07C69/82 , C07C69/88 , C07C69/90 , C07C233/12
CPC分类号： A61K31/19 , C07C69/82 , C07C69/88 , C07C69/90 , C07C233/12

93. 发明授权

US1947943A Process of preparing condensation products of the benzanthrone series and new products obtainable thereby 失效
标题翻译：制备苯醌酮缩合产物的方法及其可获得的新产品
公开(公告)号：US1947943A
公开(公告)日：1934-02-20
申请号：US42389330
申请日：1930-01-27
申请人： GEN ANILINE WORKS INC
发明人： GEORG KRAENZLEIN , MARTIN COREIL
IPC分类号： C07C69/90
CPC分类号： C07C69/90

94. 发明公开

US20240180945A1 COMPOUNDS AND PHARMACEUTICAL USES THEREOF 审中-公开
公开(公告)号：US20240180945A1
公开(公告)日：2024-06-06
申请号：US18493421
申请日：2023-10-24
申请人： SyneuRx International (Taiwan) Corp.
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/7048 , A23L33/00 , A23L33/10 , A61K31/235 , A61K31/36 , A61K31/40 , A61K31/415 , A61K31/7034 , A61P25/18 , C07C69/90 , C07D207/34 , C07D231/14 , C07D317/68 , C07H15/22 , C07H15/26
CPC分类号： A61K31/7048 , A23L33/10 , A23L33/40 , A61K31/235 , A61K31/36 , A61K31/40 , A61K31/415 , A61K31/7034 , A61P25/18 , C07C69/90 , C07D207/34 , C07D231/14 , C07D317/68 , C07H15/22 , C07H15/26 , A23V2002/00
摘要： A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC═OR6, (C═O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).

95. 发明申请

US20230028516A1 PRODRUGS OF ITACONATE AND METHYL ITACONATE 有权
公开(公告)号：US20230028516A1
公开(公告)日：2023-01-26
申请号：US17772879
申请日：2020-10-29
申请人： The Johns Hopkins University , INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I.
发明人： Barbara Slusher , Mohameed Islam , Rana Rais , Luis Garza , Benjamin Bell , Pavel Majer , Lukas Tenora , Ivan Snajdr , Marcela Krecmerova
IPC分类号： C07C69/593 , C07C69/90 , C07C271/22 , C07C237/12 , C07C229/36
摘要： Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.

96. 发明授权

US09527878B2 Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism 有权
公开(公告)号：US09527878B2
公开(公告)日：2016-12-27
申请号：US14817690
申请日：2015-08-04
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , EASTERN MICHIGAN UNIVERSITY
发明人： Daniel A. Lawrence , Cory Emal , Jacqueline Cale , Enming Joe Su , Mark Warnock , Shih-Hon Li , Jeanne Ann Cupp
IPC分类号： C07H15/203 , A61K31/7034 , A61K38/17 , C07C69/94 , A61K31/235 , C07C271/22 , A61K31/27 , C07C311/29 , A61K31/18 , C07C235/68 , A61K31/166 , C07D213/82 , A61K31/444 , C07D295/192 , A61K31/495 , C07C311/49 , C07D295/26 , A61K31/50 , A61K31/5375 , C07C69/88 , C07C69/90 , C07C229/12 , C07C229/34 , C07C271/54 , C07H13/08 , A61K38/48 , C07D295/195
CPC分类号： C07H15/203 , A61K31/166 , A61K31/18 , A61K31/235 , A61K31/27 , A61K31/444 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/7034 , A61K38/1741 , A61K38/482 , C07C69/88 , C07C69/90 , C07C69/94 , C07C229/12 , C07C229/34 , C07C235/68 , C07C271/22 , C07C271/54 , C07C311/29 , C07C311/49 , C07C2601/14 , C07D213/82 , C07D295/192 , C07D295/195 , C07D295/26 , C07H13/08 , C12Y304/21073
摘要： The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

97. 发明授权

US09295276B2 Flavor improving agent 有权
标题翻译：香精改善剂
公开(公告)号：US09295276B2
公开(公告)日：2016-03-29
申请号：US14154092
申请日：2014-01-13
申请人： TAKASAGO INTERNATIONAL CORPORATION
发明人： Yoshikazu Toyohara , Tadahiro Hiramoto
IPC分类号： C07H13/08 , C07C69/90 , A23L1/221 , A23L1/22 , A23L1/222 , A61K8/97 , A61Q11/00
CPC分类号： A23L1/2215 , A23L27/11 , A23L27/12 , A23L27/84 , A23L27/86 , A23V2002/00 , A61K8/97 , A61Q11/00 , C07C69/90 , C07C2601/16 , C07H13/08 , A23V2200/14 , A23V2200/16 , A23V2250/21
摘要： Disclosed is a flavor improving agent that is a fraction derived from fruit juice or squeeze. A fraction wherein the amount of substance ratio between polyphenols and saccharides, the latter after acid hydrolysis of the fraction, (polyphenol/saccharide) is 0.1-10, and even more preferably, wherein the amount of substance ratio of the polyphenol and the saccharide before acid hydrolysis of the fraction (polyphenol/saccharide) is 1-100, and is used as a flavor improving agent. Such fraction are obtained with a method such as by a fruit juice or squeeze being absorbed onto a synthetic resin adsorbent and the adsorbed components being eluted by a solvent, or by extracting fruit juice or squeeze with ethanol. The flavor improving agent has flavor improving effects such as suppressing sourness, bitterness and astringency of foods and beverages, reducing harsh taste, contributing to a juice-like feel and contributing to a richness. In addition to foods and beverages, the flavor improving agent can also be added to pharmaceutical products or oral care products and the like, as well as to flavor composition.
摘要翻译：公开了作为来自果汁或挤压的成分的风味改善剂。其中多酚和糖类之间的物质比例（后者在该级分酸水解后）（多酚/糖）为0.1-10，甚至更优选其中多酚和前述糖的物质比例级分（多酚/糖）的酸水解为1-100，用作风味改善剂。这样的馏分是通过果汁或挤压法吸附在合成树脂吸附剂上的方法获得的，吸附成分被溶剂洗脱，或者通过提取果汁或用乙醇挤压。风味改善剂具有抑制食品和饮料的酸味，苦味和涩味的风味改善效果，减少粗糙的味道，有助于果汁感觉并有助于丰富。除了食品和饮料之外，还可以将风味改善剂加入到药物产品或口腔护理产品等中，以及调味剂组合物。

98. 发明授权

US5938973A Swallow-tailed compound and ferrielectric liquid crystal composition containing the same 失效
标题翻译：燕尾化合物和含有它的电致液晶组合物
公开(公告)号：US5938973A
公开(公告)日：1999-08-17
申请号：US927795
申请日：1997-09-11
申请人： Yuki Motoyama , Tomoyuki Yui , Masahiro Johno , Takahiro Matsumoto
发明人： Yuki Motoyama , Tomoyuki Yui , Masahiro Johno , Takahiro Matsumoto
IPC分类号： G02F1/13 , C07C69/86 , C07C69/90 , C09K19/02 , C09K19/06 , C09K19/20 , C09K19/46 , C09K19/12 , C07C69/76
CPC分类号： C09K19/2021 , C07C69/90 , C09K19/02 , C09K19/06
摘要： A swallow-tailed compound of the following general formula (1), ##STR1## wherein m is an integer of 4 to 10, n is an integer of 2 to 6, p is 0 or 1 and each of X and Y is independently a hydrogen or fluorine atom; and a ferrielectric liquid crystal composition consisting essentially of the swallow-tailed compound of the general formula (1) and a ferrielectric liquid crystal compound of the following general formula (2), ##STR2## wherein R is a linear alkyl group having 6 to 12 carbon atoms, Z is a hydrogen or fluorine atom, r is an integer of 2 to 4 and s is an integer of 2 to 4. The ferrielectric liquid crystal composition has a ferrielectric phase in a broad temperature range and attains a fast response and a large tilt angle in a broad temperature range so that a ferrielectric liquid crystal display device having high display qualities can be provided.
摘要翻译：下述通式（1）的燕尾化合物，其中m为4〜10的整数，n为2〜6的整数，p为0或1，X和Y各自独立地为氢或氟原子; 和基本上由通式（1）的燕尾化合物和以下通式（2）的电介质液晶化合物组成的电介质液晶组合物，其中R是具有6至12个碳原子的直链烷基， Z为氢或氟原子，r为2〜4的整数，s为2〜4的整数。电介质液晶组合物具有宽温度范围内的电介质相，具有快速响应和大倾角在宽的温度范围内，可以提供具有高显示质量的电介质液晶显示装置。

99. 发明授权

US5853613A Chiral cyclohexyl compounds 失效
标题翻译：手性环己基化合物
公开(公告)号：US5853613A
公开(公告)日：1998-12-29
申请号：US765713
申请日：1997-01-16
申请人： John William Goodby , Kenneth Johnson Toyne , Michael Hird , Stephen John Lock
发明人： John William Goodby , Kenneth Johnson Toyne , Michael Hird , Stephen John Lock
IPC分类号： G02F1/13 , C07C13/28 , C07C25/18 , C07C35/21 , C07C43/188 , C07C43/192 , C07C43/21 , C07C43/225 , C07C43/23 , C07C69/90 , C07C255/46 , C09K19/02 , C09K19/30 , C09K19/34 , C09K19/42 , C09K19/46 , C07C29/20 , C09K19/12
CPC分类号： C07C43/192 , C07C43/21 , C07C43/225 , C07C43/23 , C09K19/0233 , C09K19/3003 , C09K19/3066 , C09K19/42 , C09K19/46 , C07C2101/14 , C09K2019/123
摘要： The present invention describes liquid crystal compounds which are suitable for use in liquid crystal devices including those which exploit the electroclinic effect.
摘要翻译： PCT No.PCT / GB95 / 01538 Sec。 371日期1997年1月16日 102（e）日期1997年1月16日PCT Filed 1995年6月29日PCT公布。出版物WO96 / 00710 日本1996年1月11日本发明描述了适用于液晶装置的液晶化合物，包括利用电极效应的液晶化合物。

100. 发明授权

US5618839A Retinoid-like compounds 失效
标题翻译：类视黄醇样化合物
公开(公告)号：US5618839A
公开(公告)日：1997-04-08
申请号：US643142
申请日：1996-05-02
申请人： John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek
发明人： John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek
IPC分类号： A61K31/695 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/255 , A61P17/00 , A61P35/00 , A61P43/00 , C07C17/16 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/67 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C51/09 , C07C63/331 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/28 , C07C65/36 , C07C67/14 , C07C67/317 , C07C67/333 , C07C67/343 , C07C69/00 , C07C69/618 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/82 , C07C69/83 , C07C69/90 , C07C69/92 , C07C69/94 , C07C205/06 , C07C205/45 , C07C205/58 , C07C227/18 , C07C229/38 , C07C229/60 , C07C231/02 , C07C231/12 , C07C233/15 , C07C233/54 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/81 , C07C233/87 , C07C309/71 , C07C309/75 , C07C319/14 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07F7/10 , A61K31/21 , A61K31/185 , C07C229/34
CPC分类号： C07C69/00 , C07C17/16 , C07C205/06 , C07C205/45 , C07C205/58 , C07C229/38 , C07C229/60 , C07C233/65 , C07C233/76 , C07C233/81 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/673 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/36 , C07C69/618 , C07C69/76 , C07C69/82 , C07C69/90 , C07C69/92 , C07C2102/08 , C07C2102/10 , C07C2103/00 , C07C2103/24 , Y10S514/825
摘要： The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 -- or --CR.sup.5 .dbd.CR.sup.6 --;R.sup.m and R.sup.k are independently hydrogen, halogen, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkyloxy or nitro;n is zero or one;R.sup.4 is --(CH.sub.2).sub.t --Y, C.sub.1-6 alkyl, or C.sub.3-6 cycloalkyl;R.sup.1 is --CO.sub.2 Z, C.sub.1-6 alkyl, CH.sub.2 OH, --CONHR.sup.y, or CHO;R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl;R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl; but when n is one, R.sup.a and R.sup.b together can form a radical of the formula ##STR2## Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C.sub.1-6 alkyl or halogen;Z is hydrogen or C.sub.1-6 alkyl;R.sup.5, R.sup.6 and R.sup.y are independently hydrogen or C.sub.1-6 alkyl; andt is zero to six.
摘要翻译：本发明涉及式I的化合物或其无毒的药学上可接受的盐，生理上可水解的酯或其溶剂合物，其中X是-O-CO-，-NH-CO-，-CS-NH-， -CO-O-，-CO-NH-，-COS-，-SCO-，-SCH 2 - ， - CH 2 -CH 2 - ， - C 3BOND C - ， - CH 2 -NH-，-COCH 2 - ， - NHCS-， -CH 2 S - ， - CH 2 O - ， - OCH 2 - ， - NHCH 2 - 或-CR 5 = CR 6 - ; R m和R k独立地是氢，卤素，C 1-6烷基，羟基，C 1-6烷氧基或硝基; n为零或一; R4是 - （CH2）t-Y，C1-6烷基或C3-6环烷基; R1是-CO2Z，C1-6烷基，CH2OH，-CONHRy或CHO; R2和R3独立地是氢或C1-6烷基; R a和R b独立地是氢或C 1-6烷基; 但是当n为1时，R a和R b可以一起形成下式的基团：Y是萘基或苯基，两个基团可任选地被一至三个相同或不同的C 1-6烷基或卤素取代; Z是氢或C 1-6烷基; R5，R6和Ry独立地是氢或C1-6烷基; t为0〜6。

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