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91. 发明专利

CA2014965A1 RELEASE OF CELLS FROM AFFINITY MATRICES 未知
公开(公告)号：CA2014965A1
公开(公告)日：1990-10-25
申请号：CA2014965
申请日：1990-04-19
申请人： UNIV JOHNS HOPKINS
发明人： CIVIN CURT I
IPC分类号： A61K35/28 , C12N5/06 , C12N5/08 , C12Q1/24 , C12S3/00 , C12S3/22

92. 发明专利

RU2008129408A ЭКСПРЕСС-СПОСОБ ОПРЕДЕЛЕНИЯ АКТИВНОСТИ АЦЕТИЛХОЛИНЭСТЕРАЗЫ 未知
公开(公告)号：RU2008129408A
公开(公告)日：2010-01-27
申请号：RU2008129408
申请日：2008-07-18
IPC分类号： A61B5/145 , C12Q1/46 , C12S3/22
摘要： 1. Экспресс-способопределенияактивностиацетилхолинэстеразы, включающийеевзаимодействиес обратимымингибитором-флуорогеномс образованиемфлуоресцирующегокомплекса, отличающийсятем, чтов качествеингибитора-флуорогенаиспользуютиндикатормолекулярныйротор, напримертиофлавинТ, образующийс ацетилхолинэстеразойустойчивыйинтенсивнофлуоресцирующийкомплекс, чтообеспечиваетболеевысокуючувствительностьопределенияактивностиацетилхолинэстеразыи позволяетрасширитьдиапазонопределенияактивностиацетилхолинэстеразыв областьеенизкойактивности. ! 2. Способпоп.1, отличающийсяселективностьютиофлавинаТ поотношениюк ацетилхолинэстеразеи позволяющийпонизитьпогрешностьрезультатованализа.

93. 发明专利

EA200501323A1 ПОЛУЧЕНИЕ ЭРИТРОЦИТОВ С МОДИФИЦИРОВАННЫМ УРОВНЕМ ЭКСПРЕССИИ АНТИГЕНОВ ГРУПП КРОВИ И ИХ ПРИМЕНЕНИЕ В КОНТРОЛЕ КАЧЕСТВА РЕАГЕНТОВ ДЛЯ ОПРЕДЕЛЕНИЯ ГРУППЫ КРОВИ 未知
公开(公告)号：EA200501323A1
公开(公告)日：2006-04-28
申请号：EA200501323
申请日：2004-02-17
IPC分类号： C12S3/22 , C12N5/078 , G01N33/80 , G01N33/96
摘要： Способполученияэритроцитов, экспрессирующихуменьшенныеуровниантигеновгруппкрови, сиспользованиемпоменьшеймереодногомодифицирующегоиммунодоминантныйсахарфермента, напримеральфа-N-ацетилгалактозаминидазыилиальфа-галактозидазы. Полученныеэритроцитыпредпочтительноэкспрессируютуровеньантигена, посуществуэквивалентныйклиническизначимомупорогудляэтогоантигена. Эритроциты, полученныев соответствиис указаннымспособом, используютдляконтролякачествареагентовдляопределениягруппыкровии калибровкитестирующихсистемдляобеспеченияточныхи стандартизованныхопределенийтиповгруппкрови.

94. 发明专利

DE69232928D1 未知
公开(公告)号：DE69232928D1
公开(公告)日：2003-03-27
申请号：DE69232928
申请日：1992-08-21
申请人： ALBERTA RES COUNCIL , INTEGRIS BAPTIST MED CENTER INC
发明人： GOOD A HEATHER , COOPER DAVID K C , MALCOLM ANDREW J
IPC分类号： A61K35/12 , A61K35/14 , A61K39/00 , A61M1/36 , A61P37/00 , A61K31/70 , A61K31/715 , A01N1/00 , C12S3/02 , C12S3/22 , A61P37/06
摘要： Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.

95. 发明专利

CA2096654C REMOVAL OF ANTIBODIES FROM BLOOD-DERIVED COMPOSITIONS WHILE RETAINING COAGULATION FACTORS 未知
公开(公告)号：CA2096654C
公开(公告)日：2001-02-27
申请号：CA2096654
申请日：1993-05-19
申请人： NEW YORK BLOOD CT INC
发明人： HOROWITZ BERNARD , CHIN SING N
IPC分类号： A61K35/16 , A61K38/16 , A61K38/43 , C12S3/22 , G01N33/86 , C12N7/06 , C07K17/00 , A61K35/14 , A61L2/16 , A61M1/36 , A61K38/46
摘要： This invention relates to methods of removing undesired antibodies from blood-derived compositions containing both the antibodies and coagulation factors, such that the coagulation factors are substantially retained in the composition. The undesired antibodies may be blood group antibodies. This invention also relates to compositions in which undesired antibodies have been removed and desired coagulation factors are retained. This invention further relates to methods of inactivating virus and removing undesired antibodies from blood-derived compositions containing virus, antibodies and coagulation factors without removing coagulation factors therefrom, and to the resulting compositions.

96. 发明专利

AT183098T 未知
公开(公告)号：AT183098T
公开(公告)日：1999-08-15
申请号：AT93303997
申请日：1993-05-24
申请人： NEW YORK BLOOD CENTER INC
发明人： HOROWITZ BERNARD , CHIN SING N
IPC分类号： A61K35/16 , A61K38/16 , A61K38/43 , C12S3/22 , G01N33/86
摘要： This invention relates to methods of removing undesired antibodies from blood-derived compositions containing both the antibodies and coagulation factors, such that the coagulation factors are substantially retained in the composition. The undesired antibodies may be blood group antibodies. This invention also relates to compositions in which undesired antibodies have been removed and desired coagulation factors are retained. This invention further relates to methods of inactivating virus an removing undesired antibodies from blood-derived compositions containing virus, antibodies and coagulation factors without removing coagulation factors therefrom, and to the resulting compositions.

97. 发明专利

DK0516313T3 未知
公开(公告)号：DK0516313T3
公开(公告)日：1999-06-14
申请号：DK92304374
申请日：1992-05-14
申请人： ORTHO DIAGNOSTIC SYSTEMS INC
发明人： MOCHNAL DENNIS , JAKWAY JANICE , QUINTON GILBERT J
IPC分类号： A61K35/18 , C12S3/22 , G01N33/50 , G01N33/543 , G01N33/554 , G01N33/80
摘要： A method for preparing treated naturally occurring or synthetic particles using a blood cell processor is provided. The method comprises adjusting the blood cell processor to allow a dispersion of such particles to come into contact with a treatment material in an amount and for a period of time sufficient to modify all or a portion of the surface of such particles. In a preferred embodiment, the method comprises washing collected red blood cells; separating a selected volume of said washed red blood cells; and treating one portion of said separated washed cells with a selected proteolytic enzyme, to prepare a red blood cell reagent.

98. 发明专利

DE69227067T2 未知
公开(公告)号：DE69227067T2
公开(公告)日：1999-04-08
申请号：DE69227067
申请日：1992-05-14
申请人： ORTHO DIAGNOSTIC SYSTEMS INC
发明人： MOCHNAL DENNIS , JAKWAY JANICE , QUINTON GILBERT J
IPC分类号： A61K35/18 , C12S3/22 , G01N33/50 , G01N33/543 , G01N33/554 , G01N33/80
摘要： A method for preparing treated naturally occurring or synthetic particles using a blood cell processor is provided. The method comprises adjusting the blood cell processor to allow a dispersion of such particles to come into contact with a treatment material in an amount and for a period of time sufficient to modify all or a portion of the surface of such particles. In a preferred embodiment, the method comprises washing collected red blood cells; separating a selected volume of said washed red blood cells; and treating one portion of said separated washed cells with a selected proteolytic enzyme, to prepare a red blood cell reagent.

99. 发明专利

DE69416510D1 未知
公开(公告)号：DE69416510D1
公开(公告)日：1999-03-25
申请号：DE69416510
申请日：1994-03-17
申请人： BAXTER INT
发明人： CHAPMAN ARTHUR S , DENNEHEY T , BROWN RICHARD , WILLIAMSON WARREN
IPC分类号： A61M1/10 , A61M1/36 , C12S3/22 , F02B75/02 , F04B43/12 , F04C5/00 , F04B43/08
摘要： A peristaltic pump tube holder has a body having first and second pump tube connectors extending outside of it. The pump tube connectors extend at an acute angle relative to a surface of the body to receive a flexible tubing loop and orient the tubing loop for engagement with an external peristaltic pump rotor.

100. 发明专利

ES2121823T3 未知
公开(公告)号：ES2121823T3
公开(公告)日：1998-12-16
申请号：ES92304374
申请日：1992-05-14
申请人： ORTHO DIAGNOSTIC SYSTEMS INC
发明人： MOCHNAL DENNIS , JAKWAY JANICE , QUINTON GILBERT J
IPC分类号： A61K35/18 , C12S3/22 , G01N33/50 , G01N33/543 , G01N33/554 , G01N33/80
摘要： A method for preparing treated naturally occurring or synthetic particles using a blood cell processor is provided. The method comprises adjusting the blood cell processor to allow a dispersion of such particles to come into contact with a treatment material in an amount and for a period of time sufficient to modify all or a portion of the surface of such particles. In a preferred embodiment, the method comprises washing collected red blood cells; separating a selected volume of said washed red blood cells; and treating one portion of said separated washed cells with a selected proteolytic enzyme, to prepare a red blood cell reagent.

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