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92. 发明专利

JP2006206613A Method and composition for treating and preventing mucositis 审中-公开
标题翻译：治疗和预防肌瘤的方法和组合
公开(公告)号：JP2006206613A
公开(公告)日：2006-08-10
申请号：JP2006129700
申请日：2006-05-08
申请人： Mucosal Therapeutics Llc , ミュコーサルセラピューティックスエルエルシー
发明人： SONIS STEPHEN T , FEY EDWARD G
IPC分类号： A61K45/06 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/4465 , A61K31/45 , A61K31/65 , A61P1/02 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： A61K31/454 , A61K31/235 , A61K31/65 , A61K45/06 , Y10S514/899 , A61K31/195 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an effective method for treating and preventing mucositis.
SOLUTION: The method of treating, inhibiting or preventing the mucositis in a human patient includes a step for administering a therapeutic composition having activities as an MMP inhibitor and an NO inhibitor. In one embodiment, the method further includes a step for administering an NSAID, which is a COX-1 or COX-2 inhibitor, and in another embodiment, the COX-1 inhibitors are indomethacin and flurbiprofen. In another embodiment, the method includes a step for administering an inflammatory cytokine inhibitor selected from the group consisting of an IL-6 inhibitor, a TNF-α inhibitor, an IL-1 inhibitor, and an interferon-γ inhibitor besides them.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供治疗和预防粘膜炎的有效方法。解决方案：治疗，抑制或预防人类患者的粘膜炎的方法包括给予具有作为MMP抑制剂和NO抑制剂的活性的治疗组合物的步骤。在一个实施方案中，该方法还包括施用作为COX-1或COX-2抑制剂的NSAID的步骤，在另一个实施方案中，所述COX-1抑制剂是吲哚美辛和氟比洛芬。在另一个实施方案中，该方法包括除了它们之外，还施用选自由IL-6抑制剂，TNF-α抑制剂，IL-1抑制剂和干扰素-γ抑制剂组成的组的炎性细胞因子抑制剂的步骤。版权所有（C）2006，JPO＆NCIPI

93. 发明专利

JP2005068112A Extract from grifola frondosa (a kind of mushroom) and glycoprotein and method for producing the same 有权
标题翻译：来自GRIFOLA FRONDOSA（一种MUSHROOM）和GLYCOPROTEIN的提取物及其生产方法
公开(公告)号：JP2005068112A
公开(公告)日：2005-03-17
申请号：JP2003303462
申请日：2003-08-27
申请人： Shirata Masaki , 白田正樹
发明人： SHIYOU MURA , KAWAGISHI HIROKAZU , PREUSS HENRY G
IPC分类号： A23L1/30 , A61K36/07 , A61K38/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , C07K1/14 , C07K14/375 , C12P21/00 , C12R1/645 , A61K35/84
CPC分类号： A61K36/07 , A61K36/074 , Y10S514/899
摘要： PROBLEM TO BE SOLVED: To provide the extract and glycoprotein originating from Grifola frondosa that can be applied for prevention and therapy of syndrome X or visceral fat syndrome as well as diabetes, hypertension, obesity, hyperlipemia and provide a production method that can stably give the practical and physiologically active substance. SOLUTION: A method for obtaining an extract from the fruit body of Grifola frondosa is disclosed in which the fruit body is extracted with no use of solvent hazardous to human body, for example, acetone or ether and the inadequate substances as a healthy food, because they has immunosuppressive action, can be removed almost perfectly. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供可用于预防和治疗综合症X或内脏脂肪综合征以及糖尿病，高血压，肥胖症，高脂血症的来源于叶柄菌的提取物和糖蛋白，并提供可以稳定地给予实用和生理活性物质。解决方案：公开了一种获得来自三叶草果实的提取物的方法，其中不使用对人体有害的溶剂（例如丙酮或乙醚）提取果实体，并且不适当的物质作为健康食物，因为它们具有免疫抑制作用，可以几乎完全去除。版权所有（C）2005，JPO＆NCIPI

94. 发明专利

JP2003002838A Soybean extract, preparation method therefor and pharmaceutical composition 审中-公开
标题翻译：大豆提取物，其制备方法和药物组合物
公开(公告)号：JP2003002838A
公开(公告)日：2003-01-08
申请号：JP2002120590
申请日：2002-04-23
申请人： Indena Spa , インデナエッセピア
发明人： BOMBARDELLI EZIO , GABETTA BRUNO
IPC分类号： A61K31/704 , A61K20060101 , A61K9/64 , A61K31/7048 , A61K36/00 , A61K36/48 , A61K131/00 , A61P20060101 , A61P5/00 , A61P13/08 , A61P15/00 , A61P15/12 , A61P25/32 , A61P31/00 , A61P35/00 , A61P35/02 , B01D11/02 , C07D311/04 , C07G11/00 , C07H15/00 , C07H17/07 , C07J1/00 , C07K1/14 , A61K35/78
CPC分类号： A61K36/48 , Y10S514/811 , Y10S514/899
摘要： PROBLEM TO BE SOLVED: To obtain a new soybean extract containing soybean saponin in a predetermined proportion to isoflavone glucoside, a preparation method therefor and a pharmaceutical composition containing the extract.
SOLUTION: The soybean extract contains isoflavone glucoside of at least 13 wt.% and a group B soybean saponin of 0.6-1.5 pts.wt. with respect to isoflavone glucoside of 1 pt.wt. The preparation method for producing the extract and the pharmaceutical preparation containing the extract for treating cancers, or the like, are also provided.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：为了获得含有大豆皂甙的新的大豆皂甙，其规定比例为异黄酮糖苷，其制备方法和含有提取物的药物组合物。解决方案：大豆提取物含有至少13重量％的异黄酮糖苷和0.6-1.5重量份的B组大豆皂角苷。相对于1重量％的异黄酮糖苷还提供了用于制备提取物的制备方法和含有用于治疗癌症的提取物的药物制剂等。

95. 发明授权

KR101901170B1 능이버섯 추출물을 유효성분으로 함유하는 월경전 증후군의 예방 또는 치료용 약학적 조성물 有权
公开(公告)号：KR101901170B1
公开(公告)日：2018-09-27
申请号：KR1020170071366
申请日：2017-06-08
申请人： 우혜진
发明人： 우대하 , 우혜진
IPC分类号： A61K36/07 , A23L33/105
CPC分类号： A61K36/07 , A23L33/105 , A23V2002/00 , A23V2200/30 , A23V2250/208 , Y10S514/899
摘要： 본발명은능이버섯추출물을유효성분으로함유하는월경전증후군의예방또는치료용조성물에관한것이다. 구체적으로, 본발명의능이버섯추출물은 1회만복용하여도하복부통증, 요통, 유방통, 두통, 폭식, 불면증, 무기력함, 감정기복또는우울증등과같은월경전증후군의증상을없애주고, 상기효과가 1년이상지속되도록하며, 월경통을완화시키고, 월경기간, 월경의양, 월경불순및 어혈을감소시키며, 월경의색을맑게함을확인함으로써월경전증후군의예방또는치료에유용하게사용될수 있다.

96. 发明公开

KR1020050098296A 아로마타제 억제제, 프로게스틴 및 에스트로겐의 조합물을포함하는 조성물 및 자궁내막증의 치료를 위한 이의 용도 失效
标题翻译：包含AROMATASE抑制剂，PROGESTIN和雌激素的组合的组合物及其用于治疗子宫内膜异位症的用途
公开(公告)号：KR1020050098296A
公开(公告)日：2005-10-11
申请号：KR1020057014375
申请日：2004-02-03
申请人： 아스트라제네카 아베
发明人： 러빈스티븐
IPC分类号： A61K31/5685 , A61K31/567 , A61K31/519
CPC分类号： A61K31/519 , A61K31/4184 , A61K31/4196 , A61K31/567 , A61K31/5685 , Y10S514/899 , A61K2300/00
摘要： The invention relates to a method of treating endometriosis using a combination of an aromatase inhibitor, a progestin and an oestrogen. The invention also relates to pharmaceutical formulations comprising said combination.
摘要翻译：本发明涉及使用芳香酶抑制剂，孕激素和雌激素的组合治疗子宫内膜异位症的方法。本发明还涉及包含所述组合的药物制剂。

97. 发明公开

KR1020030064725A 월경 곤란증 치료효과가 있는 약제 有权
标题翻译：药物有效治疗痛经
公开(公告)号：KR1020030064725A
公开(公告)日：2003-08-02
申请号：KR1020030048678
申请日：2003-07-16
申请人： 아답트겐 세이야쿠 가부시키가이샤
发明人： 하야시세이지
IPC分类号： A61K38/00
CPC分类号： A61K35/57 , A23L33/10 , A23V2002/00 , A23V2250/55 , Y10S514/899
摘要： 본 발명은 월경곤란증 치료효과가 기대되는 펩티드와 히알루론산을 함유한 계관추출물을 유효성분으로하는 건강보조식품 또는 약제로서의 용도에 관한 것이다.

98. 发明公开

KR1020030018625A 한약 추출물을 이용한 여성 생리질환용 한방 기능성 내의제조방법 및 이로부터 제조된 생리질환용 한방 기능성 내의 无效
标题翻译：生产功能性治疗方法，用于使用草药提取物治疗妇科疾病及其获得的功能治疗
公开(公告)号：KR1020030018625A
公开(公告)日：2003-03-06
申请号：KR1020010052840
申请日：2001-08-30
申请人： 주식회사 허브메디
发明人： 신광호
IPC分类号： A41B9/00
CPC分类号： A41B9/04 , A61K9/50 , A61K36/282 , A61K36/324 , A61K36/61 , A61K36/65 , Y10S514/899
摘要： PURPOSE: Provided is a method for producing a functional undergarment for treatment of gynecologic disease using herbal extract which can be used for treatment and prevention of gynecologic disease such as menstral pain, itch and the functional undergarment obtained therefrom. CONSTITUTION: The method for producing a functional undergarment for treatment of gynecologic disease comprises extracting and filtering oil-soluble components from at least one herb; mixing the filtered herbal extract with 5 to 30 % by weight of polyvinylalcohol; mixing 5 to 30% by weight of melamine in the liquid phase with the herbal extract at a temperature of 60 to 80 deg.C, followed by cooling and formulating the mixture of the herbal extract/polyvinyl alcohol/melamine into micro-capsules; and mixing the micro-capsules with a binder and subject to a dipping process with a fabric to attach the micro-capsules to the fabric.
摘要翻译：目的：提供一种使用草药提取物治疗妇科疾病的功能性内衣的方法，所述草药提取物可用于治疗和预防妇科疾病如月经痛，瘙痒和由其获得的功能性内衣。构成：用于治疗妇科疾病的功能性内衣的制备方法包括从至少一种药草中提取和过滤油溶性成分; 将过滤的草药提取物与5至30重量％的聚乙烯醇混合; 将5〜30重量％的液相中的三聚氰胺与草药提取物在60〜80℃的温度下混合，然后将草药提取物/聚乙烯醇/三聚氰胺的混合物冷却并配制成微胶囊; 并将微胶囊与粘合剂混合并进行与织物的浸渍过程以将微胶囊连接到织物上。

99. 发明申请

WO2004069260A1 COMPOSITON COMPRISING A COMBINATION OF AN AROMATASE INHIBITOR, A PROGESTIN AND AN OESTROGEN AND ITS USE FOR THE TREATMENT OF ENDOMETRIOSIS 审中-公开
标题翻译：包含芳香酶抑制剂，丙酸和雌激素的组合的组合物及其用于治疗子宫内膜异位症的用途
公开(公告)号：WO2004069260A1
公开(公告)日：2004-08-19
申请号：PCT/GB2004/000414
申请日：2004-02-03
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , RUBIN, Stephen
发明人： RUBIN, Stephen
IPC分类号： A61K31/5685
CPC分类号： A61K31/519 , A61K31/4184 , A61K31/4196 , A61K31/567 , A61K31/5685 , Y10S514/899 , A61K2300/00
摘要： The invention relates to a method of treating endometriosis using a combination of an aromatase inhibitor, a progestin and an oestrogen. The invention also relates to pharmaceutical formulations comprising said combination.
摘要翻译：本发明涉及使用芳香酶抑制剂，孕激素和雌激素的组合治疗子宫内膜异位症的方法。本发明还涉及包含所述组合的药物制剂。

100. 发明申请

WO0229105A9 INHIBITION OF TGF- beta AND USES THEREOF 审中-公开
标题翻译： TGF-β的抑制及其用途
公开(公告)号：WO0229105A9
公开(公告)日：2003-02-13
申请号：PCT/US0130872
申请日：2001-10-03
申请人： LONG ISLAND JEWISH RES INST
发明人： TABIBZADEH SIAMAK , MASON JAMES M
IPC分类号： A61K38/18 , C07K14/47 , C12Q1/68 , A01N37/18 , A61K38/00 , C07K1/00 , C07K14/00 , C07K17/00 , G01N33/574
CPC分类号： A61K38/1841 , C07K14/47 , C12Q1/6883 , Y10S514/899
摘要： The present invention provides a method for inhibiting activity of TGF- beta , comprising contacting tissue expressing TGF- beta with an amount of ebaf or an ebaf analogue. The present invention further provides a method for treating a condition associated with overactivity of TGF- beta , particularly fibrosis, a defect in cell proliferation, or a coagulation defect. The present invention also provides a method for inhibiting activity of TGF- beta , comprising contacting tissue expressing TGF- beta with a modulator of ebaf expression, or a modulator of expression of an ebaf analogue. The present invention is further directed to a method for treating fibrosis in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the fibrosis. Finally, the present invention provides a method for treating a defect in cell proliferation in a subject in need of treatment, comprising administering to the subject an amount of ebar or an ebaf analogue effective to treat the defect in cell proliferation.
摘要翻译：本发明提供了一种抑制TGF-β活性的方法，包括使表达TGF-β的组织与一定量的ebaf或ebaf类似物接触。本发明还提供了一种治疗与TGF-β过度活跃，特别是纤维化，细胞增殖缺陷或凝血缺陷有关的病症的方法。本发明还提供一种抑制TGF-β活性的方法，包括使表达TGF-β的组织与ebaf表达的调节剂或ebaf类似物的表达调节剂接触。本发明还涉及在需要治疗的受试者中治疗纤维化的方法，其包括对受试者施用一定量的有效治疗纤维化的ebaf或ebaf类似物。最后，本发明提供了一种治疗需要治疗的受试者的细胞增殖缺陷的方法，其包括对受试者施用一定量的有效治疗细胞增殖缺陷的ebar或ebaf类似物。

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